Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQC8_LEIMU

TriTrypDb:

LmxM.15.1345

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.507
CLV_C14_Caspase3-7	255	259	PF00656	0.572
CLV_NRD_NRD_1	65	67	PF00675	0.596
CLV_PCSK_KEX2_1	277	279	PF00082	0.538
CLV_PCSK_KEX2_1	65	67	PF00082	0.560
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.536
CLV_PCSK_SKI1_1	57	61	PF00082	0.592
CLV_PCSK_SKI1_1	65	69	PF00082	0.533
DEG_SCF_FBW7_1	154	161	PF00400	0.517
DEG_SPOP_SBC_1	165	169	PF00917	0.528
DEG_SPOP_SBC_1	183	187	PF00917	0.686
DOC_CKS1_1	14	19	PF01111	0.648
DOC_CYCLIN_RxL_1	62	72	PF00134	0.571
DOC_USP7_MATH_1	129	133	PF00917	0.638
DOC_USP7_MATH_1	152	156	PF00917	0.578
DOC_USP7_MATH_1	165	169	PF00917	0.636
DOC_USP7_MATH_1	175	179	PF00917	0.719
DOC_USP7_MATH_1	191	195	PF00917	0.529
DOC_USP7_MATH_1	70	74	PF00917	0.571
DOC_WW_Pin1_4	10	15	PF00397	0.539
DOC_WW_Pin1_4	118	123	PF00397	0.724
DOC_WW_Pin1_4	154	159	PF00397	0.542
DOC_WW_Pin1_4	185	190	PF00397	0.728
DOC_WW_Pin1_4	2	7	PF00397	0.815
DOC_WW_Pin1_4	280	285	PF00397	0.516
LIG_14-3-3_CanoR_1	37	41	PF00244	0.466
LIG_BRCT_BRCA1_1	286	290	PF00533	0.584
LIG_FHA_1	14	20	PF00498	0.720
LIG_FHA_1	201	207	PF00498	0.685
LIG_FHA_1	216	222	PF00498	0.532
LIG_FHA_1	62	68	PF00498	0.553
LIG_FHA_2	106	112	PF00498	0.695
LIG_Integrin_RGD_1	278	280	PF01839	0.688
LIG_MYND_1	118	122	PF01753	0.668
LIG_RPA_C_Fungi	48	60	PF08784	0.542
LIG_SH2_STAP1	286	290	PF00017	0.605
LIG_SH3_1	11	17	PF00018	0.609
LIG_SH3_3	11	17	PF00018	0.628
LIG_SH3_3	148	154	PF00018	0.619
LIG_SH3_3	190	196	PF00018	0.732
LIG_SH3_3	22	28	PF00018	0.631
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.520
LIG_SUMO_SIM_par_1	203	209	PF11976	0.535
LIG_TRAF2_1	211	214	PF00917	0.594
LIG_WW_2	17	20	PF00397	0.651
LIG_WW_3	195	199	PF00397	0.667
MOD_CDK_SPK_2	118	123	PF00069	0.599
MOD_CDK_SPxxK_3	2	9	PF00069	0.676
MOD_CK1_1	116	122	PF00069	0.733
MOD_CK1_1	13	19	PF00069	0.628
MOD_CK1_1	178	184	PF00069	0.685
MOD_CK1_1	185	191	PF00069	0.621
MOD_CK1_1	230	236	PF00069	0.570
MOD_CK1_1	294	300	PF00069	0.590
MOD_CK1_1	73	79	PF00069	0.516
MOD_CK2_1	139	145	PF00069	0.548
MOD_CK2_1	208	214	PF00069	0.598
MOD_CK2_1	222	228	PF00069	0.449
MOD_Cter_Amidation	169	172	PF01082	0.581
MOD_Cter_Amidation	275	278	PF01082	0.539
MOD_GlcNHglycan	115	118	PF01048	0.701
MOD_GlcNHglycan	130	134	PF01048	0.582
MOD_GlcNHglycan	141	144	PF01048	0.485
MOD_GlcNHglycan	177	180	PF01048	0.650
MOD_GlcNHglycan	198	201	PF01048	0.635
MOD_GlcNHglycan	2	5	PF01048	0.743
MOD_GlcNHglycan	208	211	PF01048	0.629
MOD_GlcNHglycan	224	227	PF01048	0.562
MOD_GlcNHglycan	234	237	PF01048	0.639
MOD_GlcNHglycan	245	248	PF01048	0.565
MOD_GlcNHglycan	297	300	PF01048	0.772
MOD_GSK3_1	112	119	PF00069	0.742
MOD_GSK3_1	154	161	PF00069	0.745
MOD_GSK3_1	178	185	PF00069	0.773
MOD_GSK3_1	196	203	PF00069	0.481
MOD_GSK3_1	280	287	PF00069	0.629
MOD_GSK3_1	291	298	PF00069	0.730
MOD_NEK2_1	206	211	PF00069	0.558
MOD_NEK2_1	227	232	PF00069	0.582
MOD_NEK2_1	61	66	PF00069	0.539
MOD_PKA_2	165	171	PF00069	0.711
MOD_PKA_2	292	298	PF00069	0.560
MOD_PKA_2	36	42	PF00069	0.478
MOD_Plk_1	227	233	PF00069	0.518
MOD_Plk_1	87	93	PF00069	0.471
MOD_Plk_4	227	233	PF00069	0.525
MOD_ProDKin_1	10	16	PF00069	0.539
MOD_ProDKin_1	118	124	PF00069	0.725
MOD_ProDKin_1	154	160	PF00069	0.543
MOD_ProDKin_1	185	191	PF00069	0.728
MOD_ProDKin_1	2	8	PF00069	0.818
MOD_ProDKin_1	280	286	PF00069	0.517
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.602
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.399
TRG_ER_diArg_1	50	53	PF00400	0.509
TRG_ER_diArg_1	65	67	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC2	Leptomonas seymouri	40%	88%
A0A3Q8IDH2	Leishmania donovani	86%	100%
A4H899	Leishmania braziliensis	62%	100%
A4HWM1	Leishmania infantum	85%	100%
Q4QF47	Leishmania major	84%	100%