Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQG3_LEIMU

TriTrypDb:

LmxM.16.0070

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.536
CLV_NRD_NRD_1	286	288	PF00675	0.414
CLV_NRD_NRD_1	372	374	PF00675	0.588
CLV_NRD_NRD_1	41	43	PF00675	0.466
CLV_NRD_NRD_1	76	78	PF00675	0.622
CLV_PCSK_KEX2_1	187	189	PF00082	0.483
CLV_PCSK_KEX2_1	323	325	PF00082	0.517
CLV_PCSK_KEX2_1	372	374	PF00082	0.588
CLV_PCSK_KEX2_1	41	43	PF00082	0.466
CLV_PCSK_KEX2_1	75	77	PF00082	0.623
CLV_PCSK_KEX2_1	89	91	PF00082	0.609
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.447
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.517
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.609
CLV_PCSK_PC7_1	85	91	PF00082	0.677
CLV_PCSK_SKI1_1	263	267	PF00082	0.490
CLV_PCSK_SKI1_1	295	299	PF00082	0.501
CLV_PCSK_SKI1_1	77	81	PF00082	0.706
CLV_Separin_Metazoa	222	226	PF03568	0.385
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_SPOP_SBC_1	10	14	PF00917	0.528
DEG_SPOP_SBC_1	191	195	PF00917	0.504
DOC_MAPK_gen_1	261	270	PF00069	0.500
DOC_MAPK_gen_1	75	81	PF00069	0.785
DOC_MAPK_MEF2A_6	46	54	PF00069	0.492
DOC_PP2B_LxvP_1	255	258	PF13499	0.573
DOC_PP2B_LxvP_1	268	271	PF13499	0.405
DOC_USP7_MATH_1	10	14	PF00917	0.543
DOC_USP7_MATH_1	191	195	PF00917	0.495
DOC_USP7_MATH_1	207	211	PF00917	0.384
DOC_WW_Pin1_4	101	106	PF00397	0.736
DOC_WW_Pin1_4	11	16	PF00397	0.642
DOC_WW_Pin1_4	372	377	PF00397	0.610
DOC_WW_Pin1_4	389	394	PF00397	0.537
DOC_WW_Pin1_4	70	75	PF00397	0.620
DOC_WW_Pin1_4	80	85	PF00397	0.581
LIG_14-3-3_CanoR_1	199	204	PF00244	0.479
LIG_14-3-3_CanoR_1	261	266	PF00244	0.534
LIG_14-3-3_CanoR_1	372	376	PF00244	0.589
LIG_14-3-3_CanoR_1	75	80	PF00244	0.687
LIG_Actin_WH2_2	248	265	PF00022	0.441
LIG_AP2alpha_2	117	119	PF02296	0.560
LIG_APCC_ABBA_1	116	121	PF00400	0.570
LIG_CaM_NSCaTE_8	305	312	PF13499	0.542
LIG_CtBP_PxDLS_1	137	141	PF00389	0.634
LIG_CtBP_PxDLS_1	220	224	PF00389	0.389
LIG_eIF4E_1	273	279	PF01652	0.475
LIG_FHA_1	207	213	PF00498	0.423
LIG_FHA_2	25	31	PF00498	0.421
LIG_GBD_Chelix_1	238	246	PF00786	0.469
LIG_LIR_Apic_2	149	155	PF02991	0.614
LIG_LIR_Gen_1	240	250	PF02991	0.474
LIG_LIR_Gen_1	27	37	PF02991	0.471
LIG_LIR_Gen_1	329	338	PF02991	0.529
LIG_LIR_Nem_3	156	160	PF02991	0.573
LIG_LIR_Nem_3	240	246	PF02991	0.469
LIG_LIR_Nem_3	27	32	PF02991	0.448
LIG_LIR_Nem_3	329	334	PF02991	0.521
LIG_LIR_Nem_3	94	100	PF02991	0.674
LIG_PCNA_yPIPBox_3	249	263	PF02747	0.454
LIG_SH2_CRK	331	335	PF00017	0.626
LIG_SH2_PTP2	152	155	PF00017	0.569
LIG_SH2_PTP2	157	160	PF00017	0.539
LIG_SH2_SRC	157	160	PF00017	0.454
LIG_SH2_STAP1	243	247	PF00017	0.403
LIG_SH2_STAP1	331	335	PF00017	0.510
LIG_SH2_STAT3	273	276	PF00017	0.482
