Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQK0_LEIMU

TriTrypDb:

LmxM.16.0430

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.646
CLV_NRD_NRD_1	126	128	PF00675	0.537
CLV_NRD_NRD_1	133	135	PF00675	0.591
CLV_NRD_NRD_1	16	18	PF00675	0.688
CLV_PCSK_KEX2_1	126	128	PF00082	0.533
CLV_PCSK_KEX2_1	14	16	PF00082	0.702
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.702
CLV_PCSK_PC7_1	10	16	PF00082	0.461
CLV_PCSK_SKI1_1	139	143	PF00082	0.678
DEG_SPOP_SBC_1	68	72	PF00917	0.468
DOC_MAPK_gen_1	131	140	PF00069	0.672
DOC_MAPK_gen_1	14	23	PF00069	0.629
DOC_MAPK_gen_1	151	160	PF00069	0.592
DOC_USP7_MATH_1	27	31	PF00917	0.692
DOC_USP7_MATH_1	39	43	PF00917	0.364
DOC_USP7_MATH_1	68	72	PF00917	0.659
DOC_USP7_MATH_1	78	82	PF00917	0.654
DOC_USP7_MATH_1	85	89	PF00917	0.589
DOC_USP7_UBL2_3	131	135	PF12436	0.598
LIG_14-3-3_CanoR_1	153	158	PF00244	0.593
LIG_14-3-3_CanoR_1	31	39	PF00244	0.565
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BRCT_BRCA1_1	29	33	PF00533	0.627
LIG_BRCT_BRCA1_1	79	83	PF00533	0.617
LIG_FHA_1	33	39	PF00498	0.588
LIG_FHA_2	111	117	PF00498	0.693
LIG_LIR_Apic_2	98	104	PF02991	0.508
LIG_LIR_Gen_1	53	59	PF02991	0.633
LIG_LIR_Gen_1	89	100	PF02991	0.534
LIG_LIR_Nem_3	119	124	PF02991	0.601
LIG_LIR_Nem_3	53	58	PF02991	0.641
LIG_LIR_Nem_3	80	86	PF02991	0.564
LIG_LIR_Nem_3	89	95	PF02991	0.486
LIG_RPA_C_Fungi	26	38	PF08784	0.669
LIG_SH3_3	142	148	PF00018	0.688
LIG_TRAF2_1	105	108	PF00917	0.546
LIG_TRAF2_2	45	50	PF00917	0.635
LIG_UBA3_1	91	99	PF00899	0.589
MOD_CK1_1	161	167	PF00069	0.700
MOD_CK1_1	63	69	PF00069	0.652
MOD_CK2_1	102	108	PF00069	0.548
MOD_Cter_Amidation	12	15	PF01082	0.673
MOD_GlcNHglycan	167	170	PF01048	0.598
MOD_GlcNHglycan	62	65	PF01048	0.615
MOD_GlcNHglycan	75	78	PF01048	0.662
MOD_GlcNHglycan	80	83	PF01048	0.605
MOD_GSK3_1	158	165	PF00069	0.714
MOD_GSK3_1	27	34	PF00069	0.624
MOD_GSK3_1	59	66	PF00069	0.654
MOD_GSK3_1	69	76	PF00069	0.658
MOD_NEK2_1	160	165	PF00069	0.706
MOD_PKA_2	21	27	PF00069	0.555
MOD_PKA_2	39	45	PF00069	0.650
MOD_PKA_2	60	66	PF00069	0.503
MOD_Plk_4	153	159	PF00069	0.617
MOD_Plk_4	50	56	PF00069	0.626
MOD_SUMO_for_1	141	144	PF00179	0.699
MOD_SUMO_rev_2	123	133	PF00179	0.589
TRG_ENDOCYTIC_2	55	58	PF00928	0.685
TRG_ER_diArg_1	15	17	PF00400	0.600
TRG_ER_diArg_1	20	23	PF00400	0.565
TRG_NLS_MonoCore_2	13	18	PF00514	0.694
TRG_NLS_MonoExtC_3	13	18	PF00514	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B0	Leptomonas seymouri	67%	100%
A0A0S4JAB3	Bodo saltans	44%	100%
A0A1X0P0C9	Trypanosomatidae	51%	100%
A0A3R7M9R7	Trypanosoma rangeli	56%	100%
A0A3S7WTU8	Leishmania donovani	77%	99%
A4H8G8	Leishmania braziliensis	69%	100%
A4HWU1	Leishmania infantum	77%	99%
C9ZW40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4QEX7	Leishmania major	81%	98%