ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQF5_LEIMU

TriTrypDb:

LmxM.15.1570

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.565
CLV_C14_Caspase3-7	26	30	PF00656	0.431
CLV_C14_Caspase3-7	400	404	PF00656	0.627
CLV_C14_Caspase3-7	466	470	PF00656	0.445
CLV_NRD_NRD_1	217	219	PF00675	0.370
CLV_NRD_NRD_1	271	273	PF00675	0.542
CLV_NRD_NRD_1	374	376	PF00675	0.626
CLV_NRD_NRD_1	4	6	PF00675	0.596
CLV_NRD_NRD_1	84	86	PF00675	0.457
CLV_NRD_NRD_1	9	11	PF00675	0.538
CLV_PCSK_FUR_1	374	378	PF00082	0.602
CLV_PCSK_KEX2_1	167	169	PF00082	0.479
CLV_PCSK_KEX2_1	217	219	PF00082	0.353
CLV_PCSK_KEX2_1	374	376	PF00082	0.615
CLV_PCSK_KEX2_1	4	6	PF00082	0.588
CLV_PCSK_KEX2_1	418	420	PF00082	0.547
CLV_PCSK_KEX2_1	86	88	PF00082	0.460
CLV_PCSK_KEX2_1	9	11	PF00082	0.545
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.348
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.610
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.617
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.595
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.536
CLV_PCSK_PC7_1	414	420	PF00082	0.564
CLV_PCSK_PC7_1	5	11	PF00082	0.696
CLV_PCSK_SKI1_1	164	168	PF00082	0.421
CLV_PCSK_SKI1_1	243	247	PF00082	0.386
CLV_PCSK_SKI1_1	274	278	PF00082	0.520
CLV_PCSK_SKI1_1	353	357	PF00082	0.466
CLV_PCSK_SKI1_1	414	418	PF00082	0.552
CLV_PCSK_SKI1_1	419	423	PF00082	0.562
CLV_PCSK_SKI1_1	437	441	PF00082	0.470
CLV_PCSK_SKI1_1	510	514	PF00082	0.661
CLV_PCSK_SKI1_1	536	540	PF00082	0.605
DEG_SCF_FBW7_1	460	467	PF00400	0.526
DOC_CYCLIN_RxL_1	414	426	PF00134	0.624
DOC_CYCLIN_RxL_1	507	517	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.401
DOC_MAPK_gen_1	167	175	PF00069	0.293
DOC_MAPK_gen_1	272	279	PF00069	0.459
DOC_MAPK_gen_1	529	539	PF00069	0.610
DOC_PP1_RVXF_1	119	126	PF00149	0.443
DOC_PP4_FxxP_1	70	73	PF00568	0.360
DOC_PP4_FxxP_1	76	79	PF00568	0.440
DOC_PP4_MxPP_1	71	74	PF00568	0.353
DOC_USP7_UBL2_3	484	488	PF12436	0.644
DOC_WW_Pin1_4	43	48	PF00397	0.388
DOC_WW_Pin1_4	446	451	PF00397	0.482
DOC_WW_Pin1_4	460	465	PF00397	0.555
DOC_WW_Pin1_4	516	521	PF00397	0.680
LIG_14-3-3_CanoR_1	101	105	PF00244	0.653
LIG_14-3-3_CanoR_1	233	242	PF00244	0.574
LIG_14-3-3_CanoR_1	431	439	PF00244	0.530
LIG_14-3-3_CanoR_1	493	498	PF00244	0.482
LIG_Actin_WH2_2	228	245	PF00022	0.508
LIG_eIF4E_1	55	61	PF01652	0.328
