Phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP specific phosphodiesterase, putative

Species:

Leishmania mexicana

UniProt:

E9AQE4_LEIMU

TriTrypDb:

LmxM.15.1480

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQE4

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.462
CLV_NRD_NRD_1	219	221	PF00675	0.498
CLV_NRD_NRD_1	362	364	PF00675	0.473
CLV_NRD_NRD_1	663	665	PF00675	0.449
CLV_NRD_NRD_1	666	668	PF00675	0.478
CLV_NRD_NRD_1	813	815	PF00675	0.517
CLV_NRD_NRD_1	921	923	PF00675	0.710
CLV_PCSK_FUR_1	37	41	PF00082	0.584
CLV_PCSK_FUR_1	664	668	PF00082	0.581
CLV_PCSK_KEX2_1	36	38	PF00082	0.567
CLV_PCSK_KEX2_1	362	364	PF00082	0.350
CLV_PCSK_KEX2_1	39	41	PF00082	0.594
CLV_PCSK_KEX2_1	662	664	PF00082	0.541
CLV_PCSK_KEX2_1	666	668	PF00082	0.564
CLV_PCSK_KEX2_1	7	9	PF00082	0.716
CLV_PCSK_KEX2_1	813	815	PF00082	0.517
CLV_PCSK_KEX2_1	921	923	PF00082	0.710
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.494
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.517
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.716
CLV_PCSK_PC7_1	358	364	PF00082	0.350
CLV_PCSK_PC7_1	662	668	PF00082	0.547
CLV_PCSK_SKI1_1	251	255	PF00082	0.374
CLV_PCSK_SKI1_1	323	327	PF00082	0.374
CLV_PCSK_SKI1_1	418	422	PF00082	0.374
CLV_PCSK_SKI1_1	425	429	PF00082	0.374
CLV_PCSK_SKI1_1	583	587	PF00082	0.629
CLV_PCSK_SKI1_1	7	11	PF00082	0.618
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	502	508	PF00134	0.374
DOC_MAPK_gen_1	36	45	PF00069	0.559
DOC_MAPK_gen_1	392	401	PF00069	0.498
DOC_MAPK_gen_1	580	590	PF00069	0.634
DOC_MAPK_MEF2A_6	323	332	PF00069	0.486
DOC_MAPK_MEF2A_6	564	571	PF00069	0.721
DOC_MAPK_MEF2A_6	595	603	PF00069	0.564
DOC_MAPK_NFAT4_5	323	331	PF00069	0.486
DOC_MAPK_NFAT4_5	564	572	PF00069	0.723
DOC_PP1_RVXF_1	93	100	PF00149	0.432
DOC_PP2B_LxvP_1	326	329	PF13499	0.374
DOC_PP2B_LxvP_1	579	582	PF13499	0.473
DOC_PP4_FxxP_1	609	612	PF00568	0.541
DOC_PP4_FxxP_1	99	102	PF00568	0.643
DOC_USP7_MATH_1	16	20	PF00917	0.700
DOC_USP7_MATH_1	224	228	PF00917	0.466
DOC_USP7_MATH_1	266	270	PF00917	0.482
DOC_USP7_MATH_1	375	379	PF00917	0.368
DOC_USP7_MATH_1	430	434	PF00917	0.374
DOC_USP7_MATH_1	597	601	PF00917	0.571
DOC_USP7_MATH_1	629	633	PF00917	0.359
DOC_WW_Pin1_4	14	19	PF00397	0.625
DOC_WW_Pin1_4	146	151	PF00397	0.509
DOC_WW_Pin1_4	189	194	PF00397	0.526
DOC_WW_Pin1_4	529	534	PF00397	0.438
DOC_WW_Pin1_4	608	613	PF00397	0.410
DOC_WW_Pin1_4	725	730	PF00397	0.374
LIG_14-3-3_CanoR_1	309	315	PF00244	0.517
LIG_14-3-3_CanoR_1	432	436	PF00244	0.417
