Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQI4_LEIMU

TriTrypDb:

LmxM.16.0270

Length:

1040

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.508
CLV_C14_Caspase3-7	713	717	PF00656	0.462
CLV_NRD_NRD_1	247	249	PF00675	0.595
CLV_NRD_NRD_1	263	265	PF00675	0.574
CLV_NRD_NRD_1	883	885	PF00675	0.437
CLV_NRD_NRD_1	905	907	PF00675	0.456
CLV_NRD_NRD_1	980	982	PF00675	0.661
CLV_NRD_NRD_1	992	994	PF00675	0.519
CLV_PCSK_KEX2_1	246	248	PF00082	0.588
CLV_PCSK_KEX2_1	263	265	PF00082	0.577
CLV_PCSK_KEX2_1	883	885	PF00082	0.339
CLV_PCSK_KEX2_1	905	907	PF00082	0.456
CLV_PCSK_KEX2_1	980	982	PF00082	0.661
CLV_PCSK_KEX2_1	992	994	PF00082	0.519
CLV_PCSK_SKI1_1	192	196	PF00082	0.549
CLV_PCSK_SKI1_1	232	236	PF00082	0.395
CLV_PCSK_SKI1_1	291	295	PF00082	0.509
CLV_PCSK_SKI1_1	664	668	PF00082	0.451
CLV_PCSK_SKI1_1	755	759	PF00082	0.539
CLV_PCSK_SKI1_1	924	928	PF00082	0.484
CLV_PCSK_SKI1_1	995	999	PF00082	0.583
CLV_Separin_Metazoa	202	206	PF03568	0.518
DEG_APCC_DBOX_1	663	671	PF00400	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.692
DEG_SCF_FBW7_1	172	179	PF00400	0.768
DEG_SCF_FBW7_2	403	410	PF00400	0.687
DEG_SPOP_SBC_1	171	175	PF00917	0.766
DOC_CKS1_1	404	409	PF01111	0.556
DOC_CKS1_1	454	459	PF01111	0.448
DOC_CYCLIN_RxL_1	261	272	PF00134	0.570
DOC_CYCLIN_RxL_1	881	890	PF00134	0.301
DOC_CYCLIN_yClb1_LxF_4	922	927	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	919	925	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	984	990	PF00134	0.546
DOC_MAPK_DCC_7	746	756	PF00069	0.577
DOC_MAPK_gen_1	12	21	PF00069	0.620
DOC_MAPK_gen_1	246	254	PF00069	0.565
DOC_MAPK_gen_1	780	790	PF00069	0.531
DOC_MAPK_gen_1	798	807	PF00069	0.437
DOC_MAPK_gen_1	980	988	PF00069	0.607
DOC_MAPK_MEF2A_6	15	23	PF00069	0.581
DOC_MAPK_MEF2A_6	587	596	PF00069	0.489
DOC_MAPK_MEF2A_6	700	709	PF00069	0.489
DOC_MAPK_MEF2A_6	780	788	PF00069	0.487
DOC_MAPK_MEF2A_6	980	988	PF00069	0.607
DOC_MAPK_NFAT4_5	783	791	PF00069	0.530
DOC_PP1_RVXF_1	292	299	PF00149	0.475
DOC_PP1_RVXF_1	922	928	PF00149	0.493
DOC_PP2B_LxvP_1	592	595	PF13499	0.568
DOC_PP2B_LxvP_1	919	922	PF13499	0.510
DOC_PP2B_LxvP_1	984	987	PF13499	0.559
DOC_PP4_FxxP_1	300	303	PF00568	0.551
DOC_USP7_MATH_1	1015	1019	PF00917	0.346
DOC_USP7_MATH_1	171	175	PF00917	0.784
DOC_USP7_MATH_1	183	187	PF00917	0.634
DOC_USP7_MATH_1	227	231	PF00917	0.696
DOC_USP7_MATH_1	329	333	PF00917	0.715
DOC_USP7_MATH_1	434	438	PF00917	0.685
DOC_USP7_MATH_1	517	521	PF00917	0.717
DOC_USP7_MATH_1	559	563	PF00917	0.553
DOC_USP7_MATH_1	732	736	PF00917	0.591
DOC_USP7_MATH_1	830	834	PF00917	0.416
DOC_USP7_MATH_1	855	859	PF00917	0.675
DOC_USP7_MATH_1	89	93	PF00917	0.713
DOC_USP7_MATH_1	896	900	PF00917	0.504
DOC_WW_Pin1_4	172	177	PF00397	0.706
