Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQB9_LEIMU

TriTrypDb:

LmxM.15.1270

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.398
CLV_C14_Caspase3-7	295	299	PF00656	0.491
CLV_C14_Caspase3-7	448	452	PF00656	0.444
CLV_NRD_NRD_1	101	103	PF00675	0.422
CLV_NRD_NRD_1	120	122	PF00675	0.355
CLV_NRD_NRD_1	14	16	PF00675	0.677
CLV_NRD_NRD_1	338	340	PF00675	0.355
CLV_NRD_NRD_1	409	411	PF00675	0.515
CLV_NRD_NRD_1	506	508	PF00675	0.521
CLV_NRD_NRD_1	519	521	PF00675	0.593
CLV_NRD_NRD_1	535	537	PF00675	0.508
CLV_PCSK_KEX2_1	120	122	PF00082	0.434
CLV_PCSK_KEX2_1	14	16	PF00082	0.660
CLV_PCSK_KEX2_1	409	411	PF00082	0.558
CLV_PCSK_KEX2_1	506	508	PF00082	0.536
CLV_PCSK_KEX2_1	535	537	PF00082	0.543
CLV_PCSK_KEX2_1	75	77	PF00082	0.398
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.412
CLV_PCSK_PC7_1	531	537	PF00082	0.546
CLV_PCSK_SKI1_1	246	250	PF00082	0.368
CLV_PCSK_SKI1_1	324	328	PF00082	0.538
CLV_PCSK_SKI1_1	340	344	PF00082	0.295
CLV_PCSK_SKI1_1	345	349	PF00082	0.339
CLV_PCSK_SKI1_1	352	356	PF00082	0.386
CLV_PCSK_SKI1_1	410	414	PF00082	0.533
CLV_PCSK_SKI1_1	480	484	PF00082	0.707
DEG_APCC_DBOX_1	154	162	PF00400	0.416
DEG_APCC_DBOX_1	344	352	PF00400	0.343
DEG_APCC_DBOX_1	505	513	PF00400	0.494
DEG_SPOP_SBC_1	2	6	PF00917	0.694
DOC_CYCLIN_RxL_1	349	360	PF00134	0.369
DOC_CYCLIN_yClb1_LxF_4	220	226	PF00134	0.358
DOC_MAPK_DCC_7	506	514	PF00069	0.495
DOC_MAPK_FxFP_2	365	368	PF00069	0.524
DOC_MAPK_gen_1	102	110	PF00069	0.499
DOC_MAPK_gen_1	14	20	PF00069	0.520
DOC_MAPK_gen_1	506	514	PF00069	0.495
DOC_MAPK_MEF2A_6	397	405	PF00069	0.609
DOC_PP2B_LxvP_1	354	357	PF13499	0.379
DOC_PP2B_LxvP_1	52	55	PF13499	0.530
DOC_PP4_FxxP_1	365	368	PF00568	0.524
DOC_PP4_FxxP_1	80	83	PF00568	0.440
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_USP7_MATH_1	267	271	PF00917	0.518
DOC_USP7_MATH_1	296	300	PF00917	0.737
DOC_USP7_MATH_2	492	498	PF00917	0.497
DOC_USP7_MATH_2	57	63	PF00917	0.460
DOC_USP7_UBL2_3	327	331	PF12436	0.450
DOC_USP7_UBL2_3	467	471	PF12436	0.632
DOC_WW_Pin1_4	254	259	PF00397	0.429
DOC_WW_Pin1_4	488	493	PF00397	0.774
DOC_WW_Pin1_4	8	13	PF00397	0.526
LIG_14-3-3_CanoR_1	23	32	PF00244	0.547
LIG_14-3-3_CanoR_1	339	347	PF00244	0.466
LIG_Actin_WH2_2	400	415	PF00022	0.408
LIG_Clathr_ClatBox_1	162	166	PF01394	0.325
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.529
