Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQC9_LEIMU

TriTrypDb:

LmxM.15.1350

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.475
CLV_C14_Caspase3-7	448	452	PF00656	0.368
CLV_C14_Caspase3-7	607	611	PF00656	0.342
CLV_MEL_PAP_1	342	348	PF00089	0.377
CLV_NRD_NRD_1	206	208	PF00675	0.486
CLV_NRD_NRD_1	218	220	PF00675	0.480
CLV_NRD_NRD_1	366	368	PF00675	0.264
CLV_NRD_NRD_1	419	421	PF00675	0.560
CLV_NRD_NRD_1	631	633	PF00675	0.599
CLV_PCSK_FUR_1	416	420	PF00082	0.448
CLV_PCSK_KEX2_1	366	368	PF00082	0.264
CLV_PCSK_KEX2_1	418	420	PF00082	0.560
CLV_PCSK_KEX2_1	631	633	PF00082	0.599
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.635
CLV_PCSK_PC7_1	414	420	PF00082	0.587
CLV_PCSK_PC7_1	627	633	PF00082	0.589
CLV_PCSK_SKI1_1	219	223	PF00082	0.510
CLV_PCSK_SKI1_1	326	330	PF00082	0.376
CLV_PCSK_SKI1_1	366	370	PF00082	0.258
CLV_PCSK_SKI1_1	384	388	PF00082	0.571
CLV_PCSK_SKI1_1	404	408	PF00082	0.408
CLV_PCSK_SKI1_1	439	443	PF00082	0.582
CLV_PCSK_SKI1_1	599	603	PF00082	0.499
CLV_PCSK_SKI1_1	695	699	PF00082	0.350
DEG_APCC_DBOX_1	234	242	PF00400	0.613
DEG_APCC_DBOX_1	438	446	PF00400	0.384
DEG_APCC_DBOX_1	694	702	PF00400	0.489
DOC_ANK_TNKS_1	245	252	PF00023	0.579
DOC_CKS1_1	3	8	PF01111	0.514
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.344
DOC_MAPK_DCC_7	235	243	PF00069	0.599
DOC_MAPK_gen_1	433	442	PF00069	0.394
DOC_MAPK_gen_1	631	637	PF00069	0.357
DOC_MAPK_MEF2A_6	235	243	PF00069	0.599
DOC_MAPK_MEF2A_6	372	380	PF00069	0.321
DOC_MAPK_MEF2A_6	587	596	PF00069	0.258
DOC_MAPK_MEF2A_6	677	686	PF00069	0.600
DOC_PP2B_LxvP_1	374	377	PF13499	0.346
DOC_PP2B_LxvP_1	577	580	PF13499	0.319
DOC_PP2B_LxvP_1	635	638	PF13499	0.349
DOC_USP7_MATH_1	160	164	PF00917	0.601
DOC_USP7_MATH_1	27	31	PF00917	0.494
DOC_USP7_MATH_1	271	275	PF00917	0.665
DOC_USP7_MATH_1	328	332	PF00917	0.670
DOC_USP7_MATH_1	58	62	PF00917	0.534
DOC_WW_Pin1_4	2	7	PF00397	0.546
DOC_WW_Pin1_4	214	219	PF00397	0.796
DOC_WW_Pin1_4	37	42	PF00397	0.561
DOC_WW_Pin1_4	557	562	PF00397	0.258
DOC_WW_Pin1_4	630	635	PF00397	0.370
DOC_WW_Pin1_4	648	653	PF00397	0.417
LIG_14-3-3_CanoR_1	142	150	PF00244	0.405
LIG_14-3-3_CanoR_1	195	203	PF00244	0.538
LIG_14-3-3_CanoR_1	45	52	PF00244	0.546
LIG_14-3-3_CanoR_1	632	638	PF00244	0.355
LIG_14-3-3_CanoR_1	677	686	PF00244	0.471
LIG_14-3-3_CanoR_1	693	698	PF00244	0.570
LIG_APCC_ABBAyCdc20_2	454	460	PF00400	0.308
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	197	201	PF00533	0.584
LIG_BRCT_BRCA1_1	241	245	PF00533	0.526
LIG_deltaCOP1_diTrp_1	66	71	PF00928	0.477
LIG_DLG_GKlike_1	693	701	PF00625	0.585
LIG_eIF4E_1	503	509	PF01652	0.433
LIG_FHA_1	220	226	PF00498	0.769
LIG_FHA_1	261	267	PF00498	0.549
LIG_FHA_1	330	336	PF00498	0.662
LIG_FHA_1	393	399	PF00498	0.499
LIG_FHA_1	457	463	PF00498	0.305
LIG_FHA_1	465	471	PF00498	0.285
LIG_FHA_1	523	529	PF00498	0.298
