Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQF2_LEIMU

TriTrypDb:

LmxM.15.1545

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.484
CLV_PCSK_KEX2_1	200	202	PF00082	0.646
CLV_PCSK_KEX2_1	47	49	PF00082	0.586
CLV_PCSK_KEX2_1	91	93	PF00082	0.530
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.664
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.595
DEG_Nend_UBRbox_3	1	3	PF02207	0.650
DOC_PP1_RVXF_1	13	19	PF00149	0.466
DOC_PP1_RVXF_1	22	28	PF00149	0.530
DOC_PP2B_LxvP_1	190	193	PF13499	0.700
DOC_USP7_MATH_1	123	127	PF00917	0.670
DOC_USP7_MATH_1	179	183	PF00917	0.545
DOC_USP7_MATH_1	55	59	PF00917	0.706
DOC_USP7_MATH_1	74	78	PF00917	0.419
DOC_USP7_UBL2_3	196	200	PF12436	0.541
DOC_WW_Pin1_4	127	132	PF00397	0.575
DOC_WW_Pin1_4	151	156	PF00397	0.537
LIG_14-3-3_CanoR_1	158	166	PF00244	0.639
LIG_14-3-3_CanoR_1	183	193	PF00244	0.666
LIG_14-3-3_CanoR_1	209	214	PF00244	0.705
LIG_14-3-3_CanoR_1	50	55	PF00244	0.446
LIG_14-3-3_CanoR_1	95	99	PF00244	0.679
LIG_FHA_1	65	71	PF00498	0.564
LIG_LIR_Apic_2	117	121	PF02991	0.660
LIG_LIR_Gen_1	77	83	PF02991	0.584
LIG_LIR_Nem_3	57	63	PF02991	0.541
LIG_LIR_Nem_3	77	82	PF02991	0.403
LIG_Pex14_2	60	64	PF04695	0.600
LIG_SH2_PTP2	79	82	PF00017	0.591
LIG_SH2_STAT3	98	101	PF00017	0.602
LIG_SH2_STAT5	149	152	PF00017	0.496
LIG_SH2_STAT5	165	168	PF00017	0.525
LIG_SH2_STAT5	79	82	PF00017	0.684
LIG_SH3_1	196	202	PF00018	0.621
LIG_SH3_3	117	123	PF00018	0.668
LIG_SH3_3	125	131	PF00018	0.691
LIG_SH3_3	192	198	PF00018	0.696
LIG_SH3_4	196	203	PF00018	0.454
LIG_SUMO_SIM_par_1	67	73	PF11976	0.644
LIG_TRAF2_1	154	157	PF00917	0.498
MOD_CDK_SPxxK_3	151	158	PF00069	0.536
MOD_CK1_1	86	92	PF00069	0.677
MOD_CK2_1	151	157	PF00069	0.477
MOD_GlcNHglycan	190	193	PF01048	0.730
MOD_GlcNHglycan	92	95	PF01048	0.638
MOD_GSK3_1	103	110	PF00069	0.454
MOD_GSK3_1	123	130	PF00069	0.571
MOD_GSK3_1	184	191	PF00069	0.598
MOD_GSK3_1	50	57	PF00069	0.574
MOD_GSK3_1	86	93	PF00069	0.677
MOD_LATS_1	169	175	PF00433	0.388
MOD_NEK2_1	114	119	PF00069	0.623
MOD_NEK2_1	72	77	PF00069	0.610
MOD_PIKK_1	185	191	PF00454	0.544
MOD_PK_1	209	215	PF00069	0.706
MOD_PKA_2	157	163	PF00069	0.602
MOD_PKA_2	90	96	PF00069	0.735
MOD_PKB_1	48	56	PF00069	0.403
MOD_Plk_1	9	15	PF00069	0.467
MOD_Plk_4	144	150	PF00069	0.464
MOD_ProDKin_1	127	133	PF00069	0.574
MOD_ProDKin_1	151	157	PF00069	0.536
TRG_ENDOCYTIC_2	79	82	PF00928	0.591
TRG_ER_diArg_1	181	184	PF00400	0.671
TRG_ER_diArg_1	48	51	PF00400	0.402
TRG_NLS_Bipartite_1	37	51	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M0	Leptomonas seymouri	57%	100%
A0A0S4J706	Bodo saltans	33%	94%
A0A1X0NU63	Trypanosomatidae	35%	96%
A0A3R7MDP5	Trypanosoma rangeli	34%	97%
A0A3S7WTQ3	Leishmania donovani	92%	100%
A4H8C3	Leishmania braziliensis	81%	100%
A4HWP4	Leishmania infantum	93%	100%
C9ZXP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	93%
Q4QF24	Leishmania major	90%	100%