LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AQJ8_LEIMU
TriTrypDb:
LmxM.16.0410
Length:
576

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQJ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQJ8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 389 393 PF00656 0.783
CLV_C14_Caspase3-7 484 488 PF00656 0.771
CLV_NRD_NRD_1 159 161 PF00675 0.520
CLV_NRD_NRD_1 362 364 PF00675 0.723
CLV_NRD_NRD_1 446 448 PF00675 0.621
CLV_NRD_NRD_1 546 548 PF00675 0.808
CLV_PCSK_KEX2_1 158 160 PF00082 0.546
CLV_PCSK_KEX2_1 211 213 PF00082 0.435
CLV_PCSK_KEX2_1 321 323 PF00082 0.605
CLV_PCSK_KEX2_1 375 377 PF00082 0.793
CLV_PCSK_KEX2_1 445 447 PF00082 0.634
CLV_PCSK_KEX2_1 545 547 PF00082 0.670
CLV_PCSK_PC1ET2_1 158 160 PF00082 0.546
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.442
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.600
CLV_PCSK_PC1ET2_1 375 377 PF00082 0.793
CLV_PCSK_SKI1_1 137 141 PF00082 0.417
CLV_PCSK_SKI1_1 285 289 PF00082 0.391
CLV_PCSK_SKI1_1 328 332 PF00082 0.435
CLV_PCSK_SKI1_1 407 411 PF00082 0.677
DEG_Nend_Nbox_1 1 3 PF02207 0.489
DEG_SCF_FBW7_1 477 484 PF00400 0.499
DEG_SPOP_SBC_1 101 105 PF00917 0.510
DEG_SPOP_SBC_1 339 343 PF00917 0.557
DEG_SPOP_SBC_1 457 461 PF00917 0.493
DEG_SPOP_SBC_1 519 523 PF00917 0.504
DOC_CKS1_1 277 282 PF01111 0.539
DOC_CKS1_1 478 483 PF01111 0.502
DOC_CKS1_1 71 76 PF01111 0.314
DOC_CYCLIN_RxL_1 230 241 PF00134 0.520
DOC_CYCLIN_yClb5_NLxxxL_5 185 194 PF00134 0.399
DOC_CYCLIN_yCln2_LP_2 277 283 PF00134 0.598
DOC_MAPK_gen_1 244 253 PF00069 0.405
DOC_MAPK_MEF2A_6 191 198 PF00069 0.428
DOC_MAPK_MEF2A_6 246 255 PF00069 0.402
DOC_MAPK_MEF2A_6 69 78 PF00069 0.463
DOC_MAPK_RevD_3 144 159 PF00069 0.304
DOC_PP2B_LxvP_1 146 149 PF13499 0.492
DOC_PP2B_LxvP_1 194 197 PF13499 0.337
DOC_PP2B_LxvP_1 235 238 PF13499 0.506
DOC_USP7_MATH_1 101 105 PF00917 0.735
DOC_USP7_MATH_1 292 296 PF00917 0.522
DOC_USP7_MATH_1 340 344 PF00917 0.750
DOC_USP7_MATH_1 356 360 PF00917 0.640
DOC_USP7_MATH_1 390 394 PF00917 0.760
DOC_USP7_MATH_1 430 434 PF00917 0.624
DOC_USP7_MATH_1 457 461 PF00917 0.753
DOC_USP7_MATH_1 472 476 PF00917 0.519
DOC_USP7_MATH_1 481 485 PF00917 0.522
DOC_USP7_MATH_1 491 495 PF00917 0.551
DOC_USP7_MATH_1 519 523 PF00917 0.694
DOC_USP7_MATH_1 535 539 PF00917 0.613
DOC_USP7_MATH_1 552 556 PF00917 0.611
DOC_USP7_UBL2_3 371 375 PF12436 0.721
DOC_WW_Pin1_4 276 281 PF00397 0.541
DOC_WW_Pin1_4 45 50 PF00397 0.588
DOC_WW_Pin1_4 470 475 PF00397 0.629
DOC_WW_Pin1_4 477 482 PF00397 0.540
DOC_WW_Pin1_4 520 525 PF00397 0.568
DOC_WW_Pin1_4 61 66 PF00397 0.301
DOC_WW_Pin1_4 70 75 PF00397 0.279
DOC_WW_Pin1_4 97 102 PF00397 0.753
LIG_14-3-3_CanoR_1 120 129 PF00244 0.658
LIG_14-3-3_CanoR_1 137 146 PF00244 0.393
LIG_14-3-3_CanoR_1 212 220 PF00244 0.480
LIG_14-3-3_CanoR_1 230 236 PF00244 0.567
LIG_14-3-3_CanoR_1 304 309 PF00244 0.480
LIG_14-3-3_CanoR_1 401 409 PF00244 0.673
LIG_14-3-3_CanoR_1 419 427 PF00244 0.388
