LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AQI7_LEIMU
TriTrypDb:
LmxM.16.0300
Length:
631

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQI7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQI7

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0007165 signal transduction 2 1
GO:0009966 regulation of signal transduction 4 1
GO:0010646 regulation of cell communication 4 1
GO:0023051 regulation of signaling 3 1
GO:0035556 intracellular signal transduction 3 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0048583 regulation of response to stimulus 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004674 protein serine/threonine kinase activity 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 303 307 PF00656 0.547
CLV_NRD_NRD_1 113 115 PF00675 0.279
CLV_NRD_NRD_1 175 177 PF00675 0.345
CLV_NRD_NRD_1 254 256 PF00675 0.279
CLV_NRD_NRD_1 298 300 PF00675 0.427
CLV_NRD_NRD_1 362 364 PF00675 0.598
CLV_NRD_NRD_1 417 419 PF00675 0.480
CLV_PCSK_KEX2_1 113 115 PF00082 0.279
CLV_PCSK_KEX2_1 175 177 PF00082 0.348
CLV_PCSK_KEX2_1 254 256 PF00082 0.279
CLV_PCSK_KEX2_1 297 299 PF00082 0.424
CLV_PCSK_KEX2_1 304 306 PF00082 0.519
CLV_PCSK_KEX2_1 362 364 PF00082 0.596
CLV_PCSK_KEX2_1 417 419 PF00082 0.480
CLV_PCSK_PC1ET2_1 304 306 PF00082 0.450
CLV_PCSK_SKI1_1 143 147 PF00082 0.271
CLV_PCSK_SKI1_1 18 22 PF00082 0.396
CLV_PCSK_SKI1_1 226 230 PF00082 0.279
CLV_PCSK_SKI1_1 254 258 PF00082 0.332
CLV_PCSK_SKI1_1 362 366 PF00082 0.492
CLV_PCSK_SKI1_1 396 400 PF00082 0.591
CLV_PCSK_SKI1_1 418 422 PF00082 0.557
CLV_PCSK_SKI1_1 583 587 PF00082 0.497
DEG_APCC_DBOX_1 125 133 PF00400 0.332
DEG_APCC_DBOX_1 395 403 PF00400 0.586
DOC_CDC14_PxL_1 397 405 PF14671 0.546
DOC_CYCLIN_RxL_1 251 260 PF00134 0.331
DOC_CYCLIN_RxL_1 415 425 PF00134 0.507
DOC_CYCLIN_yCln2_LP_2 116 122 PF00134 0.309
DOC_MAPK_DCC_7 396 405 PF00069 0.579
DOC_MAPK_gen_1 143 152 PF00069 0.332
DOC_MAPK_HePTP_8 393 405 PF00069 0.582
DOC_MAPK_MEF2A_6 396 405 PF00069 0.579
DOC_MAPK_MEF2A_6 506 514 PF00069 0.509
DOC_PP1_RVXF_1 224 231 PF00149 0.309
DOC_PP2B_LxvP_1 512 515 PF13499 0.537
DOC_PP4_FxxP_1 229 232 PF00568 0.306
DOC_PP4_FxxP_1 275 278 PF00568 0.402
DOC_USP7_MATH_1 280 284 PF00917 0.515
DOC_USP7_MATH_1 429 433 PF00917 0.559
DOC_USP7_MATH_1 442 446 PF00917 0.566
DOC_USP7_MATH_2 491 497 PF00917 0.485
DOC_WW_Pin1_4 243 248 PF00397 0.279
DOC_WW_Pin1_4 527 532 PF00397 0.593
DOC_WW_Pin1_4 564 569 PF00397 0.469
LIG_14-3-3_CanoR_1 113 119 PF00244 0.298
LIG_14-3-3_CanoR_1 126 130 PF00244 0.381
LIG_14-3-3_CanoR_1 175 180 PF00244 0.286
LIG_14-3-3_CanoR_1 297 302 PF00244 0.476
LIG_14-3-3_CanoR_1 322 327 PF00244 0.557
LIG_14-3-3_CanoR_1 39 49 PF00244 0.269
LIG_14-3-3_CanoR_1 417 421 PF00244 0.482
