MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AQG6_LEIMU

TriTrypDb:

LmxM.16.0100

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AQG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.567
CLV_C14_Caspase3-7	221	225	PF00656	0.558
CLV_C14_Caspase3-7	392	396	PF00656	0.662
CLV_C14_Caspase3-7	656	660	PF00656	0.712
CLV_C14_Caspase3-7	95	99	PF00656	0.386
CLV_NRD_NRD_1	380	382	PF00675	0.445
CLV_NRD_NRD_1	502	504	PF00675	0.475
CLV_NRD_NRD_1	618	620	PF00675	0.516
CLV_PCSK_KEX2_1	380	382	PF00082	0.445
CLV_PCSK_KEX2_1	502	504	PF00082	0.475
CLV_PCSK_KEX2_1	618	620	PF00082	0.516
CLV_PCSK_SKI1_1	138	142	PF00082	0.638
CLV_PCSK_SKI1_1	162	166	PF00082	0.766
CLV_PCSK_SKI1_1	366	370	PF00082	0.462
CLV_PCSK_SKI1_1	380	384	PF00082	0.449
CLV_PCSK_SKI1_1	421	425	PF00082	0.349
CLV_PCSK_SKI1_1	525	529	PF00082	0.511
DEG_APCC_DBOX_1	331	339	PF00400	0.502
DEG_APCC_DBOX_1	420	428	PF00400	0.581
DEG_APCC_DBOX_1	487	495	PF00400	0.667
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.475
DOC_MAPK_FxFP_2	268	271	PF00069	0.363
DOC_MAPK_FxFP_2	369	372	PF00069	0.732
DOC_MAPK_gen_1	416	425	PF00069	0.674
DOC_MAPK_gen_1	485	493	PF00069	0.723
DOC_MAPK_gen_1	551	559	PF00069	0.677
DOC_PP1_RVXF_1	419	426	PF00149	0.562
DOC_PP1_RVXF_1	556	562	PF00149	0.525
DOC_PP2B_LxvP_1	273	276	PF13499	0.344
DOC_PP2B_LxvP_1	343	346	PF13499	0.472
DOC_PP2B_LxvP_1	435	438	PF13499	0.390
DOC_PP4_FxxP_1	268	271	PF00568	0.338
DOC_PP4_FxxP_1	305	308	PF00568	0.662
DOC_PP4_FxxP_1	369	372	PF00568	0.713
DOC_USP7_MATH_1	157	161	PF00917	0.487
DOC_USP7_MATH_1	167	171	PF00917	0.386
DOC_USP7_MATH_1	218	222	PF00917	0.573
DOC_USP7_MATH_1	27	31	PF00917	0.433
DOC_USP7_MATH_1	300	304	PF00917	0.755
DOC_USP7_MATH_1	396	400	PF00917	0.729
DOC_USP7_MATH_2	252	258	PF00917	0.519
DOC_WW_Pin1_4	187	192	PF00397	0.538
DOC_WW_Pin1_4	237	242	PF00397	0.490
DOC_WW_Pin1_4	380	385	PF00397	0.655
DOC_WW_Pin1_4	504	509	PF00397	0.730
LIG_14-3-3_CanoR_1	15	20	PF00244	0.487
LIG_14-3-3_CanoR_1	260	264	PF00244	0.520
LIG_14-3-3_CanoR_1	284	289	PF00244	0.691
LIG_14-3-3_CanoR_1	551	561	PF00244	0.605
LIG_14-3-3_CanoR_1	587	597	PF00244	0.415
LIG_Actin_WH2_2	268	286	PF00022	0.449
LIG_Actin_WH2_2	466	481	PF00022	0.330
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BIR_III_2	659	663	PF00653	0.692
LIG_BIR_III_4	186	190	PF00653	0.475
LIG_BRCT_BRCA1_1	450	454	PF00533	0.516
LIG_BRCT_BRCA1_1	593	597	PF00533	0.353
LIG_BRCT_BRCA1_1	92	96	PF00533	0.380
LIG_CSL_BTD_1	276	279	PF09270	0.475
LIG_eIF4E_1	418	424	PF01652	0.653
LIG_eIF4E_1	535	541	PF01652	0.693
LIG_FHA_1	159	165	PF00498	0.567
LIG_FHA_1	201	207	PF00498	0.442
LIG_FHA_1	381	387	PF00498	0.651
LIG_FHA_1	472	478	PF00498	0.402
LIG_FHA_1	675	681	PF00498	0.441
LIG_FHA_2	142	148	PF00498	0.476
LIG_FHA_2	342	348	PF00498	0.432
LIG_FHA_2	402	408	PF00498	0.620
LIG_FHA_2	615	621	PF00498	0.602
