Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQH5_LEIMU

TriTrypDb:

LmxM.16.0180

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.496
CLV_PCSK_KEX2_1	122	124	PF00082	0.656
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.656
CLV_PCSK_SKI1_1	106	110	PF00082	0.490
CLV_PCSK_SKI1_1	125	129	PF00082	0.617
DEG_Nend_UBRbox_2	1	3	PF02207	0.590
DOC_CKS1_1	12	17	PF01111	0.583
DOC_MAPK_gen_1	104	111	PF00069	0.509
DOC_WW_Pin1_4	11	16	PF00397	0.560
DOC_WW_Pin1_4	128	133	PF00397	0.610
LIG_14-3-3_CanoR_1	6	16	PF00244	0.700
LIG_BRCT_BRCA1_1	41	45	PF00533	0.594
LIG_FHA_2	12	18	PF00498	0.581
LIG_FHA_2	55	61	PF00498	0.511
LIG_LIR_Apic_2	10	15	PF02991	0.577
LIG_LIR_Gen_1	14	24	PF02991	0.433
LIG_LIR_Gen_1	62	72	PF02991	0.650
LIG_LIR_Nem_3	14	19	PF02991	0.512
LIG_LIR_Nem_3	62	67	PF02991	0.628
LIG_SH2_CRK	16	20	PF00017	0.430
LIG_SH2_CRK	64	68	PF00017	0.547
LIG_SH2_NCK_1	16	20	PF00017	0.430
LIG_SH2_PTP2	12	15	PF00017	0.634
LIG_SH2_STAT5	12	15	PF00017	0.634
LIG_SUMO_SIM_par_1	107	112	PF11976	0.348
LIG_TYR_ITSM	12	19	PF00017	0.426
MOD_CK1_1	11	17	PF00069	0.742
MOD_CK1_1	121	127	PF00069	0.709
MOD_CK1_1	33	39	PF00069	0.577
MOD_CK1_1	88	94	PF00069	0.700
MOD_CK2_1	128	134	PF00069	0.611
MOD_CK2_1	33	39	PF00069	0.671
MOD_CK2_1	54	60	PF00069	0.503
MOD_GlcNHglycan	32	35	PF01048	0.591
MOD_GlcNHglycan	87	90	PF01048	0.719
MOD_GSK3_1	26	33	PF00069	0.598
MOD_GSK3_1	35	42	PF00069	0.590
MOD_GSK3_1	4	11	PF00069	0.723
MOD_GSK3_1	56	63	PF00069	0.516
MOD_NEK2_1	109	114	PF00069	0.598
MOD_NEK2_1	44	49	PF00069	0.552
MOD_NEK2_1	67	72	PF00069	0.539
MOD_PIKK_1	109	115	PF00454	0.457
MOD_PKA_2	60	66	PF00069	0.551
MOD_Plk_2-3	130	136	PF00069	0.664
MOD_Plk_4	26	32	PF00069	0.457
MOD_Plk_4	39	45	PF00069	0.569
MOD_Plk_4	8	14	PF00069	0.650
MOD_ProDKin_1	11	17	PF00069	0.559
MOD_ProDKin_1	128	134	PF00069	0.611
MOD_SUMO_rev_2	140	149	PF00179	0.470
TRG_ENDOCYTIC_2	16	19	PF00928	0.426
TRG_ENDOCYTIC_2	64	67	PF00928	0.627
TRG_ENDOCYTIC_2	99	102	PF00928	0.523
TRG_ER_diArg_1	123	126	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NG26	Trypanosomatidae	33%	81%
A0A3S7WTR1	Leishmania donovani	90%	99%
A0A422NDE0	Trypanosoma rangeli	40%	80%
A4HWR7	Leishmania infantum	89%	99%
C9ZW57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	76%
E9AI52	Leishmania braziliensis	91%	100%
Q4QF02	Leishmania major	93%	100%
V5AP83	Trypanosoma cruzi	36%	80%