LIG_SH2_STAT5	125	128	PF00017	0.520
LIG_SH2_STAT5	152	155	PF00017	0.569
LIG_SH2_STAT5	157	160	PF00017	0.539
LIG_SH2_STAT5	243	246	PF00017	0.405
LIG_SH2_STAT5	348	351	PF00017	0.464
LIG_SH2_STAT5	56	59	PF00017	0.575
LIG_SH3_3	200	206	PF00018	0.442
LIG_SH3_3	76	82	PF00018	0.634
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.424
LIG_SUMO_SIM_par_1	136	141	PF11976	0.636
LIG_SUMO_SIM_par_1	348	354	PF11976	0.484
LIG_TRAF2_1	146	149	PF00917	0.498
LIG_WRC_WIRS_1	57	62	PF05994	0.423
MOD_CDC14_SPxK_1	73	76	PF00782	0.634
MOD_CDK_SPK_2	101	106	PF00069	0.616
MOD_CDK_SPK_2	70	75	PF00069	0.620
MOD_CDK_SPK_2	80	85	PF00069	0.533
MOD_CDK_SPxK_1	70	76	PF00069	0.623
MOD_CDK_SPxxK_3	101	108	PF00069	0.614
MOD_CDK_SPxxK_3	70	77	PF00069	0.627
MOD_CK1_1	193	199	PF00069	0.561
MOD_CK1_1	70	76	PF00069	0.640
MOD_CK2_1	11	17	PF00069	0.709
MOD_CK2_1	138	144	PF00069	0.562
MOD_CK2_1	80	86	PF00069	0.625
MOD_CK2_1	88	94	PF00069	0.615
MOD_Cter_Amidation	87	90	PF01082	0.623
MOD_GlcNHglycan	169	172	PF01048	0.473
MOD_GlcNHglycan	180	183	PF01048	0.449
MOD_GlcNHglycan	310	313	PF01048	0.535
MOD_GSK3_1	237	244	PF00069	0.474
MOD_GSK3_1	63	70	PF00069	0.591
MOD_N-GLC_1	207	212	PF02516	0.369
MOD_NEK2_1	176	181	PF00069	0.536
MOD_NEK2_1	19	24	PF00069	0.482
MOD_NEK2_1	190	195	PF00069	0.491
MOD_NEK2_1	279	284	PF00069	0.466
MOD_NEK2_2	56	61	PF00069	0.424
MOD_PIKK_1	313	319	PF00454	0.491
MOD_PIKK_1	329	335	PF00454	0.455
MOD_PIKK_1	4	10	PF00454	0.524
MOD_PK_1	199	205	PF00069	0.536
MOD_PK_1	261	267	PF00069	0.458
MOD_PK_1	75	81	PF00069	0.689
MOD_PKA_1	75	81	PF00069	0.779
MOD_PKA_2	228	234	PF00069	0.551
MOD_PKA_2	371	377	PF00069	0.613
MOD_PKA_2	75	81	PF00069	0.713
MOD_PKB_1	261	269	PF00069	0.361
MOD_PKB_1	293	301	PF00069	0.507
MOD_PKB_1	75	83	PF00069	0.820
MOD_Plk_1	279	285	PF00069	0.496
MOD_Plk_1	298	304	PF00069	0.365
MOD_Plk_4	153	159	PF00069	0.627
MOD_Plk_4	263	269	PF00069	0.430
MOD_Plk_4	279	285	PF00069	0.429
MOD_ProDKin_1	101	107	PF00069	0.734
MOD_ProDKin_1	11	17	PF00069	0.641
MOD_ProDKin_1	372	378	PF00069	0.612
MOD_ProDKin_1	389	395	PF00069	0.536
MOD_ProDKin_1	70	76	PF00069	0.623
MOD_ProDKin_1	80	86	PF00069	0.581
MOD_SUMO_rev_2	139	146	PF00179	0.575
TRG_ENDOCYTIC_2	157	160	PF00928	0.575
TRG_ENDOCYTIC_2	243	246	PF00928	0.405
TRG_ENDOCYTIC_2	331	334	PF00928	0.518
TRG_ER_diArg_1	105	108	PF00400	0.736
TRG_ER_diArg_1	260	263	PF00400	0.530
TRG_ER_diArg_1	41	43	PF00400	0.459
TRG_ER_diArg_1	74	77	PF00400	0.684
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDJ0	Leishmania donovani	84%	100%
A4H8D4	Leishmania braziliensis	65%	100%
A4HWQ6	Leishmania infantum	84%	100%
Q4QF13	Leishmania major	82%	100%
Q8IS09	Leptomonas seymouri	30%	100%