DUF4110 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative

Species:

Leishmania mexicana

UniProt:

E9AQG4_LEIMU

TriTrypDb:

LmxM.16.0080

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.340
CLV_C14_Caspase3-7	511	515	PF00656	0.563
CLV_C14_Caspase3-7	545	549	PF00656	0.658
CLV_NRD_NRD_1	372	374	PF00675	0.456
CLV_NRD_NRD_1	400	402	PF00675	0.726
CLV_NRD_NRD_1	450	452	PF00675	0.392
CLV_NRD_NRD_1	661	663	PF00675	0.263
CLV_NRD_NRD_1	7	9	PF00675	0.596
CLV_NRD_NRD_1	702	704	PF00675	0.285
CLV_NRD_NRD_1	718	720	PF00675	0.467
CLV_PCSK_FUR_1	5	9	PF00082	0.592
CLV_PCSK_FUR_1	700	704	PF00082	0.360
CLV_PCSK_KEX2_1	119	121	PF00082	0.304
CLV_PCSK_KEX2_1	19	21	PF00082	0.503
CLV_PCSK_KEX2_1	200	202	PF00082	0.339
CLV_PCSK_KEX2_1	330	332	PF00082	0.447
CLV_PCSK_KEX2_1	364	366	PF00082	0.354
CLV_PCSK_KEX2_1	372	374	PF00082	0.425
CLV_PCSK_KEX2_1	376	378	PF00082	0.515
CLV_PCSK_KEX2_1	383	385	PF00082	0.478
CLV_PCSK_KEX2_1	400	402	PF00082	0.661
CLV_PCSK_KEX2_1	450	452	PF00082	0.385
CLV_PCSK_KEX2_1	55	57	PF00082	0.519
CLV_PCSK_KEX2_1	661	663	PF00082	0.250
CLV_PCSK_KEX2_1	7	9	PF00082	0.593
CLV_PCSK_KEX2_1	702	704	PF00082	0.285
CLV_PCSK_KEX2_1	718	720	PF00082	0.467
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.304
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.506
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.431
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.443
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.356
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.547
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.440
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.519
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.620
CLV_PCSK_PC7_1	372	378	PF00082	0.585
CLV_PCSK_SKI1_1	16	20	PF00082	0.514
CLV_PCSK_SKI1_1	182	186	PF00082	0.304
CLV_PCSK_SKI1_1	195	199	PF00082	0.362
CLV_PCSK_SKI1_1	23	27	PF00082	0.524
CLV_PCSK_SKI1_1	30	34	PF00082	0.572
CLV_PCSK_SKI1_1	373	377	PF00082	0.592
CLV_PCSK_SKI1_1	475	479	PF00082	0.350
CLV_PCSK_SKI1_1	607	611	PF00082	0.407
CLV_PCSK_SKI1_1	661	665	PF00082	0.362
CLV_PCSK_SKI1_1	679	683	PF00082	0.168
DEG_APCC_DBOX_1	383	391	PF00400	0.572
DEG_APCC_DBOX_1	678	686	PF00400	0.393
DEG_SCF_FBW7_2	585	592	PF00400	0.522
DEG_SCF_FBW7_2	626	632	PF00400	0.402
DEG_SPOP_SBC_1	134	138	PF00917	0.284
DEG_SPOP_SBC_1	640	644	PF00917	0.393
DOC_ANK_TNKS_1	650	657	PF00023	0.393
DOC_CKS1_1	626	631	PF01111	0.268
DOC_CKS1_1	75	80	PF01111	0.454
DOC_MAPK_gen_1	19	28	PF00069	0.633
DOC_MAPK_gen_1	200	206	PF00069	0.306
DOC_MAPK_gen_1	364	371	PF00069	0.362
DOC_MAPK_gen_1	450	458	PF00069	0.374
DOC_MAPK_gen_1	603	611	PF00069	0.465
DOC_USP7_MATH_1	134	138	PF00917	0.268
DOC_USP7_MATH_1	428	432	PF00917	0.714
DOC_USP7_MATH_1	587	591	PF00917	0.434
DOC_USP7_MATH_1	597	601	PF00917	0.335
DOC_USP7_MATH_1	640	644	PF00917	0.343
DOC_USP7_MATH_1	650	654	PF00917	0.226
DOC_USP7_UBL2_3	3	7	PF12436	0.633
DOC_USP7_UBL2_3	30	34	PF12436	0.593
DOC_USP7_UBL2_3	55	59	PF12436	0.411
DOC_USP7_UBL2_3	606	610	PF12436	0.421
DOC_WW_Pin1_4	340	345	PF00397	0.368
DOC_WW_Pin1_4	585	590	PF00397	0.476
DOC_WW_Pin1_4	625	630	PF00397	0.268
DOC_WW_Pin1_4	74	79	PF00397	0.378
LIG_14-3-3_CanoR_1	125	134	PF00244	0.278
LIG_14-3-3_CanoR_1	135	143	PF00244	0.302
LIG_14-3-3_CanoR_1	174	181	PF00244	0.402
LIG_14-3-3_CanoR_1	249	255	PF00244	0.369
LIG_14-3-3_CanoR_1	274	282	PF00244	0.428
LIG_14-3-3_CanoR_1	641	646	PF00244	0.305
LIG_Actin_WH2_2	387	402	PF00022	0.522
LIG_Actin_WH2_2	50	67	PF00022	0.375
LIG_APCC_ABBA_1	254	259	PF00400	0.382
LIG_APCC_ABBA_1	609	614	PF00400	0.387
LIG_APCC_ABBA_1	84	89	PF00400	0.344
LIG_BRCT_BRCA1_1	323	327	PF00533	0.409
LIG_BRCT_BRCA1_1	479	483	PF00533	0.365
LIG_deltaCOP1_diTrp_1	167	171	PF00928	0.268
LIG_eIF4E_1	676	682	PF01652	0.393
LIG_FHA_1	460	466	PF00498	0.367
LIG_FHA_1	482	488	PF00498	0.406
LIG_FHA_1	586	592	PF00498	0.509
LIG_FHA_1	75	81	PF00498	0.363
LIG_FHA_2	34	40	PF00498	0.531
LIG_FHA_2	411	417	PF00498	0.771
LIG_FHA_2	476	482	PF00498	0.338
LIG_FHA_2	64	70	PF00498	0.422
LIG_FHA_2	647	653	PF00498	0.384
LIG_LIR_Gen_1	160	168	PF02991	0.278
LIG_LIR_Gen_1	175	184	PF02991	0.268
LIG_LIR_Gen_1	269	280	PF02991	0.429
LIG_LIR_Gen_1	350	361	PF02991	0.437
LIG_LIR_Gen_1	632	640	PF02991	0.348
LIG_LIR_Nem_3	160	165	PF02991	0.278
LIG_LIR_Nem_3	175	181	PF02991	0.333
LIG_LIR_Nem_3	269	275	PF02991	0.435
LIG_LIR_Nem_3	350	356	PF02991	0.417
LIG_LIR_Nem_3	363	369	PF02991	0.242
LIG_LIR_Nem_3	491	496	PF02991	0.362
LIG_LIR_Nem_3	632	638	PF02991	0.379
LIG_LIR_Nem_3	707	713	PF02991	0.293
LIG_LYPXL_S_1	366	370	PF13949	0.337
LIG_LYPXL_SIV_4	712	720	PF13949	0.310
LIG_LYPXL_yS_3	367	370	PF13949	0.344
LIG_MYND_1	564	568	PF01753	0.672
LIG_Pex14_2	150	154	PF04695	0.334
LIG_Pex14_2	165	169	PF04695	0.189
LIG_Pex14_2	219	223	PF04695	0.321
LIG_Pex14_2	635	639	PF04695	0.402
LIG_Pex14_2	97	101	PF04695	0.402
LIG_PTB_Apo_2	351	358	PF02174	0.352
LIG_PTB_Apo_2	458	465	PF02174	0.352
LIG_PTB_Phospho_1	351	357	PF10480	0.444
LIG_PTB_Phospho_1	458	464	PF10480	0.356
LIG_REV1ctd_RIR_1	113	124	PF16727	0.402
LIG_REV1ctd_RIR_1	636	645	PF16727	0.284
LIG_REV1ctd_RIR_1	696	707	PF16727	0.268
LIG_SH2_CRK	493	497	PF00017	0.398
