Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQJ3_LEIMU

TriTrypDb:

LmxM.16.0360

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.530
CLV_C14_Caspase3-7	529	533	PF00656	0.550
CLV_C14_Caspase3-7	54	58	PF00656	0.455
CLV_NRD_NRD_1	114	116	PF00675	0.560
CLV_NRD_NRD_1	241	243	PF00675	0.699
CLV_NRD_NRD_1	434	436	PF00675	0.668
CLV_NRD_NRD_1	581	583	PF00675	0.608
CLV_NRD_NRD_1	619	621	PF00675	0.608
CLV_NRD_NRD_1	63	65	PF00675	0.626
CLV_PCSK_KEX2_1	114	116	PF00082	0.560
CLV_PCSK_KEX2_1	241	243	PF00082	0.680
CLV_PCSK_KEX2_1	434	436	PF00082	0.668
CLV_PCSK_KEX2_1	581	583	PF00082	0.605
CLV_PCSK_KEX2_1	590	592	PF00082	0.591
CLV_PCSK_KEX2_1	63	65	PF00082	0.626
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.533
CLV_PCSK_SKI1_1	137	141	PF00082	0.532
CLV_PCSK_SKI1_1	196	200	PF00082	0.568
CLV_PCSK_SKI1_1	395	399	PF00082	0.594
CLV_PCSK_SKI1_1	414	418	PF00082	0.440
CLV_PCSK_SKI1_1	429	433	PF00082	0.807
CLV_PCSK_SKI1_1	44	48	PF00082	0.477
CLV_PCSK_SKI1_1	475	479	PF00082	0.687
CLV_PCSK_SKI1_1	8	12	PF00082	0.364
CLV_Separin_Metazoa	392	396	PF03568	0.549
DEG_Nend_UBRbox_2	1	3	PF02207	0.589
DEG_SPOP_SBC_1	197	201	PF00917	0.597
DEG_SPOP_SBC_1	485	489	PF00917	0.521
DOC_CKS1_1	612	617	PF01111	0.577
DOC_MAPK_gen_1	411	420	PF00069	0.453
DOC_MAPK_gen_1	94	103	PF00069	0.560
DOC_MAPK_MEF2A_6	263	270	PF00069	0.505
DOC_USP7_MATH_1	118	122	PF00917	0.654
DOC_USP7_MATH_1	131	135	PF00917	0.597
DOC_USP7_MATH_1	147	151	PF00917	0.612
DOC_USP7_MATH_1	197	201	PF00917	0.597
DOC_USP7_MATH_1	204	208	PF00917	0.519
DOC_USP7_MATH_1	361	365	PF00917	0.655
DOC_USP7_MATH_1	449	453	PF00917	0.629
DOC_USP7_MATH_1	458	462	PF00917	0.622
DOC_USP7_MATH_1	551	555	PF00917	0.648
DOC_USP7_MATH_2	380	386	PF00917	0.595
DOC_WW_Pin1_4	125	130	PF00397	0.650
DOC_WW_Pin1_4	143	148	PF00397	0.569
DOC_WW_Pin1_4	234	239	PF00397	0.664
DOC_WW_Pin1_4	283	288	PF00397	0.592
DOC_WW_Pin1_4	307	312	PF00397	0.391
DOC_WW_Pin1_4	429	434	PF00397	0.719
DOC_WW_Pin1_4	497	502	PF00397	0.645
DOC_WW_Pin1_4	507	512	PF00397	0.653
DOC_WW_Pin1_4	590	595	PF00397	0.603
DOC_WW_Pin1_4	611	616	PF00397	0.654
DOC_WW_Pin1_4	67	72	PF00397	0.555
DOC_WW_Pin1_4	676	681	PF00397	0.665
LIG_14-3-3_CanoR_1	196	205	PF00244	0.519
LIG_14-3-3_CanoR_1	263	269	PF00244	0.578
LIG_14-3-3_CanoR_1	271	279	PF00244	0.452
LIG_14-3-3_CanoR_1	383	391	PF00244	0.610