LIG_FHA_1	151	157	PF00498	0.430
LIG_FHA_1	478	484	PF00498	0.598
LIG_FHA_1	48	54	PF00498	0.412
LIG_FHA_1	507	513	PF00498	0.597
LIG_FHA_1	55	61	PF00498	0.276
LIG_FHA_2	203	209	PF00498	0.453
LIG_FHA_2	222	228	PF00498	0.534
LIG_FHA_2	338	344	PF00498	0.760
LIG_FHA_2	363	369	PF00498	0.502
LIG_FHA_2	400	406	PF00498	0.679
LIG_Integrin_RGD_1	106	108	PF01839	0.526
LIG_LIR_Apic_2	139	144	PF02991	0.328
LIG_LIR_Gen_1	204	215	PF02991	0.477
LIG_LIR_Gen_1	288	297	PF02991	0.500
LIG_LIR_Gen_1	426	434	PF02991	0.570
LIG_LIR_Gen_1	473	482	PF02991	0.604
LIG_LIR_Nem_3	130	135	PF02991	0.413
LIG_LIR_Nem_3	204	210	PF02991	0.522
LIG_LIR_Nem_3	248	253	PF02991	0.441
LIG_LIR_Nem_3	288	292	PF02991	0.426
LIG_LIR_Nem_3	426	432	PF02991	0.501
LIG_LIR_Nem_3	473	477	PF02991	0.522
LIG_MYND_1	526	530	PF01753	0.577
LIG_PTB_Apo_2	64	71	PF02174	0.394
LIG_REV1ctd_RIR_1	437	446	PF16727	0.559
LIG_SH2_CRK	289	293	PF00017	0.365
LIG_SH2_CRK	294	298	PF00017	0.354
LIG_SH2_GRB2like	249	252	PF00017	0.502
LIG_SH2_PTP2	141	144	PF00017	0.282
LIG_SH2_STAP1	147	151	PF00017	0.449
LIG_SH2_STAP1	406	410	PF00017	0.525
LIG_SH2_STAT3	124	127	PF00017	0.428
LIG_SH2_STAT5	124	127	PF00017	0.434
LIG_SH2_STAT5	133	136	PF00017	0.393
LIG_SH2_STAT5	141	144	PF00017	0.302
LIG_SH2_STAT5	150	153	PF00017	0.343
LIG_SH2_STAT5	349	352	PF00017	0.704
LIG_SH2_STAT5	428	431	PF00017	0.562
LIG_SH3_2	348	353	PF14604	0.465
LIG_SH3_2	35	40	PF14604	0.424
LIG_SH3_3	172	178	PF00018	0.375
LIG_SH3_3	32	38	PF00018	0.425
LIG_SH3_3	345	351	PF00018	0.686
LIG_SH3_3	41	47	PF00018	0.395
LIG_SH3_3	520	526	PF00018	0.574
LIG_SH3_3	527	533	PF00018	0.582
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.426
LIG_SUMO_SIM_anti_2	503	509	PF11976	0.438
LIG_SUMO_SIM_par_1	177	183	PF11976	0.506
LIG_SUMO_SIM_par_1	199	205	PF11976	0.492
LIG_TRAF2_2	450	455	PF00917	0.689
LIG_TRFH_1	133	137	PF08558	0.406
LIG_TYR_ITIM	292	297	PF00017	0.363
MOD_CDC14_SPxK_1	46	49	PF00782	0.485
MOD_CDK_SPxK_1	43	49	PF00069	0.468
MOD_CK1_1	100	106	PF00069	0.653
MOD_CK1_1	382	388	PF00069	0.613
MOD_CK1_1	389	395	PF00069	0.600
MOD_CK1_1	396	402	PF00069	0.549
MOD_CK1_1	430	436	PF00069	0.525
MOD_CK1_1	443	449	PF00069	0.609
MOD_CK2_1	221	227	PF00069	0.406
MOD_CK2_1	363	369	PF00069	0.647
MOD_Cter_Amidation	92	95	PF01082	0.419
MOD_GlcNHglycan	170	173	PF01048	0.541
MOD_GlcNHglycan	235	238	PF01048	0.464
