Pyridoxal-dependent decarboxylase conserved domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pyridoxal-dependent decarboxylase conserved domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQJ9_LEIMU

TriTrypDb:

LmxM.16.0420

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016829	lyase activity	2	10
GO:0016830	carbon-carbon lyase activity	3	10
GO:0019842	vitamin binding	3	10
GO:0030170	pyridoxal phosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0070279	vitamin B6 binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016831	carboxy-lyase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.412
CLV_C14_Caspase3-7	473	477	PF00656	0.519
CLV_C14_Caspase3-7	59	63	PF00656	0.639
CLV_MEL_PAP_1	379	385	PF00089	0.546
CLV_NRD_NRD_1	302	304	PF00675	0.488
CLV_NRD_NRD_1	498	500	PF00675	0.558
CLV_PCSK_KEX2_1	498	500	PF00082	0.560
CLV_PCSK_SKI1_1	109	113	PF00082	0.330
CLV_PCSK_SKI1_1	391	395	PF00082	0.694
CLV_PCSK_SKI1_1	418	422	PF00082	0.482
CLV_PCSK_SKI1_1	43	47	PF00082	0.630
CLV_PCSK_SKI1_1	543	547	PF00082	0.670
DEG_APCC_DBOX_1	365	373	PF00400	0.560
DEG_APCC_DBOX_1	390	398	PF00400	0.531
DEG_COP1_1	261	272	PF00400	0.432
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DEG_SCF_FBW7_1	54	59	PF00400	0.580
DOC_CKS1_1	323	328	PF01111	0.574
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.465
DOC_MAPK_MEF2A_6	482	491	PF00069	0.571
DOC_PP2B_LxvP_1	129	132	PF13499	0.513
DOC_PP2B_LxvP_1	146	149	PF13499	0.618
DOC_PP2B_LxvP_1	510	513	PF13499	0.568
DOC_USP7_MATH_1	150	154	PF00917	0.474
DOC_USP7_MATH_1	237	241	PF00917	0.457
DOC_USP7_MATH_1	258	262	PF00917	0.508
DOC_USP7_MATH_1	458	462	PF00917	0.700
DOC_USP7_MATH_1	47	51	PF00917	0.688
DOC_WW_Pin1_4	281	286	PF00397	0.651
DOC_WW_Pin1_4	322	327	PF00397	0.576
DOC_WW_Pin1_4	334	339	PF00397	0.649
DOC_WW_Pin1_4	441	446	PF00397	0.663
DOC_WW_Pin1_4	463	468	PF00397	0.758
DOC_WW_Pin1_4	52	57	PF00397	0.676
LIG_14-3-3_CanoR_1	135	141	PF00244	0.421
LIG_14-3-3_CanoR_1	316	321	PF00244	0.561
LIG_14-3-3_CanoR_1	382	390	PF00244	0.642
LIG_14-3-3_CanoR_1	543	548	PF00244	0.566
LIG_14-3-3_CanoR_1	8	16	PF00244	0.654
LIG_deltaCOP1_diTrp_1	343	347	PF00928	0.533
LIG_Dynein_DLC8_1	133	139	PF01221	0.375
LIG_FHA_1	135	141	PF00498	0.427
LIG_FHA_1	323	329	PF00498	0.542
LIG_FHA_1	350	356	PF00498	0.519
LIG_FHA_1	409	415	PF00498	0.508
LIG_FHA_1	425	431	PF00498	0.467
LIG_FHA_1	74	80	PF00498	0.465
LIG_FHA_2	39	45	PF00498	0.579
LIG_FHA_2	419	425	PF00498	0.503
LIG_FHA_2	57	63	PF00498	0.644
LIG_FHA_2	68	74	PF00498	0.401
LIG_Integrin_RGD_1	398	400	PF01839	0.546
LIG_LIR_Gen_1	130	141	PF02991	0.277
LIG_LIR_Gen_1	250	260	PF02991	0.285
LIG_LIR_Gen_1	73	82	PF02991	0.502
LIG_LIR_Nem_3	130	136	PF02991	0.515
LIG_LIR_Nem_3	250	256	PF02991	0.356
LIG_LIR_Nem_3	411	415	PF02991	0.437
LIG_LIR_Nem_3	505	509	PF02991	0.639
LIG_LIR_Nem_3	73	78	PF02991	0.504
LIG_LYPXL_S_1	188	192	PF13949	0.269
LIG_LYPXL_yS_3	189	192	PF13949	0.269
LIG_RPA_C_Fungi	427	439	PF08784	0.511
LIG_SH2_CRK	278	282	PF00017	0.551
LIG_SH2_CRK	75	79	PF00017	0.449
LIG_SH2_NCK_1	257	261	PF00017	0.429
LIG_SH2_PTP2	133	136	PF00017	0.334
LIG_SH2_STAP1	169	173	PF00017	0.336
LIG_SH2_STAP1	452	456	PF00017	0.496
