Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQG8_LEIMU

TriTrypDb:

LmxM.16.0120

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.444
CLV_C14_Caspase3-7	467	471	PF00656	0.587
CLV_C14_Caspase3-7	529	533	PF00656	0.537
CLV_C14_Caspase3-7	751	755	PF00656	0.293
CLV_NRD_NRD_1	195	197	PF00675	0.513
CLV_NRD_NRD_1	316	318	PF00675	0.540
CLV_NRD_NRD_1	446	448	PF00675	0.602
CLV_NRD_NRD_1	500	502	PF00675	0.492
CLV_NRD_NRD_1	606	608	PF00675	0.492
CLV_NRD_NRD_1	779	781	PF00675	0.568
CLV_PCSK_KEX2_1	195	197	PF00082	0.558
CLV_PCSK_KEX2_1	316	318	PF00082	0.540
CLV_PCSK_KEX2_1	380	382	PF00082	0.536
CLV_PCSK_KEX2_1	500	502	PF00082	0.503
CLV_PCSK_KEX2_1	606	608	PF00082	0.412
CLV_PCSK_KEX2_1	779	781	PF00082	0.568
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.489
CLV_PCSK_SKI1_1	269	273	PF00082	0.453
CLV_PCSK_SKI1_1	288	292	PF00082	0.510
CLV_PCSK_SKI1_1	360	364	PF00082	0.498
CLV_PCSK_SKI1_1	508	512	PF00082	0.457
CLV_PCSK_SKI1_1	558	562	PF00082	0.424
CLV_PCSK_SKI1_1	578	582	PF00082	0.414
CLV_PCSK_SKI1_1	583	587	PF00082	0.392
CLV_PCSK_SKI1_1	614	618	PF00082	0.460
CLV_PCSK_SKI1_1	724	728	PF00082	0.518
CLV_Separin_Metazoa	776	780	PF03568	0.600
DEG_APCC_DBOX_1	203	211	PF00400	0.356
DEG_APCC_DBOX_1	577	585	PF00400	0.412
DEG_APCC_DBOX_1	613	621	PF00400	0.499
DEG_COP1_1	126	136	PF00400	0.675
DEG_Nend_UBRbox_1	1	4	PF02207	0.632
DEG_SPOP_SBC_1	154	158	PF00917	0.677
DEG_SPOP_SBC_1	18	22	PF00917	0.451
DOC_ANK_TNKS_1	315	322	PF00023	0.295
DOC_ANK_TNKS_1	9	16	PF00023	0.745
DOC_CYCLIN_RxL_1	558	568	PF00134	0.416
DOC_CYCLIN_RxL_1	80	91	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	740	746	PF00134	0.503
DOC_MAPK_gen_1	215	225	PF00069	0.537
DOC_MAPK_gen_1	500	507	PF00069	0.245
DOC_MAPK_gen_1	80	89	PF00069	0.519
DOC_MAPK_MEF2A_6	500	509	PF00069	0.245
DOC_PP2B_LxvP_1	367	370	PF13499	0.553
DOC_PP2B_LxvP_1	620	623	PF13499	0.557
DOC_USP7_MATH_1	124	128	PF00917	0.540
DOC_USP7_MATH_1	150	154	PF00917	0.746
DOC_USP7_MATH_1	18	22	PF00917	0.727
DOC_USP7_MATH_1	292	296	PF00917	0.576
DOC_USP7_MATH_1	465	469	PF00917	0.619
DOC_USP7_MATH_1	525	529	PF00917	0.453
DOC_USP7_MATH_1	553	557	PF00917	0.550
DOC_USP7_MATH_1	599	603	PF00917	0.555
DOC_WW_Pin1_4	142	147	PF00397	0.608
