Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQK3_LEIMU

TriTrypDb:

LmxM.16.0450

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AQK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.351
CLV_PCSK_KEX2_1	122	124	PF00082	0.425
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.419
CLV_PCSK_SKI1_1	99	103	PF00082	0.384
DEG_APCC_DBOX_1	131	139	PF00400	0.355
DEG_SCF_FBW7_1	71	78	PF00400	0.514
DEG_SPOP_SBC_1	5	9	PF00917	0.644
DOC_CKS1_1	51	56	PF01111	0.497
DOC_MAPK_MEF2A_6	132	140	PF00069	0.433
DOC_USP7_MATH_1	148	152	PF00917	0.382
DOC_USP7_MATH_1	3	7	PF00917	0.726
DOC_WW_Pin1_4	50	55	PF00397	0.520
DOC_WW_Pin1_4	71	76	PF00397	0.497
LIG_14-3-3_CanoR_1	106	115	PF00244	0.491
LIG_14-3-3_CanoR_1	11	21	PF00244	0.689
LIG_14-3-3_CanoR_1	63	68	PF00244	0.505
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_FHA_1	135	141	PF00498	0.345
LIG_FHA_1	208	214	PF00498	0.332
LIG_FHA_2	204	210	PF00498	0.402
LIG_FHA_2	53	59	PF00498	0.639
LIG_LIR_Apic_2	19	24	PF02991	0.690
LIG_LIR_Gen_1	110	121	PF02991	0.409
LIG_LIR_Gen_1	55	65	PF02991	0.613
LIG_LIR_Nem_3	110	116	PF02991	0.525
LIG_LIR_Nem_3	170	175	PF02991	0.348
LIG_LIR_Nem_3	55	60	PF02991	0.653
LIG_LIR_Nem_3	86	91	PF02991	0.514
LIG_PDZ_Class_2	229	234	PF00595	0.433
LIG_SH2_CRK	172	176	PF00017	0.345
LIG_SH2_STAP1	77	81	PF00017	0.571
LIG_SH2_STAT5	77	80	PF00017	0.493
LIG_SH2_STAT5	84	87	PF00017	0.465
LIG_SH3_3	138	144	PF00018	0.362
LIG_SH3_3	210	216	PF00018	0.338
LIG_SH3_3	94	100	PF00018	0.590
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.504
LIG_SUMO_SIM_par_1	69	74	PF11976	0.384
LIG_TYR_ITIM	111	116	PF00017	0.533
LIG_TYR_ITIM	82	87	PF00017	0.575
LIG_UBA3_1	116	122	PF00899	0.515
MOD_CDK_SPxK_1	50	56	PF00069	0.500
MOD_CK1_1	13	19	PF00069	0.658
MOD_CK1_1	178	184	PF00069	0.454
MOD_CK1_1	6	12	PF00069	0.705
MOD_CK2_1	203	209	PF00069	0.376
MOD_CK2_1	63	69	PF00069	0.511
MOD_GlcNHglycan	150	153	PF01048	0.478
MOD_GlcNHglycan	177	180	PF01048	0.649
MOD_GlcNHglycan	18	21	PF01048	0.398
MOD_GlcNHglycan	8	11	PF01048	0.546
MOD_GSK3_1	157	164	PF00069	0.316
MOD_GSK3_1	170	177	PF00069	0.380
MOD_GSK3_1	203	210	PF00069	0.324
MOD_GSK3_1	6	13	PF00069	0.719
MOD_GSK3_1	71	78	PF00069	0.508
MOD_LATS_1	61	67	PF00433	0.505
MOD_N-GLC_1	175	180	PF02516	0.447
MOD_NEK2_1	147	152	PF00069	0.373
MOD_NEK2_1	175	180	PF00069	0.429
MOD_NEK2_1	207	212	PF00069	0.414
MOD_NEK2_1	39	44	PF00069	0.593
MOD_NEK2_2	203	208	PF00069	0.389
MOD_PIKK_1	207	213	PF00454	0.288
MOD_PKA_2	10	16	PF00069	0.690
MOD_PKA_2	3	9	PF00069	0.762
MOD_Plk_4	26	32	PF00069	0.657
MOD_ProDKin_1	50	56	PF00069	0.518
MOD_ProDKin_1	71	77	PF00069	0.502
TRG_ENDOCYTIC_2	113	116	PF00928	0.541
TRG_ENDOCYTIC_2	172	175	PF00928	0.324
TRG_ENDOCYTIC_2	84	87	PF00928	0.583
TRG_ER_diArg_1	105	108	PF00400	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I779	Leptomonas seymouri	61%	98%
A0A0S4JEF8	Bodo saltans	39%	100%
A0A1X0NHP7	Trypanosomatidae	47%	100%
A0A3S7WTT8	Leishmania donovani	91%	100%
A0A422N958	Trypanosoma rangeli	46%	91%
A4H8G9	Leishmania braziliensis	82%	100%
A4HWU3	Leishmania infantum	90%	100%
C9ZW39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QEX5	Leishmania major	88%	100%
V5D515	Trypanosoma cruzi	42%	100%