LIG_14-3-3_CanoR_1	435	444	PF00244	0.666
LIG_14-3-3_CanoR_1	496	501	PF00244	0.642
LIG_14-3-3_CanoR_1	513	522	PF00244	0.518
LIG_14-3-3_CanoR_1	538	543	PF00244	0.524
LIG_Actin_WH2_2	257	273	PF00022	0.491
LIG_APCC_ABBA_1	418	423	PF00400	0.472
LIG_APCC_ABBAyCdc20_2	417	423	PF00400	0.471
LIG_BIR_III_4	622	626	PF00653	0.637
LIG_BRCT_BRCA1_1	210	214	PF00533	0.515
LIG_BRCT_BRCA1_1	309	313	PF00533	0.384
LIG_BRCT_BRCA1_1	659	663	PF00533	0.603
LIG_Clathr_ClatBox_1	347	351	PF01394	0.515
LIG_deltaCOP1_diTrp_1	19	24	PF00928	0.498
LIG_deltaCOP1_diTrp_1	523	530	PF00928	0.455
LIG_FHA_1	131	137	PF00498	0.624
LIG_FHA_1	197	203	PF00498	0.587
LIG_FHA_1	265	271	PF00498	0.489
LIG_FHA_1	27	33	PF00498	0.485
LIG_FHA_1	317	323	PF00498	0.694
LIG_FHA_1	361	367	PF00498	0.556
LIG_FHA_1	487	493	PF00498	0.530
LIG_FHA_1	548	554	PF00498	0.650
LIG_FHA_2	130	136	PF00498	0.580
LIG_FHA_2	171	177	PF00498	0.516
LIG_FHA_2	25	31	PF00498	0.487
LIG_FHA_2	341	347	PF00498	0.492
LIG_FHA_2	437	443	PF00498	0.667
LIG_FHA_2	462	468	PF00498	0.666
LIG_FHA_2	515	521	PF00498	0.667
LIG_FHA_2	52	58	PF00498	0.514
LIG_FHA_2	590	596	PF00498	0.651
LIG_FHA_2	60	66	PF00498	0.655
LIG_LIR_Gen_1	27	35	PF02991	0.331
LIG_LIR_Gen_1	524	533	PF02991	0.547
LIG_LIR_Gen_1	534	543	PF02991	0.555
LIG_LIR_Gen_1	614	624	PF02991	0.517
LIG_LIR_Gen_1	7	17	PF02991	0.506
LIG_LIR_LC3C_4	346	350	PF02991	0.499
LIG_LIR_LC3C_4	98	103	PF02991	0.528
LIG_LIR_Nem_3	27	31	PF02991	0.339
LIG_LIR_Nem_3	310	316	PF02991	0.353
LIG_LIR_Nem_3	42	46	PF02991	0.376
LIG_LIR_Nem_3	472	477	PF02991	0.713
LIG_LIR_Nem_3	524	530	PF02991	0.580
LIG_LIR_Nem_3	534	539	PF02991	0.728
LIG_LIR_Nem_3	614	619	PF02991	0.517
LIG_LIR_Nem_3	7	12	PF02991	0.495
LIG_MLH1_MIPbox_1	659	663	PF16413	0.445
LIG_PCNA_PIPBox_1	368	377	PF02747	0.747
LIG_PCNA_yPIPBox_3	651	663	PF02747	0.445
LIG_Pex14_1	24	28	PF04695	0.494
LIG_Pex14_1	39	43	PF04695	0.376
LIG_Pex14_2	43	47	PF04695	0.471
LIG_SH2_CRK	474	478	PF00017	0.686
LIG_SH2_CRK	49	53	PF00017	0.519
LIG_SH2_CRK	536	540	PF00017	0.590
LIG_SH2_PTP2	315	318	PF00017	0.486
LIG_SH2_STAP1	28	32	PF00017	0.476
LIG_SH2_STAP1	375	379	PF00017	0.569
LIG_SH2_STAP1	536	540	PF00017	0.590
LIG_SH2_STAT5	119	122	PF00017	0.672
LIG_SH2_STAT5	28	31	PF00017	0.481
LIG_SH2_STAT5	315	318	PF00017	0.536
LIG_SH2_STAT5	662	665	PF00017	0.479
LIG_SH3_2	215	220	PF14604	0.534
LIG_SH3_3	189	195	PF00018	0.670
