Phosphomevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomevalonate kinase-like protein

Species:

Leishmania mexicana

UniProt:

E9AQE1_LEIMU

TriTrypDb:

LmxM.15.1460

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQE1

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006629	lipid metabolic process	3	10
GO:0006637	acyl-CoA metabolic process	4	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009240	isopentenyl diphosphate biosynthetic process	6	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0033865	nucleoside bisphosphate metabolic process	5	10
GO:0033875	ribonucleoside bisphosphate metabolic process	6	10
GO:0034032	purine nucleoside bisphosphate metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0035383	thioester metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046490	isopentenyl diphosphate metabolic process	5	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006720	isoprenoid metabolic process	4	1
GO:0006721	terpenoid metabolic process	5	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	1
GO:0016114	terpenoid biosynthetic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045337	farnesyl diphosphate biosynthetic process	6	1
GO:0045338	farnesyl diphosphate metabolic process	5	1
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004631	phosphomevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.506
CLV_NRD_NRD_1	221	223	PF00675	0.368
CLV_NRD_NRD_1	247	249	PF00675	0.414
CLV_NRD_NRD_1	292	294	PF00675	0.378
CLV_NRD_NRD_1	308	310	PF00675	0.407
CLV_NRD_NRD_1	319	321	PF00675	0.511
CLV_PCSK_KEX2_1	221	223	PF00082	0.332
CLV_PCSK_KEX2_1	247	249	PF00082	0.502
CLV_PCSK_KEX2_1	308	310	PF00082	0.441
CLV_PCSK_KEX2_1	319	321	PF00082	0.498
CLV_PCSK_SKI1_1	269	273	PF00082	0.397
CLV_PCSK_SKI1_1	369	373	PF00082	0.313
CLV_PCSK_SKI1_1	39	43	PF00082	0.394
DEG_APCC_DBOX_1	368	376	PF00400	0.457
DEG_Nend_UBRbox_2	1	3	PF02207	0.468
DEG_SPOP_SBC_1	166	170	PF00917	0.470
DOC_CDC14_PxL_1	339	347	PF14671	0.424
DOC_CYCLIN_RxL_1	363	374	PF00134	0.523
DOC_CYCLIN_RxL_1	5	14	PF00134	0.333
DOC_MAPK_DCC_7	144	152	PF00069	0.520
DOC_MAPK_MEF2A_6	144	152	PF00069	0.520
DOC_MAPK_MEF2A_6	263	272	PF00069	0.404
DOC_PP4_FxxP_1	262	265	PF00568	0.370
DOC_USP7_MATH_1	102	106	PF00917	0.445
DOC_USP7_MATH_1	365	369	PF00917	0.508
DOC_USP7_MATH_1	71	75	PF00917	0.471
DOC_WW_Pin1_4	19	24	PF00397	0.492
DOC_WW_Pin1_4	279	284	PF00397	0.460
DOC_WW_Pin1_4	296	301	PF00397	0.412
DOC_WW_Pin1_4	57	62	PF00397	0.412
DOC_WW_Pin1_4	86	91	PF00397	0.407
LIG_14-3-3_CanoR_1	227	231	PF00244	0.464
LIG_14-3-3_CanoR_1	293	297	PF00244	0.411
LIG_14-3-3_CanoR_1	35	43	PF00244	0.441
LIG_14-3-3_CanoR_1	52	57	PF00244	0.347
LIG_14-3-3_CanoR_1	64	68	PF00244	0.535
LIG_BRCT_BRCA1_1	59	63	PF00533	0.355
LIG_BRCT_BRCA1_1	65	69	PF00533	0.355
LIG_CSL_BTD_1	255	258	PF09270	0.521
LIG_CtBP_PxDLS_1	385	389	PF00389	0.538
LIG_deltaCOP1_diTrp_1	253	262	PF00928	0.421
LIG_EVH1_2	258	262	PF00568	0.431
LIG_FHA_1	166	172	PF00498	0.470
LIG_FHA_1	35	41	PF00498	0.360
LIG_FHA_1	387	393	PF00498	0.464
LIG_FHA_1	435	441	PF00498	0.443
LIG_FHA_1	45	51	PF00498	0.498
LIG_FHA_1	76	82	PF00498	0.373
LIG_FHA_2	108	114	PF00498	0.424
LIG_FHA_2	237	243	PF00498	0.363
LIG_LIR_Apic_2	253	259	PF02991	0.495
LIG_LIR_Apic_2	260	265	PF02991	0.446
LIG_LIR_Gen_1	113	120	PF02991	0.468
LIG_LIR_Gen_1	14	23	PF02991	0.377
LIG_LIR_Gen_1	209	219	PF02991	0.518
LIG_LIR_Gen_1	413	420	PF02991	0.457
LIG_LIR_Gen_1	433	443	PF02991	0.421
LIG_LIR_Gen_1	66	75	PF02991	0.394
LIG_LIR_Nem_3	113	118	PF02991	0.443
LIG_LIR_Nem_3	14	18	PF02991	0.344
LIG_LIR_Nem_3	206	211	PF02991	0.457
LIG_LIR_Nem_3	217	223	PF02991	0.321
LIG_LIR_Nem_3	413	419	PF02991	0.457
LIG_LIR_Nem_3	429	435	PF02991	0.457
LIG_LIR_Nem_3	66	70	PF02991	0.393
