Phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP specific phosphodiesterase, putative

Species:

Leishmania mexicana

UniProt:

E9AQE5_LEIMU

TriTrypDb:

LmxM.15.1481

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQE5

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	612	616	PF00656	0.465
CLV_NRD_NRD_1	36	38	PF00675	0.673
CLV_NRD_NRD_1	372	374	PF00675	0.463
CLV_NRD_NRD_1	673	675	PF00675	0.438
CLV_NRD_NRD_1	676	678	PF00675	0.463
CLV_NRD_NRD_1	823	825	PF00675	0.517
CLV_NRD_NRD_1	931	933	PF00675	0.755
CLV_PCSK_FUR_1	34	38	PF00082	0.585
CLV_PCSK_FUR_1	674	678	PF00082	0.583
CLV_PCSK_KEX2_1	36	38	PF00082	0.597
CLV_PCSK_KEX2_1	372	374	PF00082	0.335
CLV_PCSK_KEX2_1	672	674	PF00082	0.536
CLV_PCSK_KEX2_1	676	678	PF00082	0.556
CLV_PCSK_KEX2_1	823	825	PF00082	0.517
CLV_PCSK_KEX2_1	931	933	PF00082	0.755
CLV_PCSK_PC7_1	368	374	PF00082	0.335
CLV_PCSK_PC7_1	672	678	PF00082	0.540
CLV_PCSK_SKI1_1	210	214	PF00082	0.484
CLV_PCSK_SKI1_1	261	265	PF00082	0.359
CLV_PCSK_SKI1_1	333	337	PF00082	0.359
CLV_PCSK_SKI1_1	428	432	PF00082	0.359
CLV_PCSK_SKI1_1	435	439	PF00082	0.359
CLV_PCSK_SKI1_1	593	597	PF00082	0.627
DEG_Nend_Nbox_1	1	3	PF02207	0.648
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.359
DOC_MAPK_gen_1	129	137	PF00069	0.424
DOC_MAPK_gen_1	402	411	PF00069	0.483
DOC_MAPK_gen_1	590	600	PF00069	0.626
DOC_MAPK_MEF2A_6	217	224	PF00069	0.491
DOC_MAPK_MEF2A_6	333	342	PF00069	0.478
DOC_MAPK_MEF2A_6	574	581	PF00069	0.714
DOC_MAPK_MEF2A_6	605	613	PF00069	0.556
DOC_MAPK_NFAT4_5	333	341	PF00069	0.478
DOC_MAPK_NFAT4_5	574	582	PF00069	0.716
DOC_MAPK_RevD_3	212	226	PF00069	0.483
DOC_PP2B_LxvP_1	176	179	PF13499	0.404
DOC_PP2B_LxvP_1	336	339	PF13499	0.359
DOC_PP2B_LxvP_1	589	592	PF13499	0.470
DOC_PP4_FxxP_1	619	622	PF00568	0.534
DOC_USP7_MATH_1	15	19	PF00917	0.669
DOC_USP7_MATH_1	234	238	PF00917	0.482
DOC_USP7_MATH_1	276	280	PF00917	0.473
DOC_USP7_MATH_1	440	444	PF00917	0.359
DOC_USP7_MATH_1	607	611	PF00917	0.565
DOC_USP7_MATH_1	639	643	PF00917	0.344
DOC_USP7_MATH_1	65	69	PF00917	0.693
DOC_USP7_MATH_1	798	802	PF00917	0.373
DOC_WW_Pin1_4	4	9	PF00397	0.704
DOC_WW_Pin1_4	539	544	PF00397	0.438
DOC_WW_Pin1_4	618	623	PF00397	0.397
DOC_WW_Pin1_4	68	73	PF00397	0.692
DOC_WW_Pin1_4	735	740	PF00397	0.359
LIG_14-3-3_CanoR_1	129	135	PF00244	0.465
LIG_14-3-3_CanoR_1	210	215	PF00244	0.413
LIG_14-3-3_CanoR_1	319	325	PF00244	0.517
LIG_14-3-3_CanoR_1	37	43	PF00244	0.603
LIG_14-3-3_CanoR_1	442	446	PF00244	0.403
LIG_14-3-3_CanoR_1	495	504	PF00244	0.512
