GINS complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQE8_LEIMU

TriTrypDb:

LmxM.15.1510

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000811	GINS complex	4	11
GO:0031261	DNA replication preinitiation complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0032993	protein-DNA complex	2	11
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

E9AQE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQE8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0022402	cell cycle process	2	1
GO:0022616	DNA strand elongation	5	1
GO:1902296	DNA strand elongation involved in cell cycle DNA replication	3	1
GO:1902319	DNA strand elongation involved in nuclear cell cycle DNA replication	4	1
GO:1902983	DNA strand elongation involved in mitotic DNA replication	4	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.382
CLV_PCSK_FUR_1	77	81	PF00082	0.370
CLV_PCSK_KEX2_1	79	81	PF00082	0.377
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.380
CLV_PCSK_SKI1_1	80	84	PF00082	0.416
DEG_APCC_DBOX_1	79	87	PF00400	0.416
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.502
DOC_PP4_FxxP_1	131	134	PF00568	0.414
DOC_PP4_FxxP_1	160	163	PF00568	0.307
DOC_USP7_UBL2_3	91	95	PF12436	0.439
DOC_WW_Pin1_4	159	164	PF00397	0.313
LIG_14-3-3_CanoR_1	80	86	PF00244	0.396
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_CtBP_PxDLS_1	134	138	PF00389	0.397
LIG_FHA_1	166	172	PF00498	0.435
LIG_FHA_1	82	88	PF00498	0.479
LIG_FHA_2	121	127	PF00498	0.515
LIG_FHA_2	26	32	PF00498	0.547
LIG_IBAR_NPY_1	54	56	PF08397	0.439
LIG_LIR_Apic_2	129	134	PF02991	0.402
LIG_LIR_Apic_2	159	163	PF02991	0.452
LIG_LIR_Gen_1	175	186	PF02991	0.487
LIG_LIR_Gen_1	43	52	PF02991	0.499
LIG_LIR_Gen_1	53	64	PF02991	0.519
LIG_LIR_Nem_3	175	181	PF02991	0.491
LIG_LIR_Nem_3	43	48	PF02991	0.403
LIG_LIR_Nem_3	53	59	PF02991	0.494
LIG_NRBOX	82	88	PF00104	0.512
LIG_PCNA_yPIPBox_3	115	128	PF02747	0.463
LIG_SH2_CRK	45	49	PF00017	0.455
LIG_SH2_STAT5	116	119	PF00017	0.491
LIG_SH2_STAT5	140	143	PF00017	0.536
LIG_SH2_STAT5	85	88	PF00017	0.429
LIG_SUMO_SIM_par_1	167	173	PF11976	0.361
LIG_TRAF2_1	180	183	PF00917	0.448
LIG_TYR_ITAM	42	59	PF00017	0.423
LIG_UBA3_1	82	91	PF00899	0.478
LIG_WRC_WIRS_1	128	133	PF05994	0.385
LIG_WRC_WIRS_1	178	183	PF05994	0.488
MOD_CK1_1	162	168	PF00069	0.415
MOD_CK1_1	22	28	PF00069	0.460
MOD_CK1_1	50	56	PF00069	0.517
MOD_CK2_1	107	113	PF00069	0.501
MOD_CK2_1	120	126	PF00069	0.498
MOD_CK2_1	177	183	PF00069	0.487
MOD_CK2_1	25	31	PF00069	0.478
MOD_CK2_1	33	39	PF00069	0.426
MOD_GlcNHglycan	109	112	PF01048	0.507
MOD_GlcNHglycan	164	167	PF01048	0.445
MOD_GlcNHglycan	172	175	PF01048	0.421
MOD_GlcNHglycan	21	24	PF01048	0.432
MOD_GlcNHglycan	7	11	PF01048	0.422
MOD_N-GLC_1	41	46	PF02516	0.499
MOD_NEK2_2	96	101	PF00069	0.437
MOD_PIKK_1	57	63	PF00454	0.484
MOD_PK_1	143	149	PF00069	0.508
MOD_PK_1	33	39	PF00069	0.505
MOD_Plk_1	41	47	PF00069	0.526
MOD_Plk_4	120	126	PF00069	0.484
MOD_Plk_4	165	171	PF00069	0.455
MOD_Plk_4	81	87	PF00069	0.426
MOD_ProDKin_1	159	165	PF00069	0.315
MOD_SUMO_rev_2	110	117	PF00179	0.493
MOD_SUMO_rev_2	25	34	PF00179	0.454
TRG_DiLeu_LyEn_5	183	188	PF01217	0.429
TRG_ENDOCYTIC_2	45	48	PF00928	0.493
TRG_ENDOCYTIC_2	56	59	PF00928	0.493
TRG_ER_diArg_1	152	155	PF00400	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD99	Leptomonas seymouri	77%	100%
A0A0S4J8J8	Bodo saltans	46%	99%
A0A1X0NUK0	Trypanosomatidae	58%	100%
A0A3R7K2K3	Trypanosoma rangeli	58%	100%
A0A3S7WTQ1	Leishmania donovani	94%	100%
A4H8B9	Leishmania braziliensis	90%	100%
A4HWP0	Leishmania infantum	94%	100%
A4IFH4	Bos taurus	26%	100%
C9ZXP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q14691	Homo sapiens	25%	100%
Q4QF28	Leishmania major	95%	100%
Q54HR6	Dictyostelium discoideum	24%	100%
Q7ZT47	Xenopus laevis	26%	100%
Q9CZ15	Mus musculus	26%	100%