Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acethyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AQI1_LEIMU

TriTrypDb:

LmxM.16.0240

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AQI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQI1

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	18
GO:0003676	nucleic acid binding	3	18
GO:0003723	RNA binding	4	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0016407	acetyltransferase activity	5	18
GO:0016740	transferase activity	2	18
GO:0016746	acyltransferase activity	3	18
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	18
GO:0043167	ion binding	2	18
GO:0043169	cation binding	3	18
GO:0046872	metal ion binding	4	18
GO:0051536	iron-sulfur cluster binding	3	18
GO:0051539	4 iron, 4 sulfur cluster binding	4	18
GO:0051540	metal cluster binding	2	18
GO:0097159	organic cyclic compound binding	2	18
GO:1901363	heterocyclic compound binding	2	18
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.292
CLV_C14_Caspase3-7	5	9	PF00656	0.497
CLV_NRD_NRD_1	231	233	PF00675	0.223
CLV_NRD_NRD_1	300	302	PF00675	0.257
CLV_NRD_NRD_1	341	343	PF00675	0.233
CLV_NRD_NRD_1	529	531	PF00675	0.316
CLV_NRD_NRD_1	642	644	PF00675	0.286
CLV_NRD_NRD_1	691	693	PF00675	0.560
CLV_NRD_NRD_1	740	742	PF00675	0.575
CLV_NRD_NRD_1	76	78	PF00675	0.398
CLV_NRD_NRD_1	84	86	PF00675	0.422
CLV_PCSK_KEX2_1	231	233	PF00082	0.223
CLV_PCSK_KEX2_1	300	302	PF00082	0.254
CLV_PCSK_KEX2_1	341	343	PF00082	0.233
CLV_PCSK_KEX2_1	529	531	PF00082	0.333
CLV_PCSK_KEX2_1	641	643	PF00082	0.280
CLV_PCSK_KEX2_1	691	693	PF00082	0.651
CLV_PCSK_KEX2_1	742	744	PF00082	0.505
CLV_PCSK_KEX2_1	84	86	PF00082	0.562
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.481
CLV_PCSK_PC7_1	637	643	PF00082	0.239
CLV_PCSK_SKI1_1	283	287	PF00082	0.197
CLV_PCSK_SKI1_1	377	381	PF00082	0.193
CLV_PCSK_SKI1_1	403	407	PF00082	0.276
CLV_PCSK_SKI1_1	489	493	PF00082	0.206
CLV_PCSK_SKI1_1	509	513	PF00082	0.232
CLV_PCSK_SKI1_1	515	519	PF00082	0.416
CLV_PCSK_SKI1_1	522	526	PF00082	0.366
CLV_PCSK_SKI1_1	84	88	PF00082	0.364
CLV_PCSK_SKI1_1	89	93	PF00082	0.304
DEG_APCC_DBOX_1	300	308	PF00400	0.436
DEG_SCF_FBW7_1	150	156	PF00400	0.470
DOC_CDC14_PxL_1	28	36	PF14671	0.370
DOC_CKS1_1	150	155	PF01111	0.454
DOC_CKS1_1	426	431	PF01111	0.397
DOC_CKS1_1	565	570	PF01111	0.233
DOC_CYCLIN_yClb1_LxF_4	233	238	PF00134	0.397
DOC_CYCLIN_yClb5_NLxxxL_5	483	492	PF00134	0.406
DOC_MAPK_gen_1	180	190	PF00069	0.373
DOC_MAPK_gen_1	231	238	PF00069	0.423
DOC_MAPK_gen_1	247	254	PF00069	0.397
DOC_MAPK_gen_1	300	306	PF00069	0.483
DOC_MAPK_gen_1	458	467	PF00069	0.397
DOC_MAPK_gen_1	84	93	PF00069	0.376
DOC_MAPK_HePTP_8	455	467	PF00069	0.397
DOC_MAPK_MEF2A_6	458	467	PF00069	0.397
DOC_PP1_RVXF_1	173	180	PF00149	0.479
DOC_PP1_RVXF_1	233	239	PF00149	0.397
DOC_PP2B_PxIxI_1	462	468	PF00149	0.502
DOC_PP4_FxxP_1	179	182	PF00568	0.487
DOC_PP4_FxxP_1	293	296	PF00568	0.502
DOC_USP7_MATH_1	106	110	PF00917	0.624
DOC_USP7_MATH_1	153	157	PF00917	0.657
DOC_USP7_MATH_1	160	164	PF00917	0.654
DOC_USP7_MATH_1	603	607	PF00917	0.338
DOC_USP7_MATH_1	752	756	PF00917	0.485
DOC_USP7_UBL2_3	74	78	PF12436	0.291
DOC_WW_Pin1_4	146	151	PF00397	0.680
DOC_WW_Pin1_4	158	163	PF00397	0.648
DOC_WW_Pin1_4	395	400	PF00397	0.315
DOC_WW_Pin1_4	409	414	PF00397	0.313
DOC_WW_Pin1_4	425	430	PF00397	0.397
DOC_WW_Pin1_4	440	445	PF00397	0.411
DOC_WW_Pin1_4	564	569	PF00397	0.231
DOC_WW_Pin1_4	597	602	PF00397	0.217
DOC_WW_Pin1_4	699	704	PF00397	0.631
LIG_14-3-3_CanoR_1	247	252	PF00244	0.397
LIG_14-3-3_CanoR_1	522	527	PF00244	0.377
LIG_14-3-3_CanoR_1	697	706	PF00244	0.646
LIG_14-3-3_CanoR_1	731	735	PF00244	0.450
LIG_Actin_WH2_2	473	491	PF00022	0.336
LIG_Actin_WH2_2	676	693	PF00022	0.462
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_eIF4E_1	445	451	PF01652	0.423
LIG_FHA_1	164	170	PF00498	0.425
LIG_FHA_1	516	522	PF00498	0.554
LIG_FHA_1	669	675	PF00498	0.680
LIG_FHA_2	15	21	PF00498	0.410
LIG_FHA_2	289	295	PF00498	0.445
LIG_FHA_2	325	331	PF00498	0.411
LIG_FHA_2	366	372	PF00498	0.437
LIG_FHA_2	5	11	PF00498	0.550
LIG_FHA_2	514	520	PF00498	0.577
LIG_FHA_2	523	529	PF00498	0.472
LIG_FHA_2	588	594	PF00498	0.272
LIG_FHA_2	68	74	PF00498	0.495
LIG_LIR_Apic_2	271	276	PF02991	0.391
LIG_LIR_Apic_2	291	296	PF02991	0.415
LIG_LIR_Gen_1	174	182	PF02991	0.510
LIG_LIR_Gen_1	427	437	PF02991	0.441
LIG_LIR_Gen_1	537	546	PF02991	0.307
LIG_LIR_Gen_1	566	577	PF02991	0.227
LIG_LIR_Gen_1	622	631	PF02991	0.289
LIG_LIR_LC3C_4	186	191	PF02991	0.356
LIG_LIR_Nem_3	174	179	PF02991	0.499
LIG_LIR_Nem_3	205	211	PF02991	0.225
LIG_LIR_Nem_3	237	241	PF02991	0.407
LIG_LIR_Nem_3	269	273	PF02991	0.446
LIG_LIR_Nem_3	418	423	PF02991	0.416
LIG_LIR_Nem_3	427	433	PF02991	0.472
LIG_LIR_Nem_3	439	445	PF02991	0.484
LIG_LIR_Nem_3	537	543	PF02991	0.277
LIG_LIR_Nem_3	566	572	PF02991	0.342
LIG_LIR_Nem_3	622	628	PF02991	0.260
LIG_MYND_3	31	35	PF01753	0.378
LIG_NRBOX	33	39	PF00104	0.362
LIG_Pex14_1	208	212	PF04695	0.397
LIG_Pex14_1	565	569	PF04695	0.239
LIG_Pex14_2	204	208	PF04695	0.225
LIG_SH2_CRK	584	588	PF00017	0.296
LIG_SH2_CRK	625	629	PF00017	0.232
LIG_SH2_CRK	645	649	PF00017	0.469
LIG_SH2_CRK	727	731	PF00017	0.399
LIG_SH2_CRK	83	87	PF00017	0.399
LIG_SH2_NCK_1	625	629	PF00017	0.275
LIG_SH2_STAP1	625	629	PF00017	0.275
LIG_SH2_STAT3	423	426	PF00017	0.397
LIG_SH2_STAT5	176	179	PF00017	0.320
LIG_SH2_STAT5	212	215	PF00017	0.427
LIG_SH2_STAT5	223	226	PF00017	0.427
