Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQJ0_LEIMU

TriTrypDb:

LmxM.16.0330

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.358
CLV_NRD_NRD_1	313	315	PF00675	0.555
CLV_NRD_NRD_1	348	350	PF00675	0.363
CLV_PCSK_KEX2_1	189	191	PF00082	0.625
CLV_PCSK_KEX2_1	216	218	PF00082	0.358
CLV_PCSK_KEX2_1	348	350	PF00082	0.362
CLV_PCSK_KEX2_1	84	86	PF00082	0.486
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.525
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.438
CLV_PCSK_SKI1_1	197	201	PF00082	0.557
CLV_PCSK_SKI1_1	314	318	PF00082	0.393
CLV_PCSK_SKI1_1	340	344	PF00082	0.386
CLV_PCSK_SKI1_1	349	353	PF00082	0.290
DEG_APCC_DBOX_1	216	224	PF00400	0.345
DOC_CKS1_1	178	183	PF01111	0.569
DOC_CYCLIN_RxL_1	345	353	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.524
DOC_MAPK_gen_1	348	356	PF00069	0.393
DOC_PP1_RVXF_1	318	325	PF00149	0.318
DOC_PP1_RVXF_1	346	353	PF00149	0.403
DOC_PP2B_LxvP_1	266	269	PF13499	0.523
DOC_USP7_MATH_1	144	148	PF00917	0.501
DOC_USP7_MATH_1	149	153	PF00917	0.753
DOC_USP7_MATH_1	156	160	PF00917	0.750
DOC_USP7_MATH_1	17	21	PF00917	0.442
DOC_USP7_MATH_1	308	312	PF00917	0.460
DOC_USP7_MATH_1	47	51	PF00917	0.765
DOC_USP7_MATH_1	53	57	PF00917	0.698
DOC_USP7_MATH_1	99	103	PF00917	0.360
DOC_WW_Pin1_4	150	155	PF00397	0.734
DOC_WW_Pin1_4	173	178	PF00397	0.685
DOC_WW_Pin1_4	240	245	PF00397	0.493
DOC_WW_Pin1_4	372	377	PF00397	0.542
LIG_14-3-3_CanoR_1	203	211	PF00244	0.552
LIG_14-3-3_CanoR_1	7	17	PF00244	0.647
LIG_BRCT_BRCA1_1	108	112	PF00533	0.498
LIG_BRCT_BRCA1_1	175	179	PF00533	0.479
LIG_Clathr_ClatBox_1	326	330	PF01394	0.415
LIG_eIF4E_1	120	126	PF01652	0.519
LIG_FAT_LD_1	220	228	PF03623	0.430
LIG_FHA_1	106	112	PF00498	0.437
LIG_FHA_1	203	209	PF00498	0.657
LIG_FHA_2	132	138	PF00498	0.653
LIG_LIR_Gen_1	289	300	PF02991	0.342
LIG_LIR_Gen_1	86	95	PF02991	0.358
LIG_LIR_Nem_3	109	115	PF02991	0.513
LIG_LIR_Nem_3	194	199	PF02991	0.520
LIG_LIR_Nem_3	20	26	PF02991	0.443
LIG_LIR_Nem_3	289	295	PF02991	0.345
LIG_LIR_Nem_3	86	90	PF02991	0.353
LIG_LYPXL_S_1	266	270	PF13949	0.426
LIG_LYPXL_yS_3	267	270	PF13949	0.420
LIG_MAD2	261	269	PF02301	0.426
LIG_MYND_1	49	53	PF01753	0.491
LIG_NRBOX	110	116	PF00104	0.396
LIG_NRBOX	219	225	PF00104	0.467
LIG_Pex14_2	192	196	PF04695	0.526
LIG_Pex14_2	352	356	PF04695	0.396
LIG_PTB_Apo_2	94	101	PF02174	0.330
LIG_Rb_LxCxE_1	325	344	PF01857	0.404
LIG_REV1ctd_RIR_1	315	324	PF16727	0.362
LIG_SH2_CRK	23	27	PF00017	0.449
LIG_SH2_CRK	292	296	PF00017	0.379