DOC_WW_Pin1_4	2	7	PF00397	0.519
DOC_WW_Pin1_4	403	408	PF00397	0.689
DOC_WW_Pin1_4	422	427	PF00397	0.496
DOC_WW_Pin1_4	453	458	PF00397	0.465
DOC_WW_Pin1_4	50	55	PF00397	0.526
DOC_WW_Pin1_4	541	546	PF00397	0.518
DOC_WW_Pin1_4	562	567	PF00397	0.464
DOC_WW_Pin1_4	64	69	PF00397	0.549
DOC_WW_Pin1_4	730	735	PF00397	0.510
DOC_WW_Pin1_4	78	83	PF00397	0.724
DOC_WW_Pin1_4	805	810	PF00397	0.550
LIG_14-3-3_CanoR_1	15	19	PF00244	0.556
LIG_14-3-3_CanoR_1	205	211	PF00244	0.526
LIG_14-3-3_CanoR_1	232	242	PF00244	0.410
LIG_14-3-3_CanoR_1	516	526	PF00244	0.742
LIG_14-3-3_CanoR_1	677	686	PF00244	0.523
LIG_14-3-3_CanoR_1	798	807	PF00244	0.476
LIG_Actin_WH2_2	733	748	PF00022	0.473
LIG_Actin_WH2_2	781	797	PF00022	0.298
LIG_APCC_ABBA_1	807	812	PF00400	0.502
LIG_BIR_III_2	940	944	PF00653	0.536
LIG_Clathr_ClatBox_1	862	866	PF01394	0.608
LIG_Clathr_ClatBox_1	913	917	PF01394	0.341
LIG_CtBP_PxDLS_1	615	619	PF00389	0.556
LIG_deltaCOP1_diTrp_1	152	156	PF00928	0.416
LIG_eIF4E_1	1034	1040	PF01652	0.523
LIG_EVH1_1	144	148	PF00568	0.621
LIG_FHA_1	1034	1040	PF00498	0.431
LIG_FHA_1	198	204	PF00498	0.637
LIG_FHA_1	442	448	PF00498	0.518
LIG_FHA_1	542	548	PF00498	0.445
LIG_FHA_1	627	633	PF00498	0.561
LIG_FHA_1	678	684	PF00498	0.494
LIG_FHA_1	702	708	PF00498	0.545
LIG_FHA_1	812	818	PF00498	0.446
LIG_FHA_1	845	851	PF00498	0.658
LIG_FHA_1	952	958	PF00498	0.510
LIG_FHA_2	267	273	PF00498	0.597
LIG_FHA_2	276	282	PF00498	0.677
LIG_FHA_2	363	369	PF00498	0.556
LIG_FHA_2	39	45	PF00498	0.626
LIG_FHA_2	454	460	PF00498	0.435
LIG_FHA_2	486	492	PF00498	0.627
LIG_FHA_2	934	940	PF00498	0.550
LIG_GBD_Chelix_1	600	608	PF00786	0.536
LIG_LIR_Apic_2	142	147	PF02991	0.567
LIG_LIR_Apic_2	749	753	PF02991	0.476
LIG_LIR_Gen_1	17	23	PF02991	0.567
LIG_LIR_Gen_1	808	818	PF02991	0.462
LIG_LIR_Nem_3	1000	1005	PF02991	0.538
LIG_LIR_Nem_3	17	21	PF02991	0.587
LIG_LIR_Nem_3	465	471	PF02991	0.451
LIG_LIR_Nem_3	716	721	PF02991	0.408
LIG_LIR_Nem_3	766	771	PF02991	0.464
LIG_LIR_Nem_3	808	813	PF02991	0.438
LIG_NRBOX	470	476	PF00104	0.558
LIG_NRBOX	493	499	PF00104	0.460
LIG_NRBOX	909	915	PF00104	0.462
LIG_PCNA_PIPBox_1	66	75	PF02747	0.745
LIG_Pex14_1	714	718	PF04695	0.476
LIG_PTB_Apo_2	767	774	PF02174	0.441
LIG_PTB_Phospho_1	767	773	PF10480	0.444
LIG_REV1ctd_RIR_1	788	796	PF16727	0.546
LIG_SH2_NCK_1	825	829	PF00017	0.409
LIG_SH2_PTP2	985	988	PF00017	0.665
LIG_SH2_SRC	481	484	PF00017	0.580
LIG_SH2_SRC	723	726	PF00017	0.544
LIG_SH2_SRC	985	988	PF00017	0.621
LIG_SH2_STAP1	554	558	PF00017	0.532
LIG_SH2_STAT5	1034	1037	PF00017	0.608
LIG_SH2_STAT5	481	484	PF00017	0.580
LIG_SH2_STAT5	631	634	PF00017	0.589
LIG_SH2_STAT5	723	726	PF00017	0.544
LIG_SH2_STAT5	771	774	PF00017	0.440
LIG_SH2_STAT5	985	988	PF00017	0.665
LIG_SH3_1	51	57	PF00018	0.527
