Arginine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase, type I

Species:

Leishmania mexicana

UniProt:

E9AQF9_LEIMU

TriTrypDb:

LmxM.16.0030

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AQF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQF9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0008213	protein alkylation	5	13
GO:0009987	cellular process	1	13
GO:0018193	peptidyl-amino acid modification	5	13
GO:0018195	peptidyl-arginine modification	6	13
GO:0018216	peptidyl-arginine methylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0032259	methylation	2	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	8	1
GO:0034969	histone arginine methylation	6	1
GO:0035246	peptidyl-arginine N-methylation	6	1
GO:0035247	peptidyl-arginine omega-N-methylation	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0008170	N-methyltransferase activity	5	13
GO:0008276	protein methyltransferase activity	3	13
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	13
GO:0016273	arginine N-methyltransferase activity	6	13
GO:0016274	protein-arginine N-methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0008169	C-methyltransferase activity	5	1
GO:0008469	histone arginine N-methyltransferase activity	5	1
GO:0035244	protein-arginine C-methyltransferase activity	4	1
GO:0042054	histone methyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.380
CLV_NRD_NRD_1	336	338	PF00675	0.269
CLV_PCSK_KEX2_1	336	338	PF00082	0.354
CLV_PCSK_SKI1_1	235	239	PF00082	0.407
CLV_PCSK_SKI1_1	28	32	PF00082	0.345
CLV_PCSK_SKI1_1	41	45	PF00082	0.362
DEG_Nend_UBRbox_3	1	3	PF02207	0.696
DEG_ODPH_VHL_1	310	323	PF01847	0.385
DOC_ANK_TNKS_1	46	53	PF00023	0.411
DOC_CYCLIN_RxL_1	232	240	PF00134	0.449
DOC_CYCLIN_RxL_1	36	48	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.330
DOC_MAPK_gen_1	32	39	PF00069	0.444
DOC_MAPK_gen_1	326	335	PF00069	0.443
DOC_MAPK_gen_1	336	344	PF00069	0.447
DOC_MAPK_MEF2A_6	128	137	PF00069	0.340
DOC_MAPK_MEF2A_6	337	346	PF00069	0.403
DOC_PP1_RVXF_1	329	336	PF00149	0.430
DOC_PP1_RVXF_1	357	363	PF00149	0.493
DOC_PP2B_LxvP_1	184	187	PF13499	0.327
DOC_PP2B_LxvP_1	310	313	PF13499	0.512
DOC_USP7_MATH_1	167	171	PF00917	0.391
DOC_USP7_MATH_1	277	281	PF00917	0.459
DOC_USP7_MATH_1	69	73	PF00917	0.503
DOC_WW_Pin1_4	223	228	PF00397	0.422
DOC_WW_Pin1_4	305	310	PF00397	0.340
LIG_14-3-3_CanoR_1	101	105	PF00244	0.478
LIG_14-3-3_CanoR_1	347	353	PF00244	0.438
LIG_APCC_ABBA_1	143	148	PF00400	0.387
LIG_APCC_ABBA_1	198	203	PF00400	0.324
LIG_deltaCOP1_diTrp_1	139	146	PF00928	0.328
LIG_FHA_1	223	229	PF00498	0.465
LIG_FHA_1	249	255	PF00498	0.491
LIG_FHA_1	256	262	PF00498	0.446
LIG_FHA_1	305	311	PF00498	0.415
LIG_FHA_1	317	323	PF00498	0.265
LIG_FHA_1	343	349	PF00498	0.342
LIG_FHA_2	347	353	PF00498	0.397
LIG_Integrin_isoDGR_2	180	182	PF01839	0.233
LIG_LIR_Gen_1	19	29	PF02991	0.430
LIG_LIR_Gen_1	246	257	PF02991	0.372
LIG_LIR_Nem_3	138	143	PF02991	0.328
