Putative peroxisome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome assembly protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQG2_LEIMU

TriTrypDb:

LmxM.16.0060

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005778	peroxisomal membrane	6	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG2

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0016558	protein import into peroxisome matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.471
CLV_C14_Caspase3-7	168	172	PF00656	0.465
CLV_C14_Caspase3-7	522	526	PF00656	0.601
CLV_C14_Caspase3-7	536	540	PF00656	0.445
CLV_C14_Caspase3-7	747	751	PF00656	0.292
CLV_C14_Caspase3-7	895	899	PF00656	0.460
CLV_C14_Caspase3-7	900	904	PF00656	0.491
CLV_NRD_NRD_1	299	301	PF00675	0.413
CLV_NRD_NRD_1	318	320	PF00675	0.594
CLV_NRD_NRD_1	406	408	PF00675	0.387
CLV_NRD_NRD_1	838	840	PF00675	0.415
CLV_NRD_NRD_1	917	919	PF00675	0.585
CLV_NRD_NRD_1	950	952	PF00675	0.340
CLV_PCSK_KEX2_1	299	301	PF00082	0.408
CLV_PCSK_KEX2_1	406	408	PF00082	0.387
CLV_PCSK_KEX2_1	657	659	PF00082	0.363
CLV_PCSK_KEX2_1	680	682	PF00082	0.386
CLV_PCSK_KEX2_1	783	785	PF00082	0.359
CLV_PCSK_KEX2_1	917	919	PF00082	0.437
CLV_PCSK_KEX2_1	950	952	PF00082	0.445
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.375
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.386
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.359
CLV_PCSK_SKI1_1	12	16	PF00082	0.407
CLV_PCSK_SKI1_1	153	157	PF00082	0.617
CLV_PCSK_SKI1_1	185	189	PF00082	0.547
CLV_PCSK_SKI1_1	241	245	PF00082	0.543
CLV_PCSK_SKI1_1	407	411	PF00082	0.545
CLV_PCSK_SKI1_1	463	467	PF00082	0.541
CLV_PCSK_SKI1_1	515	519	PF00082	0.316
CLV_PCSK_SKI1_1	552	556	PF00082	0.535
CLV_PCSK_SKI1_1	676	680	PF00082	0.418
CLV_PCSK_SKI1_1	694	698	PF00082	0.248
CLV_PCSK_SKI1_1	730	734	PF00082	0.292
CLV_PCSK_SKI1_1	756	760	PF00082	0.273
CLV_PCSK_SKI1_1	835	839	PF00082	0.384
CLV_PCSK_SKI1_1	887	891	PF00082	0.387
CLV_PCSK_SKI1_1	918	922	PF00082	0.515
DEG_APCC_DBOX_1	462	470	PF00400	0.350
DEG_APCC_KENBOX_2	425	429	PF00400	0.387
DEG_SCF_FBW7_1	161	168	PF00400	0.539
DEG_SCF_FBW7_2	408	414	PF00400	0.474
DOC_CKS1_1	128	133	PF01111	0.617
DOC_CKS1_1	408	413	PF01111	0.468
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	574	577	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	804	810	PF00134	0.322
DOC_MAPK_gen_1	299	306	PF00069	0.404
DOC_MAPK_gen_1	342	352	PF00069	0.475
DOC_MAPK_gen_1	657	666	PF00069	0.332
DOC_MAPK_gen_1	676	686	PF00069	0.395
DOC_MAPK_gen_1	814	823	PF00069	0.305
DOC_MAPK_gen_1	917	924	PF00069	0.304
DOC_MAPK_HePTP_8	765	777	PF00069	0.381
DOC_MAPK_MEF2A_6	737	745	PF00069	0.292
DOC_MAPK_MEF2A_6	768	777	PF00069	0.248
DOC_MAPK_MEF2A_6	917	924	PF00069	0.388
DOC_PP1_RVXF_1	513	519	PF00149	0.329
DOC_PP1_RVXF_1	728	734	PF00149	0.248
DOC_PP2B_LxvP_1	210	213	PF13499	0.541
DOC_PP2B_LxvP_1	574	577	PF13499	0.310
