Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AQC3_LEIMU

TriTrypDb:

LmxM.15.1310

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0005886	plasma membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AQC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQC3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006811	monoatomic ion transport	4	7
GO:0006812	monoatomic cation transport	5	7
GO:0015693	magnesium ion transport	7	7
GO:0030001	metal ion transport	6	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0008324	monoatomic cation transmembrane transporter activity	4	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8
GO:0022890	inorganic cation transmembrane transporter activity	4	8
GO:0046873	metal ion transmembrane transporter activity	5	8
GO:0000287	magnesium ion binding	5	1
GO:0005488	binding	1	1
GO:0015087	cobalt ion transmembrane transporter activity	7	1
GO:0015095	magnesium ion transmembrane transporter activity	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1
GO:0050897	cobalt ion binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.546
CLV_NRD_NRD_1	144	146	PF00675	0.550
CLV_NRD_NRD_1	147	149	PF00675	0.545
CLV_NRD_NRD_1	442	444	PF00675	0.454
CLV_NRD_NRD_1	459	461	PF00675	0.585
CLV_NRD_NRD_1	660	662	PF00675	0.381
CLV_NRD_NRD_1	685	687	PF00675	0.308
CLV_PCSK_FUR_1	138	142	PF00082	0.559
CLV_PCSK_FUR_1	145	149	PF00082	0.609
CLV_PCSK_KEX2_1	135	137	PF00082	0.542
CLV_PCSK_KEX2_1	140	142	PF00082	0.546
CLV_PCSK_KEX2_1	143	145	PF00082	0.554
CLV_PCSK_KEX2_1	147	149	PF00082	0.545
CLV_PCSK_KEX2_1	442	444	PF00082	0.440
CLV_PCSK_KEX2_1	459	461	PF00082	0.436
CLV_PCSK_KEX2_1	582	584	PF00082	0.411
CLV_PCSK_KEX2_1	629	631	PF00082	0.341
CLV_PCSK_KEX2_1	644	646	PF00082	0.354
CLV_PCSK_KEX2_1	660	662	PF00082	0.338
CLV_PCSK_KEX2_1	685	687	PF00082	0.308
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.542
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.394
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.341
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.326
CLV_PCSK_PC7_1	136	142	PF00082	0.541
CLV_PCSK_PC7_1	143	149	PF00082	0.557
CLV_PCSK_PC7_1	578	584	PF00082	0.381
CLV_PCSK_SKI1_1	308	312	PF00082	0.404
CLV_PCSK_SKI1_1	459	463	PF00082	0.532
CLV_PCSK_SKI1_1	492	496	PF00082	0.308
CLV_PCSK_SKI1_1	532	536	PF00082	0.294
CLV_PCSK_SKI1_1	630	634	PF00082	0.342
CLV_PCSK_SKI1_1	644	648	PF00082	0.354
CLV_PCSK_SKI1_1	660	664	PF00082	0.297
CLV_PCSK_SKI1_1	703	707	PF00082	0.333
CLV_PCSK_SKI1_1	738	742	PF00082	0.284
DEG_MDM2_SWIB_1	470	477	PF02201	0.544
DEG_SCF_FBW7_1	632	638	PF00400	0.647
DEG_SCF_TRCP1_1	121	126	PF00400	0.583
DOC_CDC14_PxL_1	235	243	PF14671	0.692
DOC_CKS1_1	35	40	PF01111	0.709
DOC_CKS1_1	632	637	PF01111	0.652
DOC_CKS1_1	765	770	PF01111	0.351
DOC_CYCLIN_RxL_1	655	667	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	765	771	PF00134	0.351
DOC_MAPK_MEF2A_6	551	558	PF00069	0.484
DOC_MAPK_MEF2A_6	559	566	PF00069	0.500
DOC_MAPK_MEF2A_6	738	747	PF00069	0.484
DOC_MAPK_NFAT4_5	738	746	PF00069	0.457
DOC_PP2B_LxvP_1	36	39	PF13499	0.646
DOC_PP2B_LxvP_1	512	515	PF13499	0.583
DOC_PP4_FxxP_1	35	38	PF00568	0.690
DOC_PP4_FxxP_1	41	44	PF00568	0.661
DOC_SPAK_OSR1_1	205	209	PF12202	0.698
DOC_USP7_MATH_1	185	189	PF00917	0.798
DOC_USP7_MATH_1	285	289	PF00917	0.714
DOC_USP7_MATH_1	313	317	PF00917	0.789
DOC_USP7_MATH_1	326	330	PF00917	0.676
DOC_USP7_MATH_1	407	411	PF00917	0.796
DOC_USP7_MATH_1	461	465	PF00917	0.687
DOC_USP7_MATH_1	635	639	PF00917	0.655
DOC_USP7_MATH_1	651	655	PF00917	0.636
DOC_USP7_UBL2_3	131	135	PF12436	0.741
DOC_USP7_UBL2_3	620	624	PF12436	0.551
DOC_USP7_UBL2_3	703	707	PF12436	0.541
DOC_WW_Pin1_4	20	25	PF00397	0.726
DOC_WW_Pin1_4	241	246	PF00397	0.697
DOC_WW_Pin1_4	311	316	PF00397	0.662
DOC_WW_Pin1_4	34	39	PF00397	0.737
DOC_WW_Pin1_4	412	417	PF00397	0.696
DOC_WW_Pin1_4	517	522	PF00397	0.559
DOC_WW_Pin1_4	631	636	PF00397	0.697
DOC_WW_Pin1_4	653	658	PF00397	0.546
DOC_WW_Pin1_4	666	671	PF00397	0.571
DOC_WW_Pin1_4	7	12	PF00397	0.722
DOC_WW_Pin1_4	764	769	PF00397	0.351
LIG_14-3-3_CanoR_1	154	164	PF00244	0.797
LIG_14-3-3_CanoR_1	408	412	PF00244	0.741
LIG_14-3-3_CanoR_1	460	466	PF00244	0.738
LIG_14-3-3_CanoR_1	532	540	PF00244	0.578
LIG_14-3-3_CanoR_1	630	635	PF00244	0.541
LIG_14-3-3_CanoR_1	751	759	PF00244	0.541
LIG_14-3-3_CanoR_1	761	765	PF00244	0.292
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	202	206	PF00533	0.672
LIG_BRCT_BRCA1_1	428	432	PF00533	0.702
LIG_BRCT_BRCA1_1	462	466	PF00533	0.655
LIG_CORNRBOX	596	604	PF00104	0.526
LIG_deltaCOP1_diTrp_1	786	796	PF00928	0.290
LIG_FHA_1	171	177	PF00498	0.709
LIG_FHA_1	285	291	PF00498	0.685
LIG_FHA_1	509	515	PF00498	0.707
LIG_FHA_1	533	539	PF00498	0.544