LIG_14-3-3_CanoR_1 434 442 PF00244 0.517
LIG_14-3-3_CanoR_1 490 498 PF00244 0.574
LIG_Actin_WH2_2 424 441 PF00022 0.637
LIG_BRCT_BRCA1_1 248 252 PF00533 0.456
LIG_deltaCOP1_diTrp_1 169 175 PF00928 0.442
LIG_eIF4E_1 266 272 PF01652 0.333
LIG_FHA_1 117 123 PF00498 0.595
LIG_FHA_1 143 149 PF00498 0.556
LIG_FHA_1 150 156 PF00498 0.569
LIG_FHA_1 180 186 PF00498 0.363
LIG_FHA_1 22 28 PF00498 0.598
LIG_FHA_1 240 246 PF00498 0.525
LIG_FHA_1 304 310 PF00498 0.529
LIG_FHA_1 34 40 PF00498 0.449
LIG_FHA_1 457 463 PF00498 0.494
LIG_FHA_1 62 68 PF00498 0.442
LIG_FHA_1 71 77 PF00498 0.332
LIG_FHA_2 23 29 PF00498 0.546
LIG_FHA_2 339 345 PF00498 0.629
LIG_FHA_2 419 425 PF00498 0.585
LIG_FHA_2 46 52 PF00498 0.455
LIG_FHA_2 567 573 PF00498 0.460
LIG_Integrin_isoDGR_2 228 230 PF01839 0.413
LIG_LIR_Gen_1 169 180 PF02991 0.364
LIG_LIR_Gen_1 263 274 PF02991 0.421
LIG_LIR_Gen_1 73 83 PF02991 0.350
LIG_LIR_Nem_3 169 175 PF02991 0.410
LIG_LIR_Nem_3 192 198 PF02991 0.484
LIG_LIR_Nem_3 249 255 PF02991 0.350
LIG_LIR_Nem_3 263 269 PF02991 0.386
LIG_LIR_Nem_3 318 323 PF02991 0.430
LIG_LIR_Nem_3 403 409 PF02991 0.638
LIG_LIR_Nem_3 66 71 PF02991 0.334
LIG_LIR_Nem_3 73 78 PF02991 0.371
LIG_MAD2 57 65 PF02301 0.502
LIG_NRBOX 66 72 PF00104 0.394
LIG_PCNA_yPIPBox_3 284 296 PF02747 0.371
LIG_PDZ_Class_2 571 576 PF00595 0.636
LIG_Pex14_1 316 320 PF04695 0.427
LIG_RPA_C_Fungi 155 167 PF08784 0.446
LIG_SH2_CRK 320 324 PF00017 0.411
LIG_SH2_CRK 68 72 PF00017 0.448
LIG_SH2_NCK_1 517 521 PF00017 0.506
LIG_SH2_PTP2 195 198 PF00017 0.444
LIG_SH2_STAT5 195 198 PF00017 0.454
LIG_SH2_STAT5 266 269 PF00017 0.339
LIG_SH2_STAT5 408 411 PF00017 0.544
LIG_SH2_STAT5 63 66 PF00017 0.394
LIG_SH2_STAT5 72 75 PF00017 0.361
LIG_SH3_2 478 483 PF14604 0.575
LIG_SH3_3 125 131 PF00018 0.622
LIG_SH3_3 468 474 PF00018 0.763
LIG_SH3_3 475 481 PF00018 0.544
LIG_SUMO_SIM_anti_2 77 83 PF11976 0.383
LIG_SUMO_SIM_par_1 569 575 PF11976 0.455
LIG_TRAF2_1 43 46 PF00917 0.517
LIG_TRAF2_1 450 453 PF00917 0.663
LIG_TYR_ITIM 264 269 PF00017 0.352
MOD_CDK_SPK_2 520 525 PF00069 0.495
MOD_CDK_SPxK_1 477 483 PF00069 0.631
MOD_CK1_1 100 106 PF00069 0.643
MOD_CK1_1 109 115 PF00069 0.648
MOD_CK1_1 118 124 PF00069 0.582
MOD_CK1_1 343 349 PF00069 0.638
MOD_CK1_1 433 439 PF00069 0.566
MOD_CK1_1 461 467 PF00069 0.663
MOD_CK1_1 482 488 PF00069 0.613
MOD_CK1_1 61 67 PF00069 0.370
MOD_CK2_1 170 176 PF00069 0.319
MOD_CK2_1 22 28 PF00069 0.655
MOD_CK2_1 237 243 PF00069 0.431
MOD_CK2_1 292 298 PF00069 0.497
MOD_CK2_1 339 345 PF00069 0.662
MOD_CK2_1 390 396 PF00069 0.731
MOD_CK2_1 418 424 PF00069 0.458
MOD_CK2_1 447 453 PF00069 0.725
MOD_CK2_1 45 51 PF00069 0.472
MOD_CK2_1 470 476 PF00069 0.710
MOD_CK2_1 527 533 PF00069 0.804
MOD_CK2_1 566 572 PF00069 0.463
MOD_Cter_Amidation 156 159 PF01082 0.528
MOD_Cter_Amidation 373 376 PF01082 0.666
MOD_GlcNHglycan 106 109 PF01048 0.743
MOD_GlcNHglycan 172 175 PF01048 0.417
MOD_GlcNHglycan 213 216 PF01048 0.508
MOD_GlcNHglycan 281 284 PF01048 0.513
MOD_GlcNHglycan 344 348 PF01048 0.678
MOD_GlcNHglycan 537 540 PF01048 0.665
MOD_GlcNHglycan 60 63 PF01048 0.497
MOD_GSK3_1 106 113 PF00069 0.770
MOD_GSK3_1 116 123 PF00069 0.701
MOD_GSK3_1 207 214 PF00069 0.533
MOD_GSK3_1 292 299 PF00069 0.395
MOD_GSK3_1 335 342 PF00069 0.621
MOD_GSK3_1 352 359 PF00069 0.505
MOD_GSK3_1 374 381 PF00069 0.768
MOD_GSK3_1 391 398 PF00069 0.472
MOD_GSK3_1 457 464 PF00069 0.607
MOD_GSK3_1 466 473 PF00069 0.523
MOD_GSK3_1 47 54 PF00069 0.508
MOD_GSK3_1 477 484 PF00069 0.783
MOD_GSK3_1 529 536 PF00069 0.622
MOD_GSK3_1 552 559 PF00069 0.612
MOD_GSK3_1 96 103 PF00069 0.714
MOD_N-GLC_1 101 106 PF02516 0.632
MOD_NEK2_1 22 27 PF00069 0.554
MOD_NEK2_1 303 308 PF00069 0.483
MOD_NEK2_1 309 314 PF00069 0.449
MOD_NEK2_1 96 101 PF00069 0.692
MOD_PKA_1 211 217 PF00069 0.543
MOD_PKA_1 447 453 PF00069 0.656
MOD_PKA_2 211 217 PF00069 0.518
MOD_PKA_2 303 309 PF00069 0.473
MOD_PKA_2 335 341 PF00069 0.414
MOD_PKA_2 400 406 PF00069 0.662
MOD_PKA_2 418 424 PF00069 0.390
MOD_PKA_2 433 439 PF00069 0.509
MOD_PKA_2 482 488 PF00069 0.682
MOD_PKA_2 492 498 PF00069 0.636
MOD_PKB_1 244 252 PF00069 0.406
MOD_PKB_1 445 453 PF00069 0.679
MOD_Plk_1 391 397 PF00069 0.633
MOD_Plk_1 415 421 PF00069 0.597
MOD_Plk_1 465 471 PF00069 0.783
MOD_Plk_2-3 6 12 PF00069 0.554
MOD_Plk_4 304 310 PF00069 0.564
MOD_Plk_4 566 572 PF00069 0.463
MOD_Plk_4 63 69 PF00069 0.444
MOD_ProDKin_1 276 282 PF00069 0.543
MOD_ProDKin_1 45 51 PF00069 0.585
MOD_ProDKin_1 470 476 PF00069 0.632
MOD_ProDKin_1 477 483 PF00069 0.544
MOD_ProDKin_1 520 526 PF00069 0.570
MOD_ProDKin_1 61 67 PF00069 0.296
MOD_ProDKin_1 70 76 PF00069 0.288
MOD_ProDKin_1 97 103 PF00069 0.755
MOD_SUMO_for_1 515 518 PF00179 0.620
TRG_DiLeu_BaEn_1 243 248 PF01217 0.419
TRG_DiLeu_BaLyEn_6 66 71 PF01217 0.447
TRG_ENDOCYTIC_2 195 198 PF00928 0.444
TRG_ENDOCYTIC_2 266 269 PF00928 0.339
TRG_ENDOCYTIC_2 320 323 PF00928 0.403
TRG_ENDOCYTIC_2 406 409 PF00928 0.701
TRG_ENDOCYTIC_2 68 71 PF00928 0.363
TRG_ENDOCYTIC_2 72 75 PF00928 0.354
TRG_ER_diArg_1 14 17 PF00400 0.568
TRG_ER_diArg_1 159 161 PF00400 0.520
TRG_ER_diArg_1 244 247 PF00400 0.413
TRG_ER_diArg_1 445 447 PF00400 0.485
TRG_ER_diArg_1 544 547 PF00400 0.641
TRG_ER_diArg_1 55 58 PF00400 0.536
TRG_NES_CRM1_1 192 208 PF08389 0.330
TRG_NLS_Bipartite_1 363 379 PF00514 0.661
TRG_NLS_MonoExtC_3 446 451 PF00514 0.676
TRG_NLS_MonoExtN_4 445 451 PF00514 0.691
TRG_Pf-PMV_PEXEL_1 200 205 PF00026 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7X8 Leptomonas seymouri 60% 86%
A0A1X0NZC8 Trypanosomatidae 40% 95%
A0A3S7WTU1 Leishmania donovani 91% 100%
A0A422N971 Trypanosoma rangeli 42% 96%
A4H8G6 Leishmania braziliensis 84% 100%
A4HWT9 Leishmania infantum 91% 100%
C9ZPR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
Q4QEX9 Leishmania major 89% 100%
V5B948 Trypanosoma cruzi 41% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS