Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQJ7_LEIMU

TriTrypDb:

LmxM.16.0400

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AQJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.509
CLV_C14_Caspase3-7	254	258	PF00656	0.535
CLV_NRD_NRD_1	196	198	PF00675	0.728
CLV_NRD_NRD_1	20	22	PF00675	0.441
CLV_PCSK_KEX2_1	196	198	PF00082	0.728
CLV_PCSK_KEX2_1	20	22	PF00082	0.415
CLV_PCSK_PC7_1	16	22	PF00082	0.371
CLV_PCSK_SKI1_1	16	20	PF00082	0.400
CLV_PCSK_SKI1_1	162	166	PF00082	0.634
CLV_PCSK_SKI1_1	202	206	PF00082	0.703
CLV_PCSK_SKI1_1	24	28	PF00082	0.249
DEG_APCC_DBOX_1	15	23	PF00400	0.600
DEG_APCC_DBOX_1	161	169	PF00400	0.445
DEG_SPOP_SBC_1	232	236	PF00917	0.510
DOC_CYCLIN_RxL_1	20	31	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.575
DOC_MAPK_gen_1	20	30	PF00069	0.617
DOC_MAPK_gen_1	202	210	PF00069	0.451
DOC_MAPK_gen_1	291	299	PF00069	0.462
DOC_MAPK_JIP1_4	291	297	PF00069	0.453
DOC_MAPK_MEF2A_6	21	30	PF00069	0.481
DOC_MAPK_MEF2A_6	291	299	PF00069	0.462
DOC_MAPK_MEF2A_6	323	332	PF00069	0.372
DOC_PP1_RVXF_1	175	181	PF00149	0.520
DOC_PP2B_LxvP_1	295	298	PF13499	0.469
DOC_SPAK_OSR1_1	308	312	PF12202	0.454
DOC_USP7_MATH_1	156	160	PF00917	0.449
DOC_USP7_MATH_1	170	174	PF00917	0.327
DOC_USP7_MATH_1	38	42	PF00917	0.411
DOC_USP7_MATH_1	84	88	PF00917	0.513
DOC_WW_Pin1_4	180	185	PF00397	0.455
DOC_WW_Pin1_4	212	217	PF00397	0.603
DOC_WW_Pin1_4	82	87	PF00397	0.564
LIG_14-3-3_CanoR_1	101	108	PF00244	0.497
LIG_14-3-3_CanoR_1	177	181	PF00244	0.449
LIG_14-3-3_CanoR_1	196	201	PF00244	0.522
LIG_14-3-3_CanoR_1	315	321	PF00244	0.429
LIG_14-3-3_CanoR_1	47	51	PF00244	0.544
LIG_AP2alpha_2	282	284	PF02296	0.517
LIG_BRCT_BRCA1_1	184	188	PF00533	0.443
LIG_BRCT_BRCA1_1	316	320	PF00533	0.464
LIG_CaMK_CASK_1	248	253	PF00069	0.580
LIG_eIF4E_1	331	337	PF01652	0.424
LIG_FHA_1	226	232	PF00498	0.477
LIG_FHA_1	37	43	PF00498	0.423
LIG_FHA_2	233	239	PF00498	0.579
LIG_LIR_Apic_2	300	305	PF02991	0.528
LIG_LIR_Gen_1	106	115	PF02991	0.478
LIG_LIR_Gen_1	185	195	PF02991	0.422
LIG_LIR_Nem_3	109	115	PF02991	0.454
LIG_LIR_Nem_3	185	191	PF02991	0.419
LIG_LIR_Nem_3	281	287	PF02991	0.445
LIG_LIR_Nem_3	40	46	PF02991	0.454
LIG_LIR_Nem_3	55	60	PF02991	0.525
LIG_Pex14_1	334	338	PF04695	0.411
LIG_Pex14_2	67	71	PF04695	0.542
LIG_SH2_CRK	112	116	PF00017	0.442
LIG_SH2_CRK	302	306	PF00017	0.585
LIG_SH2_CRK	345	349	PF00017	0.411
LIG_SH2_NCK_1	345	349	PF00017	0.389
LIG_SH2_STAP1	108	112	PF00017	0.535
LIG_SH2_STAT5	108	111	PF00017	0.545
LIG_SH2_STAT5	163	166	PF00017	0.428
LIG_SH2_STAT5	331	334	PF00017	0.400