LIG_14-3-3_CanoR_1	485	494	PF00244	0.516
LIG_14-3-3_CanoR_1	573	582	PF00244	0.631
LIG_BRCT_BRCA1_1	190	194	PF00533	0.431
LIG_BRCT_BRCA1_1	432	436	PF00533	0.374
LIG_BRCT_BRCA1_1	599	603	PF00533	0.582
LIG_BRCT_BRCA1_1	610	614	PF00533	0.448
LIG_BRCT_BRCA1_1	793	797	PF00533	0.313
LIG_BRCT_BRCA1_1	893	897	PF00533	0.235
LIG_eIF4E_1	773	779	PF01652	0.517
LIG_FHA_1	102	108	PF00498	0.313
LIG_FHA_1	122	128	PF00498	0.455
LIG_FHA_1	158	164	PF00498	0.517
LIG_FHA_1	320	326	PF00498	0.374
LIG_FHA_1	496	502	PF00498	0.374
LIG_FHA_1	536	542	PF00498	0.387
LIG_FHA_1	566	572	PF00498	0.738
LIG_FHA_1	705	711	PF00498	0.374
LIG_FHA_2	184	190	PF00498	0.585
LIG_FHA_2	208	214	PF00498	0.617
LIG_FHA_2	234	240	PF00498	0.619
LIG_FHA_2	250	256	PF00498	0.315
LIG_FHA_2	27	33	PF00498	0.575
LIG_FHA_2	465	471	PF00498	0.517
LIG_FHA_2	530	536	PF00498	0.389
LIG_FHA_2	589	595	PF00498	0.492
LIG_FHA_2	608	614	PF00498	0.456
LIG_FHA_2	695	701	PF00498	0.350
LIG_GBD_Chelix_1	705	713	PF00786	0.395
LIG_GBD_Chelix_1	892	900	PF00786	0.438
LIG_LIR_Apic_2	608	612	PF02991	0.548
LIG_LIR_Apic_2	621	626	PF02991	0.586
LIG_LIR_Gen_1	113	122	PF02991	0.585
LIG_LIR_Gen_1	365	376	PF02991	0.374
LIG_LIR_Gen_1	444	453	PF02991	0.417
LIG_LIR_Gen_1	543	550	PF02991	0.425
LIG_LIR_Gen_1	611	619	PF02991	0.428
LIG_LIR_Gen_1	632	643	PF02991	0.273
LIG_LIR_Gen_1	700	710	PF02991	0.423
LIG_LIR_Gen_1	794	805	PF02991	0.463
LIG_LIR_Gen_1	88	97	PF02991	0.582
LIG_LIR_Nem_3	113	117	PF02991	0.579
LIG_LIR_Nem_3	166	171	PF02991	0.470
LIG_LIR_Nem_3	191	197	PF02991	0.588
LIG_LIR_Nem_3	365	371	PF02991	0.374
LIG_LIR_Nem_3	537	542	PF02991	0.372
LIG_LIR_Nem_3	543	548	PF02991	0.371
LIG_LIR_Nem_3	611	617	PF02991	0.432
LIG_LIR_Nem_3	632	638	PF02991	0.260
LIG_LIR_Nem_3	700	705	PF02991	0.423
LIG_LIR_Nem_3	761	766	PF02991	0.398
LIG_LIR_Nem_3	88	92	PF02991	0.484
LIG_PCNA_yPIPBox_3	509	521	PF02747	0.417
LIG_PDZ_Class_1	925	930	PF00595	0.684
LIG_PTB_Apo_2	717	724	PF02174	0.374
LIG_PTB_Phospho_1	717	723	PF10480	0.374
LIG_Rb_pABgroove_1	859	867	PF01858	0.394
LIG_REV1ctd_RIR_1	886	894	PF16727	0.394
LIG_SH2_CRK	665	669	PF00017	0.435
LIG_SH2_CRK	775	779	PF00017	0.517
LIG_SH2_CRK	89	93	PF00017	0.605
LIG_SH2_GRB2like	126	129	PF00017	0.614
LIG_SH2_GRB2like	670	673	PF00017	0.374
LIG_SH2_PTP2	168	171	PF00017	0.422
LIG_SH2_PTP2	702	705	PF00017	0.486
LIG_SH2_SRC	126	129	PF00017	0.393
LIG_SH2_SRC	481	484	PF00017	0.374
LIG_SH2_STAP1	197	201	PF00017	0.452
LIG_SH2_STAP1	446	450	PF00017	0.417
LIG_SH2_STAP1	773	777	PF00017	0.438
LIG_SH2_STAP1	89	93	PF00017	0.433