LIG_GBD_Chelix_1	427	435	PF00786	0.367
LIG_LIR_Apic_2	236	241	PF02991	0.537
LIG_LIR_Apic_2	303	308	PF02991	0.669
LIG_LIR_Apic_2	367	372	PF02991	0.730
LIG_LIR_Gen_1	210	218	PF02991	0.549
LIG_LIR_Gen_1	22	29	PF02991	0.506
LIG_LIR_Gen_1	462	471	PF02991	0.399
LIG_LIR_Gen_1	472	483	PF02991	0.610
LIG_LIR_Gen_1	594	602	PF02991	0.301
LIG_LIR_Gen_1	671	680	PF02991	0.394
LIG_LIR_Nem_3	210	214	PF02991	0.500
LIG_LIR_Nem_3	22	26	PF02991	0.508
LIG_LIR_Nem_3	274	280	PF02991	0.428
LIG_LIR_Nem_3	364	368	PF02991	0.574
LIG_LIR_Nem_3	462	467	PF02991	0.404
LIG_LIR_Nem_3	472	478	PF02991	0.386
LIG_LIR_Nem_3	594	600	PF02991	0.292
LIG_LIR_Nem_3	671	675	PF02991	0.421
LIG_LIR_Nem_3	99	105	PF02991	0.427
LIG_Pex14_2	266	270	PF04695	0.340
LIG_Pex14_2	463	467	PF04695	0.413
LIG_Pex14_2	598	602	PF04695	0.475
LIG_Pex14_2	69	73	PF04695	0.341
LIG_Pex14_2	92	96	PF04695	0.343
LIG_PTAP_UEV_1	190	195	PF05743	0.460
LIG_PTB_Apo_2	205	212	PF02174	0.367
LIG_PTB_Apo_2	412	419	PF02174	0.614
LIG_PTB_Apo_2	493	500	PF02174	0.700
LIG_PTB_Phospho_1	412	418	PF10480	0.613
LIG_REV1ctd_RIR_1	366	371	PF16727	0.709
LIG_SH2_CRK	102	106	PF00017	0.407
LIG_SH2_CRK	238	242	PF00017	0.553
LIG_SH2_CRK	634	638	PF00017	0.663
LIG_SH2_CRK	670	674	PF00017	0.475
LIG_SH2_GRB2like	40	43	PF00017	0.457
LIG_SH2_PTP2	612	615	PF00017	0.540
LIG_SH2_SRC	610	613	PF00017	0.399
LIG_SH2_STAP1	670	674	PF00017	0.281
LIG_SH2_STAT3	106	109	PF00017	0.403
LIG_SH2_STAT5	152	155	PF00017	0.502
LIG_SH2_STAT5	37	40	PF00017	0.411
LIG_SH2_STAT5	610	613	PF00017	0.330
LIG_SH2_STAT5	626	629	PF00017	0.611
LIG_SH3_2	279	284	PF14604	0.586
LIG_SH3_3	188	194	PF00018	0.583
LIG_SH3_3	273	279	PF00018	0.344
LIG_SUMO_SIM_par_1	176	186	PF11976	0.557
LIG_SUMO_SIM_par_1	325	331	PF11976	0.451
LIG_SUMO_SIM_par_1	665	671	PF11976	0.672
LIG_TYR_ITIM	608	613	PF00017	0.243
LIG_TYR_ITSM	98	105	PF00017	0.392
LIG_WRC_WIRS_1	365	370	PF05994	0.683
LIG_WRC_WIRS_1	460	465	PF05994	0.432
LIG_WRC_WIRS_1	597	602	PF05994	0.449
LIG_WRC_WIRS_1	669	674	PF05994	0.281
MOD_CDC14_SPxK_1	507	510	PF00782	0.724
MOD_CDK_SPK_2	380	385	PF00069	0.671
MOD_CDK_SPxK_1	504	510	PF00069	0.730
MOD_CK1_1	182	188	PF00069	0.520
MOD_CK1_1	2	8	PF00069	0.544
MOD_CK1_1	240	246	PF00069	0.510
MOD_CK1_1	30	36	PF00069	0.454
MOD_CK1_1	364	370	PF00069	0.682
MOD_CK1_1	536	542	PF00069	0.683
MOD_CK1_1	642	648	PF00069	0.553
MOD_CK2_1	141	147	PF00069	0.476
MOD_CK2_1	284	290	PF00069	0.692
MOD_CK2_1	341	347	PF00069	0.448
MOD_CK2_1	614	620	PF00069	0.595
MOD_CK2_1	637	643	PF00069	0.690
MOD_GlcNHglycan	165	168	PF01048	0.737
MOD_GlcNHglycan	169	172	PF01048	0.734
MOD_GlcNHglycan	229	232	PF01048	0.695
MOD_GlcNHglycan	296	299	PF01048	0.449
MOD_GlcNHglycan	386	389	PF01048	0.439
MOD_GlcNHglycan	4	7	PF01048	0.698
MOD_GlcNHglycan	435	438	PF01048	0.421
MOD_GlcNHglycan	528	531	PF01048	0.508
MOD_GlcNHglycan	544	547	PF01048	0.361
