P4Hc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AQG0_LEIMU

TriTrypDb:

LmxM.16.0040

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AQG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQG0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0018126	protein hydroxylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	7	1
GO:0019511	peptidyl-proline hydroxylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0019842	vitamin binding	3	12
GO:0030246	carbohydrate binding	2	12
GO:0031406	carboxylic acid binding	4	12
GO:0031418	L-ascorbic acid binding	3	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0043177	organic acid binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0048029	monosaccharide binding	3	12
GO:0051213	dioxygenase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004656	procollagen-proline 4-dioxygenase activity	5	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0019798	procollagen-proline dioxygenase activity	4	1
GO:0031543	peptidyl-proline dioxygenase activity	3	1
GO:0031545	peptidyl-proline 4-dioxygenase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.575
CLV_C14_Caspase3-7	36	40	PF00656	0.578
CLV_NRD_NRD_1	303	305	PF00675	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DOC_CKS1_1	29	34	PF01111	0.587
DOC_MAPK_HePTP_8	175	187	PF00069	0.328
DOC_MAPK_MEF2A_6	178	187	PF00069	0.328
DOC_PIKK_1	126	134	PF02985	0.547
DOC_PP4_FxxP_1	29	32	PF00568	0.584
DOC_USP7_MATH_1	33	37	PF00917	0.373
DOC_WW_Pin1_4	262	267	PF00397	0.515
DOC_WW_Pin1_4	28	33	PF00397	0.547
LIG_14-3-3_CanoR_1	178	184	PF00244	0.328
LIG_14-3-3_CanoR_1	217	227	PF00244	0.475
LIG_APCC_ABBA_1	163	168	PF00400	0.328
LIG_APCC_ABBA_1	278	283	PF00400	0.471
LIG_BIR_III_4	78	82	PF00653	0.654
LIG_BRCT_BRCA1_1	232	236	PF00533	0.364
LIG_CSL_BTD_1	142	145	PF09270	0.410
LIG_FHA_1	180	186	PF00498	0.327
LIG_FHA_1	219	225	PF00498	0.478
LIG_FHA_1	263	269	PF00498	0.514
LIG_FHA_1	67	73	PF00498	0.570
LIG_FHA_2	169	175	PF00498	0.336
LIG_FHA_2	268	274	PF00498	0.387
LIG_FHA_2	50	56	PF00498	0.494
LIG_LIR_Apic_2	27	32	PF02991	0.597
LIG_LIR_Gen_1	179	187	PF02991	0.328
LIG_LIR_Gen_1	20	30	PF02991	0.391
LIG_LIR_Gen_1	3	8	PF02991	0.505
LIG_LIR_Nem_3	177	183	PF02991	0.334
LIG_LIR_Nem_3	20	26	PF02991	0.372
LIG_LIR_Nem_3	233	239	PF02991	0.367
LIG_LIR_Nem_3	275	281	PF02991	0.479
LIG_LIR_Nem_3	3	7	PF02991	0.513
LIG_LIR_Nem_3	99	105	PF02991	0.401
LIG_SH2_CRK	110	114	PF00017	0.488
LIG_SH2_CRK	181	185	PF00017	0.344
LIG_SH2_CRK	239	243	PF00017	0.385
LIG_SH2_CRK	4	8	PF00017	0.535
LIG_SH2_GRB2like	186	189	PF00017	0.323
LIG_SH2_GRB2like	238	241	PF00017	0.398
LIG_SH2_NCK_1	110	114	PF00017	0.499
LIG_SH2_SRC	281	284	PF00017	0.495
LIG_SH2_STAP1	110	114	PF00017	0.448
LIG_SH2_STAP1	181	185	PF00017	0.344
LIG_SH2_STAP1	68	72	PF00017	0.564
LIG_SH2_STAT5	181	184	PF00017	0.332
LIG_SH2_STAT5	186	189	PF00017	0.323
LIG_SH2_STAT5	208	211	PF00017	0.391
LIG_SH2_STAT5	254	257	PF00017	0.321
LIG_SH2_STAT5	68	71	PF00017	0.438
LIG_SH3_1	115	121	PF00018	0.267
LIG_SH3_3	115	121	PF00018	0.441
LIG_SUMO_SIM_par_1	170	177	PF11976	0.298
LIG_SUMO_SIM_par_1	33	39	PF11976	0.592
LIG_TRAF2_1	270	273	PF00917	0.389
LIG_TRAF2_1	52	55	PF00917	0.451
LIG_TYR_ITIM	2	7	PF00017	0.472
MOD_CK1_1	179	185	PF00069	0.343
MOD_CK2_1	267	273	PF00069	0.274
MOD_CK2_1	49	55	PF00069	0.391
MOD_GlcNHglycan	105	108	PF01048	0.255
MOD_GlcNHglycan	232	235	PF01048	0.364
MOD_GlcNHglycan	86	89	PF01048	0.558
MOD_GSK3_1	24	31	PF00069	0.515
MOD_LATS_1	228	234	PF00433	0.361
MOD_N-GLC_1	218	223	PF02516	0.398
MOD_N-GLC_2	188	190	PF02516	0.339
MOD_NEK2_1	139	144	PF00069	0.441
MOD_NEK2_1	286	291	PF00069	0.569
MOD_NEK2_2	309	314	PF00069	0.439
MOD_PIKK_1	218	224	PF00454	0.398
MOD_PKA_1	230	236	PF00069	0.413
MOD_PKA_1	304	310	PF00069	0.426
MOD_PKB_1	302	310	PF00069	0.447
MOD_Plk_2-3	168	174	PF00069	0.344
MOD_Plk_4	139	145	PF00069	0.421
MOD_Plk_4	168	174	PF00069	0.344
MOD_Plk_4	179	185	PF00069	0.339
MOD_Plk_4	193	199	PF00069	0.300
MOD_Plk_4	309	315	PF00069	0.449
MOD_Plk_4	66	72	PF00069	0.407
MOD_ProDKin_1	262	268	PF00069	0.515
MOD_ProDKin_1	28	34	PF00069	0.547
MOD_SUMO_rev_2	271	278	PF00179	0.444
MOD_SUMO_rev_2	36	42	PF00179	0.496
TRG_DiLeu_BaEn_1	55	60	PF01217	0.449
TRG_ENDOCYTIC_2	110	113	PF00928	0.486
TRG_ENDOCYTIC_2	181	184	PF00928	0.344
TRG_ENDOCYTIC_2	238	241	PF00928	0.363
TRG_ENDOCYTIC_2	4	7	PF00928	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX6	Leptomonas seymouri	79%	100%
A0A0S4JJ67	Bodo saltans	41%	90%
A0A1X0NZK5	Trypanosomatidae	60%	100%
A0A3Q8IA78	Leishmania donovani	95%	100%
A0A3R7K694	Trypanosoma rangeli	56%	100%
A4H8D1	Leishmania braziliensis	84%	100%
A4HWQ3	Leishmania infantum	96%	100%
C9ZPS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4QF16	Leishmania major	95%	100%
V5D783	Trypanosoma cruzi	56%	83%