LIG_SH3_2	299	304	PF14604	0.705
LIG_SH3_3	142	148	PF00018	0.636
LIG_SH3_3	293	299	PF00018	0.486
LIG_SH3_3	320	326	PF00018	0.577
LIG_SH3_3	401	407	PF00018	0.662
LIG_SH3_3	423	429	PF00018	0.531
LIG_SH3_3	474	480	PF00018	0.578
LIG_SH3_3	51	57	PF00018	0.527
LIG_SH3_3	560	566	PF00018	0.464
LIG_SH3_3	591	597	PF00018	0.425
LIG_SH3_3	609	615	PF00018	0.479
LIG_SH3_3	82	88	PF00018	0.644
LIG_SH3_3	939	945	PF00018	0.767
LIG_SH3_CIN85_PxpxPR_1	299	304	PF14604	0.552
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.562
LIG_SUMO_SIM_par_1	802	808	PF11976	0.586
LIG_SUMO_SIM_par_1	861	866	PF11976	0.608
LIG_TRFH_1	476	480	PF08558	0.594
LIG_UBA3_1	384	388	PF00899	0.416
LIG_UBA3_1	497	505	PF00899	0.542
LIG_UBA3_1	581	587	PF00899	0.514
LIG_UBA3_1	705	710	PF00899	0.445
LIG_WRC_WIRS_1	184	189	PF05994	0.753
LIG_WRC_WIRS_1	831	836	PF05994	0.423
LIG_WW_1	335	338	PF00397	0.556
LIG_WW_3	301	305	PF00397	0.586
MOD_CDC14_SPxK_1	53	56	PF00782	0.532
MOD_CDK_SPK_2	422	427	PF00069	0.531
MOD_CDK_SPxK_1	172	178	PF00069	0.768
MOD_CDK_SPxK_1	50	56	PF00069	0.530
MOD_CDK_SPxxK_3	2	9	PF00069	0.520
MOD_CK1_1	186	192	PF00069	0.698
MOD_CK1_1	220	226	PF00069	0.553
MOD_CK1_1	279	285	PF00069	0.705
MOD_CK1_1	395	401	PF00069	0.635
MOD_CK1_1	422	428	PF00069	0.773
MOD_CK1_1	446	452	PF00069	0.552
MOD_CK1_1	453	459	PF00069	0.548
MOD_CK1_1	5	11	PF00069	0.756
MOD_CK1_1	515	521	PF00069	0.726
MOD_CK1_1	562	568	PF00069	0.481
MOD_CK1_1	621	627	PF00069	0.675
MOD_CK1_1	76	82	PF00069	0.744
MOD_CK2_1	1021	1027	PF00069	0.512
MOD_CK2_1	146	152	PF00069	0.511
MOD_CK2_1	266	272	PF00069	0.548
MOD_CK2_1	319	325	PF00069	0.618
MOD_CK2_1	453	459	PF00069	0.457
MOD_CK2_1	485	491	PF00069	0.623
MOD_CK2_1	933	939	PF00069	0.535
MOD_GlcNHglycan	113	116	PF01048	0.607
MOD_GlcNHglycan	278	281	PF01048	0.740
MOD_GlcNHglycan	313	316	PF01048	0.779
MOD_GlcNHglycan	327	330	PF01048	0.597
MOD_GlcNHglycan	331	334	PF01048	0.508
MOD_GlcNHglycan	394	397	PF01048	0.573
MOD_GlcNHglycan	421	424	PF01048	0.746
MOD_GlcNHglycan	438	441	PF01048	0.520
MOD_GlcNHglycan	494	497	PF01048	0.590
MOD_GlcNHglycan	519	522	PF01048	0.780
MOD_GlcNHglycan	652	656	PF01048	0.605
MOD_GlcNHglycan	658	661	PF01048	0.502
MOD_GlcNHglycan	667	670	PF01048	0.338
MOD_GlcNHglycan	680	683	PF01048	0.458
MOD_GlcNHglycan	801	804	PF01048	0.696
MOD_GlcNHglycan	834	837	PF01048	0.542
MOD_GlcNHglycan	85	88	PF01048	0.632
MOD_GSK3_1	1029	1036	PF00069	0.325
MOD_GSK3_1	127	134	PF00069	0.626
MOD_GSK3_1	172	179	PF00069	0.685
MOD_GSK3_1	217	224	PF00069	0.724
MOD_GSK3_1	268	275	PF00069	0.669
MOD_GSK3_1	311	318	PF00069	0.630
MOD_GSK3_1	325	332	PF00069	0.762
MOD_GSK3_1	38	45	PF00069	0.593
MOD_GSK3_1	430	437	PF00069	0.617
MOD_GSK3_1	446	453	PF00069	0.613
MOD_GSK3_1	512	519	PF00069	0.707
