LeishMANIAdb
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Putative nucleoside transporter 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleoside transporter 1
Gene product:
nucleoside transporter 1, putative
Species:
Leishmania mexicana
UniProt:
E9AQB5_LEIMU
TriTrypDb:
LmxM.15.1230
Length:
491

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 47
NetGPI no yes: 0, no: 47
Cellular components
Term Name Level Count
GO:0016020 membrane 2 48
GO:0110165 cellular anatomical entity 1 48
GO:0005886 plasma membrane 3 4

Expansion

Sequence features

E9AQB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQB5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015851 nucleobase transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 48
GO:0005337 nucleoside transmembrane transporter activity 4 48
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 48
GO:0022857 transmembrane transporter activity 2 48
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 48
GO:0015205 nucleobase transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.606
CLV_C14_Caspase3-7 295 299 PF00656 0.570
CLV_MEL_PAP_1 375 381 PF00089 0.277
CLV_NRD_NRD_1 103 105 PF00675 0.336
CLV_NRD_NRD_1 16 18 PF00675 0.387
CLV_PCSK_KEX2_1 103 105 PF00082 0.315
CLV_PCSK_KEX2_1 458 460 PF00082 0.253
CLV_PCSK_PC1ET2_1 458 460 PF00082 0.253
CLV_PCSK_SKI1_1 153 157 PF00082 0.484
CLV_PCSK_SKI1_1 194 198 PF00082 0.595
CLV_PCSK_SKI1_1 328 332 PF00082 0.349
CLV_PCSK_SKI1_1 404 408 PF00082 0.353
DEG_Nend_UBRbox_2 1 3 PF02207 0.685
DOC_CYCLIN_yClb5_NLxxxL_5 79 88 PF00134 0.406
DOC_MAPK_DCC_7 404 413 PF00069 0.326
DOC_MAPK_FxFP_2 346 349 PF00069 0.376
DOC_MAPK_gen_1 108 117 PF00069 0.494
DOC_MAPK_gen_1 205 216 PF00069 0.354
DOC_MAPK_gen_1 389 398 PF00069 0.544
DOC_MAPK_HePTP_8 107 119 PF00069 0.514
DOC_MAPK_MEF2A_6 110 119 PF00069 0.345
DOC_MAPK_MEF2A_6 209 218 PF00069 0.409
DOC_MAPK_MEF2A_6 360 369 PF00069 0.396
DOC_MAPK_MEF2A_6 378 385 PF00069 0.454
DOC_MAPK_MEF2A_6 404 413 PF00069 0.352
DOC_PP1_RVXF_1 326 333 PF00149 0.595
DOC_PP1_RVXF_1 402 408 PF00149 0.470
DOC_PP2B_PxIxI_1 348 354 PF00149 0.493
DOC_PP4_FxxP_1 346 349 PF00568 0.392
DOC_PP4_FxxP_1 385 388 PF00568 0.599
DOC_PP4_FxxP_1 48 51 PF00568 0.396
DOC_USP7_MATH_1 166 170 PF00917 0.551
DOC_USP7_MATH_1 244 248 PF00917 0.600
DOC_USP7_UBL2_3 205 209 PF12436 0.255
DOC_WW_Pin1_4 252 257 PF00397 0.506
DOC_WW_Pin1_4 293 298 PF00397 0.522
DOC_WW_Pin1_4 377 382 PF00397 0.402
LIG_14-3-3_CanoR_1 230 235 PF00244 0.508
LIG_14-3-3_CanoR_1 273 282 PF00244 0.431
LIG_APCC_ABBA_1 353 358 PF00400 0.248
LIG_BIR_III_2 66 70 PF00653 0.293
LIG_BRCT_BRCA1_1 358 362 PF00533 0.395
LIG_BRCT_BRCA1_1 381 385 PF00533 0.500
LIG_deltaCOP1_diTrp_1 358 368 PF00928 0.248
LIG_FHA_1 184 190 PF00498 0.339
LIG_FHA_1 342 348 PF00498 0.325
LIG_FHA_1 362 368 PF00498 0.370
LIG_FHA_1 482 488 PF00498 0.493
LIG_FHA_2 1 7 PF00498 0.681
LIG_FHA_2 311 317 PF00498 0.523
LIG_FHA_2 484 490 PF00498 0.298
LIG_GBD_Chelix_1 319 327 PF00786 0.359
