Mitochondrial ornithine transporter 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial ornithine transporter 1-like protein

Species:

Leishmania mexicana

UniProt:

E9AQH8_LEIMU

TriTrypDb:

LmxM.16.0210

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AQH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQH8

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006820	monoatomic anion transport	5	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	1
GO:0015807	L-amino acid transport	5	1
GO:0015822	ornithine transport	6	1
GO:0015849	organic acid transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0046942	carboxylic acid transport	6	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1902475	L-alpha-amino acid transmembrane transport	6	1
GO:1903352	L-ornithine transmembrane transport	5	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1
GO:1990542	mitochondrial transmembrane transport	3	1
GO:1990575	mitochondrial L-ornithine transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000064	L-ornithine transmembrane transporter activity	5	1
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015179	L-amino acid transmembrane transporter activity	6	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.508
CLV_NRD_NRD_1	109	111	PF00675	0.330
CLV_NRD_NRD_1	198	200	PF00675	0.345
CLV_PCSK_KEX2_1	197	199	PF00082	0.402
CLV_PCSK_PC7_1	193	199	PF00082	0.321
CLV_PCSK_SKI1_1	229	233	PF00082	0.378
CLV_PCSK_SKI1_1	329	333	PF00082	0.388
CLV_PCSK_SKI1_1	36	40	PF00082	0.417
DEG_APCC_DBOX_1	228	236	PF00400	0.321
DOC_CKS1_1	176	181	PF01111	0.267
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.397
DOC_MAPK_FxFP_2	21	24	PF00069	0.151
DOC_PP2B_LxvP_1	83	86	PF13499	0.397
DOC_PP4_FxxP_1	21	24	PF00568	0.151
DOC_USP7_MATH_1	152	156	PF00917	0.594
DOC_USP7_MATH_1	359	363	PF00917	0.520
DOC_USP7_MATH_1	51	55	PF00917	0.441
DOC_WW_Pin1_4	156	161	PF00397	0.566
DOC_WW_Pin1_4	175	180	PF00397	0.231
DOC_WW_Pin1_4	42	47	PF00397	0.289
LIG_14-3-3_CanoR_1	197	206	PF00244	0.356
LIG_14-3-3_CanoR_1	305	311	PF00244	0.415
LIG_14-3-3_CanoR_1	329	338	PF00244	0.380
LIG_14-3-3_CanoR_1	36	41	PF00244	0.185
LIG_BRCT_BRCA1_1	334	338	PF00533	0.321
LIG_BRCT_MDC1_1	379	383	PF00533	0.515
LIG_CSL_BTD_1	264	267	PF09270	0.151
LIG_CtBP_PxDLS_1	253	257	PF00389	0.327
LIG_FHA_1	15	21	PF00498	0.339
LIG_FHA_1	211	217	PF00498	0.343
LIG_FHA_1	222	228	PF00498	0.317
LIG_FHA_1	302	308	PF00498	0.327
LIG_FHA_2	176	182	PF00498	0.298
LIG_FHA_2	337	343	PF00498	0.397
LIG_FHA_2	345	351	PF00498	0.503
LIG_LIR_Apic_2	155	160	PF02991	0.591
LIG_LIR_Nem_3	352	358	PF02991	0.528
LIG_LIR_Nem_3	78	83	PF02991	0.291
LIG_PCNA_yPIPBox_3	102	116	PF02747	0.321
LIG_Pex14_1	279	283	PF04695	0.335
LIG_PTB_Apo_2	231	238	PF02174	0.397
LIG_PTB_Phospho_1	231	237	PF10480	0.397
LIG_SH2_CRK	355	359	PF00017	0.436
LIG_SH2_CRK	80	84	PF00017	0.314
LIG_SH2_STAT5	220	223	PF00017	0.425
LIG_SH2_STAT5	237	240	PF00017	0.167
LIG_SH2_STAT5	80	83	PF00017	0.426
LIG_WRC_WIRS_1	76	81	PF05994	0.312
MOD_CK1_1	344	350	PF00069	0.409
MOD_CK1_1	362	368	PF00069	0.531
MOD_CK1_1	54	60	PF00069	0.207
MOD_CK2_1	140	146	PF00069	0.737