LIG_deltaCOP1_diTrp_1	399	405	PF00928	0.490
LIG_FHA_1	20	26	PF00498	0.720
LIG_FHA_1	339	345	PF00498	0.298
LIG_FHA_2	128	134	PF00498	0.394
LIG_FHA_2	232	238	PF00498	0.293
LIG_FHA_2	371	377	PF00498	0.515
LIG_GBD_Chelix_1	383	391	PF00786	0.367
LIG_LIR_Gen_1	109	119	PF02991	0.400
LIG_LIR_Gen_1	141	150	PF02991	0.679
LIG_LIR_Gen_1	156	165	PF02991	0.233
LIG_LIR_Gen_1	218	226	PF02991	0.350
LIG_LIR_Gen_1	399	407	PF02991	0.436
LIG_LIR_Nem_3	109	115	PF02991	0.532
LIG_LIR_Nem_3	141	146	PF02991	0.512
LIG_LIR_Nem_3	156	162	PF02991	0.243
LIG_LIR_Nem_3	218	222	PF02991	0.370
LIG_LIR_Nem_3	399	405	PF02991	0.425
LIG_NRBOX	350	356	PF00104	0.469
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.421
LIG_Pex14_2	207	211	PF04695	0.558
LIG_SH2_CRK	112	116	PF00017	0.475
LIG_SH2_CRK	143	147	PF00017	0.452
LIG_SH2_CRK	159	163	PF00017	0.306
LIG_SH2_CRK	219	223	PF00017	0.377
LIG_SH2_GRB2like	219	222	PF00017	0.387
LIG_SH2_GRB2like	276	279	PF00017	0.501
LIG_SH2_STAP1	112	116	PF00017	0.378
LIG_SH2_STAP1	159	163	PF00017	0.310
LIG_SH2_STAP1	219	223	PF00017	0.377
LIG_SH2_STAP1	276	280	PF00017	0.502
LIG_SH2_STAT3	443	446	PF00017	0.510
LIG_SH2_STAT5	180	183	PF00017	0.435
LIG_SH2_STAT5	242	245	PF00017	0.329
LIG_SH3_3	252	258	PF00018	0.417
LIG_SH3_3	421	427	PF00018	0.504
LIG_SH3_3	48	54	PF00018	0.654
LIG_SH3_3	496	502	PF00018	0.592
LIG_SH3_3	505	511	PF00018	0.542
LIG_SUMO_SIM_par_1	370	376	PF11976	0.390
LIG_SUMO_SIM_par_1	382	388	PF11976	0.378
LIG_TRAF2_1	332	335	PF00917	0.580
LIG_TRAF2_1	357	360	PF00917	0.459
LIG_TYR_ITIM	110	115	PF00017	0.543
LIG_WRC_WIRS_1	128	133	PF05994	0.564
MOD_CDC14_SPxK_1	11	14	PF00782	0.499
MOD_CDK_SPK_2	488	493	PF00069	0.494
MOD_CDK_SPxK_1	8	14	PF00069	0.524
MOD_CDK_SPxxK_3	8	15	PF00069	0.512
MOD_CK1_1	176	182	PF00069	0.501
MOD_CK1_1	270	276	PF00069	0.526
MOD_CK1_1	283	289	PF00069	0.490
MOD_CK1_1	290	296	PF00069	0.431
MOD_CK1_1	3	9	PF00069	0.780
MOD_CK1_1	338	344	PF00069	0.462
MOD_CK1_1	497	503	PF00069	0.737
MOD_CK2_1	127	133	PF00069	0.621
MOD_CK2_1	329	335	PF00069	0.625
MOD_CK2_1	370	376	PF00069	0.518
MOD_CK2_1	488	494	PF00069	0.571
MOD_GlcNHglycan	270	273	PF01048	0.515
MOD_GlcNHglycan	294	297	PF01048	0.729
MOD_GlcNHglycan	304	307	PF01048	0.716
MOD_GlcNHglycan	310	313	PF01048	0.622
MOD_GlcNHglycan	414	417	PF01048	0.444