LIG_14-3-3_CanoR_1	583	592	PF00244	0.614
LIG_BRCT_BRCA1_1	2	6	PF00533	0.605
LIG_BRCT_BRCA1_1	442	446	PF00533	0.359
LIG_BRCT_BRCA1_1	609	613	PF00533	0.575
LIG_BRCT_BRCA1_1	620	624	PF00533	0.433
LIG_BRCT_BRCA1_1	903	907	PF00533	0.235
LIG_eIF4E_1	783	789	PF01652	0.517
LIG_FHA_1	131	137	PF00498	0.460
LIG_FHA_1	173	179	PF00498	0.493
LIG_FHA_1	211	217	PF00498	0.500
LIG_FHA_1	330	336	PF00498	0.359
LIG_FHA_1	506	512	PF00498	0.359
LIG_FHA_1	546	552	PF00498	0.371
LIG_FHA_1	576	582	PF00498	0.729
LIG_FHA_1	715	721	PF00498	0.359
LIG_FHA_2	244	250	PF00498	0.611
LIG_FHA_2	260	266	PF00498	0.301
LIG_FHA_2	475	481	PF00498	0.517
LIG_FHA_2	540	546	PF00498	0.374
LIG_FHA_2	58	64	PF00498	0.796
LIG_FHA_2	599	605	PF00498	0.478
LIG_FHA_2	618	624	PF00498	0.442
LIG_FHA_2	705	711	PF00498	0.335
LIG_GBD_Chelix_1	715	723	PF00786	0.379
LIG_GBD_Chelix_1	902	910	PF00786	0.438
LIG_LIR_Apic_2	618	622	PF02991	0.541
LIG_LIR_Apic_2	631	636	PF02991	0.578
LIG_LIR_Gen_1	112	122	PF02991	0.544
LIG_LIR_Gen_1	133	142	PF02991	0.494
LIG_LIR_Gen_1	375	386	PF02991	0.359
LIG_LIR_Gen_1	454	463	PF02991	0.403
LIG_LIR_Gen_1	548	556	PF02991	0.402
LIG_LIR_Gen_1	621	629	PF02991	0.414
LIG_LIR_Gen_1	642	653	PF02991	0.273
LIG_LIR_Gen_1	710	720	PF02991	0.408
LIG_LIR_Gen_1	76	86	PF02991	0.526
LIG_LIR_Nem_3	112	118	PF02991	0.556
LIG_LIR_Nem_3	133	137	PF02991	0.469
LIG_LIR_Nem_3	175	180	PF02991	0.464
LIG_LIR_Nem_3	375	381	PF02991	0.359
LIG_LIR_Nem_3	548	552	PF02991	0.356
LIG_LIR_Nem_3	553	558	PF02991	0.355
LIG_LIR_Nem_3	621	627	PF02991	0.417
LIG_LIR_Nem_3	642	648	PF02991	0.260
LIG_LIR_Nem_3	710	715	PF02991	0.408
LIG_LIR_Nem_3	76	82	PF02991	0.523
LIG_LIR_Nem_3	771	776	PF02991	0.382
LIG_PCNA_yPIPBox_3	119	132	PF02747	0.508
LIG_PCNA_yPIPBox_3	519	531	PF02747	0.403
LIG_PDZ_Class_1	935	940	PF00595	0.721
LIG_PTB_Apo_2	171	178	PF02174	0.536
LIG_PTB_Apo_2	727	734	PF02174	0.359
LIG_PTB_Phospho_1	171	177	PF10480	0.543
LIG_PTB_Phospho_1	727	733	PF10480	0.359
LIG_Rb_pABgroove_1	869	877	PF01858	0.378
LIG_REV1ctd_RIR_1	896	904	PF16727	0.378
LIG_SH2_CRK	134	138	PF00017	0.490
LIG_SH2_CRK	2	6	PF00017	0.659
LIG_SH2_CRK	675	679	PF00017	0.421
LIG_SH2_CRK	785	789	PF00017	0.517
LIG_SH2_GRB2like	680	683	PF00017	0.359
LIG_SH2_NCK_1	2	6	PF00017	0.548
LIG_SH2_PTP2	177	180	PF00017	0.423
LIG_SH2_PTP2	712	715	PF00017	0.478
LIG_SH2_SRC	491	494	PF00017	0.359
LIG_SH2_STAP1	2	6	PF00017	0.548
LIG_SH2_STAP1	456	460	PF00017	0.403
LIG_SH2_STAP1	783	787	PF00017	0.438
LIG_SH2_STAT3	506	509	PF00017	0.378
LIG_SH2_STAT5	12	15	PF00017	0.748
