TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TMEM164 family, putative

Species:

Leishmania mexicana

UniProt:

E9AQD4_LEIMU

TriTrypDb:

LmxM.15.1390

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AQD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	292	294	PF00675	0.440
CLV_PCSK_SKI1_1	260	264	PF00082	0.405
CLV_PCSK_SKI1_1	293	297	PF00082	0.450
CLV_PCSK_SKI1_1	76	80	PF00082	0.417
CLV_PCSK_SKI1_1	84	88	PF00082	0.369
DEG_APCC_DBOX_1	207	215	PF00400	0.380
DEG_APCC_DBOX_1	259	267	PF00400	0.366
DEG_MDM2_SWIB_1	129	136	PF02201	0.362
DEG_Nend_UBRbox_2	1	3	PF02207	0.335
DEG_ODPH_VHL_1	226	237	PF01847	0.411
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	258	264	PF00134	0.343
DOC_MAPK_DCC_7	260	268	PF00069	0.411
DOC_MAPK_gen_1	109	119	PF00069	0.300
DOC_MAPK_gen_1	257	266	PF00069	0.258
DOC_MAPK_MEF2A_6	112	119	PF00069	0.287
DOC_MAPK_MEF2A_6	260	268	PF00069	0.362
DOC_PP2B_LxvP_1	122	125	PF13499	0.362
DOC_PP2B_LxvP_1	191	194	PF13499	0.334
DOC_PP2B_LxvP_1	241	244	PF13499	0.250
DOC_PP4_FxxP_1	289	292	PF00568	0.470
DOC_PP4_FxxP_1	42	45	PF00568	0.279
DOC_WW_Pin1_4	158	163	PF00397	0.368
DOC_WW_Pin1_4	288	293	PF00397	0.473
LIG_14-3-3_CanoR_1	245	251	PF00244	0.418
LIG_14-3-3_CanoR_1	27	33	PF00244	0.274
LIG_14-3-3_CanoR_1	288	292	PF00244	0.596
LIG_14-3-3_CanoR_1	67	77	PF00244	0.520
LIG_BRCT_BRCA1_1	65	69	PF00533	0.569
LIG_CSL_BTD_1	159	162	PF09270	0.328
LIG_deltaCOP1_diTrp_1	157	160	PF00928	0.390
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.256
LIG_eIF4E_1	11	17	PF01652	0.204
LIG_eIF4E_1	150	156	PF01652	0.411
LIG_FHA_1	201	207	PF00498	0.502
LIG_FHA_1	77	83	PF00498	0.577
LIG_GBD_Chelix_1	272	280	PF00786	0.425
LIG_HCF-1_HBM_1	173	176	PF13415	0.271
LIG_LIR_Apic_2	10	14	PF02991	0.379
LIG_LIR_Gen_1	130	138	PF02991	0.301
LIG_LIR_Gen_1	15	24	PF02991	0.331
LIG_LIR_Gen_1	179	189	PF02991	0.375
LIG_LIR_Gen_1	218	228	PF02991	0.357
LIG_LIR_Nem_3	130	136	PF02991	0.284
LIG_LIR_Nem_3	15	20	PF02991	0.334
LIG_LIR_Nem_3	157	163	PF02991	0.408
LIG_LIR_Nem_3	179	184	PF02991	0.295
LIG_LIR_Nem_3	218	223	PF02991	0.328
LIG_MYND_1	261	265	PF01753	0.411
LIG_NRBOX	118	124	PF00104	0.292
LIG_NRBOX	150	156	PF00104	0.411
LIG_Pex14_1	133	137	PF04695	0.392
LIG_Pex14_1	216	220	PF04695	0.398
LIG_Pex14_2	129	133	PF04695	0.362
LIG_SH2_CRK	201	205	PF00017	0.471
LIG_SH2_PTP2	11	14	PF00017	0.377
LIG_SH2_STAT3	40	43	PF00017	0.349
LIG_SH2_STAT5	11	14	PF00017	0.377
LIG_SH2_STAT5	135	138	PF00017	0.378
LIG_SH2_STAT5	150	153	PF00017	0.172
LIG_SH2_STAT5	176	179	PF00017	0.288
LIG_SH2_STAT5	181	184	PF00017	0.297
LIG_SH2_STAT5	196	199	PF00017	0.128
LIG_SH2_STAT5	96	99	PF00017	0.442
LIG_SH3_3	156	162	PF00018	0.328
LIG_SH3_3	222	228	PF00018	0.161
LIG_SH3_4	114	121	PF00018	0.368
LIG_SUMO_SIM_anti_2	19	26	PF11976	0.400
LIG_TRFH_1	239	243	PF08558	0.240
LIG_WRC_WIRS_1	217	222	PF05994	0.261
LIG_WW_3	242	246	PF00397	0.390
MOD_CDC14_SPxK_1	291	294	PF00782	0.499
MOD_CDK_SPK_2	288	293	PF00069	0.473
MOD_CDK_SPxK_1	288	294	PF00069	0.479
MOD_CK2_1	293	299	PF00069	0.651
MOD_GlcNHglycan	146	149	PF01048	0.308
MOD_GlcNHglycan	248	251	PF01048	0.629
MOD_GlcNHglycan	70	73	PF01048	0.318
MOD_GSK3_1	212	219	PF00069	0.473
MOD_GSK3_1	68	75	PF00069	0.474
MOD_NEK2_1	246	251	PF00069	0.369
MOD_PKA_1	293	299	PF00069	0.592
MOD_PKA_2	244	250	PF00069	0.414
MOD_PKA_2	287	293	PF00069	0.466
MOD_PKA_2	63	69	PF00069	0.508
MOD_Plk_4	150	156	PF00069	0.327
MOD_Plk_4	19	25	PF00069	0.377
MOD_Plk_4	212	218	PF00069	0.453
MOD_Plk_4	268	274	PF00069	0.339
MOD_ProDKin_1	158	164	PF00069	0.368
MOD_ProDKin_1	288	294	PF00069	0.479
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.525
TRG_ENDOCYTIC_2	135	138	PF00928	0.408
TRG_ENDOCYTIC_2	181	184	PF00928	0.353
TRG_ENDOCYTIC_2	201	204	PF00928	0.328
TRG_ENDOCYTIC_2	96	99	PF00928	0.411
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P785	Leptomonas seymouri	54%	100%
A0A0S4JGE0	Bodo saltans	37%	100%
A0A1X0NUN8	Trypanosomatidae	36%	96%
A0A3Q8IIU5	Leishmania donovani	91%	100%
A0A422NBZ1	Trypanosoma rangeli	37%	97%
A4H8A7	Leishmania braziliensis	80%	100%
A4HWM7	Leishmania infantum	91%	100%
Q4QF41	Leishmania major	86%	100%
Q54KD4	Dictyostelium discoideum	22%	100%
V5DL97	Trypanosoma cruzi	41%	96%