LIG_SH3_3	212	218	PF00018	0.525
LIG_SH3_3	305	311	PF00018	0.505
LIG_SH3_3	430	436	PF00018	0.644
LIG_SH3_3	470	476	PF00018	0.650
LIG_SH3_3	479	485	PF00018	0.584
LIG_SH3_3	609	615	PF00018	0.581
LIG_SUMO_SIM_anti_2	346	351	PF11976	0.602
LIG_SUMO_SIM_par_1	100	106	PF11976	0.502
LIG_SUMO_SIM_par_1	346	351	PF11976	0.511
LIG_TRAF2_1	150	153	PF00917	0.626
LIG_TRAF2_1	517	520	PF00917	0.629
LIG_TRAF2_1	73	76	PF00917	0.661
LIG_WRC_WIRS_1	539	544	PF05994	0.484
MOD_CDK_SPK_2	429	434	PF00069	0.685
MOD_CDK_SPxK_1	429	435	PF00069	0.695
MOD_CDK_SPxK_1	507	513	PF00069	0.672
MOD_CDK_SPxK_1	676	682	PF00069	0.511
MOD_CDK_SPxxK_3	234	241	PF00069	0.653
MOD_CDK_SPxxK_3	307	314	PF00069	0.384
MOD_CDK_SPxxK_3	590	597	PF00069	0.591
MOD_CK1_1	283	289	PF00069	0.596
MOD_CK1_1	360	366	PF00069	0.545
MOD_CK1_1	450	456	PF00069	0.621
MOD_CK1_1	461	467	PF00069	0.580
MOD_CK1_1	487	493	PF00069	0.643
MOD_CK1_1	499	505	PF00069	0.641
MOD_CK1_1	506	512	PF00069	0.673
MOD_CK1_1	541	547	PF00069	0.559
MOD_CK1_1	554	560	PF00069	0.609
MOD_CK1_1	90	96	PF00069	0.615
MOD_CK2_1	147	153	PF00069	0.637
MOD_CK2_1	170	176	PF00069	0.523
MOD_CK2_1	24	30	PF00069	0.496
MOD_CK2_1	340	346	PF00069	0.532
MOD_CK2_1	436	442	PF00069	0.599
MOD_CK2_1	449	455	PF00069	0.550
MOD_CK2_1	461	467	PF00069	0.653
MOD_CK2_1	514	520	PF00069	0.665
MOD_CK2_1	554	560	PF00069	0.657
MOD_CK2_1	589	595	PF00069	0.660
MOD_CK2_1	59	65	PF00069	0.659
MOD_DYRK1A_RPxSP_1	429	433	PF00069	0.657
MOD_GlcNHglycan	12	15	PF01048	0.499
MOD_GlcNHglycan	120	123	PF01048	0.641
MOD_GlcNHglycan	149	152	PF01048	0.656
MOD_GlcNHglycan	206	209	PF01048	0.615
MOD_GlcNHglycan	272	275	PF01048	0.620
MOD_GlcNHglycan	287	290	PF01048	0.689
MOD_GlcNHglycan	354	357	PF01048	0.633
MOD_GlcNHglycan	359	362	PF01048	0.582
MOD_GlcNHglycan	363	366	PF01048	0.533
MOD_GlcNHglycan	426	429	PF01048	0.681
MOD_GlcNHglycan	449	452	PF01048	0.637
MOD_GlcNHglycan	543	546	PF01048	0.568
MOD_GlcNHglycan	554	557	PF01048	0.687
MOD_GlcNHglycan	671	674	PF01048	0.610
MOD_GlcNHglycan	87	90	PF01048	0.636
MOD_GlcNHglycan	97	100	PF01048	0.470
MOD_GSK3_1	125	132	PF00069	0.651
MOD_GSK3_1	143	150	PF00069	0.603
MOD_GSK3_1	166	173	PF00069	0.656
MOD_GSK3_1	204	211	PF00069	0.579
MOD_GSK3_1	222	229	PF00069	0.599
MOD_GSK3_1	281	288	PF00069	0.571
MOD_GSK3_1	316	323	PF00069	0.630
MOD_GSK3_1	357	364	PF00069	0.597
MOD_GSK3_1	447	454	PF00069	0.605