LIG_SH2_GRB2like	210	213	PF00017	0.349
LIG_SH2_NCK_1	210	214	PF00017	0.361
LIG_SH2_NCK_1	713	717	PF00017	0.544
LIG_SH2_SRC	210	213	PF00017	0.349
LIG_SH2_SRC	464	467	PF00017	0.446
LIG_SH2_SRC	713	716	PF00017	0.543
LIG_SH2_STAP1	529	533	PF00017	0.579
LIG_SH2_STAT3	267	270	PF00017	0.449
LIG_SH2_STAT3	466	469	PF00017	0.455
LIG_SH2_STAT5	114	117	PF00017	0.284
LIG_SH2_STAT5	146	149	PF00017	0.370
LIG_SH2_STAT5	162	165	PF00017	0.363
LIG_SH2_STAT5	218	221	PF00017	0.328
LIG_SH2_STAT5	333	336	PF00017	0.311
LIG_SH2_STAT5	357	360	PF00017	0.415
LIG_SH2_STAT5	464	467	PF00017	0.327
LIG_SH3_3	558	564	PF00018	0.627
LIG_SH3_3	623	629	PF00018	0.268
LIG_SH3_3	70	76	PF00018	0.406
LIG_SH3_3	80	86	PF00018	0.283
LIG_SUMO_SIM_par_1	337	343	PF11976	0.333
LIG_TRAF2_1	36	39	PF00917	0.433
LIG_TRAF2_1	405	408	PF00917	0.704
LIG_TRAF2_1	430	433	PF00917	0.697
LIG_TRAF2_1	66	69	PF00917	0.511
LIG_TRAF2_1	712	715	PF00917	0.357
LIG_UBA3_1	482	489	PF00899	0.474
LIG_WRC_WIRS_1	349	354	PF05994	0.337
MOD_CDK_SPK_2	74	79	PF00069	0.371
MOD_CDK_SPxK_1	625	631	PF00069	0.285
MOD_CDK_SPxxK_3	340	347	PF00069	0.382
MOD_CK1_1	189	195	PF00069	0.320
MOD_CK1_1	250	256	PF00069	0.349
MOD_CK1_1	278	284	PF00069	0.362
MOD_CK1_1	411	417	PF00069	0.649
MOD_CK1_1	437	443	PF00069	0.545
MOD_CK1_1	517	523	PF00069	0.488
MOD_CK2_1	173	179	PF00069	0.402
MOD_CK2_1	33	39	PF00069	0.428
MOD_CK2_1	401	407	PF00069	0.648
MOD_CK2_1	410	416	PF00069	0.605
MOD_CK2_1	470	476	PF00069	0.524
MOD_CK2_1	63	69	PF00069	0.421
MOD_CK2_1	646	652	PF00069	0.379
MOD_CK2_1	721	727	PF00069	0.474
MOD_CK2_1	728	734	PF00069	0.477
MOD_Cter_Amidation	381	384	PF01082	0.530
MOD_Cter_Amidation	604	607	PF01082	0.469
MOD_GlcNHglycan	127	130	PF01048	0.379
MOD_GlcNHglycan	191	194	PF01048	0.322
MOD_GlcNHglycan	249	252	PF01048	0.345
MOD_GlcNHglycan	394	397	PF01048	0.571
MOD_GlcNHglycan	453	456	PF01048	0.452
MOD_GlcNHglycan	500	504	PF01048	0.497
MOD_GlcNHglycan	519	522	PF01048	0.503
MOD_GlcNHglycan	525	528	PF01048	0.472
MOD_GlcNHglycan	623	626	PF01048	0.292
MOD_GSK3_1	153	160	PF00069	0.268
MOD_GSK3_1	232	239	PF00069	0.381
MOD_GSK3_1	407	414	PF00069	0.636
MOD_GSK3_1	424	431	PF00069	0.647
MOD_GSK3_1	477	484	PF00069	0.360
MOD_GSK3_1	495	502	PF00069	0.316
MOD_GSK3_1	510	517	PF00069	0.492
MOD_GSK3_1	519	526	PF00069	0.439
MOD_GSK3_1	597	604	PF00069	0.310
MOD_GSK3_1	621	628	PF00069	0.309
MOD_GSK3_1	646	653	PF00069	0.324
MOD_LATS_1	449	455	PF00433	0.483
MOD_N-GLC_1	110	115	PF02516	0.402
MOD_NEK2_1	28	33	PF00069	0.480
MOD_NEK2_1	348	353	PF00069	0.411
MOD_NEK2_1	470	475	PF00069	0.519
MOD_NEK2_1	620	625	PF00069	0.356
