Proliferating cell nuclear antigen

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proliferative cell nuclear antigen (PCNA), putative

Species:

Leishmania mexicana

UniProt:

E9AQE0_LEIMU

TriTrypDb:

LmxM.15.1450

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043626	PCNA complex	3	1
GO:0044796	DNA polymerase processivity factor complex	3	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9AQE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQE0

Function

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Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006272	leading strand elongation	7	1
GO:0006275	regulation of DNA replication	6	12
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006301	postreplication repair	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0008047	enzyme activator activity	3	12
GO:0030234	enzyme regulator activity	2	12
GO:0030337	DNA polymerase processivity factor activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.261
CLV_NRD_NRD_1	109	111	PF00675	0.261
CLV_NRD_NRD_1	214	216	PF00675	0.726
CLV_PCSK_KEX2_1	13	15	PF00082	0.246
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.252
CLV_PCSK_SKI1_1	190	194	PF00082	0.355
CLV_PCSK_SKI1_1	262	266	PF00082	0.345
CLV_PCSK_SKI1_1	77	81	PF00082	0.246
DEG_Nend_Nbox_1	1	3	PF02207	0.231
DOC_MAPK_gen_1	108	118	PF00069	0.261

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I656	Leptomonas seymouri	94%	100%
A0A0S4JJ69	Bodo saltans	60%	95%
A0A1X0NVI3	Trypanosomatidae	75%	100%
A0A3R7LTI5	Trypanosoma rangeli	74%	100%
A0B7Y8	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	25%	100%
A0RXH7	Cenarchaeum symbiosum (strain A)	27%	100%
A1RXU8	Thermofilum pendens (strain DSM 2475 / Hrk 5)	22%	100%
A2SSW6	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	21%	100%
A4H8B2	Leishmania braziliensis	95%	100%
A4HWN2	Leishmania infantum	98%	100%

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