LIG_SH2_STAT5	117	120	PF00017	0.468
LIG_SH2_STAT5	198	201	PF00017	0.466
LIG_SH2_STAT5	226	229	PF00017	0.430
LIG_SH3_3	10	16	PF00018	0.674
LIG_SH3_3	161	167	PF00018	0.537
LIG_Sin3_3	112	119	PF02671	0.412
LIG_TRAF2_1	377	380	PF00917	0.479
MOD_CK1_1	147	153	PF00069	0.751
MOD_CK1_1	83	89	PF00069	0.519
MOD_CK2_1	131	137	PF00069	0.625
MOD_CK2_1	283	289	PF00069	0.360
MOD_CK2_1	374	380	PF00069	0.468
MOD_CK2_1	53	59	PF00069	0.625
MOD_GlcNHglycan	185	188	PF01048	0.539
MOD_GlcNHglycan	270	273	PF01048	0.424
MOD_GSK3_1	1	8	PF00069	0.587
MOD_GSK3_1	173	180	PF00069	0.628
MOD_GSK3_1	197	204	PF00069	0.568
MOD_GSK3_1	55	62	PF00069	0.606
MOD_N-GLC_1	276	281	PF02516	0.404
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	115	120	PF00069	0.489
MOD_NEK2_1	341	346	PF00069	0.443
MOD_NEK2_1	63	68	PF00069	0.636
MOD_PIKK_1	147	153	PF00454	0.561
MOD_PIKK_1	276	282	PF00454	0.374
MOD_PKA_2	202	208	PF00069	0.625
MOD_Plk_1	105	111	PF00069	0.313
MOD_Plk_2-3	333	339	PF00069	0.419
MOD_Plk_4	1	7	PF00069	0.732
MOD_Plk_4	106	112	PF00069	0.513
MOD_Plk_4	18	24	PF00069	0.558
MOD_Plk_4	191	197	PF00069	0.652
MOD_Plk_4	47	53	PF00069	0.732
MOD_Plk_4	59	65	PF00069	0.558
MOD_Plk_4	9	15	PF00069	0.640
MOD_ProDKin_1	150	156	PF00069	0.736
MOD_ProDKin_1	173	179	PF00069	0.684
MOD_ProDKin_1	240	246	PF00069	0.493
MOD_ProDKin_1	372	378	PF00069	0.542
MOD_SUMO_rev_2	310	317	PF00179	0.414
MOD_SUMO_rev_2	333	342	PF00179	0.512
MOD_SUMO_rev_2	375	384	PF00179	0.465
TRG_DiLeu_BaEn_1	219	224	PF01217	0.411
TRG_DiLeu_BaEn_1	337	342	PF01217	0.413
TRG_DiLeu_BaEn_1	59	64	PF01217	0.566
TRG_DiLeu_BaEn_4	337	343	PF01217	0.403
TRG_DiLeu_BaEn_4	379	385	PF01217	0.421
TRG_ENDOCYTIC_2	23	26	PF00928	0.449
TRG_ENDOCYTIC_2	267	270	PF00928	0.420
TRG_ENDOCYTIC_2	292	295	PF00928	0.361
TRG_ER_diArg_1	215	217	PF00400	0.398
TRG_ER_diArg_1	347	349	PF00400	0.365
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	320	325	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y6	Leptomonas seymouri	51%	90%
A0A0S4JDY7	Bodo saltans	43%	100%
A0A1X0NZ18	Trypanosomatidae	51%	100%
A0A1X0NZ32	Trypanosomatidae	27%	91%
A0A3Q8IAF9	Leishmania donovani	93%	100%
A0A3R7KLW2	Trypanosoma rangeli	29%	87%
A0A422N3A0	Trypanosoma rangeli	51%	100%
A4H8F9	Leishmania braziliensis	82%	100%
A4HWT2	Leishmania infantum	92%	100%
C9ZW42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZW43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
Q4QEY7	Leishmania major	90%	100%
V5AX32	Trypanosoma cruzi	27%	73%
V5D513	Trypanosoma cruzi	30%	100%