MOD_NEK2_1	639	644	PF00069	0.140
MOD_NEK2_2	287	292	PF00069	0.411
MOD_PIKK_1	135	141	PF00454	0.285
MOD_PIKK_1	153	159	PF00454	0.268
MOD_PIKK_1	232	238	PF00454	0.472
MOD_PIKK_1	266	272	PF00454	0.416
MOD_PIKK_1	428	434	PF00454	0.720
MOD_PIKK_1	495	501	PF00454	0.406
MOD_PKA_1	33	39	PF00069	0.653
MOD_PKA_2	124	130	PF00069	0.297
MOD_PKA_2	134	140	PF00069	0.234
MOD_PKA_2	173	179	PF00069	0.410
MOD_PKA_2	640	646	PF00069	0.294
MOD_PKA_2	650	656	PF00069	0.270
MOD_PKA_2	89	95	PF00069	0.340
MOD_Plk_1	110	116	PF00069	0.331
MOD_Plk_1	278	284	PF00069	0.406
MOD_Plk_1	475	481	PF00069	0.346
MOD_Plk_1	50	56	PF00069	0.383
MOD_Plk_1	631	637	PF00069	0.400
MOD_Plk_2-3	514	520	PF00069	0.543
MOD_Plk_2-3	721	727	PF00069	0.474
MOD_Plk_4	110	116	PF00069	0.375
MOD_Plk_4	252	258	PF00069	0.358
MOD_Plk_4	348	354	PF00069	0.472
MOD_Plk_4	459	465	PF00069	0.367
MOD_Plk_4	520	526	PF00069	0.456
MOD_Plk_4	641	647	PF00069	0.379
MOD_ProDKin_1	340	346	PF00069	0.375
MOD_ProDKin_1	585	591	PF00069	0.467
MOD_ProDKin_1	625	631	PF00069	0.268
MOD_ProDKin_1	74	80	PF00069	0.376
MOD_SUMO_for_1	32	35	PF00179	0.518
MOD_SUMO_for_1	663	666	PF00179	0.381
MOD_SUMO_rev_2	175	184	PF00179	0.266
MOD_SUMO_rev_2	431	437	PF00179	0.533
MOD_SUMO_rev_2	652	659	PF00179	0.384
MOD_SUMO_rev_2	689	699	PF00179	0.402
TRG_DiLeu_BaEn_1	677	682	PF01217	0.268
TRG_DiLeu_BaEn_4	179	185	PF01217	0.304
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.496
TRG_ENDOCYTIC_2	146	149	PF00928	0.360
TRG_ENDOCYTIC_2	162	165	PF00928	0.363
TRG_ENDOCYTIC_2	353	356	PF00928	0.434
TRG_ENDOCYTIC_2	367	370	PF00928	0.251
TRG_ENDOCYTIC_2	493	496	PF00928	0.398
TRG_ER_diArg_1	371	373	PF00400	0.432
TRG_ER_diArg_1	399	401	PF00400	0.629
TRG_ER_diArg_1	450	452	PF00400	0.374
TRG_ER_diArg_1	661	663	PF00400	0.261
TRG_ER_diArg_1	702	704	PF00400	0.360
TRG_ER_diArg_1	718	720	PF00400	0.547
TRG_NES_CRM1_1	388	403	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	661	666	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	679	684	PF00026	0.222
TRG_Pf-PMV_PEXEL_1	702	707	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R8	Leptomonas seymouri	76%	100%
A0A0S4JR73	Bodo saltans	50%	94%
A0A1X0NZQ9	Trypanosomatidae	60%	100%
A0A3Q8I9A1	Leishmania donovani	94%	100%
A0A422NAE1	Trypanosoma rangeli	60%	100%
A4H8D5	Leishmania braziliensis	85%	100%
A4HWQ7	Leishmania infantum	94%	100%
C9ZPS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
Q4QF12	Leishmania major	94%	100%
Q5R8W1	Pongo abelii	32%	100%
Q8TBB5	Homo sapiens	32%	100%
Q921I2	Mus musculus	32%	100%
V5BBA4	Trypanosoma cruzi	59%	100%