DOC_WW_Pin1_4	155	160	PF00397	0.579
DOC_WW_Pin1_4	181	186	PF00397	0.502
DOC_WW_Pin1_4	33	38	PF00397	0.516
DOC_WW_Pin1_4	415	420	PF00397	0.627
DOC_WW_Pin1_4	510	515	PF00397	0.452
DOC_WW_Pin1_4	677	682	PF00397	0.723
LIG_14-3-3_CanoR_1	117	124	PF00244	0.485
LIG_14-3-3_CanoR_1	177	182	PF00244	0.580
LIG_14-3-3_CanoR_1	2	8	PF00244	0.658
LIG_14-3-3_CanoR_1	204	208	PF00244	0.506
LIG_14-3-3_CanoR_1	360	369	PF00244	0.577
LIG_14-3-3_CanoR_1	508	516	PF00244	0.478
LIG_14-3-3_CanoR_1	569	573	PF00244	0.470
LIG_14-3-3_CanoR_1	583	589	PF00244	0.365
LIG_14-3-3_CanoR_1	632	640	PF00244	0.526
LIG_14-3-3_CanoR_1	686	696	PF00244	0.582
LIG_14-3-3_CanoR_1	724	732	PF00244	0.512
LIG_14-3-3_CanoR_1	85	90	PF00244	0.503
LIG_14-3-3_CanoR_1	92	97	PF00244	0.475
LIG_Actin_WH2_2	200	217	PF00022	0.464
LIG_APCC_ABBA_1	396	401	PF00400	0.260
LIG_BIR_III_2	781	785	PF00653	0.592
LIG_BRCT_BRCA1_1	679	683	PF00533	0.447
LIG_Clathr_ClatBox_1	536	540	PF01394	0.604
LIG_FHA_1	149	155	PF00498	0.773
LIG_FHA_1	220	226	PF00498	0.540
LIG_FHA_1	234	240	PF00498	0.503
LIG_FHA_1	275	281	PF00498	0.462
LIG_FHA_1	406	412	PF00498	0.429
LIG_FHA_1	477	483	PF00498	0.482
LIG_FHA_1	713	719	PF00498	0.541
LIG_FHA_1	84	90	PF00498	0.636
LIG_FHA_2	637	643	PF00498	0.424
LIG_FHA_2	74	80	PF00498	0.448
LIG_FHA_2	93	99	PF00498	0.515
LIG_GBD_Chelix_1	732	740	PF00786	0.446
LIG_LIR_Apic_2	363	369	PF02991	0.567
LIG_LIR_Gen_1	160	171	PF02991	0.646
LIG_LIR_Gen_1	270	280	PF02991	0.532
LIG_LIR_Gen_1	571	580	PF02991	0.384
LIG_LIR_Gen_1	754	764	PF02991	0.379
LIG_LIR_Nem_3	160	166	PF02991	0.646
LIG_LIR_Nem_3	270	275	PF02991	0.501
LIG_LIR_Nem_3	571	575	PF02991	0.527
LIG_LIR_Nem_3	602	608	PF02991	0.417
LIG_LIR_Nem_3	664	669	PF02991	0.538
LIG_LIR_Nem_3	754	759	PF02991	0.537
LIG_NRBOX	177	183	PF00104	0.433
LIG_NRBOX	560	566	PF00104	0.395
LIG_PDZ_Class_2	785	790	PF00595	0.723
LIG_Pex14_2	723	727	PF04695	0.280
LIG_REV1ctd_RIR_1	135	145	PF16727	0.659
LIG_RPA_C_Fungi	725	737	PF08784	0.526
LIG_SH2_CRK	572	576	PF00017	0.553
LIG_SH2_GRB2like	596	599	PF00017	0.334
LIG_SH2_NCK_1	572	576	PF00017	0.261
LIG_SH2_STAP1	41	45	PF00017	0.644
LIG_SH2_STAP1	572	576	PF00017	0.261
LIG_SH2_STAT3	406	409	PF00017	0.561
LIG_SH2_STAT5	136	139	PF00017	0.562
LIG_SH2_STAT5	336	339	PF00017	0.494