LIG_FHA_1	558	564	PF00498	0.258
LIG_FHA_1	584	590	PF00498	0.260
LIG_FHA_1	67	73	PF00498	0.431
LIG_FHA_1	692	698	PF00498	0.571
LIG_FHA_2	126	132	PF00498	0.341
LIG_FHA_2	142	148	PF00498	0.469
LIG_FHA_2	154	160	PF00498	0.553
LIG_FHA_2	284	290	PF00498	0.552
LIG_FHA_2	676	682	PF00498	0.505
LIG_GBD_Chelix_1	115	123	PF00786	0.622
LIG_GBD_Chelix_1	544	552	PF00786	0.499
LIG_LIR_Gen_1	310	320	PF02991	0.586
LIG_LIR_Gen_1	340	349	PF02991	0.548
LIG_LIR_Gen_1	443	453	PF02991	0.383
LIG_LIR_Gen_1	522	531	PF02991	0.373
LIG_LIR_Gen_1	603	612	PF02991	0.267
LIG_LIR_Gen_1	616	626	PF02991	0.240
LIG_LIR_Nem_3	242	248	PF02991	0.531
LIG_LIR_Nem_3	310	315	PF02991	0.506
LIG_LIR_Nem_3	340	346	PF02991	0.547
LIG_LIR_Nem_3	443	449	PF02991	0.322
LIG_LIR_Nem_3	452	458	PF02991	0.282
LIG_LIR_Nem_3	495	500	PF02991	0.311
LIG_LIR_Nem_3	522	527	PF02991	0.294
LIG_LIR_Nem_3	550	556	PF02991	0.208
LIG_LIR_Nem_3	588	594	PF02991	0.284
LIG_LIR_Nem_3	603	608	PF02991	0.242
LIG_LIR_Nem_3	610	615	PF02991	0.258
LIG_LIR_Nem_3	616	621	PF02991	0.258
LIG_LIR_Nem_3	66	71	PF02991	0.477
LIG_LYPXL_yS_3	591	594	PF13949	0.274
LIG_MYND_3	302	306	PF01753	0.588
LIG_NRBOX	181	187	PF00104	0.323
LIG_NRBOX	697	703	PF00104	0.486
LIG_PCNA_yPIPBox_3	281	290	PF02747	0.625
LIG_SH2_CRK	9	13	PF00017	0.558
LIG_SH2_NCK_1	542	546	PF00017	0.272
LIG_SH2_STAP1	370	374	PF00017	0.302
LIG_SH2_STAP1	458	462	PF00017	0.376
LIG_SH2_STAP1	542	546	PF00017	0.348
LIG_SH2_STAP1	661	665	PF00017	0.427
LIG_SH2_STAT5	311	314	PF00017	0.543
LIG_SH2_STAT5	405	408	PF00017	0.379
LIG_SH2_STAT5	425	428	PF00017	0.373
LIG_SH2_STAT5	455	458	PF00017	0.306
LIG_SH2_STAT5	497	500	PF00017	0.304
LIG_SH2_STAT5	52	55	PF00017	0.504
LIG_SH3_3	233	239	PF00018	0.640
LIG_SH3_3	89	95	PF00018	0.509
LIG_SUMO_SIM_anti_2	459	467	PF11976	0.368
LIG_SUMO_SIM_anti_2	680	686	PF11976	0.598
LIG_SUMO_SIM_par_1	283	289	PF11976	0.556
LIG_SUMO_SIM_par_1	330	337	PF11976	0.650
LIG_SUMO_SIM_par_1	376	382	PF11976	0.348
LIG_SUMO_SIM_par_1	633	639	PF11976	0.370
LIG_TRAF2_1	128	131	PF00917	0.443
LIG_TRAF2_1	230	233	PF00917	0.670
LIG_TRAF2_1	428	431	PF00917	0.406
LIG_TYR_ITIM	589	594	PF00017	0.323
LIG_TYR_ITIM	7	12	PF00017	0.724
LIG_WRC_WIRS_1	614	619	PF05994	0.354
MOD_CDC14_SPxK_1	217	220	PF00782	0.721
MOD_CDK_SPK_2	214	219	PF00069	0.654
MOD_CDK_SPxK_1	214	220	PF00069	0.718
MOD_CK1_1	104	110	PF00069	0.448
MOD_CK1_1	13	19	PF00069	0.638
MOD_CK1_1	141	147	PF00069	0.657
MOD_CK1_1	2	8	PF00069	0.742
MOD_CK1_1	496	502	PF00069	0.486
MOD_CK1_1	61	67	PF00069	0.645
MOD_CK1_1	633	639	PF00069	0.458
MOD_CK2_1	125	131	PF00069	0.528
MOD_CK2_1	141	147	PF00069	0.610
MOD_CK2_1	153	159	PF00069	0.713
MOD_CK2_1	168	174	PF00069	0.548
MOD_CK2_1	283	289	PF00069	0.564
MOD_CK2_1	328	334	PF00069	0.618
MOD_CK2_1	424	430	PF00069	0.558
MOD_CK2_1	675	681	PF00069	0.375
MOD_GlcNHglycan	144	147	PF01048	0.718
