Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AQD0_LEIMU

TriTrypDb:

LmxM.15.1355

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQD0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.657
CLV_C14_Caspase3-7	255	259	PF00656	0.498
CLV_NRD_NRD_1	230	232	PF00675	0.502
CLV_NRD_NRD_1	239	241	PF00675	0.645
CLV_NRD_NRD_1	45	47	PF00675	0.639
CLV_NRD_NRD_1	53	55	PF00675	0.549
CLV_PCSK_FUR_1	228	232	PF00082	0.537
CLV_PCSK_KEX2_1	230	232	PF00082	0.502
CLV_PCSK_KEX2_1	239	241	PF00082	0.645
CLV_PCSK_KEX2_1	282	284	PF00082	0.569
CLV_PCSK_KEX2_1	44	46	PF00082	0.618
CLV_PCSK_KEX2_1	53	55	PF00082	0.551
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.569
CLV_PCSK_PC7_1	40	46	PF00082	0.533
DEG_Nend_UBRbox_1	1	4	PF02207	0.500
DOC_CKS1_1	159	164	PF01111	0.598
DOC_CKS1_1	9	14	PF01111	0.490
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.484
DOC_MAPK_gen_1	53	61	PF00069	0.453
DOC_MAPK_MEF2A_6	269	276	PF00069	0.411
DOC_MAPK_MEF2A_6	53	61	PF00069	0.456
DOC_MAPK_NFAT4_5	54	62	PF00069	0.532
DOC_SPAK_OSR1_1	269	273	PF12202	0.499
DOC_USP7_MATH_1	100	104	PF00917	0.500
DOC_USP7_MATH_1	126	130	PF00917	0.531
DOC_USP7_MATH_1	246	250	PF00917	0.508
DOC_WW_Pin1_4	158	163	PF00397	0.603
DOC_WW_Pin1_4	173	178	PF00397	0.744
DOC_WW_Pin1_4	234	239	PF00397	0.684
DOC_WW_Pin1_4	242	247	PF00397	0.722
DOC_WW_Pin1_4	296	301	PF00397	0.717
DOC_WW_Pin1_4	34	39	PF00397	0.523
DOC_WW_Pin1_4	8	13	PF00397	0.581
LIG_14-3-3_CanoR_1	116	120	PF00244	0.444
LIG_14-3-3_CanoR_1	24	30	PF00244	0.301
LIG_BRCT_BRCA1_1	264	268	PF00533	0.663
LIG_EVH1_2	292	296	PF00568	0.466
LIG_FHA_1	139	145	PF00498	0.411
LIG_FHA_1	154	160	PF00498	0.526
LIG_FHA_1	169	175	PF00498	0.668
LIG_FHA_1	4	10	PF00498	0.490
LIG_FHA_2	9	15	PF00498	0.566
LIG_LIR_Gen_1	69	78	PF02991	0.466
LIG_LIR_Nem_3	69	74	PF02991	0.492
LIG_PDZ_Class_1	299	304	PF00595	0.684
LIG_SH2_CRK	71	75	PF00017	0.423
LIG_SH2_STAP1	285	289	PF00017	0.455
LIG_SH2_STAP1	92	96	PF00017	0.511
LIG_SH3_2	278	283	PF14604	0.340
LIG_SH3_3	156	162	PF00018	0.639
LIG_SH3_3	171	177	PF00018	0.671
LIG_SH3_3	275	281	PF00018	0.333
LIG_SH3_3	297	303	PF00018	0.546
LIG_SH3_3	35	41	PF00018	0.585
MOD_CDC14_SPxK_1	37	40	PF00782	0.503
MOD_CDK_SPK_2	234	239	PF00069	0.599
MOD_CDK_SPxK_1	234	240	PF00069	0.548
MOD_CDK_SPxK_1	34	40	PF00069	0.546
MOD_CK1_1	176	182	PF00069	0.764
MOD_CK1_1	295	301	PF00069	0.665
MOD_CK1_1	33	39	PF00069	0.543
MOD_CK2_1	8	14	PF00069	0.526
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.508
MOD_GlcNHglycan	103	106	PF01048	0.535
MOD_GlcNHglycan	128	131	PF01048	0.519
MOD_GlcNHglycan	146	149	PF01048	0.314
MOD_GlcNHglycan	217	220	PF01048	0.553
MOD_GlcNHglycan	248	251	PF01048	0.510
MOD_GlcNHglycan	32	35	PF01048	0.625
MOD_GSK3_1	173	180	PF00069	0.807
MOD_GSK3_1	242	249	PF00069	0.625
MOD_GSK3_1	258	265	PF00069	0.751
MOD_GSK3_1	28	35	PF00069	0.538
MOD_GSK3_1	292	299	PF00069	0.676
MOD_NEK2_1	144	149	PF00069	0.450
MOD_NEK2_1	151	156	PF00069	0.454
MOD_NEK2_1	3	8	PF00069	0.290
MOD_PKA_2	115	121	PF00069	0.524
MOD_Plk_1	86	92	PF00069	0.355
MOD_Plk_4	115	121	PF00069	0.524
MOD_Plk_4	25	31	PF00069	0.556
MOD_Plk_4	66	72	PF00069	0.511
MOD_ProDKin_1	158	164	PF00069	0.601
MOD_ProDKin_1	173	179	PF00069	0.744
MOD_ProDKin_1	234	240	PF00069	0.692
MOD_ProDKin_1	242	248	PF00069	0.724
MOD_ProDKin_1	296	302	PF00069	0.717
MOD_ProDKin_1	34	40	PF00069	0.522
MOD_ProDKin_1	8	14	PF00069	0.579
TRG_ENDOCYTIC_2	71	74	PF00928	0.499
TRG_ER_diArg_1	228	231	PF00400	0.535
TRG_ER_diArg_1	238	240	PF00400	0.699
TRG_ER_diArg_1	43	46	PF00400	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL8	Leptomonas seymouri	53%	90%
A0A3R7RI28	Trypanosoma rangeli	32%	100%
A0A3S7WTT4	Leishmania donovani	87%	100%
A4H8A3	Leishmania braziliensis	74%	100%
A4HWM3	Leishmania infantum	87%	100%
C9ZXR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QF45	Leishmania major	84%	100%