Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQJ4_LEIMU

TriTrypDb:

LmxM.16.0370

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.480
CLV_C14_Caspase3-7	329	333	PF00656	0.398
CLV_C14_Caspase3-7	476	480	PF00656	0.489
CLV_NRD_NRD_1	177	179	PF00675	0.500
CLV_NRD_NRD_1	298	300	PF00675	0.610
CLV_NRD_NRD_1	395	397	PF00675	0.428
CLV_NRD_NRD_1	41	43	PF00675	0.606
CLV_PCSK_KEX2_1	177	179	PF00082	0.500
CLV_PCSK_KEX2_1	395	397	PF00082	0.385
CLV_PCSK_KEX2_1	41	43	PF00082	0.605
CLV_PCSK_SKI1_1	125	129	PF00082	0.545
CLV_PCSK_SKI1_1	136	140	PF00082	0.402
CLV_PCSK_SKI1_1	249	253	PF00082	0.453
CLV_PCSK_SKI1_1	269	273	PF00082	0.351
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DEG_SPOP_SBC_1	422	426	PF00917	0.321
DOC_CYCLIN_RxL_1	133	142	PF00134	0.442
DOC_MAPK_gen_1	446	454	PF00069	0.366
DOC_MAPK_MEF2A_6	331	338	PF00069	0.306
DOC_PP2B_LxvP_1	20	23	PF13499	0.481
DOC_USP7_MATH_1	105	109	PF00917	0.624
DOC_USP7_MATH_1	157	161	PF00917	0.679
DOC_USP7_MATH_1	165	169	PF00917	0.543
DOC_USP7_MATH_1	310	314	PF00917	0.359
DOC_USP7_MATH_1	406	410	PF00917	0.675
DOC_USP7_MATH_1	8	12	PF00917	0.453
DOC_USP7_MATH_1	95	99	PF00917	0.662
DOC_WW_Pin1_4	158	163	PF00397	0.639
DOC_WW_Pin1_4	4	9	PF00397	0.483
DOC_WW_Pin1_4	404	409	PF00397	0.699
LIG_14-3-3_CanoR_1	118	128	PF00244	0.497
LIG_14-3-3_CanoR_1	188	194	PF00244	0.473
LIG_14-3-3_CanoR_1	324	334	PF00244	0.526
LIG_14-3-3_CanoR_1	363	367	PF00244	0.363
LIG_Actin_WH2_2	110	127	PF00022	0.417
LIG_Actin_WH2_2	254	271	PF00022	0.360
LIG_BRCT_BRCA1_1	255	259	PF00533	0.384
LIG_BRCT_BRCA1_1	419	423	PF00533	0.445
LIG_Clathr_ClatBox_1	215	219	PF01394	0.397
LIG_FHA_1	206	212	PF00498	0.466
LIG_FHA_1	287	293	PF00498	0.707
LIG_FHA_1	362	368	PF00498	0.420
LIG_FHA_1	427	433	PF00498	0.338
LIG_FHA_1	479	485	PF00498	0.435
LIG_FHA_1	61	67	PF00498	0.677
LIG_FHA_2	187	193	PF00498	0.374
LIG_FHA_2	410	416	PF00498	0.571
LIG_FHA_2	87	93	PF00498	0.589
LIG_FHA_2	94	100	PF00498	0.449
LIG_LIR_Gen_1	374	384	PF02991	0.435
LIG_LIR_Gen_1	417	427	PF02991	0.407
LIG_LIR_Nem_3	219	224	PF02991	0.483
LIG_LIR_Nem_3	374	380	PF02991	0.411
LIG_LIR_Nem_3	417	422	PF02991	0.418
LIG_NRBOX	134	140	PF00104	0.503
LIG_PCNA_yPIPBox_3	125	139	PF02747	0.533
LIG_SH2_CRK	221	225	PF00017	0.574
LIG_SH2_CRK	377	381	PF00017	0.408
LIG_SH2_CRK	419	423	PF00017	0.461
LIG_SH2_NCK_1	419	423	PF00017	0.461
LIG_SH2_SRC	221	224	PF00017	0.433
LIG_SH2_STAP1	419	423	PF00017	0.461
LIG_SH2_STAP1	463	467	PF00017	0.376
LIG_SH2_STAT5	335	338	PF00017	0.387
LIG_SH3_3	217	223	PF00018	0.576
LIG_SH3_3	402	408	PF00018	0.630
LIG_SH3_3	429	435	PF00018	0.420
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.424
LIG_SUMO_SIM_par_1	137	142	PF11976	0.632
LIG_SUMO_SIM_par_1	206	212	PF11976	0.365
LIG_TRAF2_1	189	192	PF00917	0.440
LIG_TRFH_1	216	220	PF08558	0.410
LIG_TRFH_1	259	263	PF08558	0.307
LIG_TYR_ITSM	415	422	PF00017	0.430
LIG_UBA3_1	240	247	PF00899	0.395
MOD_CK1_1	170	176	PF00069	0.744
MOD_CK1_1	340	346	PF00069	0.400
MOD_CK1_1	365	371	PF00069	0.419
MOD_CK1_1	409	415	PF00069	0.568
MOD_CK1_1	425	431	PF00069	0.468
MOD_CK1_1	52	58	PF00069	0.652
MOD_CK1_1	7	13	PF00069	0.600
MOD_CK1_1	93	99	PF00069	0.742
MOD_CK2_1	186	192	PF00069	0.385
