Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQE7_LEIMU

TriTrypDb:

LmxM.15.1500

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.570
CLV_NRD_NRD_1	256	258	PF00675	0.498
CLV_NRD_NRD_1	34	36	PF00675	0.574
CLV_PCSK_FUR_1	32	36	PF00082	0.537
CLV_PCSK_KEX2_1	103	105	PF00082	0.631
CLV_PCSK_KEX2_1	256	258	PF00082	0.482
CLV_PCSK_KEX2_1	34	36	PF00082	0.574
CLV_PCSK_PC7_1	252	258	PF00082	0.308
CLV_PCSK_SKI1_1	103	107	PF00082	0.563
CLV_PCSK_SKI1_1	21	25	PF00082	0.412
CLV_PCSK_SKI1_1	34	38	PF00082	0.500
CLV_PCSK_SKI1_1	81	85	PF00082	0.547
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DOC_CKS1_1	131	136	PF01111	0.598
DOC_CYCLIN_RxL_1	256	270	PF00134	0.476
DOC_CYCLIN_RxL_1	280	291	PF00134	0.565
DOC_CYCLIN_RxL_1	76	85	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.594
DOC_MAPK_gen_1	202	211	PF00069	0.636
DOC_MAPK_gen_1	32	41	PF00069	0.604
DOC_MAPK_HePTP_8	29	41	PF00069	0.535
DOC_MAPK_HePTP_8	83	95	PF00069	0.514
DOC_MAPK_MEF2A_6	32	41	PF00069	0.548
DOC_MAPK_MEF2A_6	86	95	PF00069	0.480
DOC_PP2B_LxvP_1	37	40	PF13499	0.569
DOC_USP7_MATH_1	155	159	PF00917	0.662
DOC_USP7_MATH_1	251	255	PF00917	0.566
DOC_WW_Pin1_4	1	6	PF00397	0.676
DOC_WW_Pin1_4	130	135	PF00397	0.557
DOC_WW_Pin1_4	158	163	PF00397	0.721
DOC_WW_Pin1_4	180	185	PF00397	0.374
LIG_14-3-3_CanoR_1	156	162	PF00244	0.775
LIG_14-3-3_CanoR_1	177	186	PF00244	0.636
LIG_14-3-3_CanoR_1	202	211	PF00244	0.554
LIG_14-3-3_CanoR_1	256	260	PF00244	0.462
LIG_14-3-3_CanoR_1	278	284	PF00244	0.479
LIG_14-3-3_CanoR_1	47	53	PF00244	0.574
LIG_14-3-3_CanoR_1	78	84	PF00244	0.497
LIG_14-3-3_CanoR_1	86	92	PF00244	0.483
LIG_Actin_WH2_2	88	105	PF00022	0.473
LIG_BRCT_BRCA1_1	143	147	PF00533	0.664
LIG_BRCT_BRCA1_1	192	196	PF00533	0.595
LIG_BRCT_BRCA1_1	217	221	PF00533	0.594
LIG_FHA_1	181	187	PF00498	0.453
LIG_FHA_1	210	216	PF00498	0.452
LIG_FHA_1	61	67	PF00498	0.588
LIG_LIR_Gen_1	112	120	PF02991	0.477
LIG_LIR_Gen_1	279	289	PF02991	0.558
LIG_LIR_Nem_3	112	117	PF02991	0.466
LIG_LIR_Nem_3	144	150	PF02991	0.724
LIG_LIR_Nem_3	20	26	PF02991	0.382
LIG_LIR_Nem_3	279	284	PF02991	0.578
LIG_LIR_Nem_3	90	95	PF02991	0.608
LIG_MLH1_MIPbox_1	217	221	PF16413	0.536
LIG_PCNA_yPIPBox_3	202	215	PF02747	0.613
LIG_Pex14_1	174	178	PF04695	0.616
LIG_Pex14_1	245	249	PF04695	0.602
LIG_Pex14_1	88	92	PF04695	0.573
LIG_Pex14_2	65	69	PF04695	0.441
LIG_PTB_Apo_2	214	221	PF02174	0.489
LIG_REV1ctd_RIR_1	21	29	PF16727	0.502
