Putative nucleoside transporter 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside transporter 1, putative

Species:

Leishmania mexicana

UniProt:

E9AQB6_LEIMU

TriTrypDb:

LmxM.15.1240

Length:

491

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 48
NetGPI	no	yes: 0, no: 48

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	49
GO:0110165	cellular anatomical entity	1	49
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

E9AQB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQB6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015851	nucleobase transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	49
GO:0005337	nucleoside transmembrane transporter activity	4	49
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	49
GO:0022857	transmembrane transporter activity	2	49
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	49
GO:0015205	nucleobase transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.608
CLV_C14_Caspase3-7	295	299	PF00656	0.576
CLV_MEL_PAP_1	375	381	PF00089	0.291
CLV_NRD_NRD_1	103	105	PF00675	0.351
CLV_NRD_NRD_1	16	18	PF00675	0.406
CLV_PCSK_KEX2_1	103	105	PF00082	0.326
CLV_PCSK_KEX2_1	458	460	PF00082	0.257
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.257
CLV_PCSK_SKI1_1	153	157	PF00082	0.488
CLV_PCSK_SKI1_1	194	198	PF00082	0.598
CLV_PCSK_SKI1_1	328	332	PF00082	0.360
CLV_PCSK_SKI1_1	404	408	PF00082	0.348
DEG_Nend_UBRbox_2	1	3	PF02207	0.693
DOC_MAPK_DCC_7	404	413	PF00069	0.335
DOC_MAPK_FxFP_2	346	349	PF00069	0.390
DOC_MAPK_gen_1	108	117	PF00069	0.500
DOC_MAPK_gen_1	205	216	PF00069	0.346
DOC_MAPK_gen_1	389	398	PF00069	0.557
DOC_MAPK_MEF2A_6	110	119	PF00069	0.355
DOC_MAPK_MEF2A_6	209	218	PF00069	0.406
DOC_MAPK_MEF2A_6	360	369	PF00069	0.400
DOC_MAPK_MEF2A_6	378	385	PF00069	0.326
DOC_MAPK_MEF2A_6	404	413	PF00069	0.367
DOC_PP1_RVXF_1	326	333	PF00149	0.598
DOC_PP1_RVXF_1	402	408	PF00149	0.455
DOC_PP2B_PxIxI_1	348	354	PF00149	0.496
DOC_PP4_FxxP_1	346	349	PF00568	0.404
DOC_PP4_FxxP_1	385	388	PF00568	0.594
DOC_PP4_FxxP_1	48	51	PF00568	0.405
DOC_USP7_MATH_1	166	170	PF00917	0.549
DOC_USP7_MATH_1	244	248	PF00917	0.603
DOC_USP7_UBL2_3	205	209	PF12436	0.259
DOC_WW_Pin1_4	252	257	PF00397	0.460
DOC_WW_Pin1_4	293	298	PF00397	0.531
DOC_WW_Pin1_4	377	382	PF00397	0.407
LIG_14-3-3_CanoR_1	230	235	PF00244	0.518
LIG_14-3-3_CanoR_1	273	282	PF00244	0.437
LIG_14-3-3_CterR_2	488	491	PF00244	0.333
LIG_APCC_ABBA_1	353	358	PF00400	0.257
LIG_BIR_III_2	66	70	PF00653	0.302
LIG_BRCT_BRCA1_1	358	362	PF00533	0.398
LIG_BRCT_BRCA1_1	381	385	PF00533	0.503
LIG_deltaCOP1_diTrp_1	358	368	PF00928	0.257
LIG_FHA_1	139	145	PF00498	0.299
LIG_FHA_1	184	190	PF00498	0.352
LIG_FHA_1	342	348	PF00498	0.334
LIG_FHA_1	362	368	PF00498	0.374
LIG_FHA_1	482	488	PF00498	0.500
LIG_FHA_1	87	93	PF00498	0.351
LIG_FHA_2	1	7	PF00498	0.693
LIG_FHA_2	311	317	PF00498	0.530
LIG_GBD_Chelix_1	319	327	PF00786	0.366
LIG_LIR_Apic_2	344	349	PF02991	0.369
LIG_LIR_Apic_2	382	388	PF02991	0.594
LIG_LIR_Gen_1	222	231	PF02991	0.443
LIG_LIR_Gen_1	25	35	PF02991	0.481
LIG_LIR_Gen_1	321	330	PF02991	0.582
LIG_LIR_Gen_1	359	370	PF02991	0.355
LIG_LIR_Gen_1	401	410	PF02991	0.344
LIG_LIR_Gen_1	415	424	PF02991	0.419
LIG_LIR_Gen_1	72	82	PF02991	0.319