LIG_Actin_WH2_2 249 266 PF00022 0.309
LIG_Actin_WH2_2 605 620 PF00022 0.465
LIG_AP2alpha_2 273 275 PF02296 0.279
LIG_APCC_ABBA_1 272 277 PF00400 0.281
LIG_APCC_ABBAyCdc20_2 138 144 PF00400 0.279
LIG_BIR_III_4 437 441 PF00653 0.521
LIG_BRCT_BRCA1_1 446 450 PF00533 0.629
LIG_Clathr_ClatBox_1 402 406 PF01394 0.534
LIG_deltaCOP1_diTrp_1 243 252 PF00928 0.279
LIG_eIF4E_1 507 513 PF01652 0.533
LIG_FHA_1 207 213 PF00498 0.320
LIG_FHA_1 321 327 PF00498 0.564
LIG_FHA_1 41 47 PF00498 0.313
LIG_FHA_1 574 580 PF00498 0.671
LIG_FHA_1 593 599 PF00498 0.410
LIG_FHA_2 105 111 PF00498 0.281
LIG_FHA_2 206 212 PF00498 0.320
LIG_FHA_2 55 61 PF00498 0.313
LIG_FHA_2 579 585 PF00498 0.434
LIG_LIR_Apic_2 182 188 PF02991 0.332
LIG_LIR_Apic_2 273 278 PF02991 0.404
LIG_LIR_Gen_1 106 116 PF02991 0.257
LIG_LIR_Gen_1 19 29 PF02991 0.332
LIG_LIR_Nem_3 106 112 PF02991 0.327
LIG_LIR_Nem_3 407 413 PF02991 0.529
LIG_LIR_Nem_3 527 532 PF02991 0.599
LIG_PCNA_yPIPBox_3 284 298 PF02747 0.415
LIG_Rb_LxCxE_1 567 584 PF01857 0.461
LIG_SH2_CRK 109 113 PF00017 0.279
LIG_SH2_STAP1 196 200 PF00017 0.279
LIG_SH2_STAP1 594 598 PF00017 0.500
LIG_SH2_STAT5 123 126 PF00017 0.323
LIG_SH2_STAT5 134 137 PF00017 0.409
LIG_SH2_STAT5 219 222 PF00017 0.258
LIG_SH2_STAT5 507 510 PF00017 0.483
LIG_SH2_STAT5 570 573 PF00017 0.582
LIG_SH2_STAT5 591 594 PF00017 0.494
LIG_SH2_STAT5 99 102 PF00017 0.316
LIG_SH3_3 529 535 PF00018 0.583
LIG_SUMO_SIM_anti_2 68 73 PF11976 0.298
LIG_SUMO_SIM_par_1 208 214 PF11976 0.279
LIG_TRAF2_1 282 285 PF00917 0.499
LIG_TRAF2_1 333 336 PF00917 0.623
MOD_CK1_1 104 110 PF00069 0.281
MOD_CK1_1 266 272 PF00069 0.263
MOD_CK1_1 312 318 PF00069 0.583
MOD_CK1_1 496 502 PF00069 0.544
MOD_CK1_1 524 530 PF00069 0.494
MOD_CK2_1 205 211 PF00069 0.320
MOD_CK2_1 280 286 PF00069 0.482
MOD_CK2_1 297 303 PF00069 0.480
MOD_CK2_1 533 539 PF00069 0.454
MOD_CK2_1 54 60 PF00069 0.279
MOD_CK2_1 596 602 PF00069 0.427
MOD_GlcNHglycan 265 268 PF01048 0.279
MOD_GlcNHglycan 277 281 PF01048 0.490
MOD_GlcNHglycan 314 317 PF01048 0.630
MOD_GlcNHglycan 4 7 PF01048 0.435
MOD_GlcNHglycan 413 416 PF01048 0.676
MOD_GlcNHglycan 431 434 PF01048 0.506
MOD_GlcNHglycan 446 449 PF01048 0.681
MOD_GlcNHglycan 461 464 PF01048 0.732
MOD_GlcNHglycan 478 481 PF01048 0.478
MOD_GlcNHglycan 502 505 PF01048 0.742
MOD_GlcNHglycan 516 519 PF01048 0.542
MOD_GlcNHglycan 526 529 PF01048 0.543
MOD_GSK3_1 171 178 PF00069 0.279
MOD_GSK3_1 201 208 PF00069 0.292
MOD_GSK3_1 276 283 PF00069 0.358
MOD_GSK3_1 293 300 PF00069 0.396
MOD_GSK3_1 318 325 PF00069 0.593
MOD_GSK3_1 440 447 PF00069 0.553
MOD_GSK3_1 496 503 PF00069 0.584
MOD_GSK3_1 573 580 PF00069 0.460
MOD_GSK3_1 592 599 PF00069 0.482
MOD_GSK3_1 621 628 PF00069 0.451