LIG_SH2_STAT5	406	409	PF00017	0.557
LIG_SH2_STAT5	543	546	PF00017	0.592
LIG_SH2_STAT5	596	599	PF00017	0.334
LIG_SH2_STAT5	709	712	PF00017	0.508
LIG_SH3_2	681	686	PF14604	0.445
LIG_SH3_3	276	282	PF00018	0.468
LIG_SH3_3	458	464	PF00018	0.524
LIG_SH3_3	56	62	PF00018	0.582
LIG_SH3_3	678	684	PF00018	0.690
LIG_SH3_3	714	720	PF00018	0.549
LIG_SH3_3	740	746	PF00018	0.560
LIG_SUMO_SIM_anti_2	734	741	PF11976	0.436
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.631
LIG_SUMO_SIM_par_1	150	158	PF11976	0.574
LIG_SUMO_SIM_par_1	221	226	PF11976	0.517
LIG_SUMO_SIM_par_1	301	308	PF11976	0.467
LIG_SUMO_SIM_par_1	563	568	PF11976	0.368
LIG_SUMO_SIM_par_1	84	91	PF11976	0.634
LIG_TRAF2_1	167	170	PF00917	0.521
LIG_TRAF2_1	362	365	PF00917	0.670
LIG_TRAF2_1	711	714	PF00917	0.502
LIG_TRAF2_1	76	79	PF00917	0.513
LIG_TRFH_1	516	520	PF08558	0.543
LIG_TYR_ITIM	570	575	PF00017	0.544
LIG_WW_3	683	687	PF00397	0.665
LIG_WW_3	7	11	PF00397	0.565
MOD_CDC14_SPxK_1	36	39	PF00782	0.510
MOD_CDK_SPK_2	181	186	PF00069	0.534
MOD_CDK_SPxK_1	33	39	PF00069	0.520
MOD_CK1_1	153	159	PF00069	0.733
MOD_CK1_1	16	22	PF00069	0.670
MOD_CK1_1	308	314	PF00069	0.523
MOD_CK1_1	568	574	PF00069	0.498
MOD_CK1_1	725	731	PF00069	0.474
MOD_CK2_1	124	130	PF00069	0.547
MOD_CK2_1	164	170	PF00069	0.628
MOD_CK2_1	391	397	PF00069	0.585
MOD_CK2_1	636	642	PF00069	0.442
MOD_CK2_1	73	79	PF00069	0.546
MOD_CK2_1	759	765	PF00069	0.564
MOD_CK2_1	85	91	PF00069	0.470
MOD_CK2_1	92	98	PF00069	0.417
MOD_GlcNHglycan	119	122	PF01048	0.576
MOD_GlcNHglycan	126	129	PF01048	0.683
MOD_GlcNHglycan	294	297	PF01048	0.596
MOD_GlcNHglycan	393	396	PF01048	0.499
MOD_GlcNHglycan	467	470	PF01048	0.501
MOD_GlcNHglycan	555	558	PF01048	0.589
MOD_GlcNHglycan	689	692	PF01048	0.601
MOD_GlcNHglycan	751	754	PF01048	0.502
MOD_GSK3_1	13	20	PF00069	0.756
MOD_GSK3_1	150	157	PF00069	0.722
MOD_GSK3_1	177	184	PF00069	0.545
MOD_GSK3_1	292	299	PF00069	0.526
MOD_GSK3_1	33	40	PF00069	0.540
MOD_GSK3_1	64	71	PF00069	0.468
MOD_GSK3_1	759	766	PF00069	0.591
MOD_GSK3_1	81	88	PF00069	0.482
MOD_N-GLC_1	154	159	PF02516	0.675
MOD_N-GLC_1	189	194	PF02516	0.581
MOD_NEK2_1	203	208	PF00069	0.546
MOD_NEK2_1	214	219	PF00069	0.444
MOD_NEK2_1	233	238	PF00069	0.382
MOD_NEK2_1	410	415	PF00069	0.538