LIG_SH2_STAT5	414	417	PF00017	0.379
LIG_SH2_STAT5	442	445	PF00017	0.543
LIG_SH2_STAT5	478	481	PF00017	0.427
LIG_SH3_1	211	217	PF00018	0.397
LIG_SH3_2	296	301	PF14604	0.502
LIG_SH3_3	147	153	PF00018	0.667
LIG_SH3_3	165	171	PF00018	0.378
LIG_SH3_3	211	217	PF00018	0.427
LIG_SH3_3	293	299	PF00018	0.480
LIG_SH3_3	389	395	PF00018	0.451
LIG_SH3_3	540	546	PF00018	0.281
LIG_SH3_3	703	709	PF00018	0.458
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.341
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.427
LIG_SUMO_SIM_anti_2	626	632	PF11976	0.275
LIG_SUMO_SIM_par_1	186	192	PF11976	0.341
LIG_TRAF2_1	525	528	PF00917	0.331
LIG_TRAF2_1	620	623	PF00917	0.217
LIG_TRAF2_1	755	758	PF00917	0.470
LIG_UBA3_1	450	458	PF00899	0.286
LIG_WRC_WIRS_1	588	593	PF05994	0.140
MOD_CDK_SPxxK_3	158	165	PF00069	0.527
MOD_CK1_1	109	115	PF00069	0.720
MOD_CK1_1	120	126	PF00069	0.460
MOD_CK1_1	149	155	PF00069	0.628
MOD_CK1_1	163	169	PF00069	0.600
MOD_CK1_1	2	8	PF00069	0.622
MOD_CK1_1	534	540	PF00069	0.283
MOD_CK2_1	329	335	PF00069	0.267
MOD_CK2_1	364	370	PF00069	0.259
MOD_CK2_1	4	10	PF00069	0.628
MOD_CK2_1	428	434	PF00069	0.256
MOD_CK2_1	513	519	PF00069	0.527
MOD_CK2_1	522	528	PF00069	0.401
MOD_CK2_1	587	593	PF00069	0.304
MOD_CK2_1	67	73	PF00069	0.545
MOD_CK2_1	752	758	PF00069	0.548
MOD_Cter_Amidation	739	742	PF01082	0.349
MOD_DYRK1A_RPxSP_1	597	601	PF00069	0.175
MOD_GlcNHglycan	12	15	PF01048	0.763
MOD_GlcNHglycan	122	126	PF01048	0.738
MOD_GlcNHglycan	153	156	PF01048	0.661
MOD_GlcNHglycan	185	188	PF01048	0.366
MOD_GlcNHglycan	195	198	PF01048	0.319
MOD_GlcNHglycan	314	317	PF01048	0.284
MOD_GlcNHglycan	47	50	PF01048	0.461
MOD_GlcNHglycan	522	525	PF01048	0.447
MOD_GlcNHglycan	605	608	PF01048	0.324
MOD_GlcNHglycan	631	634	PF01048	0.225
MOD_GlcNHglycan	699	702	PF01048	0.536
MOD_GlcNHglycan	738	741	PF01048	0.542
MOD_GSK3_1	10	17	PF00069	0.720
MOD_GSK3_1	117	124	PF00069	0.504
MOD_GSK3_1	149	156	PF00069	0.671
MOD_GSK3_1	160	167	PF00069	0.577
MOD_GSK3_1	189	196	PF00069	0.323
MOD_GSK3_1	324	331	PF00069	0.254
MOD_GSK3_1	365	372	PF00069	0.304
MOD_GSK3_1	424	431	PF00069	0.267
MOD_GSK3_1	544	551	PF00069	0.254
MOD_GSK3_1	664	671	PF00069	0.659
MOD_GSK3_1	695	702	PF00069	0.538
MOD_N-GLC_1	202	207	PF02516	0.315
MOD_N-GLC_1	312	317	PF02516	0.225
MOD_N-GLC_1	695	700	PF02516	0.656
MOD_NEK2_1	164	169	PF00069	0.372
MOD_NEK2_1	189	194	PF00069	0.322
MOD_NEK2_1	312	317	PF00069	0.239
MOD_NEK2_1	343	348	PF00069	0.281
MOD_NEK2_1	379	384	PF00069	0.258
MOD_NEK2_1	730	735	PF00069	0.588
MOD_NEK2_1	87	92	PF00069	0.454
MOD_NEK2_2	288	293	PF00069	0.256
MOD_PIKK_1	181	187	PF00454	0.342
MOD_PIKK_1	623	629	PF00454	0.446
MOD_PIKK_1	718	724	PF00454	0.576
MOD_PKA_2	100	106	PF00069	0.521
MOD_PKA_2	364	370	PF00069	0.239
