Putative fucose kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fucose kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AQK1_LEIMU

TriTrypDb:

LmxM.16.0440

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	240	246	PF00089	0.585
CLV_NRD_NRD_1	292	294	PF00675	0.425
CLV_NRD_NRD_1	465	467	PF00675	0.606
CLV_NRD_NRD_1	77	79	PF00675	0.695
CLV_PCSK_KEX2_1	292	294	PF00082	0.425
CLV_PCSK_KEX2_1	418	420	PF00082	0.624
CLV_PCSK_KEX2_1	465	467	PF00082	0.606
CLV_PCSK_KEX2_1	77	79	PF00082	0.695
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.624
CLV_PCSK_SKI1_1	216	220	PF00082	0.539
CLV_PCSK_SKI1_1	292	296	PF00082	0.425
CLV_PCSK_SKI1_1	359	363	PF00082	0.669
CLV_PCSK_SKI1_1	370	374	PF00082	0.405
CLV_PCSK_SKI1_1	376	380	PF00082	0.311
CLV_PCSK_SKI1_1	468	472	PF00082	0.622
CLV_PCSK_SKI1_1	78	82	PF00082	0.690
CLV_Separin_Metazoa	367	371	PF03568	0.590
DEG_Kelch_Keap1_1	187	192	PF01344	0.632
DEG_Nend_UBRbox_1	1	3	PF02207	0.811
DEG_SCF_TRCP1_1	189	195	PF00400	0.629
DOC_CYCLIN_RxL_1	288	298	PF00134	0.625
DOC_CYCLIN_RxL_1	465	472	PF00134	0.616
DOC_MAPK_gen_1	176	184	PF00069	0.591
DOC_MAPK_HePTP_8	173	185	PF00069	0.586
DOC_MAPK_MEF2A_6	117	126	PF00069	0.621
DOC_MAPK_MEF2A_6	133	140	PF00069	0.269
DOC_MAPK_MEF2A_6	176	185	PF00069	0.589
DOC_PP2B_LxvP_1	82	85	PF13499	0.694
DOC_PP4_FxxP_1	212	215	PF00568	0.561
DOC_USP7_MATH_1	258	262	PF00917	0.625
DOC_USP7_MATH_1	428	432	PF00917	0.587
DOC_USP7_MATH_1	50	54	PF00917	0.657
DOC_WW_Pin1_4	144	149	PF00397	0.571
LIG_14-3-3_CanoR_1	203	209	PF00244	0.656
LIG_14-3-3_CanoR_1	376	381	PF00244	0.613
LIG_APCC_ABBA_1	122	127	PF00400	0.626
LIG_EH_1	209	213	PF12763	0.627
LIG_FHA_1	263	269	PF00498	0.625
LIG_FHA_1	377	383	PF00498	0.598
LIG_FHA_2	233	239	PF00498	0.587
LIG_LIR_Apic_2	338	344	PF02991	0.591
LIG_LIR_Gen_1	147	158	PF02991	0.582
LIG_LIR_Gen_1	197	206	PF02991	0.613
LIG_LIR_Gen_1	231	241	PF02991	0.591
LIG_LIR_Gen_1	252	258	PF02991	0.583
LIG_LIR_Gen_1	279	284	PF02991	0.625
LIG_LIR_Nem_3	147	153	PF02991	0.585
LIG_LIR_Nem_3	197	202	PF02991	0.606
LIG_LIR_Nem_3	231	236	PF02991	0.592
LIG_LIR_Nem_3	252	257	PF02991	0.577
LIG_LIR_Nem_3	279	283	PF02991	0.625
LIG_LIR_Nem_3	309	314	PF02991	0.641
LIG_LIR_Nem_3	400	406	PF02991	0.592
LIG_Pex14_1	307	311	PF04695	0.625
LIG_Pex14_2	224	228	PF04695	0.561
LIG_SH2_CRK	150	154	PF00017	0.599
LIG_SH2_CRK	233	237	PF00017	0.591
LIG_SH2_CRK	311	315	PF00017	0.541
LIG_SH2_CRK	354	358	PF00017	0.573
LIG_SH2_CRK	406	410	PF00017	0.577
LIG_SH2_PTP2	174	177	PF00017	0.588
LIG_SH2_STAP1	406	410	PF00017	0.577
LIG_SH2_STAT5	150	153	PF00017	0.592
LIG_SH2_STAT5	174	177	PF00017	0.588
