RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ERAD-associated E3 ubiquitin-protein ligase HRD1, putative

Species:

Leishmania mexicana

UniProt:

E9AQD6_LEIMU

TriTrypDb:

LmxM.15.1410

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AQD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQD6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0016746	acyltransferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.585
CLV_NRD_NRD_1	269	271	PF00675	0.372
CLV_PCSK_KEX2_1	269	271	PF00082	0.385
CLV_PCSK_KEX2_1	303	305	PF00082	0.320
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.337
CLV_PCSK_SKI1_1	236	240	PF00082	0.435
DEG_MDM2_SWIB_1	112	119	PF02201	0.422
DEG_SPOP_SBC_1	40	44	PF00917	0.397
DOC_CKS1_1	436	441	PF01111	0.702
DOC_MAPK_DCC_7	236	244	PF00069	0.409
DOC_MAPK_MEF2A_6	236	244	PF00069	0.409
DOC_MAPK_MEF2A_6	462	470	PF00069	0.693
DOC_MAPK_NFAT4_5	236	244	PF00069	0.409
DOC_PP2B_LxvP_1	398	401	PF13499	0.705
DOC_USP7_MATH_1	216	220	PF00917	0.426
DOC_USP7_MATH_1	40	44	PF00917	0.397
DOC_USP7_UBL2_3	448	452	PF12436	0.565
DOC_WW_Pin1_4	342	347	PF00397	0.605
DOC_WW_Pin1_4	435	440	PF00397	0.753
LIG_14-3-3_CanoR_1	126	131	PF00244	0.306
LIG_14-3-3_CanoR_1	192	196	PF00244	0.416
LIG_14-3-3_CanoR_1	204	210	PF00244	0.344
LIG_14-3-3_CanoR_1	270	276	PF00244	0.558
LIG_14-3-3_CanoR_1	4	8	PF00244	0.561
LIG_14-3-3_CanoR_1	427	431	PF00244	0.771
LIG_Actin_WH2_2	177	194	PF00022	0.422
LIG_APCC_ABBA_1	94	99	PF00400	0.632
LIG_BIR_III_4	341	345	PF00653	0.576
LIG_BRCT_BRCA1_1	106	110	PF00533	0.439
LIG_BRCT_BRCA1_1	222	226	PF00533	0.346
LIG_BRCT_BRCA1_1	41	45	PF00533	0.258
LIG_FHA_1	157	163	PF00498	0.502
LIG_FHA_1	3	9	PF00498	0.505
LIG_FHA_1	300	306	PF00498	0.561
LIG_FHA_1	435	441	PF00498	0.717
LIG_FHA_1	55	61	PF00498	0.353
LIG_FHA_1	76	82	PF00498	0.560
LIG_FHA_2	162	168	PF00498	0.597
LIG_FHA_2	26	32	PF00498	0.515
LIG_FHA_2	277	283	PF00498	0.597
LIG_FHA_2	377	383	PF00498	0.723
LIG_LIR_Gen_1	174	185	PF02991	0.525
LIG_LIR_Gen_1	194	203	PF02991	0.495
LIG_LIR_Gen_1	223	234	PF02991	0.333
LIG_LIR_Gen_1	263	271	PF02991	0.538
LIG_LIR_Gen_1	290	298	PF02991	0.525
LIG_LIR_Nem_3	107	112	PF02991	0.407
LIG_LIR_Nem_3	113	119	PF02991	0.384
LIG_LIR_Nem_3	174	180	PF02991	0.491
LIG_LIR_Nem_3	194	200	PF02991	0.484
LIG_LIR_Nem_3	223	229	PF02991	0.358
LIG_LIR_Nem_3	263	267	PF02991	0.527
LIG_LIR_Nem_3	28	32	PF02991	0.369
LIG_LIR_Nem_3	389	394	PF02991	0.734
LIG_LIR_Nem_3	42	48	PF02991	0.277
LIG_LIR_Nem_3	82	87	PF02991	0.609
LIG_LYPXL_S_1	32	36	PF13949	0.567
LIG_LYPXL_yS_3	33	36	PF13949	0.362
LIG_MLH1_MIPbox_1	106	110	PF16413	0.455
LIG_Pex14_2	108	112	PF04695	0.429
LIG_Pex14_2	15	19	PF04695	0.241
LIG_Pex14_2	197	201	PF04695	0.348
LIG_SH2_CRK	177	181	PF00017	0.418
LIG_SH2_CRK	183	187	PF00017	0.362
LIG_SH2_CRK	230	234	PF00017	0.455
LIG_SH2_GRB2like	25	28	PF00017	0.512
LIG_SH2_SRC	230	233	PF00017	0.466
LIG_SH2_STAP1	177	181	PF00017	0.339
LIG_SH2_STAP1	230	234	PF00017	0.457
LIG_SH2_STAP1	25	29	PF00017	0.422
LIG_SH2_STAP1	293	297	PF00017	0.537
LIG_SH2_STAT3	394	397	PF00017	0.741
LIG_SH2_STAT3	97	100	PF00017	0.645
LIG_SH2_STAT5	10	13	PF00017	0.312
LIG_SH2_STAT5	146	149	PF00017	0.347
LIG_SH2_STAT5	232	235	PF00017	0.328
LIG_SH2_STAT5	328	331	PF00017	0.463
LIG_SH2_STAT5	87	90	PF00017	0.501
LIG_SH3_3	397	403	PF00018	0.766
LIG_SH3_3	433	439	PF00018	0.700