MOD_CK2_1	175	181	PF00069	0.298
MOD_CK2_1	336	342	PF00069	0.346
MOD_CK2_1	344	350	PF00069	0.355
MOD_GlcNHglycan	124	127	PF01048	0.515
MOD_GlcNHglycan	165	168	PF01048	0.451
MOD_GlcNHglycan	190	193	PF01048	0.321
MOD_GlcNHglycan	273	276	PF01048	0.301
MOD_GlcNHglycan	312	315	PF01048	0.407
MOD_GlcNHglycan	361	364	PF01048	0.510
MOD_GlcNHglycan	365	368	PF01048	0.538
MOD_GSK3_1	152	159	PF00069	0.572
MOD_GSK3_1	171	178	PF00069	0.286
MOD_GSK3_1	221	228	PF00069	0.376
MOD_GSK3_1	306	313	PF00069	0.453
MOD_GSK3_1	32	39	PF00069	0.393
MOD_GSK3_1	332	339	PF00069	0.411
MOD_GSK3_1	359	366	PF00069	0.515
MOD_GSK3_1	47	54	PF00069	0.417
MOD_N-GLC_1	101	106	PF02516	0.321
MOD_NEK2_1	124	129	PF00069	0.403
MOD_NEK2_1	171	176	PF00069	0.397
MOD_NEK2_1	210	215	PF00069	0.410
MOD_NEK2_1	303	308	PF00069	0.413
MOD_NEK2_1	310	315	PF00069	0.410
MOD_NEK2_1	32	37	PF00069	0.427
MOD_NEK2_1	331	336	PF00069	0.369
MOD_NEK2_2	24	29	PF00069	0.298
MOD_NEK2_2	75	80	PF00069	0.297
MOD_PIKK_1	65	71	PF00454	0.410
MOD_PKA_1	198	204	PF00069	0.275
MOD_PKA_2	122	128	PF00069	0.493
MOD_PKA_2	198	204	PF00069	0.427
MOD_PKA_2	359	365	PF00069	0.508
MOD_PKB_1	197	205	PF00069	0.275
MOD_Plk_1	101	107	PF00069	0.321
MOD_Plk_1	349	355	PF00069	0.495
MOD_Plk_4	152	158	PF00069	0.562
MOD_Plk_4	171	177	PF00069	0.194
MOD_Plk_4	306	312	PF00069	0.408
MOD_Plk_4	323	329	PF00069	0.273
MOD_Plk_4	332	338	PF00069	0.381
MOD_Plk_4	350	356	PF00069	0.375
MOD_Plk_4	59	65	PF00069	0.357
MOD_ProDKin_1	156	162	PF00069	0.559
MOD_ProDKin_1	175	181	PF00069	0.231
MOD_ProDKin_1	42	48	PF00069	0.289
MOD_SUMO_rev_2	125	133	PF00179	0.502
TRG_ENDOCYTIC_2	278	281	PF00928	0.397
TRG_ENDOCYTIC_2	355	358	PF00928	0.438
TRG_ENDOCYTIC_2	80	83	PF00928	0.314
TRG_ER_diArg_1	121	124	PF00400	0.618
TRG_ER_diArg_1	196	199	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	28%	100%
A0A0N0P7X0	Leptomonas seymouri	25%	100%
A0A0N0P7Y4	Leptomonas seymouri	30%	100%
A0A0N1HX25	Leptomonas seymouri	25%	100%
A0A0N1I8T5	Leptomonas seymouri	24%	100%
A0A0N1IMA2	Leptomonas seymouri	51%	100%
A0A0S4IMF4	Bodo saltans	21%	100%
A0A0S4IV98	Bodo saltans	25%	100%
A0A0S4JIA4	Bodo saltans	24%	90%
A0A0S4JM95	Bodo saltans	32%	100%
A0A0S4JQI3	Bodo saltans	23%	100%
A0A0S4JR63	Bodo saltans	23%	100%
A0A1X0NFT4	Trypanosomatidae	32%	100%
A0A1X0NIA3	Trypanosomatidae	24%	100%
A0A1X0NJD2	Trypanosomatidae	25%	100%
A0A1X0NLW7	Trypanosomatidae	24%	100%
A0A1X0NUT2	Trypanosomatidae	26%	100%
A0A1X0P4Q9	Trypanosomatidae	27%	100%
A0A3R7KGU8	Trypanosoma rangeli	27%	100%
A0A3R7N0M4	Trypanosoma rangeli	26%	100%
A0A3R7RT89	Trypanosoma rangeli	23%	100%
A0A3S5H6W7	Leishmania donovani	90%	100%
A0A3S7WTS6	Leishmania donovani	28%	100%
A0A3S7WYS1	Leishmania donovani	27%	100%
A0A422NF39	Trypanosoma rangeli	28%	100%
A0A422NVT9	Trypanosoma rangeli	21%	100%
A0JN87	Bos taurus	23%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	25%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2Q9F0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A3LVX1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	22%	100%
A4H3F8	Leishmania braziliensis	22%	95%
A4H8E6	Leishmania braziliensis	29%	87%