MOD_GlcNHglycan	151	154	PF01048	0.690
MOD_GlcNHglycan	170	173	PF01048	0.551
MOD_GlcNHglycan	18	21	PF01048	0.711
MOD_GlcNHglycan	209	212	PF01048	0.509
MOD_GlcNHglycan	24	27	PF01048	0.632
MOD_GlcNHglycan	269	272	PF01048	0.521
MOD_GlcNHglycan	273	276	PF01048	0.588
MOD_GlcNHglycan	29	32	PF01048	0.578
MOD_GlcNHglycan	96	99	PF01048	0.560
MOD_GSK3_1	100	107	PF00069	0.486
MOD_GSK3_1	138	145	PF00069	0.699
MOD_GSK3_1	149	156	PF00069	0.677
MOD_GSK3_1	160	167	PF00069	0.595
MOD_GSK3_1	18	25	PF00069	0.648
MOD_GSK3_1	267	274	PF00069	0.487
MOD_GSK3_1	445	452	PF00069	0.437
MOD_GSK3_1	60	67	PF00069	0.578
MOD_GSK3_1	81	88	PF00069	0.526
MOD_N-GLC_1	532	537	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	101	106	PF00069	0.521
MOD_NEK2_1	140	145	PF00069	0.671
MOD_NEK2_1	406	411	PF00069	0.479
MOD_NEK2_1	445	450	PF00069	0.523
MOD_NEK2_1	569	574	PF00069	0.291
MOD_NEK2_1	620	625	PF00069	0.311
MOD_NEK2_1	71	76	PF00069	0.553
MOD_NEK2_2	283	288	PF00069	0.382
MOD_PIKK_1	173	179	PF00454	0.501
MOD_PIKK_1	195	201	PF00454	0.490
MOD_PIKK_1	547	553	PF00454	0.259
MOD_PIKK_1	71	77	PF00454	0.605
MOD_PKA_1	207	213	PF00069	0.634
MOD_PKA_1	219	225	PF00069	0.650
MOD_PKA_2	13	19	PF00069	0.669
MOD_PKA_2	141	147	PF00069	0.491
MOD_PKA_2	206	212	PF00069	0.590
MOD_PKA_2	27	33	PF00069	0.598
MOD_PKA_2	44	50	PF00069	0.693
MOD_Plk_1	164	170	PF00069	0.704
MOD_Plk_1	173	179	PF00069	0.508
MOD_Plk_1	329	335	PF00069	0.607
MOD_Plk_1	471	477	PF00069	0.404
MOD_Plk_1	58	64	PF00069	0.472
MOD_Plk_2-3	613	619	PF00069	0.346
MOD_Plk_4	104	110	PF00069	0.400
MOD_Plk_4	283	289	PF00069	0.372
MOD_Plk_4	297	303	PF00069	0.409
MOD_Plk_4	493	499	PF00069	0.379
MOD_Plk_4	569	575	PF00069	0.380
MOD_Plk_4	613	619	PF00069	0.346
MOD_Plk_4	81	87	PF00069	0.659
MOD_ProDKin_1	2	8	PF00069	0.708
MOD_ProDKin_1	214	220	PF00069	0.775
MOD_ProDKin_1	37	43	PF00069	0.727
MOD_ProDKin_1	557	563	PF00069	0.302
MOD_ProDKin_1	630	636	PF00069	0.459
MOD_ProDKin_1	648	654	PF00069	0.512
MOD_SUMO_rev_2	472	481	PF00179	0.468
TRG_DiLeu_BaEn_2	186	192	PF01217	0.494
TRG_DiLeu_BaEn_2	521	527	PF01217	0.245
TRG_DiLeu_BaEn_4	233	239	PF01217	0.555
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.508
TRG_ENDOCYTIC_2	591	594	PF00928	0.323
TRG_ENDOCYTIC_2	9	12	PF00928	0.722
TRG_ER_diArg_1	365	367	PF00400	0.348
TRG_ER_diArg_1	419	421	PF00400	0.459
TRG_ER_diArg_1	433	436	PF00400	0.417
TRG_ER_diArg_1	692	695	PF00400	0.349
TRG_NLS_MonoExtN_4	416	422	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZA9	Leptomonas seymouri	66%	99%
A0A1X0NU07	Trypanosomatidae	40%	94%
A0A3Q8I980	Leishmania donovani	92%	100%
A0A3R7NA24	Trypanosoma rangeli	40%	100%
A4H8A0	Leishmania braziliensis	78%	100%
A4HWM2	Leishmania infantum	92%	100%
C9ZXR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
Q4QF46	Leishmania major	89%	100%
V5B4P0	Trypanosoma cruzi	36%	100%