LIG_SH2_STAT5	177	180	PF00017	0.441
LIG_SH2_STAT5	301	304	PF00017	0.297
LIG_SH2_STAT5	696	699	PF00017	0.387
LIG_SH2_STAT5	712	715	PF00017	0.403
LIG_SH2_STAT5	733	736	PF00017	0.359
LIG_SH3_3	187	193	PF00018	0.394
LIG_SH3_3	2	8	PF00018	0.642
LIG_SH3_3	287	293	PF00018	0.377
LIG_SH3_3	306	312	PF00018	0.247
LIG_SH3_3	836	842	PF00018	0.378
LIG_SH3_3	87	93	PF00018	0.740
LIG_SUMO_SIM_anti_2	410	416	PF11976	0.500
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.359
LIG_SUMO_SIM_par_1	410	416	PF11976	0.496
LIG_SUMO_SIM_par_1	596	601	PF11976	0.578
LIG_SUMO_SIM_par_1	712	717	PF11976	0.359
LIG_TRAF2_1	246	249	PF00917	0.670
LIG_TRAF2_1	60	63	PF00917	0.561
LIG_TRAF2_1	601	604	PF00917	0.581
LIG_TYR_ITIM	643	648	PF00017	0.404
LIG_UBA3_1	445	450	PF00899	0.478
LIG_WRC_WIRS_1	378	383	PF05994	0.359
MOD_CDK_SPxxK_3	539	546	PF00069	0.291
MOD_CK1_1	237	243	PF00069	0.491
MOD_CK1_1	382	388	PF00069	0.387
MOD_CK1_1	41	47	PF00069	0.595
MOD_CK1_1	68	74	PF00069	0.724
MOD_CK1_1	744	750	PF00069	0.359
MOD_CK1_1	837	843	PF00069	0.378
MOD_CK1_1	934	940	PF00069	0.715
MOD_CK2_1	179	185	PF00069	0.362
MOD_CK2_1	243	249	PF00069	0.610
MOD_CK2_1	259	265	PF00069	0.294
MOD_CK2_1	4	10	PF00069	0.758
MOD_CK2_1	40	46	PF00069	0.608
MOD_CK2_1	459	465	PF00069	0.517
MOD_CK2_1	474	480	PF00069	0.239
MOD_CK2_1	57	63	PF00069	0.688
MOD_CK2_1	598	604	PF00069	0.480
MOD_CK2_1	622	628	PF00069	0.409
MOD_CK2_1	704	710	PF00069	0.354
MOD_CK2_1	748	754	PF00069	0.359
MOD_Cter_Amidation	370	373	PF01082	0.335
MOD_Cter_Amidation	929	932	PF01082	0.719
MOD_GlcNHglycan	122	125	PF01048	0.426
MOD_GlcNHglycan	2	5	PF01048	0.671
MOD_GlcNHglycan	304	307	PF01048	0.486
MOD_GlcNHglycan	361	364	PF01048	0.403
MOD_GlcNHglycan	461	464	PF01048	0.502
MOD_GlcNHglycan	480	483	PF01048	0.391
MOD_GlcNHglycan	497	500	PF01048	0.403
MOD_GlcNHglycan	650	653	PF01048	0.470
MOD_GlcNHglycan	67	70	PF01048	0.726
MOD_GlcNHglycan	744	747	PF01048	0.359
MOD_GlcNHglycan	776	779	PF01048	0.482
MOD_GSK3_1	105	112	PF00069	0.590
MOD_GSK3_1	168	175	PF00069	0.566
MOD_GSK3_1	216	223	PF00069	0.612
MOD_GSK3_1	243	250	PF00069	0.546
MOD_GSK3_1	252	259	PF00069	0.338
MOD_GSK3_1	263	270	PF00069	0.190
MOD_GSK3_1	325	332	PF00069	0.359
MOD_GSK3_1	37	44	PF00069	0.602
MOD_GSK3_1	474	481	PF00069	0.378
MOD_GSK3_1	491	498	PF00069	0.378
MOD_GSK3_1	556	563	PF00069	0.350
MOD_GSK3_1	618	625	PF00069	0.360
MOD_GSK3_1	692	699	PF00069	0.463
MOD_GSK3_1	700	707	PF00069	0.463
MOD_GSK3_1	744	751	PF00069	0.359
MOD_GSK3_1	805	812	PF00069	0.457
MOD_GSK3_1	931	938	PF00069	0.653