LIG_SH2_STAT5	341	344	PF00017	0.321
LIG_SH2_STAT5	345	348	PF00017	0.269
LIG_SH2_STAT5	44	47	PF00017	0.594
LIG_SH3_3	123	129	PF00018	0.460
LIG_SH3_3	280	286	PF00018	0.526
LIG_SH3_3	321	327	PF00018	0.400
LIG_TYR_ITIM	339	344	PF00017	0.400
MOD_CDK_SPxxK_3	212	219	PF00069	0.609
MOD_CK1_1	104	110	PF00069	0.502
MOD_CK2_1	100	106	PF00069	0.401
MOD_CK2_1	46	52	PF00069	0.491
MOD_CK2_1	84	90	PF00069	0.596
MOD_CMANNOS	71	74	PF00535	0.745
MOD_GlcNHglycan	145	148	PF01048	0.821
MOD_GlcNHglycan	260	263	PF01048	0.805
MOD_GlcNHglycan	277	280	PF01048	0.713
MOD_GlcNHglycan	349	352	PF01048	0.424
MOD_GlcNHglycan	86	89	PF01048	0.742
MOD_GSK3_1	100	107	PF00069	0.461
MOD_GSK3_1	176	183	PF00069	0.439
MOD_GSK3_1	343	350	PF00069	0.372
MOD_GSK3_1	92	99	PF00069	0.536
MOD_NEK2_1	1	6	PF00069	0.643
MOD_NEK2_1	231	236	PF00069	0.452
MOD_NEK2_1	28	33	PF00069	0.408
MOD_NEK2_1	316	321	PF00069	0.432
MOD_NEK2_1	347	352	PF00069	0.563
MOD_NEK2_1	36	41	PF00069	0.319
MOD_NEK2_1	96	101	PF00069	0.545
MOD_NEK2_2	266	271	PF00069	0.469
MOD_NEK2_2	38	43	PF00069	0.513
MOD_PIKK_1	106	112	PF00454	0.492
MOD_PIKK_1	65	71	PF00454	0.482
MOD_PK_1	196	202	PF00069	0.528
MOD_PK_1	293	299	PF00069	0.490
MOD_PKA_1	196	202	PF00069	0.528
MOD_PKA_2	100	106	PF00069	0.505
MOD_PKA_2	143	149	PF00069	0.615
MOD_PKA_2	176	182	PF00069	0.449
MOD_PKA_2	195	201	PF00069	0.520
MOD_PKA_2	314	320	PF00069	0.559
MOD_PKA_2	46	52	PF00069	0.547
MOD_PKB_1	291	299	PF00069	0.462
MOD_Plk_1	241	247	PF00069	0.523
MOD_Plk_1	266	272	PF00069	0.520
MOD_Plk_4	170	176	PF00069	0.465
MOD_Plk_4	28	34	PF00069	0.386
MOD_Plk_4	316	322	PF00069	0.454
MOD_Plk_4	343	349	PF00069	0.499
MOD_Plk_4	38	44	PF00069	0.432
MOD_Plk_4	92	98	PF00069	0.464
MOD_ProDKin_1	180	186	PF00069	0.448
MOD_ProDKin_1	212	218	PF00069	0.604
MOD_ProDKin_1	82	88	PF00069	0.562
MOD_SUMO_rev_2	356	361	PF00179	0.600
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.405
TRG_ENDOCYTIC_2	108	111	PF00928	0.472
TRG_ENDOCYTIC_2	112	115	PF00928	0.425
TRG_ENDOCYTIC_2	341	344	PF00928	0.400
TRG_ENDOCYTIC_2	345	348	PF00928	0.411
TRG_ENDOCYTIC_2	43	46	PF00928	0.541
TRG_ER_diArg_1	123	126	PF00400	0.486
TRG_ER_diArg_1	160	163	PF00400	0.450
TRG_ER_diArg_1	19	21	PF00400	0.641
TRG_ER_diArg_1	195	197	PF00400	0.525
TRG_ER_diArg_1	290	293	PF00400	0.422
TRG_ER_diArg_1	5	8	PF00400	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0F8	Leptomonas seymouri	41%	95%
A0A3S7WTU6	Leishmania donovani	90%	100%
A4H8G5	Leishmania braziliensis	62%	100%
E9AGN1	Leishmania infantum	90%	100%
Q4QEY0	Leishmania major	83%	100%