LIG_LIR_Nem_3	100	105	PF02991	0.436
LIG_LIR_Nem_3	158	164	PF02991	0.516
LIG_LIR_Nem_3	199	204	PF02991	0.323
LIG_LIR_Nem_3	208	214	PF02991	0.244
LIG_LIR_Nem_3	222	226	PF02991	0.371
LIG_LIR_Nem_3	25	31	PF02991	0.492
LIG_LIR_Nem_3	321	327	PF02991	0.542
LIG_LIR_Nem_3	359	365	PF02991	0.328
LIG_LIR_Nem_3	401	405	PF02991	0.383
LIG_LIR_Nem_3	415	419	PF02991	0.381
LIG_LIR_Nem_3	421	427	PF02991	0.341
LIG_LIR_Nem_3	56	60	PF02991	0.341
LIG_LIR_Nem_3	72	78	PF02991	0.320
LIG_LIR_Nem_3	80	85	PF02991	0.304
LIG_NRBOX	184	190	PF00104	0.305
LIG_Pex14_1	387	391	PF04695	0.598
LIG_Pex14_2	147	151	PF04695	0.488
LIG_Pex14_2	167	171	PF04695	0.463
LIG_SH2_CRK	416	420	PF00017	0.309
LIG_SH2_CRK	424	428	PF00017	0.305
LIG_SH2_CRK	82	86	PF00017	0.369
LIG_SH2_GRB2like	81	84	PF00017	0.320
LIG_SH2_NCK_1	82	86	PF00017	0.422
LIG_SH2_PTP2	28	31	PF00017	0.483
LIG_SH2_SRC	28	31	PF00017	0.444
LIG_SH2_SRC	418	421	PF00017	0.336
LIG_SH2_STAP1	20	24	PF00017	0.641
LIG_SH2_STAT3	60	63	PF00017	0.433
LIG_SH2_STAT5	238	241	PF00017	0.527
LIG_SH2_STAT5	28	31	PF00017	0.359
LIG_SH2_STAT5	418	421	PF00017	0.316
LIG_SH2_STAT5	426	429	PF00017	0.359
LIG_SH2_STAT5	438	441	PF00017	0.312
LIG_SH2_STAT5	53	56	PF00017	0.340
LIG_SH3_3	306	312	PF00018	0.584
LIG_SH3_3	442	448	PF00018	0.418
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.342
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.386
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.509
LIG_SUMO_SIM_par_1	115	121	PF11976	0.342
LIG_SUMO_SIM_par_1	409	415	PF11976	0.454
LIG_SUMO_SIM_par_1	478	484	PF11976	0.291
LIG_SUMO_SIM_par_1	94	100	PF11976	0.432
LIG_TRAF2_1	299	302	PF00917	0.579
LIG_TRAF2_1	420	423	PF00917	0.187
LIG_TYR_ITSM	78	85	PF00017	0.308
LIG_UBA3_1	188	194	PF00899	0.407
LIG_UBA3_1	323	331	PF00899	0.583
LIG_WRC_WIRS_1	220	225	PF05994	0.397
LIG_WRC_WIRS_1	231	236	PF05994	0.539
MOD_CDK_SPxxK_3	377	384	PF00069	0.291
MOD_CK1_1	169	175	PF00069	0.557
MOD_CK1_1	322	328	PF00069	0.541
MOD_CK1_1	481	487	PF00069	0.454
MOD_CK2_1	151	157	PF00069	0.409
MOD_CK2_1	20	26	PF00069	0.574
MOD_CK2_1	310	316	PF00069	0.539
MOD_Cter_Amidation	456	459	PF01082	0.257
MOD_GlcNHglycan	181	184	PF01048	0.345
MOD_GlcNHglycan	21	25	PF01048	0.331
MOD_GlcNHglycan	276	279	PF01048	0.357
MOD_GlcNHglycan	48	51	PF01048	0.567
MOD_GSK3_1	138	145	PF00069	0.375
MOD_GSK3_1	151	158	PF00069	0.250
MOD_GSK3_1	166	173	PF00069	0.444
MOD_GSK3_1	179	186	PF00069	0.328
MOD_GSK3_1	318	325	PF00069	0.569
MOD_GSK3_1	356	363	PF00069	0.351
MOD_GSK3_1	483	490	PF00069	0.564
MOD_N-GLC_1	273	278	PF02516	0.361
MOD_NEK2_1	151	156	PF00069	0.370
MOD_NEK2_1	171	176	PF00069	0.450
MOD_NEK2_1	318	323	PF00069	0.514
MOD_NEK2_1	341	346	PF00069	0.378
MOD_NEK2_1	412	417	PF00069	0.379
MOD_NEK2_1	432	437	PF00069	0.423
MOD_NEK2_1	466	471	PF00069	0.363
MOD_NEK2_1	483	488	PF00069	0.442
MOD_PIKK_1	481	487	PF00454	0.573
MOD_PKA_1	205	211	PF00069	0.257
MOD_PKA_2	130	136	PF00069	0.406
MOD_PKA_2	272	278	PF00069	0.431
MOD_Plk_1	156	162	PF00069	0.521
MOD_Plk_1	301	307	PF00069	0.617
MOD_Plk_4	151	157	PF00069	0.392
MOD_Plk_4	171	177	PF00069	0.470
MOD_Plk_4	184	190	PF00069	0.337
MOD_Plk_4	219	225	PF00069	0.362
MOD_Plk_4	319	325	PF00069	0.483
MOD_Plk_4	36	42	PF00069	0.362
MOD_Plk_4	461	467	PF00069	0.519
MOD_Plk_4	475	481	PF00069	0.305
MOD_Plk_4	53	59	PF00069	0.313
MOD_Plk_4	77	83	PF00069	0.314
MOD_Plk_4	87	93	PF00069	0.356
MOD_Plk_4	94	100	PF00069	0.311
MOD_ProDKin_1	252	258	PF00069	0.460
MOD_ProDKin_1	293	299	PF00069	0.531
MOD_ProDKin_1	377	383	PF00069	0.407
MOD_SUMO_for_1	292	295	PF00179	0.464
MOD_SUMO_rev_2	450	460	PF00179	0.457
TRG_DiLeu_BaEn_1	121	126	PF01217	0.368
TRG_DiLeu_BaEn_1	94	99	PF01217	0.291
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.389
TRG_ENDOCYTIC_2	161	164	PF00928	0.513
TRG_ENDOCYTIC_2	201	204	PF00928	0.324
TRG_ENDOCYTIC_2	211	214	PF00928	0.290
TRG_ENDOCYTIC_2	28	31	PF00928	0.356
TRG_ENDOCYTIC_2	416	419	PF00928	0.339
TRG_ENDOCYTIC_2	424	427	PF00928	0.325
TRG_ENDOCYTIC_2	81	84	PF00928	0.294
TRG_ER_diArg_1	102	104	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P486	Leptomonas seymouri	32%	100%
A0A0N0P6Z5	Leptomonas seymouri	29%	98%
A0A0N1I8E8	Leptomonas seymouri	24%	98%
A0A0N1PBQ1	Leptomonas seymouri	33%	97%
A0A0S4JBS4	Bodo saltans	30%	100%
A0A1X0NN91	Trypanosomatidae	35%	100%
A0A1X0NPL0	Trypanosomatidae	34%	100%
A0A1X0NV38	Trypanosomatidae	30%	100%
A0A1X0NWJ5	Trypanosomatidae	31%	100%
A0A3Q8ICX7	Leishmania donovani	33%	98%
A0A3R7NQR3	Trypanosoma rangeli	36%	100%
A0A3S7WTL0	Leishmania donovani	91%	100%
A0A3S7XAS5	Leishmania donovani	31%	98%
A0A422MQ08	Trypanosoma rangeli	30%	100%
A0A422N8M2	Trypanosoma rangeli	32%	100%
A0A422NHH9	Trypanosoma rangeli	30%	100%
A0A422NR81	Trypanosoma rangeli	50%	100%
A1A4N1	Bos taurus	21%	100%
A1L272	Danio rerio	24%	95%
A4H6I0	Leishmania braziliensis	29%	89%
A4H7A5	Leishmania braziliensis	33%	100%
A4HG96	Leishmania braziliensis	25%	98%
A4HP60	Leishmania braziliensis	30%	100%
A4HVP9	Leishmania infantum	33%	98%
A4HWK9	Leishmania infantum	91%	100%
A4IDG6	Leishmania infantum	31%	98%
C9ZJU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZJU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZJU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZKT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZN88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZY31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZZR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A6J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A6J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A6J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGM5	Leishmania infantum	90%	100%
E9AGM6	Leishmania infantum	91%	100%
E9AGM7	Leishmania infantum	91%	100%
E9ANK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9APE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AQB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ASW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
O54698	Rattus norvegicus	23%	100%
O54699	Rattus norvegicus	25%	100%
O76343	Leishmania donovani	92%	100%
Q14542	Homo sapiens	25%	100%
Q4Q1M9	Leishmania major	31%	100%
Q4QF58	Leishmania major	90%	100%
Q4QF59	Leishmania major	89%	100%
Q4QG33	Leishmania major	33%	100%
Q61672	Mus musculus	24%	100%
Q7RTT9	Homo sapiens	22%	93%
Q8R139	Mus musculus	26%	93%
Q8VXY7	Arabidopsis thaliana	22%	100%
Q99808	Homo sapiens	25%	100%
Q9JIM1	Mus musculus	24%	100%
V5BGB1	Trypanosoma cruzi	34%	100%
V5BRM5	Trypanosoma cruzi	30%	100%
V5DSF4	Trypanosoma cruzi	31%	100%