MOD_N-GLC_1	155	160	PF02516	0.482
MOD_N-GLC_1	220	225	PF02516	0.552
MOD_N-GLC_1	320	325	PF02516	0.498
MOD_N-GLC_1	394	399	PF02516	0.568
MOD_N-GLC_1	560	565	PF02516	0.459
MOD_N-GLC_1	728	733	PF02516	0.359
MOD_N-GLC_1	748	753	PF02516	0.190
MOD_N-GLC_1	837	842	PF02516	0.394
MOD_NEK2_1	208	213	PF00069	0.440
MOD_NEK2_1	247	252	PF00069	0.495
MOD_NEK2_1	27	32	PF00069	0.575
MOD_NEK2_1	342	347	PF00069	0.517
MOD_NEK2_1	377	382	PF00069	0.359
MOD_NEK2_1	459	464	PF00069	0.378
MOD_NEK2_1	577	582	PF00069	0.660
MOD_NEK2_1	647	652	PF00069	0.455
MOD_NEK2_1	714	719	PF00069	0.376
MOD_NEK2_1	843	848	PF00069	0.378
MOD_NEK2_1	875	880	PF00069	0.378
MOD_NEK2_2	536	541	PF00069	0.378
MOD_NEK2_2	622	627	PF00069	0.285
MOD_PIKK_1	357	363	PF00454	0.496
MOD_PIKK_1	505	511	PF00454	0.378
MOD_PIKK_1	598	604	PF00454	0.356
MOD_PK_1	507	513	PF00069	0.478
MOD_PKA_1	402	408	PF00069	0.455
MOD_PKA_1	931	937	PF00069	0.771
MOD_PKA_2	120	126	PF00069	0.551
MOD_PKA_2	216	222	PF00069	0.473
MOD_PKA_2	243	249	PF00069	0.604
MOD_PKA_2	267	273	PF00069	0.359
MOD_PKA_2	35	41	PF00069	0.656
MOD_PKA_2	441	447	PF00069	0.403
MOD_PKA_2	545	551	PF00069	0.304
MOD_PKA_2	582	588	PF00069	0.619
MOD_PKA_2	805	811	PF00069	0.435
MOD_PKA_2	931	937	PF00069	0.685
MOD_Plk_1	155	161	PF00069	0.449
MOD_Plk_1	220	226	PF00069	0.648
MOD_Plk_1	247	253	PF00069	0.505
MOD_Plk_1	320	326	PF00069	0.427
MOD_Plk_1	394	400	PF00069	0.570
MOD_Plk_1	440	446	PF00069	0.359
MOD_Plk_1	560	566	PF00069	0.459
MOD_Plk_1	622	628	PF00069	0.409
MOD_Plk_1	660	666	PF00069	0.480
MOD_Plk_1	728	734	PF00069	0.359
MOD_Plk_1	748	754	PF00069	0.190
MOD_Plk_1	843	849	PF00069	0.435
MOD_Plk_1	94	100	PF00069	0.470
MOD_Plk_2-3	704	710	PF00069	0.335
MOD_Plk_4	172	178	PF00069	0.501
MOD_Plk_4	247	253	PF00069	0.486
MOD_Plk_4	267	273	PF00069	0.190
MOD_Plk_4	27	33	PF00069	0.574
MOD_Plk_4	304	310	PF00069	0.235
MOD_Plk_4	342	348	PF00069	0.408
MOD_Plk_4	394	400	PF00069	0.549
MOD_Plk_4	422	428	PF00069	0.423
MOD_Plk_4	441	447	PF00069	0.215
MOD_Plk_4	507	513	PF00069	0.359
MOD_Plk_4	639	645	PF00069	0.253
MOD_Plk_4	660	666	PF00069	0.449
MOD_Plk_4	692	698	PF00069	0.367
MOD_Plk_4	728	734	PF00069	0.359
MOD_Plk_4	748	754	PF00069	0.190
MOD_Plk_4	826	832	PF00069	0.517
MOD_ProDKin_1	4	10	PF00069	0.707
MOD_ProDKin_1	539	545	PF00069	0.438
MOD_ProDKin_1	618	624	PF00069	0.391
MOD_ProDKin_1	68	74	PF00069	0.689
MOD_ProDKin_1	735	741	PF00069	0.359
MOD_SUMO_rev_2	396	405	PF00179	0.492
MOD_SUMO_rev_2	41	50	PF00179	0.666
TRG_DiLeu_BaEn_1	248	253	PF01217	0.609