LIG_REV1ctd_RIR_1	218	228	PF16727	0.501
LIG_SH2_GRB2like	113	116	PF00017	0.511
LIG_SH2_NCK_1	138	142	PF00017	0.609
LIG_SH2_STAP1	60	64	PF00017	0.385
LIG_SH2_STAP1	98	102	PF00017	0.502
LIG_SH2_STAT5	178	181	PF00017	0.540
LIG_SH2_STAT5	28	31	PF00017	0.412
LIG_SH2_STAT5	73	76	PF00017	0.568
LIG_SH2_STAT5	92	95	PF00017	0.318
LIG_SH3_3	147	153	PF00018	0.678
LIG_WRC_WIRS_1	246	251	PF05994	0.603
LIG_WW_2	152	155	PF00397	0.626
MOD_CDK_SPxK_1	130	136	PF00069	0.606
MOD_CK1_1	116	122	PF00069	0.553
MOD_CK1_1	158	164	PF00069	0.698
MOD_CK1_1	180	186	PF00069	0.459
MOD_CK1_1	4	10	PF00069	0.636
MOD_CK2_1	4	10	PF00069	0.588
MOD_GlcNHglycan	147	150	PF01048	0.716
MOD_GSK3_1	141	148	PF00069	0.642
MOD_GSK3_1	156	163	PF00069	0.616
MOD_GSK3_1	182	189	PF00069	0.508
MOD_GSK3_1	251	258	PF00069	0.553
MOD_GSK3_1	35	42	PF00069	0.486
MOD_GSK3_1	6	13	PF00069	0.601
MOD_N-GLC_1	239	244	PF02516	0.591
MOD_N-GLC_1	76	81	PF02516	0.353
MOD_NEK2_1	187	192	PF00069	0.550
MOD_NEK2_1	196	201	PF00069	0.514
MOD_NEK2_1	255	260	PF00069	0.487
MOD_NEK2_1	266	271	PF00069	0.446
MOD_NEK2_1	67	72	PF00069	0.510
MOD_NEK2_1	87	92	PF00069	0.306
MOD_NEK2_2	239	244	PF00069	0.601
MOD_NEK2_2	251	256	PF00069	0.566
MOD_PIKK_1	10	16	PF00454	0.566
MOD_PK_1	35	41	PF00069	0.559
MOD_PKA_1	103	109	PF00069	0.562
MOD_PKA_2	103	109	PF00069	0.460
MOD_PKA_2	155	161	PF00069	0.775
MOD_PKA_2	203	209	PF00069	0.610
MOD_PKA_2	251	257	PF00069	0.463
MOD_PKA_2	46	52	PF00069	0.530
MOD_Plk_1	209	215	PF00069	0.519
MOD_Plk_1	239	245	PF00069	0.577
MOD_Plk_1	266	272	PF00069	0.515
MOD_Plk_4	182	188	PF00069	0.582
MOD_ProDKin_1	1	7	PF00069	0.667
MOD_ProDKin_1	130	136	PF00069	0.565
MOD_ProDKin_1	158	164	PF00069	0.717
MOD_ProDKin_1	180	186	PF00069	0.375
TRG_DiLeu_BaEn_1	210	215	PF01217	0.580
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.489
TRG_ENDOCYTIC_2	92	95	PF00928	0.448
TRG_ER_diArg_1	102	104	PF00400	0.572
TRG_ER_diArg_1	201	204	PF00400	0.657
TRG_ER_diArg_1	255	257	PF00400	0.431
TRG_ER_diArg_1	32	35	PF00400	0.432
TRG_ER_diArg_1	75	78	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM1	Leptomonas seymouri	63%	100%
A0A1X0NU20	Trypanosomatidae	40%	100%
A0A3S7WTP0	Leishmania donovani	96%	100%
A0A422N5B2	Trypanosoma rangeli	38%	100%
A4H8B8	Leishmania braziliensis	88%	100%
A4HWN9	Leishmania infantum	96%	100%
C9ZXP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QF29	Leishmania major	95%	100%
V5BFJ3	Trypanosoma cruzi	37%	100%