MOD_GSK3_1	461	468	PF00069	0.576
MOD_GSK3_1	484	491	PF00069	0.674
MOD_GSK3_1	496	503	PF00069	0.682
MOD_GSK3_1	547	554	PF00069	0.612
MOD_LATS_1	164	170	PF00433	0.500
MOD_N-GLC_1	264	269	PF02516	0.484
MOD_N-GLC_1	437	442	PF02516	0.577
MOD_NEK2_1	10	15	PF00069	0.365
MOD_NEK2_1	198	203	PF00069	0.584
MOD_NEK2_1	264	269	PF00069	0.502
MOD_NEK2_1	270	275	PF00069	0.444
MOD_NEK2_1	281	286	PF00069	0.599
MOD_NEK2_1	424	429	PF00069	0.667
MOD_NEK2_1	465	470	PF00069	0.669
MOD_NEK2_1	486	491	PF00069	0.669
MOD_NEK2_1	526	531	PF00069	0.582
MOD_NEK2_1	580	585	PF00069	0.666
MOD_NEK2_1	87	92	PF00069	0.645
MOD_PIKK_1	320	326	PF00454	0.625
MOD_PKA_1	434	440	PF00069	0.667
MOD_PKA_2	165	171	PF00069	0.515
MOD_PKA_2	270	276	PF00069	0.514
MOD_PKA_2	340	346	PF00069	0.613
MOD_PKA_2	357	363	PF00069	0.465
MOD_PKA_2	382	388	PF00069	0.590
MOD_PKA_2	434	440	PF00069	0.701
MOD_PKA_2	580	586	PF00069	0.593
MOD_PKA_2	95	101	PF00069	0.560
MOD_PKB_1	494	502	PF00069	0.532
MOD_Plk_1	264	270	PF00069	0.478
MOD_Plk_2-3	467	473	PF00069	0.677
MOD_Plk_4	198	204	PF00069	0.590
MOD_Plk_4	264	270	PF00069	0.495
MOD_Plk_4	526	532	PF00069	0.595
MOD_Plk_4	538	544	PF00069	0.552
MOD_ProDKin_1	125	131	PF00069	0.650
MOD_ProDKin_1	143	149	PF00069	0.571
MOD_ProDKin_1	234	240	PF00069	0.654
MOD_ProDKin_1	283	289	PF00069	0.596
MOD_ProDKin_1	307	313	PF00069	0.385
MOD_ProDKin_1	429	435	PF00069	0.720
MOD_ProDKin_1	497	503	PF00069	0.648
MOD_ProDKin_1	507	513	PF00069	0.650
MOD_ProDKin_1	590	596	PF00069	0.654
MOD_ProDKin_1	611	617	PF00069	0.653
MOD_ProDKin_1	67	73	PF00069	0.550
MOD_ProDKin_1	676	682	PF00069	0.669
MOD_SUMO_rev_2	392	400	PF00179	0.550
MOD_SUMO_rev_2	554	564	PF00179	0.564
MOD_SUMO_rev_2	593	599	PF00179	0.641
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.680
TRG_ENDOCYTIC_2	28	31	PF00928	0.481
TRG_ENDOCYTIC_2	315	318	PF00928	0.535
TRG_ENDOCYTIC_2	474	477	PF00928	0.802
TRG_ENDOCYTIC_2	536	539	PF00928	0.771
TRG_ER_diArg_1	113	115	PF00400	0.545
TRG_ER_diArg_1	240	242	PF00400	0.669
TRG_ER_diArg_1	433	435	PF00400	0.660
TRG_ER_diArg_1	580	582	PF00400	0.600
TRG_ER_diArg_1	650	653	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.790

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA95	Leishmania donovani	82%	99%
A4H8G1	Leishmania braziliensis	57%	99%
A4HWT5	Leishmania infantum	82%	99%
Q4QEY4	Leishmania major	84%	100%