LIG_SH2_STAT3	197	200	PF00017	0.429
LIG_SH2_STAT3	496	499	PF00017	0.394
LIG_SH2_STAT5	126	129	PF00017	0.389
LIG_SH2_STAT5	168	171	PF00017	0.437
LIG_SH2_STAT5	291	294	PF00017	0.311
LIG_SH2_STAT5	686	689	PF00017	0.403
LIG_SH2_STAT5	702	705	PF00017	0.417
LIG_SH2_STAT5	723	726	PF00017	0.374
LIG_SH3_3	115	121	PF00018	0.399
LIG_SH3_3	277	283	PF00018	0.393
LIG_SH3_3	296	302	PF00018	0.256
LIG_SH3_3	826	832	PF00018	0.394
LIG_SUMO_SIM_anti_2	400	406	PF11976	0.513
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.374
LIG_SUMO_SIM_par_1	159	164	PF11976	0.467
LIG_SUMO_SIM_par_1	400	406	PF11976	0.508
LIG_SUMO_SIM_par_1	586	591	PF11976	0.587
LIG_SUMO_SIM_par_1	702	707	PF11976	0.374
LIG_TRAF2_1	236	239	PF00917	0.672
LIG_TRAF2_1	591	594	PF00917	0.587
LIG_TRAF2_1	808	811	PF00917	0.212
LIG_TYR_ITIM	633	638	PF00017	0.420
LIG_UBA3_1	435	440	PF00899	0.486
LIG_WRC_WIRS_1	368	373	PF05994	0.374
MOD_CDK_SPxxK_3	146	153	PF00069	0.493
MOD_CK1_1	227	233	PF00069	0.485
MOD_CK1_1	61	67	PF00069	0.751
MOD_CK1_1	734	740	PF00069	0.374
MOD_CK1_1	827	833	PF00069	0.394
MOD_CK1_1	924	930	PF00069	0.687
MOD_CK2_1	233	239	PF00069	0.619
MOD_CK2_1	249	255	PF00069	0.308
MOD_CK2_1	449	455	PF00069	0.517
MOD_CK2_1	464	470	PF00069	0.239
MOD_CK2_1	588	594	PF00069	0.493
MOD_CK2_1	612	618	PF00069	0.424
MOD_CK2_1	694	700	PF00069	0.370
MOD_CK2_1	738	744	PF00069	0.374
MOD_CK2_1	805	811	PF00069	0.394
MOD_Cter_Amidation	360	363	PF01082	0.350
MOD_Cter_Amidation	919	922	PF01082	0.680
MOD_GlcNHglycan	14	17	PF01048	0.677
MOD_GlcNHglycan	18	21	PF01048	0.598
MOD_GlcNHglycan	294	297	PF01048	0.493
MOD_GlcNHglycan	351	354	PF01048	0.417
MOD_GlcNHglycan	451	454	PF01048	0.508
MOD_GlcNHglycan	470	473	PF01048	0.406
MOD_GlcNHglycan	487	490	PF01048	0.417
MOD_GlcNHglycan	63	66	PF01048	0.693
MOD_GlcNHglycan	640	643	PF01048	0.485
MOD_GlcNHglycan	734	737	PF01048	0.374
MOD_GlcNHglycan	766	769	PF01048	0.490
MOD_GSK3_1	12	19	PF00069	0.719
MOD_GSK3_1	141	148	PF00069	0.667
MOD_GSK3_1	157	164	PF00069	0.580
MOD_GSK3_1	183	190	PF00069	0.487
MOD_GSK3_1	233	240	PF00069	0.559
MOD_GSK3_1	242	249	PF00069	0.353
MOD_GSK3_1	253	260	PF00069	0.190
MOD_GSK3_1	315	322	PF00069	0.374
MOD_GSK3_1	464	471	PF00069	0.394
MOD_GSK3_1	481	488	PF00069	0.394
MOD_GSK3_1	546	553	PF00069	0.366
MOD_GSK3_1	608	615	PF00069	0.373
MOD_GSK3_1	682	689	PF00069	0.473
MOD_GSK3_1	690	697	PF00069	0.473
MOD_GSK3_1	734	741	PF00069	0.374
MOD_GSK3_1	805	812	PF00069	0.406
MOD_GSK3_1	921	928	PF00069	0.622
MOD_N-GLC_1	207	212	PF02516	0.509
MOD_N-GLC_1	310	315	PF02516	0.505