LIG_FHA_1	604	610	PF00498	0.571
LIG_FHA_1	613	619	PF00498	0.494
LIG_FHA_1	632	638	PF00498	0.643
LIG_FHA_1	695	701	PF00498	0.457
LIG_FHA_1	750	756	PF00498	0.521
LIG_FHA_2	106	112	PF00498	0.595
LIG_FHA_2	172	178	PF00498	0.707
LIG_FHA_2	20	26	PF00498	0.726
LIG_FHA_2	215	221	PF00498	0.696
LIG_FHA_2	436	442	PF00498	0.716
LIG_FHA_2	476	482	PF00498	0.560
LIG_FHA_2	631	637	PF00498	0.634
LIG_IRF3_LxIS_1	740	746	PF10401	0.457
LIG_LIR_Apic_2	32	38	PF02991	0.691
LIG_LIR_Apic_2	40	44	PF02991	0.645
LIG_LIR_Gen_1	203	214	PF02991	0.683
LIG_LIR_Gen_1	549	558	PF02991	0.484
LIG_LIR_Gen_1	591	600	PF02991	0.495
LIG_LIR_Gen_1	790	801	PF02991	0.241
LIG_LIR_Nem_3	203	209	PF02991	0.703
LIG_LIR_Nem_3	212	218	PF02991	0.712
LIG_LIR_Nem_3	467	473	PF02991	0.599
LIG_LIR_Nem_3	549	555	PF02991	0.482
LIG_LIR_Nem_3	579	584	PF02991	0.546
LIG_LIR_Nem_3	591	595	PF02991	0.484
LIG_LIR_Nem_3	763	769	PF02991	0.298
LIG_LIR_Nem_3	790	796	PF02991	0.300
LIG_MLH1_MIPbox_1	462	466	PF16413	0.655
LIG_NRBOX	658	664	PF00104	0.535
LIG_Pex14_1	789	793	PF04695	0.257
LIG_Pex14_2	466	470	PF04695	0.584
LIG_Pex14_2	780	784	PF04695	0.300
LIG_SH2_CRK	277	281	PF00017	0.601
LIG_SH2_GRB2like	368	371	PF00017	0.513
LIG_SH2_NCK_1	235	239	PF00017	0.688
LIG_SH2_STAP1	605	609	PF00017	0.547
LIG_SH2_STAP1	793	797	PF00017	0.305
LIG_SH2_STAT3	465	468	PF00017	0.608
LIG_SH2_STAT5	267	270	PF00017	0.653
LIG_SH2_STAT5	368	371	PF00017	0.513
LIG_SH2_STAT5	465	468	PF00017	0.608
LIG_SH2_STAT5	493	496	PF00017	0.565
LIG_SH2_STAT5	527	530	PF00017	0.553
LIG_SH2_STAT5	605	608	PF00017	0.540
LIG_SH2_STAT5	641	644	PF00017	0.576
LIG_SH3_1	413	419	PF00018	0.616
LIG_SH3_3	239	245	PF00018	0.688
LIG_SH3_3	401	407	PF00018	0.711
LIG_SH3_3	408	414	PF00018	0.777
LIG_SH3_3	52	58	PF00018	0.820
LIG_SH3_3	629	635	PF00018	0.638
LIG_SH3_3	64	70	PF00018	0.804
LIG_SUMO_SIM_par_1	552	557	PF11976	0.481
LIG_SUMO_SIM_par_1	87	94	PF11976	0.752
LIG_TRAF2_1	108	111	PF00917	0.604
LIG_TRAF2_1	221	224	PF00917	0.735
LIG_TRAF2_1	438	441	PF00917	0.682
LIG_TRAF2_1	444	447	PF00917	0.656
LIG_TRAF2_1	591	594	PF00917	0.497
LIG_UBA3_1	300	308	PF00899	0.491
LIG_WRC_WIRS_1	747	752	PF05994	0.292
LIG_WW_3	57	61	PF00397	0.609
MOD_CDC14_SPxK_1	23	26	PF00782	0.562
MOD_CDK_SPxK_1	20	26	PF00069	0.569
MOD_CDK_SPxxK_3	653	660	PF00069	0.513
MOD_CDK_SPxxK_3	666	673	PF00069	0.488
MOD_CK1_1	122	128	PF00069	0.569
MOD_CK1_1	134	140	PF00069	0.607