MOD_PKA_2	730	736	PF00069	0.456
MOD_Plk_1	513	519	PF00069	0.522
MOD_Plk_1	52	58	PF00069	0.319
MOD_Plk_1	679	685	PF00069	0.587
MOD_Plk_2-3	4	10	PF00069	0.553
MOD_Plk_4	164	170	PF00069	0.557
MOD_Plk_4	189	195	PF00069	0.330
MOD_Plk_4	288	294	PF00069	0.314
MOD_Plk_4	358	364	PF00069	0.361
MOD_Plk_4	548	554	PF00069	0.225
MOD_Plk_4	87	93	PF00069	0.307
MOD_ProDKin_1	146	152	PF00069	0.682
MOD_ProDKin_1	158	164	PF00069	0.646
MOD_ProDKin_1	395	401	PF00069	0.315
MOD_ProDKin_1	409	415	PF00069	0.308
MOD_ProDKin_1	425	431	PF00069	0.225
MOD_ProDKin_1	440	446	PF00069	0.245
MOD_ProDKin_1	564	570	PF00069	0.231
MOD_ProDKin_1	597	603	PF00069	0.217
MOD_ProDKin_1	699	705	PF00069	0.633
MOD_SUMO_rev_2	20	29	PF00179	0.441
MOD_SUMO_rev_2	434	443	PF00179	0.279
TRG_DiLeu_BaEn_3	52	58	PF01217	0.319
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.384
TRG_DiLeu_BaLyEn_6	608	613	PF01217	0.316
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.318
TRG_ENDOCYTIC_2	176	179	PF00928	0.467
TRG_ENDOCYTIC_2	241	244	PF00928	0.239
TRG_ENDOCYTIC_2	584	587	PF00928	0.267
TRG_ENDOCYTIC_2	625	628	PF00928	0.280
TRG_ENDOCYTIC_2	645	648	PF00928	0.289
TRG_ENDOCYTIC_2	727	730	PF00928	0.532
TRG_ENDOCYTIC_2	83	86	PF00928	0.412
TRG_ENDOCYTIC_2	96	99	PF00928	0.390
TRG_ER_diArg_1	21	24	PF00400	0.302
TRG_ER_diArg_1	230	232	PF00400	0.247
TRG_ER_diArg_1	299	301	PF00400	0.318
TRG_ER_diArg_1	340	342	PF00400	0.276
TRG_ER_diArg_1	506	509	PF00400	0.320
TRG_ER_diArg_1	529	531	PF00400	0.333
TRG_ER_diArg_1	556	559	PF00400	0.267
TRG_ER_diArg_1	640	643	PF00400	0.244
TRG_ER_diArg_1	690	692	PF00400	0.600
TRG_ER_diArg_1	83	85	PF00400	0.546
TRG_NLS_MonoExtC_3	740	745	PF00514	0.599
TRG_NLS_MonoExtC_3	80	85	PF00514	0.422
TRG_NLS_MonoExtN_4	78	85	PF00514	0.272
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU7	Leptomonas seymouri	70%	100%
A0A0S4KPU1	Bodo saltans	60%	100%
A0A1X0NG94	Trypanosomatidae	59%	100%
A0A3Q8ICG0	Leishmania donovani	92%	100%
A0A3S7WXV4	Leishmania donovani	46%	100%
A0A422NDG5	Trypanosoma rangeli	60%	100%
A4H8F0	Leishmania braziliensis	81%	99%
A4HD08	Leishmania braziliensis	45%	100%
A4HWS3	Leishmania infantum	92%	100%
A4I0J4	Leishmania infantum	46%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q23651	Caenorhabditis elegans	33%	100%
Q2KJ61	Bos taurus	33%	100%
Q4QB17	Leishmania major	46%	100%
Q4QEZ6	Leishmania major	92%	99%
Q5HZM6	Xenopus laevis	34%	100%
Q5RIC0	Danio rerio	34%	100%
Q5ZHS1	Gallus gallus	33%	100%
Q60LW7	Caenorhabditis briggsae	34%	100%
Q6NVL5	Xenopus tropicalis	33%	100%
Q93ZR1	Arabidopsis thaliana	35%	100%
Q9CZX0	Mus musculus	32%	100%
Q9H9T3	Homo sapiens	33%	100%
V5B5L2	Trypanosoma cruzi	70%	100%
V5BNQ5	Trypanosoma cruzi	46%	100%