A4H8E7	Leishmania braziliensis	78%	100%
A4HDW8	Leishmania braziliensis	25%	88%
A4HWR9	Leishmania infantum	29%	100%
A4HWS0	Leishmania infantum	90%	100%
A4I163	Leishmania infantum	27%	100%
A4QNX2	Danio rerio	26%	100%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	23%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A9N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AMX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	96%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	87%
E9AX97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
K3VFR5	Fusarium pseudograminearum (strain CS3096)	24%	100%
O43772	Homo sapiens	25%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P38087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P97521	Rattus norvegicus	24%	100%
Q01356	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q08DK7	Bos taurus	24%	100%
Q09461	Caenorhabditis elegans	21%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	100%
Q10248	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q12375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q17QI7	Bos taurus	23%	100%
Q1ECW7	Danio rerio	25%	100%
Q1LZB3	Bos taurus	23%	100%
Q27257	Caenorhabditis elegans	23%	100%
Q3MHI3	Bos taurus	25%	100%
Q3TZX3	Mus musculus	23%	100%
Q498U3	Rattus norvegicus	22%	100%
Q4QA75	Leishmania major	26%	86%
Q4QEZ9	Leishmania major	90%	100%
Q4QF00	Leishmania major	28%	88%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54BM3	Dictyostelium discoideum	22%	100%
Q54FE6	Dictyostelium discoideum	25%	100%
Q54VS7	Dictyostelium discoideum	21%	100%
Q55DY8	Dictyostelium discoideum	22%	100%
Q55E85	Dictyostelium discoideum	23%	100%
Q5HZE0	Rattus norvegicus	23%	100%
Q5RFB7	Pongo abelii	23%	100%
Q5ZKP7	Gallus gallus	23%	100%
Q6DFK2	Xenopus laevis	24%	100%
Q6DG32	Danio rerio	24%	100%
Q6DHS9	Danio rerio	25%	100%
Q6IS41	Mus musculus	27%	100%
Q6J329	Rattus norvegicus	25%	100%
Q6P036	Danio rerio	24%	100%
Q6Q0C1	Homo sapiens	26%	100%
Q6ZT89	Homo sapiens	26%	100%
Q84UC7	Arabidopsis thaliana	26%	100%
Q86AV5	Dictyostelium discoideum	25%	100%
Q86HN8	Dictyostelium discoideum	22%	88%
Q8BL03	Mus musculus	22%	100%
Q8BW66	Mus musculus	27%	100%
Q8BZ09	Mus musculus	23%	100%
Q8CFJ7	Mus musculus	24%	100%
Q8HXY2	Macaca fascicularis	25%	100%
Q8N413	Homo sapiens	24%	100%
Q8N8R3	Homo sapiens	24%	100%
Q922G0	Mus musculus	23%	100%
Q93XM7	Arabidopsis thaliana	27%	100%
Q94AG6	Arabidopsis thaliana	25%	100%
Q96CQ1	Homo sapiens	23%	100%
Q99JD3	Rattus norvegicus	23%	100%
Q9BQT8	Homo sapiens	24%	100%
Q9BSK2	Homo sapiens	23%	100%
Q9BXI2	Homo sapiens	27%	100%
Q9BZJ4	Homo sapiens	24%	100%
Q9D8K8	Mus musculus	23%	100%
Q9SB52	Arabidopsis thaliana	23%	100%
Q9VM51	Drosophila melanogaster	25%	100%
Q9VQ37	Drosophila melanogaster	24%	100%
Q9VQG4	Drosophila melanogaster	24%	100%
Q9WVD5	Mus musculus	29%	100%
Q9Y619	Homo sapiens	28%	100%
Q9Z2Z6	Mus musculus	25%	100%
V5BD15	Trypanosoma cruzi	23%	100%
V5BDR1	Trypanosoma cruzi	32%	100%
V5BI33	Trypanosoma cruzi	25%	100%
V5BP20	Trypanosoma cruzi	27%	100%
V5BSW1	Trypanosoma cruzi	27%	100%
V5BVW0	Trypanosoma cruzi	23%	100%