Las1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Las1 family protein

Gene product:

Las1-like, putative

Species:

Leishmania mexicana

UniProt:

E9AQH6_LEIMU

TriTrypDb:

LmxM.16.0190

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0090730	Las1 complex	4	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1902555	endoribonuclease complex	4	11
GO:1902911	protein kinase complex	5	11
GO:1905348	endonuclease complex	3	11
GO:1905354	exoribonuclease complex	3	11
GO:1990234	transferase complex	3	11
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AQH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQH6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.719
CLV_C14_Caspase3-7	33	37	PF00656	0.499
CLV_NRD_NRD_1	11	13	PF00675	0.528
CLV_NRD_NRD_1	121	123	PF00675	0.377
CLV_NRD_NRD_1	18	20	PF00675	0.484
CLV_NRD_NRD_1	181	183	PF00675	0.307
CLV_NRD_NRD_1	2	4	PF00675	0.599
CLV_NRD_NRD_1	252	254	PF00675	0.735
CLV_NRD_NRD_1	26	28	PF00675	0.475
CLV_NRD_NRD_1	353	355	PF00675	0.506
CLV_NRD_NRD_1	40	42	PF00675	0.670
CLV_NRD_NRD_1	43	45	PF00675	0.671
CLV_PCSK_FUR_1	24	28	PF00082	0.553
CLV_PCSK_KEX2_1	107	109	PF00082	0.150
CLV_PCSK_KEX2_1	11	13	PF00082	0.506
CLV_PCSK_KEX2_1	18	20	PF00082	0.500
CLV_PCSK_KEX2_1	183	185	PF00082	0.307
CLV_PCSK_KEX2_1	2	4	PF00082	0.554
CLV_PCSK_KEX2_1	26	28	PF00082	0.456
CLV_PCSK_KEX2_1	353	355	PF00082	0.506
CLV_PCSK_KEX2_1	40	42	PF00082	0.604
CLV_PCSK_KEX2_1	94	96	PF00082	0.373
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.150
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.307
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.714
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.373
CLV_PCSK_SKI1_1	108	112	PF00082	0.290
CLV_PCSK_SKI1_1	12	16	PF00082	0.635
CLV_PCSK_SKI1_1	290	294	PF00082	0.538
CLV_PCSK_SKI1_1	94	98	PF00082	0.316
DEG_APCC_DBOX_1	107	115	PF00400	0.307
DEG_APCC_DBOX_1	25	33	PF00400	0.651
DEG_APCC_DBOX_1	289	297	PF00400	0.483
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DEG_SPOP_SBC_1	263	267	PF00917	0.694
DOC_CYCLIN_RxL_1	92	99	PF00134	0.305
DOC_MAPK_gen_1	182	190	PF00069	0.307
DOC_MAPK_MEF2A_6	213	222	PF00069	0.307
DOC_PP1_RVXF_1	92	99	PF00149	0.321
DOC_PP2B_LxvP_1	279	282	PF13499	0.658
DOC_PP2B_LxvP_1	35	38	PF13499	0.686
DOC_USP7_MATH_1	106	110	PF00917	0.311
DOC_USP7_MATH_1	174	178	PF00917	0.379
DOC_USP7_MATH_1	207	211	PF00917	0.377
DOC_USP7_MATH_1	261	265	PF00917	0.720
DOC_USP7_MATH_2	268	274	PF00917	0.489
DOC_WW_Pin1_4	264	269	PF00397	0.760
DOC_WW_Pin1_4	317	322	PF00397	0.692
DOC_WW_Pin1_4	46	51	PF00397	0.622
DOC_WW_Pin1_4	72	77	PF00397	0.567
LIG_14-3-3_CanoR_1	182	191	PF00244	0.432
LIG_14-3-3_CanoR_1	262	268	PF00244	0.669
LIG_14-3-3_CanoR_1	53	60	PF00244	0.683
LIG_14-3-3_CterR_2	353	356	PF00244	0.710
LIG_Actin_WH2_2	134	152	PF00022	0.378
LIG_BRCT_BRCA1_1	79	83	PF00533	0.527
LIG_deltaCOP1_diTrp_1	85	90	PF00928	0.366
LIG_FHA_1	111	117	PF00498	0.399
LIG_FHA_1	132	138	PF00498	0.288
LIG_FHA_1	207	213	PF00498	0.387
LIG_FHA_1	317	323	PF00498	0.477
