LeishMANIAdb
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Eukaryotic translation initiation factor 1A,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Eukaryotic translation initiation factor 1A,putative
Gene product:
eukaryotic translation initiation factor 1A, putative
Species:
Leishmania mexicana
UniProt:
E9AQH1_LEIMU
TriTrypDb:
LmxM.16.0140
Length:
168

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 12
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AQH1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQH1

Function

Biological processes
Term Name Level Count
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0003743 translation initiation factor activity 4 11
GO:0005488 binding 1 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.608
CLV_NRD_NRD_1 70 72 PF00675 0.254
CLV_PCSK_KEX2_1 25 27 PF00082 0.569
CLV_PCSK_KEX2_1 85 87 PF00082 0.259
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.555
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.266
CLV_PCSK_SKI1_1 10 14 PF00082 0.572
CLV_PCSK_SKI1_1 26 30 PF00082 0.524
CLV_PCSK_SKI1_1 43 47 PF00082 0.241
DEG_APCC_KENBOX_2 109 113 PF00400 0.570
DOC_MAPK_gen_1 43 51 PF00069 0.453
DOC_MAPK_MEF2A_6 44 53 PF00069 0.466
DOC_USP7_MATH_1 14 18 PF00917 0.688
DOC_USP7_MATH_1 56 60 PF00917 0.481
DOC_USP7_UBL2_3 3 7 PF12436 0.569
DOC_WW_Pin1_4 98 103 PF00397 0.587
LIG_FHA_1 128 134 PF00498 0.752
LIG_FHA_2 99 105 PF00498 0.433
LIG_LIR_Apic_2 27 33 PF02991 0.566
LIG_LIR_Gen_1 130 139 PF02991 0.568
LIG_LIR_Gen_1 37 46 PF02991 0.454
LIG_LIR_Nem_3 130 135 PF02991 0.570
LIG_LIR_Nem_3 37 42 PF02991 0.454
LIG_PDZ_Class_3 163 168 PF00595 0.505
LIG_SH2_CRK 39 43 PF00017 0.453
LIG_SH2_GRB2like 30 33 PF00017 0.544
LIG_SH2_NCK_1 30 34 PF00017 0.566
LIG_SH2_PTP2 132 135 PF00017 0.586
LIG_SH2_SRC 30 33 PF00017 0.559
LIG_SH2_STAT5 132 135 PF00017 0.586
LIG_SUMO_SIM_anti_2 79 84 PF11976 0.453
LIG_SUMO_SIM_anti_2 92 98 PF11976 0.453
LIG_TRAF2_1 120 123 PF00917 0.682
LIG_TYR_ITSM 128 135 PF00017 0.636
MOD_CK2_1 117 123 PF00069 0.441
MOD_CK2_1 98 104 PF00069 0.568
MOD_GlcNHglycan 119 122 PF01048 0.661
MOD_NEK2_2 8 13 PF00069 0.548
MOD_Plk_1 26 32 PF00069 0.623
MOD_Plk_4 57 63 PF00069 0.523
MOD_ProDKin_1 98 104 PF00069 0.585
MOD_SUMO_for_1 84 87 PF00179 0.504
TRG_DiLeu_BaEn_1 104 109 PF01217 0.396
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.469
TRG_ENDOCYTIC_2 132 135 PF00928 0.586
TRG_ENDOCYTIC_2 39 42 PF00928 0.453
TRG_Pf-PMV_PEXEL_1 106 111 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Z1 Leptomonas seymouri 88% 100%
A0A0S4JME0 Bodo saltans 57% 94%
A0A1X0NFW8 Trypanosomatidae 72% 99%
A0A3S5H6W6 Leishmania donovani 99% 100%
A0A422NDF4 Trypanosoma rangeli 72% 100%
A4H8E1 Leishmania braziliensis 99% 100%
A4HWR3 Leishmania infantum 99% 100%
C9ZW61 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 98%
O14602 Homo sapiens 40% 100%
P38912 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 100%
P47813 Homo sapiens 40% 100%
P47814 Oryctolagus cuniculus 42% 100%
P47815 Triticum aestivum 40% 100%
P55877 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
P56331 Onobrychis viciifolia 38% 100%
Q4QF06 Leishmania major 99% 100%
Q54YJ6 Dictyostelium discoideum 40% 100%
Q5RA42 Pongo abelii 40% 100%
Q60872 Mus musculus 39% 100%
Q6GVM3 Pan troglodytes 37% 100%
Q6VV72 Rattus norvegicus 39% 100%
Q8BMJ3 Mus musculus 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS