Helicase C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase/Helicase conserved C-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQG1_LEIMU

TriTrypDb:

LmxM.16.0050

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003676	nucleic acid binding	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003724	RNA helicase activity	3	2
GO:0003743	translation initiation factor activity	4	2
GO:0003824	catalytic activity	1	6
GO:0004386	helicase activity	2	6
GO:0008135	translation factor activity, RNA binding	3	2
GO:0008186	ATP-dependent activity, acting on RNA	2	2
GO:0016787	hydrolase activity	2	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	6
GO:0140657	ATP-dependent activity	1	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.488
CLV_NRD_NRD_1	222	224	PF00675	0.499
CLV_NRD_NRD_1	290	292	PF00675	0.656
CLV_NRD_NRD_1	449	451	PF00675	0.306
CLV_NRD_NRD_1	548	550	PF00675	0.513
CLV_NRD_NRD_1	583	585	PF00675	0.466
CLV_PCSK_FUR_1	10	14	PF00082	0.478
CLV_PCSK_KEX2_1	12	14	PF00082	0.485
CLV_PCSK_KEX2_1	222	224	PF00082	0.521
CLV_PCSK_KEX2_1	289	291	PF00082	0.594
CLV_PCSK_KEX2_1	297	299	PF00082	0.611
CLV_PCSK_KEX2_1	471	473	PF00082	0.207
CLV_PCSK_KEX2_1	583	585	PF00082	0.397
CLV_PCSK_KEX2_1	626	628	PF00082	0.469
CLV_PCSK_KEX2_1	9	11	PF00082	0.467
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.646
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.199
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.469
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.485
CLV_PCSK_PC7_1	218	224	PF00082	0.558
CLV_PCSK_SKI1_1	113	117	PF00082	0.222
CLV_PCSK_SKI1_1	395	399	PF00082	0.304
CLV_PCSK_SKI1_1	412	416	PF00082	0.276
CLV_PCSK_SKI1_1	453	457	PF00082	0.231
CLV_PCSK_SKI1_1	47	51	PF00082	0.342
CLV_PCSK_SKI1_1	620	624	PF00082	0.362
CLV_PCSK_SKI1_1	64	68	PF00082	0.209
CLV_PCSK_SKI1_1	652	656	PF00082	0.331
DEG_APCC_DBOX_1	112	120	PF00400	0.466
DEG_APCC_DBOX_1	583	591	PF00400	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DEG_SPOP_SBC_1	606	610	PF00917	0.380
DOC_CKS1_1	176	181	PF01111	0.391
DOC_CYCLIN_RxL_1	646	657	PF00134	0.472
DOC_MAPK_DCC_7	412	422	PF00069	0.408
DOC_MAPK_gen_1	166	176	PF00069	0.451
DOC_MAPK_gen_1	296	302	PF00069	0.457
DOC_MAPK_gen_1	385	391	PF00069	0.258
DOC_MAPK_MEF2A_6	113	120	PF00069	0.401
DOC_MAPK_MEF2A_6	642	651	PF00069	0.376
DOC_PP1_RVXF_1	393	400	PF00149	0.283
DOC_PP1_RVXF_1	45	52	PF00149	0.321
DOC_PP1_RVXF_1	81	88	PF00149	0.465
DOC_PP2B_LxvP_1	27	30	PF13499	0.404
DOC_PP2B_LxvP_1	415	418	PF13499	0.415
DOC_PP2B_LxvP_1	532	535	PF13499	0.289
DOC_PP2B_LxvP_1	569	572	PF13499	0.474
DOC_PP4_FxxP_1	505	508	PF00568	0.399
DOC_PP4_FxxP_1	87	90	PF00568	0.473
DOC_SPAK_OSR1_1	249	253	PF12202	0.359
DOC_SPAK_OSR1_1	362	366	PF12202	0.297
DOC_USP7_MATH_1	348	352	PF00917	0.552
DOC_USP7_MATH_1	606	610	PF00917	0.385
DOC_USP7_MATH_1	69	73	PF00917	0.441
DOC_USP7_MATH_1	78	82	PF00917	0.421
DOC_USP7_UBL2_3	292	296	PF12436	0.724
DOC_WW_Pin1_4	118	123	PF00397	0.441
DOC_WW_Pin1_4	175	180	PF00397	0.420
DOC_WW_Pin1_4	195	200	PF00397	0.487
DOC_WW_Pin1_4	260	265	PF00397	0.349
DOC_WW_Pin1_4	282	287	PF00397	0.654
DOC_WW_Pin1_4	323	328	PF00397	0.461
DOC_WW_Pin1_4	53	58	PF00397	0.402
LIG_14-3-3_CanoR_1	10	16	PF00244	0.601
LIG_14-3-3_CanoR_1	241	247	PF00244	0.403
LIG_14-3-3_CanoR_1	267	271	PF00244	0.415
LIG_14-3-3_CanoR_1	289	299	PF00244	0.707
LIG_14-3-3_CanoR_1	402	407	PF00244	0.452
LIG_14-3-3_CanoR_1	555	560	PF00244	0.535
LIG_14-3-3_CanoR_1	612	622	PF00244	0.328
LIG_14-3-3_CanoR_1	627	633	PF00244	0.510
LIG_14-3-3_CanoR_1	64	69	PF00244	0.350
LIG_14-3-3_CanoR_1	94	103	PF00244	0.568
LIG_Actin_WH2_2	608	625	PF00022	0.387
LIG_APCC_ABBA_1	329	334	PF00400	0.270
LIG_BRCT_BRCA1_1	238	242	PF00533	0.516
LIG_BRCT_BRCA1_1	552	556	PF00533	0.550
LIG_FHA_1	128	134	PF00498	0.406
LIG_FHA_1	171	177	PF00498	0.413
LIG_FHA_1	323	329	PF00498	0.417
LIG_FHA_1	344	350	PF00498	0.359
LIG_FHA_1	409	415	PF00498	0.474
LIG_FHA_1	478	484	PF00498	0.445
LIG_FHA_1	564	570	PF00498	0.481
LIG_FHA_1	606	612	PF00498	0.353
LIG_FHA_2	123	129	PF00498	0.504
LIG_FHA_2	176	182	PF00498	0.399
LIG_FHA_2	19	25	PF00498	0.403
LIG_FHA_2	226	232	PF00498	0.725
LIG_FHA_2	614	620	PF00498	0.326
LIG_LIR_Apic_2	258	264	PF02991	0.341
LIG_LIR_Apic_2	597	602	PF02991	0.451
LIG_LIR_Apic_2	641	647	PF02991	0.419
LIG_LIR_Apic_2	84	90	PF02991	0.473
LIG_LIR_Gen_1	181	189	PF02991	0.506
LIG_LIR_Gen_1	247	257	PF02991	0.279
LIG_LIR_Gen_1	28	38	PF02991	0.399
LIG_LIR_Gen_1	315	324	PF02991	0.437
LIG_LIR_Gen_1	434	443	PF02991	0.399
LIG_LIR_Nem_3	181	185	PF02991	0.506
LIG_LIR_Nem_3	247	253	PF02991	0.290
LIG_LIR_Nem_3	28	34	PF02991	0.408
LIG_LIR_Nem_3	315	319	PF02991	0.426
LIG_LIR_Nem_3	434	439	PF02991	0.414
LIG_LIR_Nem_3	553	559	PF02991	0.523
LIG_MYND_3	186	190	PF01753	0.417
LIG_Pex14_2	143	147	PF04695	0.504
LIG_Pex14_2	371	375	PF04695	0.287
LIG_Pex14_2	390	394	PF04695	0.425
LIG_Pex14_2	466	470	PF04695	0.465
LIG_PTB_Apo_2	45	52	PF02174	0.321
LIG_SH2_NCK_1	261	265	PF00017	0.569
LIG_SH2_PTP2	599	602	PF00017	0.266
LIG_SH2_SRC	501	504	PF00017	0.399
LIG_SH2_SRC	599	602	PF00017	0.266
LIG_SH2_STAP1	332	336	PF00017	0.293
LIG_SH2_STAT3	374	377	PF00017	0.296
LIG_SH2_STAT3	614	617	PF00017	0.314
LIG_SH2_STAT5	102	105	PF00017	0.440
LIG_SH2_STAT5	219	222	PF00017	0.551
LIG_SH2_STAT5	374	377	PF00017	0.466
LIG_SH2_STAT5	416	419	PF00017	0.315
LIG_SH2_STAT5	501	504	PF00017	0.408
LIG_SH2_STAT5	514	517	PF00017	0.441
LIG_SH2_STAT5	586	589	PF00017	0.348
LIG_SH2_STAT5	599	602	PF00017	0.487
LIG_SH2_STAT5	614	617	PF00017	0.540
LIG_SH3_3	151	157	PF00018	0.504
LIG_SH3_3	173	179	PF00018	0.411
LIG_SH3_3	280	286	PF00018	0.511
LIG_SH3_3	600	606	PF00018	0.392
LIG_SH3_3	72	78	PF00018	0.401
LIG_SH3_4	564	571	PF00018	0.469
LIG_SUMO_SIM_anti_2	529	535	PF11976	0.333
LIG_SUMO_SIM_par_1	172	178	PF11976	0.465
LIG_SUMO_SIM_par_1	250	256	PF11976	0.334
LIG_SUMO_SIM_par_1	345	351	PF11976	0.485
LIG_TRAF2_1	595	598	PF00917	0.473
LIG_UBA3_1	185	194	PF00899	0.350
LIG_UBA3_1	2	9	PF00899	0.359
LIG_UBA3_1	378	386	PF00899	0.304
LIG_UBA3_1	414	419	PF00899	0.369
LIG_UBA3_1	43	47	PF00899	0.376
LIG_UBA3_1	621	626	PF00899	0.302
MOD_CDC14_SPxK_1	121	124	PF00782	0.262
MOD_CDC14_SPxK_1	287	290	PF00782	0.544
MOD_CDK_SPK_2	175	180	PF00069	0.322
MOD_CDK_SPK_2	284	289	PF00069	0.534
MOD_CDK_SPxK_1	118	124	PF00069	0.289
MOD_CDK_SPxK_1	284	290	PF00069	0.536
MOD_CDK_SPxxK_3	260	267	PF00069	0.350
MOD_CDK_SPxxK_3	282	289	PF00069	0.522
MOD_CDK_SPxxK_3	323	330	PF00069	0.435
MOD_CK1_1	198	204	PF00069	0.515
MOD_CK1_1	236	242	PF00069	0.494
MOD_CK1_1	357	363	PF00069	0.412
MOD_CK1_1	53	59	PF00069	0.256
MOD_CK1_1	575	581	PF00069	0.592
MOD_CK1_1	81	87	PF00069	0.327
MOD_CK2_1	122	128	PF00069	0.376
MOD_CK2_1	225	231	PF00069	0.718
MOD_CK2_1	241	247	PF00069	0.418
MOD_CK2_1	454	460	PF00069	0.262
MOD_CK2_1	542	548	PF00069	0.500
MOD_CK2_1	575	581	PF00069	0.556
MOD_CK2_1	591	597	PF00069	0.352
MOD_CK2_1	628	634	PF00069	0.391
MOD_GlcNHglycan	292	295	PF01048	0.681
MOD_GlcNHglycan	429	432	PF01048	0.287
MOD_GlcNHglycan	467	470	PF01048	0.257
MOD_GlcNHglycan	544	547	PF01048	0.492
MOD_GlcNHglycan	552	555	PF01048	0.543
MOD_GlcNHglycan	574	577	PF01048	0.600
MOD_GlcNHglycan	593	596	PF01048	0.404
MOD_GlcNHglycan	71	74	PF01048	0.279
MOD_GlcNHglycan	80	83	PF01048	0.316
MOD_GSK3_1	118	125	PF00069	0.331
MOD_GSK3_1	170	177	PF00069	0.262
MOD_GSK3_1	193	200	PF00069	0.374
MOD_GSK3_1	221	228	PF00069	0.461
MOD_GSK3_1	319	326	PF00069	0.327
MOD_GSK3_1	339	346	PF00069	0.199
MOD_GSK3_1	555	562	PF00069	0.540
MOD_N-GLC_1	302	307	PF02516	0.552
MOD_NEK2_1	1	6	PF00069	0.548
MOD_NEK2_1	266	271	PF00069	0.462
MOD_NEK2_1	381	386	PF00069	0.300
MOD_NEK2_1	427	432	PF00069	0.376
MOD_NEK2_1	50	55	PF00069	0.330
MOD_NEK2_1	526	531	PF00069	0.318
MOD_NEK2_2	340	345	PF00069	0.324
MOD_PIKK_1	221	227	PF00454	0.586
MOD_PIKK_1	354	360	PF00454	0.414
MOD_PIKK_1	613	619	PF00454	0.357
MOD_PIKK_1	64	70	PF00454	0.255
MOD_PK_1	402	408	PF00069	0.361
MOD_PK_1	527	533	PF00069	0.303
MOD_PKA_1	290	296	PF00069	0.608
MOD_PKA_1	563	569	PF00069	0.609
MOD_PKA_2	11	17	PF00069	0.595
MOD_PKA_2	221	227	PF00069	0.383
MOD_PKA_2	236	242	PF00069	0.524
MOD_PKA_2	266	272	PF00069	0.460
MOD_PKA_2	290	296	PF00069	0.770
MOD_Plk_1	127	133	PF00069	0.229
MOD_Plk_1	18	24	PF00069	0.429
MOD_Plk_2-3	18	24	PF00069	0.429
MOD_Plk_4	127	133	PF00069	0.238
MOD_Plk_4	170	176	PF00069	0.233
MOD_Plk_4	39	45	PF00069	0.348
MOD_Plk_4	510	516	PF00069	0.245
MOD_Plk_4	527	533	PF00069	0.287
MOD_ProDKin_1	118	124	PF00069	0.289
MOD_ProDKin_1	175	181	PF00069	0.259
MOD_ProDKin_1	195	201	PF00069	0.353
MOD_ProDKin_1	260	266	PF00069	0.346
MOD_ProDKin_1	282	288	PF00069	0.657
MOD_ProDKin_1	323	329	PF00069	0.453
MOD_ProDKin_1	53	59	PF00069	0.348
MOD_SUMO_rev_2	16	21	PF00179	0.494
MOD_SUMO_rev_2	545	551	PF00179	0.541
MOD_SUMO_rev_2	634	643	PF00179	0.456
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.374
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.350
TRG_DiLeu_LyEn_5	184	189	PF01217	0.206
TRG_ENDOCYTIC_2	424	427	PF00928	0.274
TRG_ENDOCYTIC_2	436	439	PF00928	0.271
TRG_ER_diArg_1	10	13	PF00400	0.479
TRG_ER_diArg_1	216	219	PF00400	0.437
TRG_ER_diArg_1	288	291	PF00400	0.772
TRG_NLS_MonoCore_2	449	454	PF00514	0.255
TRG_NLS_MonoExtC_3	449	454	PF00514	0.376
TRG_NLS_MonoExtC_3	8	13	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	652	657	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C1	Leptomonas seymouri	73%	98%
A0A0S4JMG7	Bodo saltans	41%	87%
A0A1X0NZ55	Trypanosomatidae	55%	100%
A0A3R7LSE5	Trypanosoma rangeli	53%	100%
A0A3S7WTP8	Leishmania donovani	93%	100%
A4H8D2	Leishmania braziliensis	84%	100%
A4HWQ4	Leishmania infantum	93%	100%
A7F8V8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	23%	75%
C9ZPS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9AKE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q2NL08	Bos taurus	23%	100%
Q4QF15	Leishmania major	92%	100%
Q6ZPL9	Mus musculus	23%	100%
Q8NHQ9	Homo sapiens	23%	100%
V5BBA0	Trypanosoma cruzi	55%	100%
V5CZW7	Trypanosoma cruzi	25%	100%