LIG_LIR_Nem_3	15	21	PF02991	0.463
LIG_LIR_Nem_3	196	201	PF02991	0.365
LIG_LIR_Nem_3	246	252	PF02991	0.360
LIG_LIR_Nem_3	293	298	PF02991	0.291
LIG_LIR_Nem_3	332	338	PF02991	0.388
LIG_LIR_Nem_3	38	43	PF02991	0.395
LIG_Pex14_1	140	144	PF04695	0.331
LIG_Pex14_1	245	249	PF04695	0.444
LIG_Pex14_2	198	202	PF04695	0.451
LIG_Pex14_2	292	296	PF04695	0.342
LIG_SH2_CRK	40	44	PF00017	0.458
LIG_SH2_SRC	218	221	PF00017	0.364
LIG_SH2_STAP1	194	198	PF00017	0.374
LIG_SH2_STAP1	218	222	PF00017	0.256
LIG_SH2_STAP1	7	11	PF00017	0.639
LIG_SH2_STAT5	144	147	PF00017	0.347
LIG_SH2_STAT5	17	20	PF00017	0.475
LIG_SH2_STAT5	84	87	PF00017	0.340
LIG_SH3_3	228	234	PF00018	0.375
LIG_SH3_3	306	312	PF00018	0.378
LIG_SH3_3	318	324	PF00018	0.339
LIG_SUMO_SIM_anti_2	99	107	PF11976	0.470
LIG_SUMO_SIM_par_1	250	256	PF11976	0.384
LIG_SUMO_SIM_par_1	76	81	PF11976	0.484
LIG_WW_3	232	236	PF00397	0.428
MOD_CK1_1	248	254	PF00069	0.486
MOD_CK1_1	271	277	PF00069	0.538
MOD_CK1_1	9	15	PF00069	0.540
MOD_CK2_1	104	110	PF00069	0.557
MOD_CK2_1	277	283	PF00069	0.622
MOD_CK2_1	45	51	PF00069	0.401
MOD_GlcNHglycan	270	273	PF01048	0.442
MOD_GlcNHglycan	275	278	PF01048	0.511
MOD_GlcNHglycan	59	62	PF01048	0.228
MOD_GlcNHglycan	71	74	PF01048	0.220
MOD_GSK3_1	262	269	PF00069	0.408
MOD_GSK3_1	273	280	PF00069	0.475
MOD_GSK3_1	281	288	PF00069	0.235
MOD_GSK3_1	342	349	PF00069	0.411
MOD_GSK3_1	59	66	PF00069	0.456
MOD_GSK3_1	76	83	PF00069	0.455
MOD_GSK3_1	96	103	PF00069	0.458
MOD_LATS_1	315	321	PF00433	0.356
MOD_LATS_1	329	335	PF00433	0.387
MOD_N-GLC_1	9	14	PF02516	0.557
MOD_NEK2_1	168	173	PF00069	0.472
MOD_NEK2_1	201	206	PF00069	0.375
MOD_NEK2_1	266	271	PF00069	0.450
MOD_NEK2_1	281	286	PF00069	0.408
MOD_NEK2_1	296	301	PF00069	0.234
MOD_NEK2_1	342	347	PF00069	0.422
MOD_NEK2_1	39	44	PF00069	0.382
MOD_NEK2_1	80	85	PF00069	0.523
MOD_NEK2_2	206	211	PF00069	0.232
MOD_NEK2_2	22	27	PF00069	0.536
MOD_PKA_2	100	106	PF00069	0.487
MOD_PKA_2	346	352	PF00069	0.379
MOD_Plk_1	22	28	PF00069	0.498
MOD_Plk_1	255	261	PF00069	0.429
MOD_Plk_1	329	335	PF00069	0.552
MOD_Plk_1	342	348	PF00069	0.359
MOD_Plk_1	45	51	PF00069	0.317
MOD_Plk_1	80	86	PF00069	0.432
MOD_Plk_4	100	106	PF00069	0.472
MOD_Plk_4	150	156	PF00069	0.334
MOD_Plk_4	256	262	PF00069	0.514
MOD_Plk_4	317	323	PF00069	0.400
MOD_Plk_4	39	45	PF00069	0.270
MOD_Plk_4	80	86	PF00069	0.389
MOD_ProDKin_1	223	229	PF00069	0.418
MOD_ProDKin_1	305	311	PF00069	0.342
MOD_SUMO_rev_2	46	55	PF00179	0.526
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.340
TRG_ENDOCYTIC_2	21	24	PF00928	0.413
TRG_ENDOCYTIC_2	40	43	PF00928	0.467
TRG_ER_diArg_1	155	158	PF00400	0.295
TRG_ER_diArg_1	335	337	PF00400	0.258
TRG_ER_diArg_1	34	37	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	25%	91%
A0A0N0P6T9	Leptomonas seymouri	30%	100%
A0A0N0P7Z0	Leptomonas seymouri	63%	100%
A0A0S4JQD8	Bodo saltans	39%	98%
A0A0S4JWH9	Bodo saltans	30%	100%
A0A1X0NMC6	Trypanosomatidae	29%	100%