MOD_GlcNHglycan	447	450	PF01048	0.542
MOD_GlcNHglycan	499	502	PF01048	0.752
MOD_GSK3_1	145	152	PF00069	0.535
MOD_GSK3_1	172	179	PF00069	0.531
MOD_GSK3_1	26	33	PF00069	0.733
MOD_GSK3_1	280	287	PF00069	0.566
MOD_GSK3_1	290	297	PF00069	0.696
MOD_GSK3_1	308	315	PF00069	0.557
MOD_GSK3_1	437	444	PF00069	0.676
MOD_GSK3_1	55	62	PF00069	0.552
MOD_N-GLC_1	30	35	PF02516	0.512
MOD_NEK2_1	110	115	PF00069	0.410
MOD_NEK2_1	280	285	PF00069	0.497
MOD_NEK2_1	291	296	PF00069	0.485
MOD_NEK2_1	412	417	PF00069	0.690
MOD_NEK2_1	442	447	PF00069	0.528
MOD_PIKK_1	110	116	PF00454	0.393
MOD_PIKK_1	442	448	PF00454	0.681
MOD_PK_1	535	541	PF00069	0.491
MOD_PKA_1	535	541	PF00069	0.491
MOD_PKA_2	176	182	PF00069	0.369
MOD_PKA_2	338	344	PF00069	0.532
MOD_PKA_2	36	42	PF00069	0.745
MOD_PKA_2	535	541	PF00069	0.491
MOD_PKB_1	35	43	PF00069	0.483
MOD_Plk_4	127	133	PF00069	0.497
MOD_Plk_4	176	182	PF00069	0.406
MOD_Plk_4	231	237	PF00069	0.306
MOD_Plk_4	3	9	PF00069	0.547
MOD_Plk_4	64	70	PF00069	0.650
MOD_ProDKin_1	254	260	PF00069	0.435
MOD_ProDKin_1	488	494	PF00069	0.776
MOD_ProDKin_1	8	14	PF00069	0.524
MOD_SUMO_for_1	163	166	PF00179	0.373
TRG_ENDOCYTIC_2	112	115	PF00928	0.376
TRG_ENDOCYTIC_2	143	146	PF00928	0.638
TRG_ENDOCYTIC_2	159	162	PF00928	0.321
TRG_ENDOCYTIC_2	219	222	PF00928	0.386
TRG_ENDOCYTIC_2	432	435	PF00928	0.521
TRG_ENDOCYTIC_2	66	69	PF00928	0.574
TRG_ER_diArg_1	119	121	PF00400	0.397
TRG_ER_diArg_1	13	15	PF00400	0.679
TRG_ER_diArg_1	35	38	PF00400	0.764
TRG_ER_diArg_1	506	508	PF00400	0.798
TRG_NES_CRM1_1	346	360	PF08389	0.355
TRG_NLS_MonoExtC_3	459	464	PF00514	0.456
TRG_NLS_MonoExtN_4	409	414	PF00514	0.428
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	23%	97%
A0A0N1ILX4	Leptomonas seymouri	58%	100%
A0A0S4JKE9	Bodo saltans	50%	100%
A0A1X0NTZ8	Trypanosomatidae	55%	100%
A0A3Q8IAB6	Leishmania donovani	91%	100%
A0A3S5IRP3	Trypanosoma rangeli	54%	100%
A0A3S7X2J5	Leishmania donovani	25%	100%
A4H889	Leishmania braziliensis	84%	100%
A4HHF5	Leishmania braziliensis	25%	100%
A4HWL2	Leishmania infantum	92%	100%
A4I4K3	Leishmania infantum	25%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AE02	Leishmania major	25%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QF55	Leishmania major	88%	100%
V5B4N1	Trypanosoma cruzi	55%	100%
V5D9T1	Trypanosoma cruzi	24%	100%