DOC_PP2B_LxvP_1	821	824	PF13499	0.378
DOC_PP4_FxxP_1	441	444	PF00568	0.512
DOC_PP4_FxxP_1	555	558	PF00568	0.456
DOC_PP4_FxxP_1	686	689	PF00568	0.248
DOC_USP7_MATH_1	165	169	PF00917	0.572
DOC_USP7_MATH_1	58	62	PF00917	0.361
DOC_USP7_MATH_1	615	619	PF00917	0.528
DOC_USP7_MATH_1	867	871	PF00917	0.298
DOC_USP7_MATH_1	897	901	PF00917	0.572
DOC_USP7_MATH_2	219	225	PF00917	0.507
DOC_USP7_UBL2_3	676	680	PF12436	0.418
DOC_USP7_UBL2_3	955	959	PF12436	0.587
DOC_WW_Pin1_4	127	132	PF00397	0.628
DOC_WW_Pin1_4	161	166	PF00397	0.537
DOC_WW_Pin1_4	345	350	PF00397	0.719
DOC_WW_Pin1_4	378	383	PF00397	0.515
DOC_WW_Pin1_4	384	389	PF00397	0.445
DOC_WW_Pin1_4	407	412	PF00397	0.595
DOC_WW_Pin1_4	737	742	PF00397	0.248
DOC_WW_Pin1_4	898	903	PF00397	0.632
LIG_14-3-3_CanoR_1	123	131	PF00244	0.527
LIG_14-3-3_CanoR_1	16	23	PF00244	0.508
LIG_14-3-3_CanoR_1	279	288	PF00244	0.552
LIG_14-3-3_CanoR_1	312	321	PF00244	0.619
LIG_14-3-3_CanoR_1	568	574	PF00244	0.635
LIG_14-3-3_CanoR_1	768	777	PF00244	0.381
LIG_14-3-3_CanoR_1	917	923	PF00244	0.568
LIG_14-3-3_CanoR_1	950	954	PF00244	0.497
LIG_Actin_WH2_2	921	937	PF00022	0.392
LIG_BIR_III_2	525	529	PF00653	0.377
LIG_BIR_III_2	57	61	PF00653	0.383
LIG_BIR_III_4	761	765	PF00653	0.248
LIG_BRCT_BRCA1_1	705	709	PF00533	0.251
LIG_CaM_NSCaTE_8	276	283	PF13499	0.606
LIG_Clathr_ClatBox_1	774	778	PF01394	0.264
LIG_EVH1_1	86	90	PF00568	0.477
LIG_FHA_1	234	240	PF00498	0.580
LIG_FHA_1	281	287	PF00498	0.555
LIG_FHA_1	31	37	PF00498	0.576
LIG_FHA_1	408	414	PF00498	0.595
LIG_FHA_1	417	423	PF00498	0.462
LIG_FHA_1	44	50	PF00498	0.553
LIG_FHA_1	472	478	PF00498	0.419
LIG_FHA_1	680	686	PF00498	0.418
LIG_FHA_1	80	86	PF00498	0.477
LIG_FHA_1	888	894	PF00498	0.610
LIG_FHA_1	9	15	PF00498	0.483
LIG_FHA_1	919	925	PF00498	0.525
LIG_FHA_2	322	328	PF00498	0.746
LIG_FHA_2	534	540	PF00498	0.552
LIG_FHA_2	586	592	PF00498	0.457
LIG_FHA_2	824	830	PF00498	0.357
LIG_FHA_2	859	865	PF00498	0.303
LIG_FHA_2	937	943	PF00498	0.458
LIG_FHA_2	94	100	PF00498	0.478
LIG_GBD_Chelix_1	114	122	PF00786	0.653
LIG_KLC1_Yacidic_2	285	290	PF13176	0.475
LIG_LIR_Apic_2	440	444	PF02991	0.328
LIG_LIR_Gen_1	396	405	PF02991	0.327
LIG_LIR_Gen_1	588	596	PF02991	0.359
LIG_LIR_Gen_1	632	642	PF02991	0.511
LIG_LIR_Gen_1	706	717	PF02991	0.215
LIG_LIR_Nem_3	179	184	PF02991	0.493
LIG_LIR_Nem_3	20	26	PF02991	0.441
LIG_LIR_Nem_3	215	220	PF02991	0.516
LIG_LIR_Nem_3	351	355	PF02991	0.567
LIG_LIR_Nem_3	396	401	PF02991	0.352
LIG_LIR_Nem_3	56	62	PF02991	0.467
LIG_LIR_Nem_3	588	592	PF02991	0.394
LIG_LIR_Nem_3	632	638	PF02991	0.509
LIG_LIR_Nem_3	706	712	PF02991	0.215
LIG_LIR_Nem_3	864	868	PF02991	0.415
LIG_LYPXL_S_1	669	673	PF13949	0.346
LIG_LYPXL_yS_3	59	62	PF13949	0.490
LIG_LYPXL_yS_3	670	673	PF13949	0.347
LIG_MYND_1	667	671	PF01753	0.360
LIG_NRBOX	133	139	PF00104	0.505
LIG_SH2_CRK	23	27	PF00017	0.471
LIG_SH2_CRK	398	402	PF00017	0.365