MOD_GlcNHglycan	64	67	PF01048	0.480
MOD_GlcNHglycan	74	77	PF01048	0.484
MOD_GlcNHglycan	92	95	PF01048	0.444
MOD_GSK3_1	121	128	PF00069	0.494
MOD_GSK3_1	163	170	PF00069	0.410
MOD_GSK3_1	196	203	PF00069	0.552
MOD_GSK3_1	233	240	PF00069	0.525
MOD_GSK3_1	380	387	PF00069	0.669
MOD_GSK3_1	433	440	PF00069	0.439
MOD_GSK3_1	459	466	PF00069	0.464
MOD_GSK3_1	5	12	PF00069	0.493
MOD_GSK3_1	587	594	PF00069	0.454
MOD_N-GLC_1	157	162	PF02516	0.598
MOD_N-GLC_1	207	212	PF02516	0.722
MOD_N-GLC_1	218	223	PF02516	0.781
MOD_NEK2_1	141	146	PF00069	0.489
MOD_NEK2_1	163	168	PF00069	0.520
MOD_NEK2_1	283	288	PF00069	0.658
MOD_NEK2_1	294	299	PF00069	0.605
MOD_NEK2_1	328	333	PF00069	0.625
MOD_NEK2_1	38	43	PF00069	0.453
MOD_NEK2_1	389	394	PF00069	0.664
MOD_NEK2_1	431	436	PF00069	0.384
MOD_NEK2_1	448	453	PF00069	0.366
MOD_NEK2_1	456	461	PF00069	0.283
MOD_NEK2_1	463	468	PF00069	0.305
MOD_NEK2_1	469	474	PF00069	0.269
MOD_NEK2_1	542	547	PF00069	0.609
MOD_NEK2_1	560	565	PF00069	0.245
MOD_NEK2_1	668	673	PF00069	0.484
MOD_NEK2_1	96	101	PF00069	0.333
MOD_NEK2_2	259	264	PF00069	0.463
MOD_NEK2_2	533	538	PF00069	0.708
MOD_NEK2_2	575	580	PF00069	0.472
MOD_PIKK_1	233	239	PF00454	0.535
MOD_PIKK_1	27	33	PF00454	0.385
MOD_PKA_2	121	127	PF00069	0.439
MOD_PKA_2	259	265	PF00069	0.532
MOD_PKA_2	283	289	PF00069	0.717
MOD_PKA_2	552	558	PF00069	0.577
MOD_PKA_2	582	588	PF00069	0.397
MOD_Plk_1	207	213	PF00069	0.522
MOD_Plk_1	218	224	PF00069	0.582
MOD_Plk_1	97	103	PF00069	0.427
MOD_Plk_4	141	147	PF00069	0.483
MOD_Plk_4	15	21	PF00069	0.511
MOD_Plk_4	240	246	PF00069	0.532
MOD_Plk_4	389	395	PF00069	0.682
MOD_Plk_4	456	462	PF00069	0.284
MOD_Plk_4	463	469	PF00069	0.356
MOD_Plk_4	471	477	PF00069	0.341
MOD_Plk_4	668	674	PF00069	0.526
MOD_Plk_4	80	86	PF00069	0.337
MOD_Plk_4	97	103	PF00069	0.409
MOD_ProDKin_1	187	193	PF00069	0.539
MOD_ProDKin_1	237	243	PF00069	0.488
MOD_ProDKin_1	380	386	PF00069	0.654
MOD_ProDKin_1	504	510	PF00069	0.730
MOD_SUMO_rev_2	221	230	PF00179	0.524
MOD_SUMO_rev_2	392	399	PF00179	0.684
MOD_SUMO_rev_2	90	99	PF00179	0.387
TRG_DiLeu_BaEn_1	501	506	PF01217	0.697
TRG_DiLeu_BaEn_2	289	295	PF01217	0.723
TRG_ENDOCYTIC_2	102	105	PF00928	0.408
TRG_ENDOCYTIC_2	365	368	PF00928	0.547
TRG_ENDOCYTIC_2	420	423	PF00928	0.613
TRG_ENDOCYTIC_2	595	598	PF00928	0.350
TRG_ENDOCYTIC_2	610	613	PF00928	0.344
TRG_ENDOCYTIC_2	634	637	PF00928	0.629
TRG_ENDOCYTIC_2	670	673	PF00928	0.434
TRG_ER_diArg_1	380	382	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD79	Leptomonas seymouri	64%	98%
A0A0S4JPR5	Bodo saltans	39%	75%
A0A1X0NZJ8	Trypanosomatidae	39%	99%
A0A3S7WTR7	Leishmania donovani	92%	100%
A0A422N036	Trypanosoma rangeli	36%	96%
A4H8D7	Leishmania braziliensis	76%	100%
A4HWQ9	Leishmania infantum	92%	100%
C9ZPS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	94%
Q4QF10	Leishmania major	90%	100%
V5D792	Trypanosoma cruzi	38%	97%