Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQG5_LEIMU

TriTrypDb:

LmxM.16.0090

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.432
CLV_NRD_NRD_1	317	319	PF00675	0.526
CLV_PCSK_KEX2_1	252	254	PF00082	0.432
CLV_PCSK_KEX2_1	317	319	PF00082	0.526
CLV_PCSK_SKI1_1	317	321	PF00082	0.616
DEG_APCC_DBOX_1	317	325	PF00400	0.480
DOC_ANK_TNKS_1	283	290	PF00023	0.395
DOC_CDC14_PxL_1	262	270	PF14671	0.496
DOC_CKS1_1	290	295	PF01111	0.437
DOC_CYCLIN_RxL_1	251	260	PF00134	0.295
DOC_CYCLIN_RxL_1	314	325	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	320	323	PF00134	0.404
DOC_MAPK_DCC_7	261	270	PF00069	0.291
DOC_MAPK_DCC_7	46	56	PF00069	0.262
DOC_MAPK_gen_1	252	259	PF00069	0.471
DOC_MAPK_MEF2A_6	226	233	PF00069	0.517
DOC_MAPK_MEF2A_6	261	270	PF00069	0.506
DOC_MAPK_MEF2A_6	46	55	PF00069	0.510
DOC_PP2B_LxvP_1	308	311	PF13499	0.538
DOC_PP2B_LxvP_1	319	322	PF13499	0.603
DOC_PP2B_LxvP_1	57	60	PF13499	0.461
DOC_PP4_FxxP_1	224	227	PF00568	0.568
DOC_PP4_FxxP_1	270	273	PF00568	0.394
DOC_PP4_FxxP_1	86	89	PF00568	0.518
DOC_PP4_MxPP_1	291	294	PF00568	0.433
DOC_USP7_MATH_1	15	19	PF00917	0.562
DOC_WW_Pin1_4	289	294	PF00397	0.636
DOC_WW_Pin1_4	61	66	PF00397	0.588
LIG_14-3-3_CanoR_1	119	127	PF00244	0.589
LIG_14-3-3_CanoR_1	154	164	PF00244	0.441
LIG_14-3-3_CanoR_1	181	186	PF00244	0.282
LIG_14-3-3_CanoR_1	206	211	PF00244	0.365
LIG_14-3-3_CanoR_1	284	288	PF00244	0.620
LIG_ActinCP_TwfCPI_2	224	234	PF01115	0.550
LIG_AP2alpha_1	170	174	PF02296	0.196
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BRCT_BRCA1_1	82	86	PF00533	0.527
LIG_Clathr_ClatBox_1	267	271	PF01394	0.368
LIG_Clathr_ClatBox_1	276	280	PF01394	0.284
LIG_CSL_BTD_1	47	50	PF09270	0.377
LIG_CtBP_PxDLS_1	273	277	PF00389	0.343
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.484
LIG_FHA_1	267	273	PF00498	0.476
LIG_FHA_2	127	133	PF00498	0.363
LIG_FHA_2	156	162	PF00498	0.344
LIG_HP1_1	52	56	PF01393	0.285
LIG_LIR_Apic_2	221	227	PF02991	0.291
LIG_LIR_Apic_2	269	273	PF02991	0.384
LIG_LIR_Apic_2	83	89	PF02991	0.549
LIG_LIR_Gen_1	205	215	PF02991	0.359
LIG_LIR_Nem_3	205	210	PF02991	0.518
LIG_LIR_Nem_3	63	69	PF02991	0.408
LIG_Pex14_2	170	174	PF04695	0.209
LIG_PTB_Apo_2	184	191	PF02174	0.196
LIG_PTB_Phospho_1	184	190	PF10480	0.196
LIG_SH2_CRK	166	170	PF00017	0.443
LIG_SH2_CRK	215	219	PF00017	0.368
LIG_SH2_CRK	240	244	PF00017	0.571
LIG_SH2_GRB2like	185	188	PF00017	0.253
LIG_SH2_NCK_1	215	219	PF00017	0.409
LIG_SH2_SRC	215	218	PF00017	0.413
LIG_SH2_STAP1	185	189	PF00017	0.293
LIG_SH2_STAT5	166	169	PF00017	0.257
LIG_SH2_STAT5	220	223	PF00017	0.304
LIG_SH3_2	65	70	PF14604	0.525
LIG_SH3_3	260	266	PF00018	0.510
LIG_SH3_3	44	50	PF00018	0.406
LIG_SH3_3	62	68	PF00018	0.510
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.508
LIG_SUMO_SIM_par_1	52	58	PF11976	0.336
LIG_TRAF2_1	137	140	PF00917	0.484
LIG_TYR_ITIM	238	243	PF00017	0.550
LIG_WRC_WIRS_1	267	272	PF05994	0.270
MOD_CK1_1	73	79	PF00069	0.531
MOD_CK2_1	126	132	PF00069	0.344
MOD_CK2_1	133	139	PF00069	0.344
MOD_CK2_1	155	161	PF00069	0.344
MOD_GlcNHglycan	135	138	PF01048	0.477
MOD_GlcNHglycan	26	29	PF01048	0.484
MOD_GlcNHglycan	285	288	PF01048	0.667
MOD_GSK3_1	115	122	PF00069	0.520
MOD_GSK3_1	198	205	PF00069	0.424
MOD_GSK3_1	279	286	PF00069	0.545
MOD_GSK3_1	70	77	PF00069	0.576
MOD_N-GLC_1	150	155	PF02516	0.422
MOD_N-GLC_1	218	223	PF02516	0.283
MOD_NEK2_1	115	120	PF00069	0.678
MOD_NEK2_1	257	262	PF00069	0.490
MOD_PIKK_1	15	21	PF00454	0.537
MOD_PIKK_1	81	87	PF00454	0.422
MOD_PKA_2	283	289	PF00069	0.638
MOD_Plk_1	150	156	PF00069	0.464
MOD_Plk_1	202	208	PF00069	0.272
MOD_Plk_1	279	285	PF00069	0.388
MOD_Plk_1	74	80	PF00069	0.423
MOD_Plk_2-3	135	141	PF00069	0.443
MOD_Plk_4	272	278	PF00069	0.341
MOD_ProDKin_1	289	295	PF00069	0.637
MOD_ProDKin_1	61	67	PF00069	0.589
MOD_SUMO_rev_2	159	165	PF00179	0.422
TRG_DiLeu_BaEn_1	316	321	PF01217	0.607
TRG_DiLeu_BaEn_2	28	34	PF01217	0.504
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.425
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.430
TRG_ENDOCYTIC_2	190	193	PF00928	0.222
TRG_ENDOCYTIC_2	215	218	PF00928	0.445
TRG_ENDOCYTIC_2	240	243	PF00928	0.460
TRG_ER_diArg_1	252	255	PF00400	0.384
TRG_ER_diArg_1	317	319	PF00400	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA4	Leptomonas seymouri	51%	98%
A0A1X0P0E9	Trypanosomatidae	34%	100%
A0A3Q8ICF1	Leishmania donovani	81%	99%
A4H8D6	Leishmania braziliensis	65%	100%
A4HWQ8	Leishmania infantum	81%	99%
C9ZPS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QF11	Leishmania major	83%	100%
V5ARD2	Trypanosoma cruzi	35%	99%