TRG_DiLeu_BaEn_1	710	715	PF01217	0.354
TRG_ENDOCYTIC_2	134	137	PF00928	0.556
TRG_ENDOCYTIC_2	177	180	PF00928	0.432
TRG_ENDOCYTIC_2	2	5	PF00928	0.690
TRG_ENDOCYTIC_2	456	459	PF00928	0.403
TRG_ENDOCYTIC_2	645	648	PF00928	0.409
TRG_ENDOCYTIC_2	675	678	PF00928	0.424
TRG_ENDOCYTIC_2	680	683	PF00928	0.359
TRG_ENDOCYTIC_2	684	687	PF00928	0.359
TRG_ENDOCYTIC_2	712	715	PF00928	0.424
TRG_ENDOCYTIC_2	785	788	PF00928	0.435
TRG_ER_diArg_1	35	37	PF00400	0.655
TRG_ER_diArg_1	672	674	PF00400	0.544
TRG_ER_diArg_1	675	677	PF00400	0.545
TRG_ER_diArg_1	823	825	PF00400	0.517
TRG_ER_diArg_1	921	924	PF00400	0.359
TRG_ER_FFAT_2	615	625	PF00635	0.308
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	823	828	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P788	Leptomonas seymouri	70%	100%
A0A1X0NUP8	Trypanosomatidae	62%	100%
A0A3Q8I987	Leishmania donovani	94%	100%
A0A3R7RI37	Trypanosoma rangeli	70%	100%
A0A3S7WTN0	Leishmania donovani	80%	100%
A4H893	Leishmania braziliensis	76%	100%
A4H8B6	Leishmania braziliensis	83%	100%
A4HWN6	Leishmania infantum	80%	100%
A4HWN7	Leishmania infantum	94%	100%
B3P3K2	Drosophila erecta	29%	83%
B4JXX2	Drosophila grimshawi	28%	87%
B4K9L4	Drosophila mojavensis	28%	84%
B4LVU6	Drosophila virilis	29%	100%
B4NAL6	Drosophila willistoni	29%	83%
B4PSS5	Drosophila yakuba	29%	82%
B4QZU1	Drosophila simulans	29%	82%
C9ZXQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZXQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AQE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O00408	Homo sapiens	30%	100%
O54735	Rattus norvegicus	28%	100%
O76074	Homo sapiens	29%	100%
O77746	Canis lupus familiaris	29%	100%
P0C1Q2	Mus musculus	32%	100%
P11541	Bos taurus	25%	100%
P14099	Bos taurus	30%	100%
P16499	Homo sapiens	25%	100%
P16586	Bos taurus	27%	100%
P23439	Bos taurus	25%	100%
P23440	Mus musculus	24%	100%
P27664	Mus musculus	25%	100%
P33726	Canis lupus familiaris	25%	100%
P35913	Homo sapiens	24%	100%
P51160	Homo sapiens	26%	100%
P52731	Gallus gallus	25%	100%
Q01062	Rattus norvegicus	31%	100%
Q1KKS3	Takifugu rubripes	31%	100%
Q28156	Bos taurus	29%	100%
Q28263	Canis lupus familiaris	25%	100%
Q298P4	Drosophila pseudoobscura pseudoobscura	29%	85%
Q4QF31	Leishmania major	92%	100%
Q8CA95	Mus musculus	30%	100%
Q8CG03	Mus musculus	29%	100%
Q8VID6	Rattus norvegicus	32%	100%
Q91ZQ1	Mus musculus	27%	100%
Q922S4	Mus musculus	31%	100%
Q9HCR9	Homo sapiens	32%	100%
Q9QYJ6	Rattus norvegicus	30%	100%
Q9VFI9	Drosophila melanogaster	29%	84%
Q9Y233	Homo sapiens	29%	100%