LIG_SH2_STAT5	341	344	PF00017	0.593
LIG_SH2_STAT5	354	357	PF00017	0.327
LIG_SH2_STAT5	439	442	PF00017	0.563
LIG_SH3_3	252	258	PF00018	0.583
LIG_SH3_3	322	328	PF00018	0.595
LIG_SH3_3	421	427	PF00018	0.623
LIG_SH3_3	432	438	PF00018	0.389
LIG_SH3_3	440	446	PF00018	0.220
LIG_SH3_3	67	73	PF00018	0.723
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.582
LIG_SUMO_SIM_par_1	293	298	PF11976	0.625
LIG_SUMO_SIM_par_1	431	437	PF11976	0.582
LIG_TRAF2_1	86	89	PF00917	0.672
LIG_TYR_ITIM	352	357	PF00017	0.548
LIG_UBA3_1	314	319	PF00899	0.548
LIG_WRC_WIRS_1	196	201	PF05994	0.605
MOD_CK1_1	154	160	PF00069	0.572
MOD_CK1_1	187	193	PF00069	0.631
MOD_CK1_1	195	201	PF00069	0.467
MOD_CK1_1	339	345	PF00069	0.592
MOD_CK2_1	195	201	PF00069	0.607
MOD_CK2_1	232	238	PF00069	0.600
MOD_CK2_1	273	279	PF00069	0.525
MOD_CK2_1	68	74	PF00069	0.708
MOD_CK2_1	83	89	PF00069	0.417
MOD_GlcNHglycan	153	156	PF01048	0.603
MOD_GlcNHglycan	189	192	PF01048	0.642
MOD_GlcNHglycan	260	263	PF01048	0.525
MOD_GlcNHglycan	27	30	PF01048	0.791
MOD_GlcNHglycan	487	490	PF01048	0.608
MOD_GlcNHglycan	70	73	PF01048	0.701
MOD_GSK3_1	144	151	PF00069	0.570
MOD_GSK3_1	228	235	PF00069	0.590
MOD_GSK3_1	258	265	PF00069	0.525
MOD_GSK3_1	269	276	PF00069	0.332
MOD_GSK3_1	483	490	PF00069	0.613
MOD_NEK2_1	194	199	PF00069	0.597
MOD_NEK2_1	249	254	PF00069	0.552
MOD_NEK2_1	263	268	PF00069	0.280
MOD_NEK2_1	352	357	PF00069	0.548
MOD_NEK2_1	485	490	PF00069	0.610
MOD_NEK2_1	492	497	PF00069	0.495
MOD_PK_1	83	89	PF00069	0.680
MOD_Plk_1	249	255	PF00069	0.555
MOD_Plk_1	483	489	PF00069	0.613
MOD_Plk_2-3	232	238	PF00069	0.600
MOD_Plk_4	148	154	PF00069	0.593
MOD_Plk_4	264	270	PF00069	0.525
MOD_Plk_4	336	342	PF00069	0.588
MOD_Plk_4	428	434	PF00069	0.584
MOD_ProDKin_1	144	150	PF00069	0.571
MOD_SUMO_for_1	458	461	PF00179	0.588
TRG_DiLeu_BaEn_1	316	321	PF01217	0.548
TRG_DiLeu_BaEn_2	249	255	PF01217	0.555
TRG_DiLeu_BaEn_4	88	94	PF01217	0.662
TRG_ENDOCYTIC_2	150	153	PF00928	0.592
TRG_ENDOCYTIC_2	174	177	PF00928	0.588
TRG_ENDOCYTIC_2	205	208	PF00928	0.657
TRG_ENDOCYTIC_2	233	236	PF00928	0.582
TRG_ENDOCYTIC_2	311	314	PF00928	0.541
TRG_ENDOCYTIC_2	354	357	PF00928	0.555
TRG_ENDOCYTIC_2	395	398	PF00928	0.600
TRG_ENDOCYTIC_2	406	409	PF00928	0.388
TRG_ENDOCYTIC_2	453	456	PF00928	0.554
TRG_ENDOCYTIC_2	48	51	PF00928	0.674
TRG_ER_diArg_1	175	178	PF00400	0.582
TRG_ER_diArg_1	292	294	PF00400	0.525
TRG_ER_diArg_1	465	468	PF00400	0.609
TRG_ER_diArg_1	77	79	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.210
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q0P8I9	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	24%	100%