LIG_IRF3_LxIS_1 185 192 PF10401 0.436
LIG_LIR_Apic_2 344 349 PF02991 0.354
LIG_LIR_Apic_2 382 388 PF02991 0.598
LIG_LIR_Gen_1 222 231 PF02991 0.438
LIG_LIR_Gen_1 25 35 PF02991 0.486
LIG_LIR_Gen_1 321 330 PF02991 0.576
LIG_LIR_Gen_1 359 370 PF02991 0.347
LIG_LIR_Gen_1 401 410 PF02991 0.336
LIG_LIR_Gen_1 415 424 PF02991 0.407
LIG_LIR_Gen_1 72 82 PF02991 0.319
LIG_LIR_Nem_3 100 105 PF02991 0.432
LIG_LIR_Nem_3 158 164 PF02991 0.506
LIG_LIR_Nem_3 199 204 PF02991 0.313
LIG_LIR_Nem_3 208 214 PF02991 0.290
LIG_LIR_Nem_3 222 226 PF02991 0.370
LIG_LIR_Nem_3 25 31 PF02991 0.495
LIG_LIR_Nem_3 321 327 PF02991 0.540
LIG_LIR_Nem_3 359 365 PF02991 0.319
LIG_LIR_Nem_3 401 405 PF02991 0.363
LIG_LIR_Nem_3 415 419 PF02991 0.372
LIG_LIR_Nem_3 421 427 PF02991 0.345
LIG_LIR_Nem_3 56 60 PF02991 0.331
LIG_LIR_Nem_3 72 78 PF02991 0.340
LIG_LIR_Nem_3 80 85 PF02991 0.305
LIG_NRBOX 184 190 PF00104 0.289
LIG_Pex14_1 387 391 PF04695 0.595
LIG_Pex14_2 147 151 PF04695 0.483
LIG_Pex14_2 167 171 PF04695 0.472
LIG_SH2_CRK 416 420 PF00017 0.307
LIG_SH2_CRK 424 428 PF00017 0.303
LIG_SH2_CRK 82 86 PF00017 0.355
LIG_SH2_GRB2like 81 84 PF00017 0.306
LIG_SH2_NCK_1 82 86 PF00017 0.410
LIG_SH2_PTP2 28 31 PF00017 0.478
LIG_SH2_SRC 28 31 PF00017 0.433
LIG_SH2_SRC 418 421 PF00017 0.326
LIG_SH2_STAP1 20 24 PF00017 0.626
LIG_SH2_STAT3 60 63 PF00017 0.428
LIG_SH2_STAT5 238 241 PF00017 0.525
LIG_SH2_STAT5 28 31 PF00017 0.344
LIG_SH2_STAT5 418 421 PF00017 0.308
LIG_SH2_STAT5 426 429 PF00017 0.351
LIG_SH2_STAT5 438 441 PF00017 0.304
LIG_SH2_STAT5 53 56 PF00017 0.332
LIG_SH3_3 306 312 PF00018 0.581
LIG_SH3_3 442 448 PF00018 0.414
LIG_SUMO_SIM_anti_2 121 127 PF11976 0.328
LIG_SUMO_SIM_anti_2 478 484 PF11976 0.372
LIG_SUMO_SIM_anti_2 94 100 PF11976 0.507
LIG_SUMO_SIM_par_1 115 121 PF11976 0.334
LIG_SUMO_SIM_par_1 409 415 PF11976 0.485
LIG_SUMO_SIM_par_1 478 484 PF11976 0.277
LIG_SUMO_SIM_par_1 94 100 PF11976 0.421
LIG_TRAF2_1 299 302 PF00917 0.573
LIG_TRAF2_1 420 423 PF00917 0.187
LIG_TYR_ITSM 78 85 PF00017 0.295
LIG_UBA3_1 188 194 PF00899 0.394
LIG_UBA3_1 323 331 PF00899 0.578
LIG_WRC_WIRS_1 220 225 PF05994 0.383
LIG_WRC_WIRS_1 231 236 PF05994 0.530
MOD_CDK_SPxxK_3 377 384 PF00069 0.277
MOD_CK1_1 169 175 PF00069 0.553
MOD_CK1_1 322 328 PF00069 0.556
MOD_CK1_1 481 487 PF00069 0.457
MOD_CK2_1 151 157 PF00069 0.395
MOD_CK2_1 20 26 PF00069 0.557
MOD_CK2_1 310 316 PF00069 0.530
MOD_CK2_1 483 489 PF00069 0.557
MOD_Cter_Amidation 456 459 PF01082 0.252
MOD_GlcNHglycan 181 184 PF01048 0.341
MOD_GlcNHglycan 21 25 PF01048 0.322
MOD_GlcNHglycan 276 279 PF01048 0.400
MOD_GlcNHglycan 48 51 PF01048 0.565
MOD_GSK3_1 151 158 PF00069 0.246
MOD_GSK3_1 166 173 PF00069 0.435
MOD_GSK3_1 179 186 PF00069 0.315
MOD_GSK3_1 318 325 PF00069 0.566
MOD_GSK3_1 356 363 PF00069 0.342
MOD_N-GLC_1 273 278 PF02516 0.224
MOD_NEK2_1 151 156 PF00069 0.360
MOD_NEK2_1 171 176 PF00069 0.504
MOD_NEK2_1 189 194 PF00069 0.330
MOD_NEK2_1 318 323 PF00069 0.508
MOD_NEK2_1 341 346 PF00069 0.365