MOD_CK2_1	272	278	PF00069	0.520
MOD_CK2_1	382	388	PF00069	0.507
MOD_CK2_1	409	415	PF00069	0.623
MOD_CK2_1	91	97	PF00069	0.746
MOD_Cter_Amidation	175	178	PF01082	0.469
MOD_Cter_Amidation	297	300	PF01082	0.591
MOD_GlcNHglycan	107	110	PF01048	0.435
MOD_GlcNHglycan	141	144	PF01048	0.531
MOD_GlcNHglycan	148	151	PF01048	0.593
MOD_GlcNHglycan	167	170	PF01048	0.678
MOD_GlcNHglycan	194	197	PF01048	0.514
MOD_GlcNHglycan	253	256	PF01048	0.392
MOD_GlcNHglycan	274	277	PF01048	0.544
MOD_GlcNHglycan	278	282	PF01048	0.534
MOD_GlcNHglycan	312	315	PF01048	0.402
MOD_GlcNHglycan	328	331	PF01048	0.507
MOD_GlcNHglycan	367	370	PF01048	0.408
MOD_GlcNHglycan	397	400	PF01048	0.553
MOD_GlcNHglycan	408	411	PF01048	0.657
MOD_GlcNHglycan	425	428	PF01048	0.317
MOD_GlcNHglycan	438	441	PF01048	0.360
MOD_GlcNHglycan	474	478	PF01048	0.546
MOD_GlcNHglycan	51	54	PF01048	0.451
MOD_GlcNHglycan	74	77	PF01048	0.610
MOD_GlcNHglycan	91	96	PF01048	0.715
MOD_GSK3_1	105	112	PF00069	0.412
MOD_GSK3_1	139	146	PF00069	0.547
MOD_GSK3_1	163	170	PF00069	0.690
MOD_GSK3_1	199	206	PF00069	0.573
MOD_GSK3_1	286	293	PF00069	0.628
MOD_GSK3_1	361	368	PF00069	0.427
MOD_GSK3_1	4	11	PF00069	0.608
MOD_GSK3_1	417	424	PF00069	0.493
MOD_GSK3_1	457	464	PF00069	0.479
MOD_GSK3_1	478	485	PF00069	0.440
MOD_GSK3_1	54	61	PF00069	0.584
MOD_GSK3_1	66	73	PF00069	0.598
MOD_GSK3_1	86	93	PF00069	0.668
MOD_GSK3_1	95	102	PF00069	0.650
MOD_LATS_1	267	273	PF00433	0.361
MOD_N-GLC_1	226	231	PF02516	0.412
MOD_N-GLC_1	236	241	PF02516	0.301
MOD_N-GLC_2	323	325	PF02516	0.333
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	139	144	PF00069	0.539
MOD_NEK2_1	423	428	PF00069	0.311
MOD_NEK2_1	51	56	PF00069	0.755
MOD_NEK2_1	60	65	PF00069	0.614
MOD_NEK2_1	66	71	PF00069	0.578
MOD_PIKK_1	128	134	PF00454	0.487
MOD_PIKK_1	141	147	PF00454	0.529
MOD_PIKK_1	388	394	PF00454	0.323
MOD_PIKK_1	8	14	PF00454	0.452
MOD_PKA_1	395	401	PF00069	0.442
MOD_PKA_2	187	193	PF00069	0.432
MOD_PKA_2	229	235	PF00069	0.421
MOD_PKA_2	323	329	PF00069	0.531
MOD_PKA_2	362	368	PF00069	0.444
MOD_PKA_2	388	394	PF00069	0.351
MOD_PKA_2	395	401	PF00069	0.437
MOD_PKA_2	445	451	PF00069	0.402
MOD_Plk_1	226	232	PF00069	0.405
MOD_Plk_1	236	242	PF00069	0.301
MOD_Plk_4	205	211	PF00069	0.365
MOD_Plk_4	229	235	PF00069	0.424
MOD_Plk_4	236	242	PF00069	0.421
MOD_Plk_4	362	368	PF00069	0.416
MOD_Plk_4	417	423	PF00069	0.483
MOD_ProDKin_1	158	164	PF00069	0.642
MOD_ProDKin_1	4	10	PF00069	0.480
MOD_ProDKin_1	404	410	PF00069	0.699
MOD_SUMO_for_1	471	474	PF00179	0.498
MOD_SUMO_rev_2	122	127	PF00179	0.604
MOD_SUMO_rev_2	206	216	PF00179	0.344
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.604
TRG_ENDOCYTIC_2	221	224	PF00928	0.481
TRG_ENDOCYTIC_2	335	338	PF00928	0.337
TRG_ENDOCYTIC_2	357	360	PF00928	0.323
TRG_ENDOCYTIC_2	377	380	PF00928	0.227
TRG_ENDOCYTIC_2	419	422	PF00928	0.466
TRG_ER_diArg_1	15	18	PF00400	0.548
TRG_ER_diArg_1	177	180	PF00400	0.485
TRG_ER_diArg_1	394	396	PF00400	0.359
TRG_ER_diArg_1	40	42	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA0	Leptomonas seymouri	53%	100%
A0A3R7NAP5	Trypanosoma rangeli	30%	100%
A0A3S7WTT1	Leishmania donovani	80%	100%
A4HWT6	Leishmania infantum	80%	100%
Q4QEY3	Leishmania major	80%	100%