LIG_NRBOX	387	393	PF00104	0.470
LIG_Pex14_2	63	67	PF04695	0.400
LIG_RPA_C_Fungi	358	370	PF08784	0.356
LIG_SH2_CRK	211	215	PF00017	0.425
LIG_SH2_CRK	412	416	PF00017	0.329
LIG_SH2_NCK_1	211	215	PF00017	0.425
LIG_SH2_NCK_1	412	416	PF00017	0.329
LIG_SH2_NCK_1	98	102	PF00017	0.324
LIG_SH2_SRC	130	133	PF00017	0.427
LIG_SH2_SRC	15	18	PF00017	0.367
LIG_SH2_STAP1	211	215	PF00017	0.310
LIG_SH2_STAP1	332	336	PF00017	0.414
LIG_SH2_STAP1	412	416	PF00017	0.310
LIG_SH2_STAP1	98	102	PF00017	0.383
LIG_SH2_STAT5	130	133	PF00017	0.384
LIG_SH2_STAT5	15	18	PF00017	0.342
LIG_SH2_STAT5	188	191	PF00017	0.356
LIG_SH2_STAT5	211	214	PF00017	0.310
LIG_SH2_STAT5	314	317	PF00017	0.339
LIG_SH3_2	258	263	PF14604	0.482
LIG_SH3_3	145	151	PF00018	0.463
LIG_SH3_3	252	258	PF00018	0.498
LIG_SH3_3	340	346	PF00018	0.423
LIG_SH3_3	401	407	PF00018	0.292
LIG_SH3_3	451	457	PF00018	0.543
LIG_SUMO_SIM_par_1	384	390	PF11976	0.450
LIG_SUMO_SIM_par_1	441	448	PF11976	0.366
LIG_SUMO_SIM_par_1	8	14	PF11976	0.337
LIG_TRFH_1	262	266	PF08558	0.487
MOD_CDK_SPxxK_3	57	64	PF00069	0.459
MOD_CK1_1	105	111	PF00069	0.534
MOD_CK1_1	226	232	PF00069	0.519
MOD_CK1_1	51	57	PF00069	0.571
MOD_CK2_1	107	113	PF00069	0.437
MOD_CK2_1	236	242	PF00069	0.510
MOD_GlcNHglycan	163	166	PF01048	0.291
MOD_GlcNHglycan	2	6	PF01048	0.339
MOD_GlcNHglycan	205	208	PF01048	0.292
MOD_GlcNHglycan	233	236	PF01048	0.668
MOD_GlcNHglycan	447	452	PF01048	0.503
MOD_GSK3_1	102	109	PF00069	0.410
MOD_GSK3_1	156	163	PF00069	0.292
MOD_GSK3_1	292	299	PF00069	0.456
MOD_GSK3_1	44	51	PF00069	0.647
MOD_GSK3_1	52	59	PF00069	0.540
MOD_GSK3_1	71	78	PF00069	0.370
MOD_N-GLC_1	392	397	PF02516	0.218
MOD_N-GLC_2	439	441	PF02516	0.387
MOD_NEK2_1	1	6	PF00069	0.455
MOD_NEK2_1	161	166	PF00069	0.328
MOD_NEK2_1	167	172	PF00069	0.355
MOD_NEK2_1	231	236	PF00069	0.512
MOD_NEK2_1	392	397	PF00069	0.292
MOD_NEK2_1	63	68	PF00069	0.426
MOD_PIKK_1	123	129	PF00454	0.354
MOD_PIKK_1	130	136	PF00454	0.397
MOD_PIKK_1	197	203	PF00454	0.408
MOD_PKA_2	226	232	PF00069	0.498
MOD_PKA_2	292	298	PF00069	0.412
MOD_PKA_2	34	40	PF00069	0.414
MOD_PKA_2	51	57	PF00069	0.486
MOD_PKA_2	63	69	PF00069	0.370
MOD_Plk_1	71	77	PF00069	0.281
MOD_Plk_4	11	17	PF00069	0.336
MOD_Plk_4	167	173	PF00069	0.310
MOD_Plk_4	226	232	PF00069	0.525
MOD_ProDKin_1	19	25	PF00069	0.483
MOD_ProDKin_1	279	285	PF00069	0.447
MOD_ProDKin_1	296	302	PF00069	0.405
MOD_ProDKin_1	57	63	PF00069	0.415
MOD_ProDKin_1	86	92	PF00069	0.398
MOD_SUMO_for_1	381	384	PF00179	0.425
MOD_SUMO_for_1	41	44	PF00179	0.510
MOD_SUMO_rev_2	374	383	PF00179	0.425
TRG_DiLeu_BaEn_1	387	392	PF01217	0.370
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.373
TRG_ENDOCYTIC_2	15	18	PF00928	0.342
TRG_ENDOCYTIC_2	211	214	PF00928	0.370
TRG_ENDOCYTIC_2	220	223	PF00928	0.252
TRG_ENDOCYTIC_2	412	415	PF00928	0.310
TRG_ENDOCYTIC_2	435	438	PF00928	0.373
TRG_ER_diArg_1	220	222	PF00400	0.328
TRG_ER_diArg_1	246	248	PF00400	0.413
TRG_ER_diArg_1	307	309	PF00400	0.440
TRG_ER_diArg_1	318	320	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P784	Leptomonas seymouri	76%	100%
A0A0S4JMH3	Bodo saltans	56%	100%
A0A1D8PLH0	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
A0A1X0NVR4	Trypanosomatidae	55%	100%
A0A3S5IQX7	Trypanosoma rangeli	54%	98%
A0A3S7WTM8	Leishmania donovani	93%	100%
A4H8B3	Leishmania braziliensis	85%	100%
A4HWN3	Leishmania infantum	93%	100%
C9ZXQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
I1RZD0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
P24521	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4QF34	Leishmania major	93%	100%
Q4WV38	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	95%
Q9C6T1	Arabidopsis thaliana	34%	91%
Q9UT88	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%