MOD_N-GLC_1 312 317 PF02516 0.574
MOD_N-GLC_1 494 499 PF02516 0.591
MOD_N-GLC_2 619 621 PF02516 0.361
MOD_NEK2_1 150 155 PF00069 0.433
MOD_NEK2_1 169 174 PF00069 0.299
MOD_NEK2_1 179 184 PF00069 0.279
MOD_NEK2_1 205 210 PF00069 0.295
MOD_NEK2_1 421 426 PF00069 0.600
MOD_NEK2_1 500 505 PF00069 0.538
MOD_NEK2_1 574 579 PF00069 0.457
MOD_NEK2_1 612 617 PF00069 0.464
MOD_NEK2_1 83 88 PF00069 0.306
MOD_NEK2_2 416 421 PF00069 0.557
MOD_PIKK_1 280 286 PF00454 0.387
MOD_PK_1 322 328 PF00069 0.587
MOD_PKA_1 175 181 PF00069 0.279
MOD_PKA_1 297 303 PF00069 0.440
MOD_PKA_2 125 131 PF00069 0.263
MOD_PKA_2 175 181 PF00069 0.332
MOD_PKA_2 263 269 PF00069 0.279
MOD_PKA_2 297 303 PF00069 0.440
MOD_PKA_2 321 327 PF00069 0.536
MOD_PKA_2 40 46 PF00069 0.279
MOD_PKA_2 416 422 PF00069 0.481
MOD_Plk_1 312 318 PF00069 0.572
MOD_Plk_1 406 412 PF00069 0.562
MOD_Plk_1 574 580 PF00069 0.454
MOD_Plk_2-3 101 107 PF00069 0.279
MOD_Plk_2-3 406 412 PF00069 0.529
MOD_Plk_4 125 131 PF00069 0.302
MOD_Plk_4 175 181 PF00069 0.270
MOD_Plk_4 266 272 PF00069 0.268
MOD_Plk_4 315 321 PF00069 0.558
MOD_Plk_4 322 328 PF00069 0.557
MOD_Plk_4 496 502 PF00069 0.570
MOD_Plk_4 508 514 PF00069 0.525
MOD_Plk_4 521 527 PF00069 0.499
MOD_Plk_4 61 67 PF00069 0.263
MOD_Plk_4 612 618 PF00069 0.439
MOD_Plk_4 83 89 PF00069 0.239
MOD_ProDKin_1 243 249 PF00069 0.279
MOD_ProDKin_1 527 533 PF00069 0.592
MOD_ProDKin_1 564 570 PF00069 0.468
MOD_SUMO_rev_2 14 20 PF00179 0.412
MOD_SUMO_rev_2 162 172 PF00179 0.345
MOD_SUMO_rev_2 599 606 PF00179 0.481
TRG_AP2beta_CARGO_1 407 417 PF09066 0.458
TRG_DiLeu_BaEn_1 554 559 PF01217 0.454
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.495
TRG_DiLeu_BaLyEn_6 252 257 PF01217 0.279
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.550
TRG_ENDOCYTIC_2 109 112 PF00928 0.289
TRG_ENDOCYTIC_2 219 222 PF00928 0.258
TRG_ENDOCYTIC_2 87 90 PF00928 0.321
TRG_ER_diArg_1 112 114 PF00400 0.279
TRG_ER_diArg_1 253 255 PF00400 0.279
TRG_ER_diArg_1 297 299 PF00400 0.454
TRG_ER_diArg_1 362 364 PF00400 0.515
TRG_NES_CRM1_1 44 58 PF08389 0.278
TRG_NES_CRM1_1 60 73 PF08389 0.320
TRG_Pf-PMV_PEXEL_1 114 118 PF00026 0.279
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 255 260 PF00026 0.258

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEW4 Leptomonas seymouri 58% 100%
A0A3S5H5G0 Leishmania donovani 27% 100%
A0A3S7WTT7 Leishmania donovani 89% 100%
A4H459 Leishmania braziliensis 27% 100%
A4H8F5 Leishmania braziliensis 80% 99%
A4HSE2 Leishmania infantum 27% 100%
A4HWS9 Leishmania infantum 89% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
Q4QEZ0 Leishmania major 93% 100%
Q4QJJ0 Leishmania major 27% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS