SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQB8_LEIMU

TriTrypDb:

LmxM.15.1260

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.283
CLV_NRD_NRD_1	242	244	PF00675	0.283
CLV_NRD_NRD_1	245	247	PF00675	0.283
CLV_NRD_NRD_1	3	5	PF00675	0.663
CLV_NRD_NRD_1	359	361	PF00675	0.636
CLV_PCSK_FUR_1	239	243	PF00082	0.332
CLV_PCSK_KEX2_1	238	240	PF00082	0.285
CLV_PCSK_KEX2_1	241	243	PF00082	0.281
CLV_PCSK_KEX2_1	245	247	PF00082	0.279
CLV_PCSK_KEX2_1	3	5	PF00082	0.661
CLV_PCSK_KEX2_1	359	361	PF00082	0.534
CLV_PCSK_PC7_1	238	244	PF00082	0.334
CLV_PCSK_SKI1_1	216	220	PF00082	0.402
CLV_PCSK_SKI1_1	295	299	PF00082	0.386
CLV_PCSK_SKI1_1	344	348	PF00082	0.710
CLV_PCSK_SKI1_1	360	364	PF00082	0.471
CLV_PCSK_SKI1_1	52	56	PF00082	0.402
CLV_PCSK_SKI1_1	77	81	PF00082	0.402
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DEG_SCF_FBW7_1	125	132	PF00400	0.285
DEG_SCF_FBW7_1	65	72	PF00400	0.272
DOC_CYCLIN_RxL_1	47	59	PF00134	0.469
DOC_MAPK_DCC_7	87	96	PF00069	0.522
DOC_MAPK_gen_1	189	195	PF00069	0.491
DOC_MAPK_HePTP_8	84	96	PF00069	0.519
DOC_MAPK_MEF2A_6	87	96	PF00069	0.522
DOC_USP7_MATH_1	175	179	PF00917	0.538
DOC_USP7_MATH_1	384	388	PF00917	0.714
DOC_USP7_MATH_1	394	398	PF00917	0.659
DOC_WW_Pin1_4	125	130	PF00397	0.502
DOC_WW_Pin1_4	149	154	PF00397	0.508
DOC_WW_Pin1_4	385	390	PF00397	0.793
DOC_WW_Pin1_4	59	64	PF00397	0.549
DOC_WW_Pin1_4	65	70	PF00397	0.502
LIG_14-3-3_CanoR_1	133	140	PF00244	0.576
LIG_14-3-3_CanoR_1	181	185	PF00244	0.455
LIG_14-3-3_CanoR_1	313	320	PF00244	0.477
LIG_14-3-3_CanoR_1	348	355	PF00244	0.598
LIG_14-3-3_CanoR_1	47	55	PF00244	0.435
LIG_14-3-3_CanoR_1	77	82	PF00244	0.421
LIG_14-3-3_CterR_2	401	403	PF00244	0.508
LIG_Actin_WH2_2	233	250	PF00022	0.502
LIG_Actin_WH2_2	280	297	PF00022	0.554
LIG_APCC_ABBA_1	258	263	PF00400	0.562
LIG_APCC_ABBA_1	36	41	PF00400	0.449
LIG_BRCT_BRCA1_1	314	318	PF00533	0.506
LIG_BRCT_BRCA1_1	7	11	PF00533	0.664
LIG_BRCT_BRCA1_2	7	13	PF00533	0.642
LIG_CaM_IQ_9	208	223	PF13499	0.498
LIG_eIF4E_1	230	236	PF01652	0.564
LIG_FHA_1	126	132	PF00498	0.501
LIG_FHA_1	142	148	PF00498	0.435
LIG_FHA_1	213	219	PF00498	0.381
LIG_FHA_1	272	278	PF00498	0.594
LIG_FHA_1	59	65	PF00498	0.527
LIG_FHA_1	70	76	PF00498	0.306
LIG_FHA_2	102	108	PF00498	0.449
LIG_FHA_2	134	140	PF00498	0.431
LIG_FHA_2	291	297	PF00498	0.586
LIG_LIR_Gen_1	152	158	PF02991	0.488
LIG_LIR_Gen_1	183	191	PF02991	0.416
LIG_LIR_Gen_1	209	219	PF02991	0.481
LIG_LIR_Nem_3	166	172	PF02991	0.608
LIG_LIR_Nem_3	209	214	PF02991	0.387
LIG_LIR_Nem_3	8	14	PF02991	0.556
LIG_MLH1_MIPbox_1	7	11	PF16413	0.384
LIG_Pex14_2	163	167	PF04695	0.463
LIG_Pex14_2	318	322	PF04695	0.398
LIG_PTB_Apo_2	200	207	PF02174	0.511
LIG_SH2_CRK	320	324	PF00017	0.408
LIG_SH2_GRB2like	230	233	PF00017	0.449
LIG_SH2_STAP1	154	158	PF00017	0.495
LIG_SH2_STAT5	10	13	PF00017	0.317
LIG_SH2_STAT5	116	119	PF00017	0.365
LIG_SH2_STAT5	261	264	PF00017	0.553
LIG_SH3_3	222	228	PF00018	0.255
LIG_SH3_5	226	230	PF00018	0.529
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.509
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.545
LIG_SUMO_SIM_par_1	326	332	PF11976	0.545
LIG_SUMO_SIM_par_1	76	82	PF11976	0.547
LIG_TRAF2_1	183	186	PF00917	0.470
LIG_TRAF2_1	299	302	PF00917	0.482
LIG_TYR_ITIM	259	264	PF00017	0.482
LIG_WW_1	227	230	PF00397	0.379
MOD_CDK_SPxxK_3	149	156	PF00069	0.507
MOD_CDK_SPxxK_3	385	392	PF00069	0.728
MOD_CK1_1	141	147	PF00069	0.584
MOD_CK1_1	59	65	PF00069	0.530
MOD_CK1_1	82	88	PF00069	0.442
MOD_CK2_1	101	107	PF00069	0.280
MOD_CK2_1	133	139	PF00069	0.585
MOD_CK2_1	180	186	PF00069	0.436
MOD_CK2_1	326	332	PF00069	0.541
MOD_GlcNHglycan	121	124	PF01048	0.366
MOD_GlcNHglycan	314	317	PF01048	0.509
MOD_GlcNHglycan	381	384	PF01048	0.688
MOD_GlcNHglycan	84	87	PF01048	0.306
MOD_GSK3_1	125	132	PF00069	0.462
MOD_GSK3_1	39	46	PF00069	0.554
MOD_GSK3_1	54	61	PF00069	0.443
MOD_GSK3_1	65	72	PF00069	0.356
MOD_GSK3_1	73	80	PF00069	0.201
MOD_N-GLC_1	141	146	PF02516	0.288
MOD_N-GLC_1	265	270	PF02516	0.335
MOD_N-GLC_1	271	276	PF02516	0.335
MOD_N-GLC_1	82	87	PF02516	0.268
MOD_NEK2_1	119	124	PF00069	0.361
MOD_NEK2_1	193	198	PF00069	0.434
MOD_NEK2_1	2	7	PF00069	0.603
MOD_NEK2_1	43	48	PF00069	0.539
MOD_NEK2_1	54	59	PF00069	0.392
MOD_NEK2_1	79	84	PF00069	0.536
MOD_NEK2_2	271	276	PF00069	0.394
MOD_PIKK_1	46	52	PF00454	0.472
MOD_PIKK_1	54	60	PF00454	0.431
MOD_PKA_2	180	186	PF00069	0.435
MOD_PKA_2	2	8	PF00069	0.675
MOD_PKA_2	212	218	PF00069	0.397
MOD_PKA_2	312	318	PF00069	0.528
MOD_PKA_2	46	52	PF00069	0.472
MOD_Plk_1	271	277	PF00069	0.478
MOD_Plk_1	39	45	PF00069	0.530
MOD_Plk_2-3	101	107	PF00069	0.280
MOD_Plk_2-3	326	332	PF00069	0.545
MOD_Plk_4	278	284	PF00069	0.405
MOD_Plk_4	39	45	PF00069	0.407
MOD_ProDKin_1	125	131	PF00069	0.508
MOD_ProDKin_1	149	155	PF00069	0.505
MOD_ProDKin_1	385	391	PF00069	0.793
MOD_ProDKin_1	59	65	PF00069	0.549
MOD_SUMO_for_1	206	209	PF00179	0.523
MOD_SUMO_for_1	349	352	PF00179	0.630
MOD_SUMO_rev_2	356	365	PF00179	0.653
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.390
TRG_ENDOCYTIC_2	116	119	PF00928	0.346
TRG_ENDOCYTIC_2	154	157	PF00928	0.489
TRG_ENDOCYTIC_2	184	187	PF00928	0.443
TRG_ENDOCYTIC_2	261	264	PF00928	0.434
TRG_ENDOCYTIC_2	320	323	PF00928	0.403
TRG_ER_diArg_1	2	4	PF00400	0.708
TRG_ER_diArg_1	237	239	PF00400	0.340
TRG_ER_diArg_1	240	243	PF00400	0.334
TRG_ER_diArg_1	244	246	PF00400	0.329
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL6	Leptomonas seymouri	68%	99%
A0A0S4JNX3	Bodo saltans	51%	99%
A0A1X0P9L0	Trypanosomatidae	59%	100%
A0A3S5H6V7	Leishmania donovani	91%	99%
A4H888	Leishmania braziliensis	86%	100%
A4HWL1	Leishmania infantum	91%	99%
C9ZMN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
Q4QF56	Leishmania major	93%	100%
V5BKH7	Trypanosoma cruzi	63%	100%