MOD_GlcNHglycan	269	272	PF01048	0.432
MOD_GlcNHglycan	313	316	PF01048	0.551
MOD_GlcNHglycan	380	384	PF01048	0.658
MOD_GlcNHglycan	432	435	PF01048	0.534
MOD_GlcNHglycan	492	496	PF01048	0.635
MOD_GSK3_1	221	228	PF00069	0.413
MOD_GSK3_1	382	389	PF00069	0.586
MOD_GSK3_1	391	398	PF00069	0.614
MOD_GSK3_1	43	50	PF00069	0.416
MOD_GSK3_1	460	467	PF00069	0.567
MOD_N-GLC_1	285	290	PF02516	0.535
MOD_N-GLC_1	317	322	PF02516	0.544
MOD_N-GLC_1	446	451	PF02516	0.674
MOD_N-GLC_1	55	60	PF02516	0.368
MOD_NEK2_1	267	272	PF00069	0.496
MOD_NEK2_1	440	445	PF00069	0.696
MOD_NEK2_1	506	511	PF00069	0.469
MOD_NEK2_1	54	59	PF00069	0.358
MOD_NEK2_2	47	52	PF00069	0.421
MOD_PIKK_1	387	393	PF00454	0.556
MOD_PIKK_1	448	454	PF00454	0.704
MOD_PKA_2	100	106	PF00069	0.596
MOD_PKA_2	392	398	PF00069	0.690
MOD_PKA_2	430	436	PF00069	0.580
MOD_PKA_2	531	537	PF00069	0.571
MOD_PKB_1	377	385	PF00069	0.617
MOD_Plk_1	285	291	PF00069	0.477
MOD_Plk_1	317	323	PF00069	0.549
MOD_Plk_1	342	348	PF00069	0.718
MOD_Plk_1	47	53	PF00069	0.531
MOD_Plk_1	55	61	PF00069	0.246
MOD_Plk_4	100	106	PF00069	0.598
MOD_Plk_4	202	208	PF00069	0.635
MOD_Plk_4	245	251	PF00069	0.504
MOD_Plk_4	56	62	PF00069	0.327
MOD_ProDKin_1	43	49	PF00069	0.395
MOD_ProDKin_1	446	452	PF00069	0.486
MOD_ProDKin_1	460	466	PF00069	0.557
MOD_ProDKin_1	516	522	PF00069	0.684
MOD_SUMO_for_1	489	492	PF00179	0.683
MOD_SUMO_rev_2	89	96	PF00179	0.546
TRG_ENDOCYTIC_2	282	285	PF00928	0.371
TRG_ENDOCYTIC_2	289	292	PF00928	0.368
TRG_ENDOCYTIC_2	294	297	PF00928	0.364
TRG_ER_diArg_1	216	218	PF00400	0.338
TRG_ER_diArg_1	240	243	PF00400	0.460
TRG_ER_diArg_1	291	294	PF00400	0.349
TRG_ER_diArg_1	374	377	PF00400	0.608
TRG_ER_diArg_1	8	10	PF00400	0.603
TRG_ER_diArg_1	84	87	PF00400	0.464
TRG_NES_CRM1_1	503	517	PF08389	0.487
TRG_NLS_MonoExtC_3	3	8	PF00514	0.613
TRG_NLS_MonoExtC_3	374	379	PF00514	0.618
TRG_NLS_MonoExtN_4	2	8	PF00514	0.619
TRG_NLS_MonoExtN_4	374	379	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P791	Leptomonas seymouri	64%	100%
A0A1X0NGQ9	Trypanosomatidae	42%	92%
A0A3R7L2Y6	Trypanosoma rangeli	43%	91%
A0A3S5H6W3	Leishmania donovani	89%	100%
A4H8C6	Leishmania braziliensis	79%	100%
A4HWP7	Leishmania infantum	88%	100%
C9ZTQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	87%
Q4QF21	Leishmania major	86%	100%
V5DPP9	Trypanosoma cruzi	42%	92%