MOD_GSK3_1	562	569	PF00069	0.513
MOD_GSK3_1	614	621	PF00069	0.579
MOD_GSK3_1	622	629	PF00069	0.661
MOD_GSK3_1	630	637	PF00069	0.440
MOD_GSK3_1	665	672	PF00069	0.412
MOD_GSK3_1	673	680	PF00069	0.418
MOD_GSK3_1	72	79	PF00069	0.755
MOD_GSK3_1	799	806	PF00069	0.654
MOD_GSK3_1	83	90	PF00069	0.619
MOD_GSK3_1	951	958	PF00069	0.502
MOD_LATS_1	514	520	PF00433	0.721
MOD_NEK2_1	42	47	PF00069	0.670
MOD_NEK2_1	430	435	PF00069	0.591
MOD_NEK2_1	501	506	PF00069	0.501
MOD_NEK2_1	608	613	PF00069	0.519
MOD_NEK2_1	73	78	PF00069	0.643
MOD_NEK2_1	790	795	PF00069	0.475
MOD_NEK2_2	227	232	PF00069	0.494
MOD_NEK2_2	443	448	PF00069	0.518
MOD_PIKK_1	446	452	PF00454	0.753
MOD_PIKK_1	62	68	PF00454	0.733
MOD_PK_1	524	530	PF00069	0.617
MOD_PK_1	56	62	PF00069	0.668
MOD_PKA_2	132	138	PF00069	0.526
MOD_PKA_2	515	521	PF00069	0.767
MOD_PKA_2	656	662	PF00069	0.478
MOD_PKA_2	799	805	PF00069	0.693
MOD_PKA_2	8	14	PF00069	0.680
MOD_PKA_2	932	938	PF00069	0.464
MOD_PKA_2	974	980	PF00069	0.625
MOD_Plk_1	362	368	PF00069	0.557
MOD_Plk_1	651	657	PF00069	0.476
MOD_Plk_1	689	695	PF00069	0.533
MOD_Plk_1	698	704	PF00069	0.496
MOD_Plk_1	811	817	PF00069	0.454
MOD_Plk_2-3	25	31	PF00069	0.362
MOD_Plk_4	1021	1027	PF00069	0.512
MOD_Plk_4	14	20	PF00069	0.605
MOD_Plk_4	292	298	PF00069	0.321
MOD_Plk_4	319	325	PF00069	0.509
MOD_Plk_4	443	449	PF00069	0.649
MOD_Plk_4	701	707	PF00069	0.587
MOD_Plk_4	732	738	PF00069	0.588
MOD_Plk_4	746	752	PF00069	0.352
MOD_Plk_4	887	893	PF00069	0.576
MOD_ProDKin_1	172	178	PF00069	0.708
MOD_ProDKin_1	2	8	PF00069	0.518
MOD_ProDKin_1	403	409	PF00069	0.686
MOD_ProDKin_1	422	428	PF00069	0.497
MOD_ProDKin_1	453	459	PF00069	0.457
MOD_ProDKin_1	50	56	PF00069	0.530
MOD_ProDKin_1	541	547	PF00069	0.509
MOD_ProDKin_1	562	568	PF00069	0.468
MOD_ProDKin_1	64	70	PF00069	0.548
MOD_ProDKin_1	730	736	PF00069	0.503
MOD_ProDKin_1	78	84	PF00069	0.725
MOD_ProDKin_1	805	811	PF00069	0.541
MOD_SUMO_for_1	234	237	PF00179	0.614
MOD_SUMO_rev_2	690	697	PF00179	0.323
TRG_DiLeu_BaEn_1	381	386	PF01217	0.431
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.494
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.567
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.470
TRG_DiLeu_BaLyEn_6	858	863	PF01217	0.614
TRG_ENDOCYTIC_2	810	813	PF00928	0.498
TRG_ENDOCYTIC_2	985	988	PF00928	0.665
TRG_ER_diArg_1	245	248	PF00400	0.569
TRG_ER_diArg_1	882	884	PF00400	0.345
TRG_ER_diArg_1	904	906	PF00400	0.458
TRG_ER_diArg_1	980	983	PF00400	0.644
TRG_NES_CRM1_1	812	826	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ5	Leptomonas seymouri	45%	100%
A0A3Q8IIY2	Leishmania donovani	84%	100%
A4H8F6	Leishmania braziliensis	71%	93%
A4HWS6	Leishmania infantum	84%	100%
Q4QEZ3	Leishmania major	85%	100%