LIG_SH2_CRK	635	639	PF00017	0.456
LIG_SH2_CRK	687	691	PF00017	0.292
LIG_SH2_GRB2like	105	108	PF00017	0.453
LIG_SH2_GRB2like	205	208	PF00017	0.621
LIG_SH2_NCK_1	189	193	PF00017	0.600
LIG_SH2_NCK_1	635	639	PF00017	0.461
LIG_SH2_SRC	589	592	PF00017	0.438
LIG_SH2_STAP1	205	209	PF00017	0.563
LIG_SH2_STAP1	589	593	PF00017	0.437
LIG_SH2_STAT3	34	37	PF00017	0.446
LIG_SH2_STAT5	288	291	PF00017	0.683
LIG_SH2_STAT5	629	632	PF00017	0.515
LIG_SH2_STAT5	7	10	PF00017	0.449
LIG_SH2_STAT5	721	724	PF00017	0.270
LIG_SH2_STAT5	820	823	PF00017	0.371
LIG_SH2_STAT5	860	863	PF00017	0.305
LIG_SH3_3	240	246	PF00018	0.429
LIG_SH3_3	374	380	PF00018	0.534
LIG_SH3_3	405	411	PF00018	0.528
LIG_SH3_3	508	514	PF00018	0.625
LIG_SH3_3	570	576	PF00018	0.380
LIG_SH3_3	709	715	PF00018	0.248
LIG_SH3_3	81	87	PF00018	0.450
LIG_SH3_3	849	855	PF00018	0.461
LIG_SH3_CIN85_PxpxPR_1	510	515	PF14604	0.400
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.663
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.550
LIG_SUMO_SIM_anti_2	474	479	PF11976	0.330
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.348
LIG_SUMO_SIM_anti_2	612	619	PF11976	0.639
LIG_SUMO_SIM_par_1	591	597	PF11976	0.443
LIG_SUMO_SIM_par_1	773	778	PF11976	0.264
LIG_TRAF2_1	452	455	PF00917	0.455
LIG_TRAF2_1	547	550	PF00917	0.493
LIG_TRAF2_1	826	829	PF00917	0.367
LIG_TRAF2_1	880	883	PF00917	0.508
LIG_TRAF2_1	912	915	PF00917	0.673
LIG_TYR_ITIM	259	264	PF00017	0.549
LIG_TYR_ITIM	587	592	PF00017	0.440
LIG_TYR_ITIM	668	673	PF00017	0.344
LIG_TYR_ITIM	818	823	PF00017	0.292
LIG_UBA3_1	831	835	PF00899	0.371
LIG_WRC_WIRS_1	417	422	PF05994	0.443
MOD_CDK_SPK_2	127	132	PF00069	0.476
MOD_CK1_1	190	196	PF00069	0.541
MOD_CK1_1	199	205	PF00069	0.526
MOD_CK1_1	35	41	PF00069	0.446
MOD_CK1_1	618	624	PF00069	0.482
MOD_CK1_1	636	642	PF00069	0.516
MOD_CK1_1	76	82	PF00069	0.466
MOD_CK1_1	785	791	PF00069	0.287
MOD_CK2_1	591	597	PF00069	0.415
MOD_CK2_1	822	828	PF00069	0.363
MOD_DYRK1A_RPxSP_1	345	349	PF00069	0.436
MOD_DYRK1A_RPxSP_1	407	411	PF00069	0.415
MOD_GlcNHglycan	147	150	PF01048	0.528
MOD_GlcNHglycan	198	201	PF01048	0.722
MOD_GlcNHglycan	221	226	PF01048	0.562
MOD_GlcNHglycan	230	233	PF01048	0.581
MOD_GlcNHglycan	271	274	PF01048	0.595
MOD_GlcNHglycan	344	348	PF01048	0.551
MOD_GlcNHglycan	4	7	PF01048	0.431
MOD_GlcNHglycan	499	502	PF01048	0.565
MOD_GlcNHglycan	75	78	PF01048	0.639
MOD_GlcNHglycan	789	792	PF01048	0.367
MOD_GlcNHglycan	842	846	PF01048	0.375
MOD_GlcNHglycan	848	852	PF01048	0.337
MOD_GlcNHglycan	890	893	PF01048	0.358
MOD_GlcNHglycan	99	103	PF01048	0.512
MOD_GSK3_1	118	125	PF00069	0.537
MOD_GSK3_1	161	168	PF00069	0.619
MOD_GSK3_1	195	202	PF00069	0.531
MOD_GSK3_1	233	240	PF00069	0.571
MOD_GSK3_1	621	628	PF00069	0.443
MOD_GSK3_1	629	636	PF00069	0.506
MOD_GSK3_1	67	74	PF00069	0.559
MOD_GSK3_1	893	900	PF00069	0.561
MOD_GSK3_1	949	956	PF00069	0.489
MOD_N-GLC_1	321	326	PF02516	0.477