MOD_CK1_1	146	152	PF00069	0.838
MOD_CK1_1	153	159	PF00069	0.662
MOD_CK1_1	170	176	PF00069	0.626
MOD_CK1_1	186	192	PF00069	0.708
MOD_CK1_1	193	199	PF00069	0.773
MOD_CK1_1	200	206	PF00069	0.642
MOD_CK1_1	3	9	PF00069	0.668
MOD_CK1_1	45	51	PF00069	0.700
MOD_CK1_1	454	460	PF00069	0.640
MOD_CK1_1	541	547	PF00069	0.462
MOD_CK1_1	588	594	PF00069	0.406
MOD_CK1_1	653	659	PF00069	0.406
MOD_CK1_1	746	752	PF00069	0.292
MOD_CK2_1	105	111	PF00069	0.495
MOD_CK2_1	412	418	PF00069	0.619
MOD_CK2_1	435	441	PF00069	0.659
MOD_CK2_1	461	467	PF00069	0.581
MOD_CK2_1	541	547	PF00069	0.444
MOD_CK2_1	588	594	PF00069	0.365
MOD_CK2_1	719	725	PF00069	0.373
MOD_Cter_Amidation	138	141	PF01082	0.766
MOD_GlcNHglycan	121	124	PF01048	0.706
MOD_GlcNHglycan	125	128	PF01048	0.616
MOD_GlcNHglycan	179	182	PF01048	0.655
MOD_GlcNHglycan	291	294	PF01048	0.661
MOD_GlcNHglycan	315	318	PF01048	0.694
MOD_GlcNHglycan	32	35	PF01048	0.593
MOD_GlcNHglycan	374	377	PF01048	0.520
MOD_GlcNHglycan	44	47	PF01048	0.613
MOD_GSK3_1	119	126	PF00069	0.569
MOD_GSK3_1	146	153	PF00069	0.730
MOD_GSK3_1	155	162	PF00069	0.673
MOD_GSK3_1	167	174	PF00069	0.590
MOD_GSK3_1	175	182	PF00069	0.571
MOD_GSK3_1	183	190	PF00069	0.706
MOD_GSK3_1	191	198	PF00069	0.789
MOD_GSK3_1	241	248	PF00069	0.655
MOD_GSK3_1	25	32	PF00069	0.645
MOD_GSK3_1	285	292	PF00069	0.656
MOD_GSK3_1	3	10	PF00069	0.577
MOD_GSK3_1	304	311	PF00069	0.657
MOD_GSK3_1	368	375	PF00069	0.456
MOD_GSK3_1	446	453	PF00069	0.593
MOD_GSK3_1	45	52	PF00069	0.682
MOD_GSK3_1	475	482	PF00069	0.272
MOD_GSK3_1	603	610	PF00069	0.366
MOD_GSK3_1	631	638	PF00069	0.581
MOD_GSK3_1	746	753	PF00069	0.444
MOD_GSK3_1	760	767	PF00069	0.255
MOD_N-GLC_1	3	8	PF02516	0.668
MOD_N-GLC_1	487	492	PF02516	0.431
MOD_N-GLC_1	588	593	PF02516	0.430
MOD_N-GLC_1	694	699	PF02516	0.381
MOD_NEK2_1	30	35	PF00069	0.623
MOD_NEK2_1	384	389	PF00069	0.552
MOD_NEK2_1	448	453	PF00069	0.647
MOD_NEK2_1	466	471	PF00069	0.591
MOD_NEK2_1	50	55	PF00069	0.651
MOD_NEK2_1	500	505	PF00069	0.434
MOD_NEK2_1	546	551	PF00069	0.351
MOD_NEK2_1	650	655	PF00069	0.412
MOD_NEK2_1	719	724	PF00069	0.494
MOD_NEK2_1	743	748	PF00069	0.326
MOD_NEK2_2	487	492	PF00069	0.431
MOD_NEK2_2	635	640	PF00069	0.360
MOD_PIKK_1	384	390	PF00454	0.549
MOD_PIKK_1	397	403	PF00454	0.514
MOD_PIKK_1	426	432	PF00454	0.635
MOD_PIKK_1	576	582	PF00454	0.407
MOD_PIKK_1	694	700	PF00454	0.292