MOD_N-GLC_1	384	389	PF02516	0.576
MOD_N-GLC_1	550	555	PF02516	0.473
MOD_N-GLC_1	718	723	PF02516	0.374
MOD_N-GLC_1	738	743	PF02516	0.190
MOD_N-GLC_1	827	832	PF02516	0.409
MOD_NEK2_1	12	17	PF00069	0.740
MOD_NEK2_1	145	150	PF00069	0.458
MOD_NEK2_1	161	166	PF00069	0.420
MOD_NEK2_1	237	242	PF00069	0.509
MOD_NEK2_1	332	337	PF00069	0.517
MOD_NEK2_1	367	372	PF00069	0.374
MOD_NEK2_1	449	454	PF00069	0.394
MOD_NEK2_1	567	572	PF00069	0.675
MOD_NEK2_1	637	642	PF00069	0.470
MOD_NEK2_1	704	709	PF00069	0.392
MOD_NEK2_1	833	838	PF00069	0.394
MOD_NEK2_1	865	870	PF00069	0.394
MOD_NEK2_2	2	7	PF00069	0.477
MOD_NEK2_2	375	380	PF00069	0.368
MOD_NEK2_2	526	531	PF00069	0.394
MOD_NEK2_2	612	617	PF00069	0.284
MOD_PIKK_1	101	107	PF00454	0.307
MOD_PIKK_1	347	353	PF00454	0.502
MOD_PIKK_1	495	501	PF00454	0.394
MOD_PIKK_1	588	594	PF00454	0.354
MOD_PIKK_1	74	80	PF00454	0.745
MOD_PK_1	497	503	PF00069	0.486
MOD_PK_1	59	65	PF00069	0.515
MOD_PKA_1	392	398	PF00069	0.469
MOD_PKA_1	921	927	PF00069	0.723
MOD_PKA_2	233	239	PF00069	0.602
MOD_PKA_2	257	263	PF00069	0.374
MOD_PKA_2	431	437	PF00069	0.417
MOD_PKA_2	572	578	PF00069	0.634
MOD_PKA_2	58	64	PF00069	0.638
MOD_PKA_2	921	927	PF00069	0.651
MOD_Plk_1	207	213	PF00069	0.604
MOD_Plk_1	237	243	PF00069	0.518
MOD_Plk_1	310	316	PF00069	0.427
MOD_Plk_1	384	390	PF00069	0.578
MOD_Plk_1	430	436	PF00069	0.374
MOD_Plk_1	550	556	PF00069	0.475
MOD_Plk_1	612	618	PF00069	0.424
MOD_Plk_1	650	656	PF00069	0.494
MOD_Plk_1	718	724	PF00069	0.374
MOD_Plk_1	738	744	PF00069	0.190
MOD_Plk_1	833	839	PF00069	0.448
MOD_Plk_2-3	26	32	PF00069	0.579
MOD_Plk_2-3	694	700	PF00069	0.350
MOD_Plk_4	163	169	PF00069	0.509
MOD_Plk_4	237	243	PF00069	0.500
MOD_Plk_4	257	263	PF00069	0.190
MOD_Plk_4	294	300	PF00069	0.235
MOD_Plk_4	332	338	PF00069	0.423
MOD_Plk_4	384	390	PF00069	0.560
MOD_Plk_4	412	418	PF00069	0.436
MOD_Plk_4	431	437	PF00069	0.219
MOD_Plk_4	497	503	PF00069	0.374
MOD_Plk_4	629	635	PF00069	0.252
MOD_Plk_4	650	656	PF00069	0.464
MOD_Plk_4	682	688	PF00069	0.383
MOD_Plk_4	718	724	PF00069	0.374
MOD_Plk_4	738	744	PF00069	0.190
MOD_Plk_4	816	822	PF00069	0.517
MOD_ProDKin_1	14	20	PF00069	0.622
MOD_ProDKin_1	146	152	PF00069	0.501
MOD_ProDKin_1	189	195	PF00069	0.515
MOD_ProDKin_1	529	535	PF00069	0.438
MOD_ProDKin_1	608	614	PF00069	0.405
MOD_ProDKin_1	725	731	PF00069	0.374
MOD_SUMO_rev_2	386	395	PF00179	0.505
TRG_DiLeu_BaEn_1	113	118	PF01217	0.491
TRG_DiLeu_BaEn_1	238	243	PF01217	0.606
TRG_DiLeu_BaEn_1	700	705	PF01217	0.370
TRG_DiLeu_BaEn_1	811	816	PF01217	0.313