MOD_N-GLC_1	328	333	PF02516	0.439
MOD_NEK2_1	118	123	PF00069	0.538
MOD_NEK2_1	196	201	PF00069	0.668
MOD_NEK2_1	203	208	PF00069	0.675
MOD_NEK2_1	228	233	PF00069	0.652
MOD_NEK2_1	343	348	PF00069	0.677
MOD_NEK2_1	461	466	PF00069	0.446
MOD_NEK2_1	560	565	PF00069	0.494
MOD_NEK2_1	637	642	PF00069	0.440
MOD_NEK2_1	858	863	PF00069	0.315
MOD_NEK2_1	953	958	PF00069	0.497
MOD_PIKK_1	190	196	PF00454	0.624
MOD_PIKK_1	768	774	PF00454	0.381
MOD_PKA_1	679	685	PF00069	0.419
MOD_PKA_2	122	128	PF00069	0.641
MOD_PKA_2	145	151	PF00069	0.641
MOD_PKA_2	372	378	PF00069	0.582
MOD_PKA_2	533	539	PF00069	0.537
MOD_PKA_2	607	613	PF00069	0.482
MOD_PKA_2	949	955	PF00069	0.338
MOD_Plk_1	118	124	PF00069	0.538
MOD_Plk_1	321	327	PF00069	0.579
MOD_Plk_1	328	334	PF00069	0.515
MOD_Plk_1	703	709	PF00069	0.229
MOD_Plk_1	847	853	PF00069	0.467
MOD_Plk_2-3	591	597	PF00069	0.421
MOD_Plk_4	205	211	PF00069	0.548
MOD_Plk_4	321	327	PF00069	0.612
MOD_Plk_4	416	422	PF00069	0.448
MOD_Plk_4	471	477	PF00069	0.498
MOD_Plk_4	490	496	PF00069	0.536
MOD_Plk_4	569	575	PF00069	0.460
MOD_Plk_4	591	597	PF00069	0.333
MOD_Plk_4	621	627	PF00069	0.354
MOD_Plk_4	633	639	PF00069	0.507
MOD_Plk_4	692	698	PF00069	0.292
MOD_Plk_4	79	85	PF00069	0.462
MOD_ProDKin_1	127	133	PF00069	0.621
MOD_ProDKin_1	161	167	PF00069	0.537
MOD_ProDKin_1	345	351	PF00069	0.722
MOD_ProDKin_1	378	384	PF00069	0.504
MOD_ProDKin_1	407	413	PF00069	0.603
MOD_ProDKin_1	737	743	PF00069	0.248
MOD_ProDKin_1	898	904	PF00069	0.636
MOD_SUMO_for_1	656	659	PF00179	0.326
TRG_DiLeu_BaEn_1	140	145	PF01217	0.426
TRG_DiLeu_BaEn_2	853	859	PF01217	0.463
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.487
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.248
TRG_ENDOCYTIC_2	23	26	PF00928	0.366
TRG_ENDOCYTIC_2	261	264	PF00928	0.406
TRG_ENDOCYTIC_2	398	401	PF00928	0.481
TRG_ENDOCYTIC_2	589	592	PF00928	0.441
TRG_ENDOCYTIC_2	59	62	PF00928	0.490
TRG_ENDOCYTIC_2	635	638	PF00928	0.455
TRG_ENDOCYTIC_2	670	673	PF00928	0.347
TRG_ENDOCYTIC_2	7	10	PF00928	0.572
TRG_ENDOCYTIC_2	820	823	PF00928	0.357
TRG_ENDOCYTIC_2	946	949	PF00928	0.405
TRG_ER_diArg_1	299	301	PF00400	0.408
TRG_ER_diArg_1	405	407	PF00400	0.372
TRG_ER_diArg_1	917	919	PF00400	0.467
TRG_ER_diArg_1	928	931	PF00400	0.352
TRG_ER_diArg_1	949	951	PF00400	0.327
TRG_NES_CRM1_1	659	672	PF08389	0.476
TRG_NLS_MonoExtN_4	676	683	PF00514	0.391
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	730	734	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z4	Leptomonas seymouri	66%	99%
A0A1X0NZ72	Trypanosomatidae	41%	100%
A0A3S5H6W4	Leishmania donovani	91%	100%
A0A422NAC8	Trypanosoma rangeli	47%	100%
A4H8D3	Leishmania braziliensis	80%	100%
A4HFM9	Leishmania braziliensis	36%	100%
A4HWQ5	Leishmania infantum	91%	100%
C9ZPS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
Q4QF14	Leishmania major	92%	100%
V5ARC8	Trypanosoma cruzi	43%	100%