MOD_PKA_1	143	149	PF00069	0.567
MOD_PKA_1	150	156	PF00069	0.543
MOD_PKA_2	143	149	PF00069	0.696
MOD_PKA_2	153	159	PF00069	0.743
MOD_PKA_2	162	168	PF00069	0.757
MOD_PKA_2	170	176	PF00069	0.628
MOD_PKA_2	183	189	PF00069	0.633
MOD_PKA_2	25	31	PF00069	0.625
MOD_PKA_2	407	413	PF00069	0.710
MOD_PKA_2	42	48	PF00069	0.543
MOD_PKA_2	426	432	PF00069	0.601
MOD_PKA_2	479	485	PF00069	0.325
MOD_PKA_2	684	690	PF00069	0.319
MOD_PKA_2	750	756	PF00069	0.409
MOD_PKA_2	760	766	PF00069	0.292
MOD_PKB_1	141	149	PF00069	0.619
MOD_PKB_1	169	177	PF00069	0.661
MOD_PKB_1	259	267	PF00069	0.500
MOD_Plk_1	17	23	PF00069	0.634
MOD_Plk_1	308	314	PF00069	0.497
MOD_Plk_1	435	441	PF00069	0.616
MOD_Plk_1	466	472	PF00069	0.468
MOD_Plk_1	487	493	PF00069	0.431
MOD_Plk_1	508	514	PF00069	0.494
MOD_Plk_1	541	547	PF00069	0.480
MOD_Plk_1	588	594	PF00069	0.365
MOD_Plk_1	785	791	PF00069	0.312
MOD_Plk_4	296	302	PF00069	0.478
MOD_Plk_4	461	467	PF00069	0.566
MOD_Plk_4	500	506	PF00069	0.386
MOD_Plk_4	508	514	PF00069	0.434
MOD_Plk_4	541	547	PF00069	0.427
MOD_Plk_4	736	742	PF00069	0.322
MOD_Plk_4	760	766	PF00069	0.310
MOD_Plk_4	767	773	PF00069	0.274
MOD_ProDKin_1	20	26	PF00069	0.669
MOD_ProDKin_1	241	247	PF00069	0.626
MOD_ProDKin_1	311	317	PF00069	0.579
MOD_ProDKin_1	34	40	PF00069	0.683
MOD_ProDKin_1	412	418	PF00069	0.627
MOD_ProDKin_1	517	523	PF00069	0.435
MOD_ProDKin_1	631	637	PF00069	0.626
MOD_ProDKin_1	653	659	PF00069	0.410
MOD_ProDKin_1	666	672	PF00069	0.446
MOD_ProDKin_1	7	13	PF00069	0.663
MOD_ProDKin_1	764	770	PF00069	0.351
MOD_SUMO_rev_2	619	626	PF00179	0.389
MOD_SUMO_rev_2	732	740	PF00179	0.292
TRG_DiLeu_BaEn_2	621	627	PF01217	0.451
TRG_DiLeu_BaEn_2	674	680	PF01217	0.460
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.452
TRG_ENDOCYTIC_2	277	280	PF00928	0.700
TRG_ENDOCYTIC_2	335	338	PF00928	0.535
TRG_ENDOCYTIC_2	793	796	PF00928	0.292
TRG_ER_diArg_1	138	141	PF00400	0.659
TRG_ER_diArg_1	143	145	PF00400	0.622
TRG_ER_diArg_1	147	150	PF00400	0.602
TRG_ER_diArg_1	161	164	PF00400	0.499
TRG_ER_diArg_1	659	661	PF00400	0.447
TRG_NLS_MonoExtN_4	133	139	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K4	Leptomonas seymouri	59%	97%
A0A3R7M2P8	Trypanosoma rangeli	41%	100%
A0A3S7WTL5	Leishmania donovani	90%	98%
A4H894	Leishmania braziliensis	73%	99%
A4HWL6	Leishmania infantum	89%	98%
Q4QF51	Leishmania major	89%	100%