MOD_NEK2_1	452	457	PF00069	0.573
MOD_NEK2_1	482	487	PF00069	0.431
MOD_NEK2_1	565	570	PF00069	0.361
MOD_NEK2_1	584	589	PF00069	0.269
MOD_NEK2_1	759	764	PF00069	0.525
MOD_NEK2_1	769	774	PF00069	0.333
MOD_NEK2_2	375	380	PF00069	0.551
MOD_NEK2_2	661	666	PF00069	0.543
MOD_PIKK_1	360	366	PF00454	0.378
MOD_PIKK_1	39	45	PF00454	0.606
MOD_PIKK_1	405	411	PF00454	0.552
MOD_PIKK_1	431	437	PF00454	0.695
MOD_PKA_2	116	122	PF00069	0.694
MOD_PKA_2	140	146	PF00069	0.592
MOD_PKA_2	203	209	PF00069	0.378
MOD_PKA_2	214	220	PF00069	0.328
MOD_PKA_2	568	574	PF00069	0.493
MOD_PKA_2	631	637	PF00069	0.638
MOD_Plk_1	189	195	PF00069	0.596
MOD_Plk_1	37	43	PF00069	0.621
MOD_Plk_1	452	458	PF00069	0.485
MOD_Plk_2-3	221	227	PF00069	0.439
MOD_Plk_2-3	636	642	PF00069	0.583
MOD_Plk_4	177	183	PF00069	0.517
MOD_Plk_4	203	209	PF00069	0.544
MOD_Plk_4	329	335	PF00069	0.586
MOD_Plk_4	636	642	PF00069	0.499
MOD_Plk_4	653	659	PF00069	0.479
MOD_Plk_4	661	667	PF00069	0.541
MOD_Plk_4	85	91	PF00069	0.488
MOD_ProDKin_1	142	148	PF00069	0.611
MOD_ProDKin_1	155	161	PF00069	0.578
MOD_ProDKin_1	181	187	PF00069	0.504
MOD_ProDKin_1	33	39	PF00069	0.512
MOD_ProDKin_1	415	421	PF00069	0.630
MOD_ProDKin_1	510	516	PF00069	0.457
MOD_ProDKin_1	677	683	PF00069	0.723
MOD_SUMO_rev_2	324	333	PF00179	0.316
MOD_SUMO_rev_2	72	81	PF00179	0.508
TRG_DiLeu_BaEn_1	329	334	PF01217	0.547
TRG_DiLeu_BaEn_4	173	179	PF01217	0.508
TRG_DiLeu_BaEn_4	697	703	PF01217	0.467
TRG_DiLeu_BaEn_4	713	719	PF01217	0.454
TRG_ENDOCYTIC_2	211	214	PF00928	0.491
TRG_ENDOCYTIC_2	572	575	PF00928	0.545
TRG_ER_diArg_1	195	198	PF00400	0.539
TRG_ER_diArg_1	315	317	PF00400	0.573
TRG_ER_diArg_1	500	502	PF00400	0.503
TRG_ER_diArg_1	605	607	PF00400	0.497
TRG_ER_diArg_1	692	695	PF00400	0.511
TRG_ER_diArg_1	778	780	PF00400	0.543
TRG_NLS_MonoExtN_4	80	86	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	730	734	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y7	Leptomonas seymouri	44%	100%
A0A1X0NZ28	Trypanosomatidae	26%	100%
A0A3R7M3M3	Trypanosoma rangeli	29%	100%
A0A3S7WTS3	Leishmania donovani	86%	100%
A4H8D9	Leishmania braziliensis	71%	100%
A4HWR1	Leishmania infantum	86%	100%
C9ZPS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QF08	Leishmania major	85%	99%