A0A1X0P0F1	Trypanosomatidae	44%	99%
A0A3R7MAM8	Trypanosoma rangeli	46%	99%
A0A3S5H6M7	Leishmania donovani	32%	100%
A0A3S7WTR5	Leishmania donovani	88%	100%
A0A451EJR0	Leishmania donovani	23%	100%
A2XYY8	Oryza sativa subsp. indica	28%	96%
A2Y953	Oryza sativa subsp. indica	30%	96%
A2YPT7	Oryza sativa subsp. indica	33%	69%
A2Z0C0	Oryza sativa subsp. indica	30%	94%
A2Z8S0	Oryza sativa subsp. indica	28%	92%
A3KPF2	Arabidopsis thaliana	29%	69%
A4H8A2	Leishmania braziliensis	24%	90%
A4H8D0	Leishmania braziliensis	84%	100%
A4HWQ2	Leishmania infantum	88%	100%
A8IEF3	Chlamydomonas reinhardtii	30%	100%
B0JYW5	Xenopus tropicalis	29%	100%
B3DLB3	Xenopus tropicalis	29%	84%
B3M1E1	Drosophila ananassae	30%	69%
B3P4N5	Drosophila erecta	30%	69%
B4GZ20	Drosophila persimilis	30%	69%
B4HJC0	Drosophila sechellia	30%	69%
B4JXV2	Drosophila grimshawi	30%	67%
B4KA23	Drosophila mojavensis	30%	68%
B4LVS8	Drosophila virilis	30%	68%
B4NKI9	Drosophila willistoni	29%	68%
B4PVH6	Drosophila yakuba	30%	69%
B4QVW6	Drosophila simulans	30%	69%
C9ZI39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZPS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
D9IVE5	Xenopus laevis	29%	84%
E9ACK5	Leishmania major	22%	100%
E9AG49	Leishmania infantum	23%	100%
E9AGI9	Leishmania infantum	31%	100%
E9AIN9	Leishmania braziliensis	34%	100%
E9AJU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AP27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O13648	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	67%
O60678	Homo sapiens	28%	69%
O70467	Rattus norvegicus	28%	69%
O82210	Arabidopsis thaliana	29%	100%
P38074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P55345	Homo sapiens	27%	84%
Q08A71	Arabidopsis thaliana	31%	84%
Q0J2C6	Oryza sativa subsp. japonica	30%	94%
Q28F07	Xenopus tropicalis	30%	100%
Q29B63	Drosophila pseudoobscura pseudoobscura	30%	69%
Q4QF17	Leishmania major	90%	100%
Q4QGG2	Leishmania major	33%	100%
Q54EF2	Dictyostelium discoideum	27%	100%
Q54HI0	Dictyostelium discoideum	27%	71%
Q5E9L5	Bos taurus	32%	97%
Q5RGQ2	Danio rerio	28%	87%
Q63009	Rattus norvegicus	30%	100%
Q68EZ3	Xenopus laevis	30%	100%
Q6NWG4	Danio rerio	30%	100%
Q6NZB1	Mus musculus	30%	97%
Q6PAK3	Mus musculus	29%	93%
Q6VRB0	Xenopus laevis	30%	100%
Q75G68	Oryza sativa subsp. japonica	28%	92%
Q7XI75	Oryza sativa subsp. japonica	33%	69%
Q7XKC0	Oryza sativa subsp. japonica	28%	93%
Q84W92	Arabidopsis thaliana	30%	68%
Q8AV13	Xenopus laevis	30%	99%
Q922H1	Mus musculus	28%	69%
Q96LA8	Homo sapiens	31%	97%
Q99873	Homo sapiens	30%	98%
Q9JIF0	Mus musculus	30%	98%
Q9NR22	Homo sapiens	29%	93%
Q9R144	Mus musculus	28%	81%
Q9SNQ2	Oryza sativa subsp. japonica	30%	96%
Q9SU94	Arabidopsis thaliana	30%	94%
Q9U2X0	Caenorhabditis elegans	32%	100%
Q9URX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q9VH48	Drosophila melanogaster	30%	69%
V5ARC3	Trypanosoma cruzi	47%	93%
V5BF38	Trypanosoma cruzi	28%	100%