LIG_FHA_1	73	79	PF00498	0.677
LIG_FHA_2	265	271	PF00498	0.695
LIG_FHA_2	283	289	PF00498	0.535
LIG_Integrin_RGD_1	315	317	PF01839	0.545
LIG_LIR_Gen_1	89	98	PF02991	0.369
LIG_LIR_Nem_3	89	93	PF02991	0.291
LIG_Pex14_2	224	228	PF04695	0.288
LIG_Pex14_2	79	83	PF04695	0.416
LIG_SH2_SRC	130	133	PF00017	0.288
LIG_SH2_STAT5	130	133	PF00017	0.307
LIG_SH2_STAT5	236	239	PF00017	0.530
LIG_SUMO_SIM_par_1	317	326	PF11976	0.609
LIG_TRAF2_1	268	271	PF00917	0.622
MOD_CDK_SPxxK_3	46	53	PF00069	0.523
MOD_CK1_1	172	178	PF00069	0.417
MOD_CK1_1	244	250	PF00069	0.592
MOD_CK1_1	264	270	PF00069	0.655
MOD_CK1_1	275	281	PF00069	0.557
MOD_CK1_1	343	349	PF00069	0.678
MOD_CK2_1	106	112	PF00069	0.459
MOD_CK2_1	264	270	PF00069	0.607
MOD_CK2_1	299	305	PF00069	0.675
MOD_CK2_1	46	52	PF00069	0.546
MOD_CMANNOS	87	90	PF00535	0.288
MOD_Cter_Amidation	351	354	PF01082	0.470
MOD_GlcNHglycan	108	111	PF01048	0.363
MOD_GlcNHglycan	174	177	PF01048	0.411
MOD_GlcNHglycan	246	249	PF01048	0.679
MOD_GlcNHglycan	259	262	PF01048	0.679
MOD_GlcNHglycan	274	277	PF01048	0.678
MOD_GlcNHglycan	297	300	PF01048	0.656
MOD_GlcNHglycan	325	328	PF01048	0.756
MOD_GlcNHglycan	342	345	PF01048	0.620
MOD_GlcNHglycan	68	71	PF01048	0.570
MOD_GSK3_1	106	113	PF00069	0.446
MOD_GSK3_1	257	264	PF00069	0.797
MOD_GSK3_1	295	302	PF00069	0.575
MOD_GSK3_1	316	323	PF00069	0.538
MOD_GSK3_1	339	346	PF00069	0.687
MOD_GSK3_1	61	68	PF00069	0.638
MOD_N-GLC_1	100	105	PF02516	0.407
MOD_N-GLC_1	66	71	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	100	105	PF00069	0.373
MOD_NEK2_1	169	174	PF00069	0.403
MOD_NEK2_1	222	227	PF00069	0.468
MOD_NEK2_2	110	115	PF00069	0.324
MOD_PIKK_1	222	228	PF00454	0.378
MOD_PIKK_1	6	12	PF00454	0.454
MOD_PKA_1	183	189	PF00069	0.378
MOD_PKA_2	1	7	PF00069	0.605
MOD_PKA_2	183	189	PF00069	0.479
MOD_PKA_2	257	263	PF00069	0.596
MOD_PKA_2	338	344	PF00069	0.639
MOD_PKA_2	52	58	PF00069	0.770
MOD_Plk_1	269	275	PF00069	0.670
MOD_Plk_4	78	84	PF00069	0.407
MOD_ProDKin_1	264	270	PF00069	0.762
MOD_ProDKin_1	317	323	PF00069	0.694
MOD_ProDKin_1	46	52	PF00069	0.622
MOD_ProDKin_1	72	78	PF00069	0.564
MOD_SUMO_rev_2	86	96	PF00179	0.329
TRG_DiLeu_BaEn_4	30	36	PF01217	0.573
TRG_ER_diArg_1	1	3	PF00400	0.656
TRG_ER_diArg_1	117	120	PF00400	0.424
TRG_ER_diArg_1	18	20	PF00400	0.512
TRG_ER_diArg_1	181	184	PF00400	0.288
TRG_ER_diArg_1	197	200	PF00400	0.288
TRG_ER_diArg_1	24	27	PF00400	0.566
TRG_ER_diArg_1	255	258	PF00400	0.710
TRG_ER_diArg_1	353	355	PF00400	0.469
TRG_NES_CRM1_1	211	221	PF08389	0.288
TRG_NLS_MonoCore_2	252	257	PF00514	0.610
TRG_NLS_MonoExtC_3	181	187	PF00514	0.332
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG6	Leptomonas seymouri	56%	100%
A0A0S4JJ56	Bodo saltans	35%	100%
A0A1X0NFY0	Trypanosomatidae	43%	100%
A0A3Q8IA87	Leishmania donovani	86%	100%
A0A3R7K8F7	Trypanosoma rangeli	45%	100%
A4H8E5	Leishmania braziliensis	75%	98%
A4HWR8	Leishmania infantum	86%	100%
C9ZW55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	94%
Q4QF01	Leishmania major	86%	100%