Putative peroxisome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome assembly protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQG2_LEIMU

TriTrypDb:

LmxM.16.0060

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005778	peroxisomal membrane	6	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

E9AQG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG2

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015919	peroxisomal membrane transport	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.471
CLV_C14_Caspase3-7	168	172	PF00656	0.465
CLV_C14_Caspase3-7	522	526	PF00656	0.601
CLV_C14_Caspase3-7	536	540	PF00656	0.445
CLV_C14_Caspase3-7	747	751	PF00656	0.292
CLV_C14_Caspase3-7	895	899	PF00656	0.460
CLV_C14_Caspase3-7	900	904	PF00656	0.491
CLV_NRD_NRD_1	299	301	PF00675	0.413
CLV_NRD_NRD_1	318	320	PF00675	0.594
CLV_NRD_NRD_1	406	408	PF00675	0.387

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z4	Leptomonas seymouri	66%	99%
A0A1X0NZ72	Trypanosomatidae	41%	100%
A0A3S5H6W4	Leishmania donovani	91%	100%
A0A422NAC8	Trypanosoma rangeli	47%	100%
A4H8D3	Leishmania braziliensis	80%	100%
A4HFM9	Leishmania braziliensis	36%	100%
A4HWQ5	Leishmania infantum	91%	100%
C9ZPS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
Q4QF14	Leishmania major	92%	100%
V5ARC8	Trypanosoma cruzi	43%	100%

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