LIG_SH2_STAP1	68	72	PF00017	0.461
LIG_SH2_STAP1	75	79	PF00017	0.388
LIG_SH2_STAT5	113	116	PF00017	0.357
LIG_SH2_STAT5	133	136	PF00017	0.237
LIG_SH2_STAT5	547	550	PF00017	0.656
LIG_SH2_STAT5	75	78	PF00017	0.550
LIG_SH3_2	244	249	PF14604	0.333
LIG_SH3_3	13	19	PF00018	0.713
LIG_SH3_3	238	244	PF00018	0.596
LIG_SH3_3	263	269	PF00018	0.476
LIG_SH3_3	279	285	PF00018	0.705
LIG_SH3_3	333	339	PF00018	0.550
LIG_SH3_3	370	376	PF00018	0.724
LIG_SH3_4	364	371	PF00018	0.450
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.288
LIG_SUMO_SIM_par_1	375	381	PF11976	0.529
LIG_SUMO_SIM_par_1	508	516	PF11976	0.596
LIG_SUMO_SIM_par_1	75	81	PF11976	0.400
LIG_TRAF2_1	513	516	PF00917	0.531
LIG_TYR_ITIM	131	136	PF00017	0.331
LIG_TYR_ITIM	276	281	PF00017	0.601
LIG_WRC_WIRS_1	194	199	PF05994	0.385
MOD_CK1_1	153	159	PF00069	0.613
MOD_CK1_1	199	205	PF00069	0.385
MOD_CK1_1	284	290	PF00069	0.557
MOD_CK1_1	337	343	PF00069	0.570
MOD_CK1_1	463	469	PF00069	0.641
MOD_CK2_1	337	343	PF00069	0.534
MOD_CK2_1	38	44	PF00069	0.577
MOD_CK2_1	67	73	PF00069	0.440
MOD_DYRK1A_RPxSP_1	52	56	PF00069	0.587
MOD_GlcNHglycan	10	13	PF01048	0.747
MOD_GlcNHglycan	101	104	PF01048	0.505
MOD_GlcNHglycan	198	201	PF01048	0.384
MOD_GlcNHglycan	25	28	PF01048	0.546
MOD_GlcNHglycan	383	386	PF01048	0.596
MOD_GlcNHglycan	454	457	PF01048	0.679
MOD_GlcNHglycan	460	463	PF01048	0.695
MOD_GlcNHglycan	472	475	PF01048	0.589
MOD_GSK3_1	2	9	PF00069	0.618
MOD_GSK3_1	258	265	PF00069	0.397
MOD_GSK3_1	267	274	PF00069	0.409
MOD_GSK3_1	284	291	PF00069	0.481
MOD_GSK3_1	48	55	PF00069	0.617
MOD_GSK3_1	550	557	PF00069	0.548
MOD_NEK2_1	262	267	PF00069	0.418
MOD_NEK2_1	558	563	PF00069	0.578
MOD_NEK2_1	7	12	PF00069	0.581
MOD_NEK2_1	78	83	PF00069	0.365
MOD_NEK2_2	160	165	PF00069	0.179
MOD_PIKK_1	134	140	PF00454	0.383
MOD_PKA_2	134	140	PF00069	0.501
MOD_PKA_2	381	387	PF00069	0.499
MOD_PKA_2	7	13	PF00069	0.685
MOD_PKB_1	541	549	PF00069	0.481
MOD_Plk_1	403	409	PF00069	0.516
MOD_Plk_1	424	430	PF00069	0.601
MOD_Plk_4	17	23	PF00069	0.571
MOD_Plk_4	262	268	PF00069	0.390
MOD_Plk_4	354	360	PF00069	0.686
MOD_Plk_4	516	522	PF00069	0.560
MOD_Plk_4	543	549	PF00069	0.605
MOD_Plk_4	73	79	PF00069	0.398
MOD_ProDKin_1	281	287	PF00069	0.646
MOD_ProDKin_1	322	328	PF00069	0.575
MOD_ProDKin_1	334	340	PF00069	0.644
MOD_ProDKin_1	441	447	PF00069	0.665
MOD_ProDKin_1	463	469	PF00069	0.757
MOD_ProDKin_1	52	58	PF00069	0.675
MOD_SUMO_rev_2	519	527	PF00179	0.501
TRG_DiLeu_BaEn_1	516	521	PF01217	0.489
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.447
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.657
TRG_ENDOCYTIC_2	133	136	PF00928	0.491
TRG_ENDOCYTIC_2	189	192	PF00928	0.269
TRG_ENDOCYTIC_2	278	281	PF00928	0.610
TRG_ENDOCYTIC_2	75	78	PF00928	0.499
TRG_ER_diArg_1	498	500	PF00400	0.519
TRG_NES_CRM1_1	213	225	PF08389	0.184

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL2	Leptomonas seymouri	45%	77%
A0A1X0P0L1	Trypanosomatidae	27%	83%
A0A3Q8IDL2	Leishmania donovani	88%	100%
A0A3R7K963	Trypanosoma rangeli	34%	100%
A4H8G7	Leishmania braziliensis	75%	100%
A4HWU0	Leishmania infantum	88%	100%
C9ZW41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
Q4QEX8	Leishmania major	87%	100%