TRG_ENDOCYTIC_2	168	171	PF00928	0.430
TRG_ENDOCYTIC_2	446	449	PF00928	0.417
TRG_ENDOCYTIC_2	635	638	PF00928	0.425
TRG_ENDOCYTIC_2	665	668	PF00928	0.439
TRG_ENDOCYTIC_2	670	673	PF00928	0.374
TRG_ENDOCYTIC_2	674	677	PF00928	0.374
TRG_ENDOCYTIC_2	702	705	PF00928	0.438
TRG_ENDOCYTIC_2	775	778	PF00928	0.448
TRG_ENDOCYTIC_2	89	92	PF00928	0.580
TRG_ER_diArg_1	662	664	PF00400	0.548
TRG_ER_diArg_1	665	667	PF00400	0.554
TRG_ER_diArg_1	813	815	PF00400	0.517
TRG_ER_diArg_1	911	914	PF00400	0.360
TRG_ER_FFAT_2	605	615	PF00635	0.306
TRG_NLS_MonoExtC_3	35	40	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	776	780	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	813	818	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P788	Leptomonas seymouri	65%	100%
A0A1X0NUP8	Trypanosomatidae	62%	100%
A0A3Q8I987	Leishmania donovani	79%	99%
A0A3R7RI37	Trypanosoma rangeli	70%	100%
A0A3S7WTN0	Leishmania donovani	95%	100%
A4H893	Leishmania braziliensis	83%	100%
A4H8B6	Leishmania braziliensis	75%	100%
A4HWN6	Leishmania infantum	94%	100%
A4HWN7	Leishmania infantum	79%	99%
B3P3K2	Drosophila erecta	28%	82%
B4G4E5	Drosophila persimilis	27%	73%
B4JXX2	Drosophila grimshawi	27%	86%
B4K9L4	Drosophila mojavensis	27%	83%
B4LVU6	Drosophila virilis	28%	100%
B4NAL6	Drosophila willistoni	28%	83%
B4PSS5	Drosophila yakuba	28%	81%
B4QZU1	Drosophila simulans	28%	81%
C9ZXQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZXQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AQE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
O00408	Homo sapiens	30%	99%
O54735	Rattus norvegicus	28%	100%
O76074	Homo sapiens	29%	100%
O77746	Canis lupus familiaris	29%	100%
P0C1Q2	Mus musculus	32%	100%
P11541	Bos taurus	25%	100%
P14099	Bos taurus	30%	100%
P16499	Homo sapiens	25%	100%
P16586	Bos taurus	26%	100%
P23439	Bos taurus	25%	100%
P23440	Mus musculus	24%	100%
P27664	Mus musculus	25%	100%
P33726	Canis lupus familiaris	25%	100%
P35913	Homo sapiens	24%	100%
P51160	Homo sapiens	26%	100%
P52731	Gallus gallus	24%	100%
Q01062	Rattus norvegicus	31%	100%
Q1KKS3	Takifugu rubripes	31%	100%
Q28156	Bos taurus	28%	100%
Q28263	Canis lupus familiaris	25%	100%
Q298P4	Drosophila pseudoobscura pseudoobscura	28%	84%
Q4QF31	Leishmania major	81%	100%
Q8CA95	Mus musculus	31%	100%
Q8CG03	Mus musculus	28%	100%
Q8VID6	Rattus norvegicus	32%	99%
Q91ZQ1	Mus musculus	26%	100%
Q922S4	Mus musculus	30%	99%
Q9HCR9	Homo sapiens	31%	100%
Q9QYJ6	Rattus norvegicus	31%	100%
Q9VFI9	Drosophila melanogaster	28%	83%
Q9Y233	Homo sapiens	30%	100%