LIG_SH3_3	89	95	PF00018	0.536
LIG_SUMO_SIM_par_1	183	190	PF11976	0.455
LIG_SUMO_SIM_par_1	46	52	PF11976	0.374
LIG_TRAF2_1	74	77	PF00917	0.615
LIG_TYR_ITIM	181	186	PF00017	0.436
LIG_UBA3_1	157	163	PF00899	0.524
LIG_WRC_WIRS_1	12	17	PF05994	0.397
LIG_WRC_WIRS_1	81	86	PF05994	0.597
MOD_CK1_1	104	110	PF00069	0.400
MOD_CK1_1	190	196	PF00069	0.385
MOD_CK1_1	75	81	PF00069	0.586
MOD_CK2_1	161	167	PF00069	0.596
MOD_CK2_1	216	222	PF00069	0.403
MOD_CK2_1	25	31	PF00069	0.507
MOD_GlcNHglycan	103	106	PF01048	0.424
MOD_GlcNHglycan	138	141	PF01048	0.401
MOD_GlcNHglycan	258	261	PF01048	0.380
MOD_GlcNHglycan	346	349	PF01048	0.571
MOD_GlcNHglycan	421	424	PF01048	0.489
MOD_GSK3_1	121	128	PF00069	0.444
MOD_GSK3_1	129	136	PF00069	0.376
MOD_GSK3_1	171	178	PF00069	0.544
MOD_GSK3_1	186	193	PF00069	0.383
MOD_GSK3_1	216	223	PF00069	0.315
MOD_GSK3_1	415	422	PF00069	0.742
MOD_GSK3_1	426	433	PF00069	0.744
MOD_GSK3_1	434	441	PF00069	0.700
MOD_GSK3_1	75	82	PF00069	0.575
MOD_N-GLC_1	40	45	PF02516	0.542
MOD_N-GLC_1	72	77	PF02516	0.344
MOD_NEK2_1	110	115	PF00069	0.377
MOD_NEK2_1	133	138	PF00069	0.357
MOD_NEK2_1	161	166	PF00069	0.543
MOD_NEK2_1	175	180	PF00069	0.320
MOD_NEK2_1	185	190	PF00069	0.125
MOD_NEK2_1	191	196	PF00069	0.306
MOD_NEK2_1	225	230	PF00069	0.354
MOD_NEK2_1	39	44	PF00069	0.342
MOD_NEK2_1	80	85	PF00069	0.513
MOD_PKA_2	125	131	PF00069	0.305
MOD_PKA_2	191	197	PF00069	0.455
MOD_PKA_2	271	277	PF00069	0.607
MOD_PKA_2	287	293	PF00069	0.414
MOD_PKA_2	3	9	PF00069	0.561
MOD_PKA_2	426	432	PF00069	0.736
MOD_Plk_1	40	46	PF00069	0.288
MOD_Plk_1	75	81	PF00069	0.586
MOD_Plk_4	104	110	PF00069	0.333
MOD_Plk_4	11	17	PF00069	0.288
MOD_Plk_4	133	139	PF00069	0.387
MOD_Plk_4	156	162	PF00069	0.462
MOD_Plk_4	175	181	PF00069	0.196
MOD_Plk_4	196	202	PF00069	0.367
MOD_Plk_4	205	211	PF00069	0.372
MOD_Plk_4	220	226	PF00069	0.264
MOD_Plk_4	3	9	PF00069	0.473
MOD_ProDKin_1	342	348	PF00069	0.604
MOD_ProDKin_1	435	441	PF00069	0.746
MOD_SUMO_rev_2	167	174	PF00179	0.658
TRG_DiLeu_BaEn_1	76	81	PF01217	0.583
TRG_DiLeu_BaEn_2	221	227	PF01217	0.422
TRG_DiLeu_BaEn_4	76	82	PF01217	0.610
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.340
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.331
TRG_ENDOCYTIC_2	146	149	PF00928	0.342
TRG_ENDOCYTIC_2	177	180	PF00928	0.330
TRG_ENDOCYTIC_2	183	186	PF00928	0.297
TRG_ENDOCYTIC_2	230	233	PF00928	0.407
TRG_ENDOCYTIC_2	29	32	PF00928	0.395
TRG_ENDOCYTIC_2	293	296	PF00928	0.510
TRG_ENDOCYTIC_2	33	36	PF00928	0.350
TRG_ER_diArg_1	269	272	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9A3	Leptomonas seymouri	55%	89%
A0A1X0NU29	Trypanosomatidae	35%	91%
A0A3R7MBX1	Trypanosoma rangeli	35%	89%
A0A3S5H6W0	Leishmania donovani	94%	100%
A4H8A9	Leishmania braziliensis	78%	100%
A4HWM9	Leishmania infantum	94%	100%
A8Y4B2	Caenorhabditis briggsae	27%	77%
C9ZXQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
O74757	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	71%
Q20798	Caenorhabditis elegans	28%	78%
Q4QF39	Leishmania major	92%	100%
Q5XHH7	Xenopus laevis	27%	80%
Q5Z880	Oryza sativa subsp. japonica	25%	96%
Q6NPT7	Arabidopsis thaliana	25%	100%
Q6NRL6	Xenopus laevis	29%	79%
Q803I8	Danio rerio	28%	76%
Q86TM6	Homo sapiens	28%	77%
Q95SP2	Drosophila melanogaster	29%	76%
Q9DBY1	Mus musculus	28%	78%
Q9LW77	Arabidopsis thaliana	25%	97%
V5BUE9	Trypanosoma cruzi	31%	90%