MOD_NEK2_1 412 417 PF00069 0.388
MOD_NEK2_1 432 437 PF00069 0.418
MOD_NEK2_1 466 471 PF00069 0.348
MOD_NEK2_1 483 488 PF00069 0.436
MOD_PIKK_1 481 487 PF00454 0.572
MOD_PKA_1 205 211 PF00069 0.248
MOD_PKA_2 130 136 PF00069 0.409
MOD_PKA_2 272 278 PF00069 0.431
MOD_Plk_1 156 162 PF00069 0.511
MOD_Plk_1 301 307 PF00069 0.620
MOD_Plk_4 143 149 PF00069 0.307
MOD_Plk_4 151 157 PF00069 0.383
MOD_Plk_4 171 177 PF00069 0.516
MOD_Plk_4 184 190 PF00069 0.343
MOD_Plk_4 219 225 PF00069 0.367
MOD_Plk_4 319 325 PF00069 0.479
MOD_Plk_4 36 42 PF00069 0.348
MOD_Plk_4 461 467 PF00069 0.514
MOD_Plk_4 475 481 PF00069 0.295
MOD_Plk_4 53 59 PF00069 0.304
MOD_Plk_4 77 83 PF00069 0.304
MOD_Plk_4 87 93 PF00069 0.342
MOD_Plk_4 94 100 PF00069 0.297
MOD_ProDKin_1 252 258 PF00069 0.506
MOD_ProDKin_1 293 299 PF00069 0.522
MOD_ProDKin_1 377 383 PF00069 0.402
MOD_SUMO_for_1 292 295 PF00179 0.453
MOD_SUMO_rev_2 450 460 PF00179 0.448
TRG_DiLeu_BaEn_1 121 126 PF01217 0.353
TRG_DiLeu_BaEn_1 94 99 PF01217 0.277
TRG_DiLeu_BaLyEn_6 406 411 PF01217 0.381
TRG_ENDOCYTIC_2 161 164 PF00928 0.504
TRG_ENDOCYTIC_2 201 204 PF00928 0.302
TRG_ENDOCYTIC_2 211 214 PF00928 0.310
TRG_ENDOCYTIC_2 28 31 PF00928 0.363
TRG_ENDOCYTIC_2 416 419 PF00928 0.340
TRG_ENDOCYTIC_2 424 427 PF00928 0.320
TRG_ENDOCYTIC_2 81 84 PF00928 0.304
TRG_ER_diArg_1 102 104 PF00400 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 31% 100%
A0A0N0P6Z5 Leptomonas seymouri 29% 98%
A0A0N1I8E8 Leptomonas seymouri 24% 98%
A0A0N1PBQ1 Leptomonas seymouri 32% 97%
A0A0S4JBS4 Bodo saltans 30% 100%
A0A1X0NN91 Trypanosomatidae 34% 100%
A0A1X0NPL0 Trypanosomatidae 34% 100%
A0A1X0NV38 Trypanosomatidae 29% 100%
A0A1X0NWJ5 Trypanosomatidae 30% 100%
A0A3Q8ICX7 Leishmania donovani 31% 98%
A0A3R7NQR3 Trypanosoma rangeli 35% 100%
A0A3S7WTL0 Leishmania donovani 90% 100%
A0A3S7XAS5 Leishmania donovani 31% 98%
A0A422MQ08 Trypanosoma rangeli 29% 100%
A0A422N8M2 Trypanosoma rangeli 31% 100%
A0A422NHH9 Trypanosoma rangeli 30% 100%
A0A422NR81 Trypanosoma rangeli 49% 100%
A1A4N1 Bos taurus 21% 100%
A1L272 Danio rerio 24% 95%
A4H6I0 Leishmania braziliensis 28% 89%
A4H7A5 Leishmania braziliensis 33% 100%
A4HG96 Leishmania braziliensis 25% 98%
A4HP60 Leishmania braziliensis 30% 100%
A4HVP9 Leishmania infantum 32% 98%
A4HWK9 Leishmania infantum 90% 100%
A4IDG6 Leishmania infantum 31% 98%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AGM5 Leishmania infantum 90% 100%
E9AGM6 Leishmania infantum 89% 100%
E9AGM7 Leishmania infantum 89% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 98%
O54698 Rattus norvegicus 24% 100%
O54699 Rattus norvegicus 25% 100%
O76343 Leishmania donovani 90% 100%
Q14542 Homo sapiens 26% 100%
Q4Q1M9 Leishmania major 31% 100%
Q4QF58 Leishmania major 88% 100%
Q4QF59 Leishmania major 88% 100%
Q4QG33 Leishmania major 32% 100%
Q61672 Mus musculus 25% 100%
Q7RTT9 Homo sapiens 23% 93%
Q80WK7 Rattus norvegicus 22% 100%
Q8R139 Mus musculus 26% 93%
Q8VXY7 Arabidopsis thaliana 22% 100%
Q99808 Homo sapiens 27% 100%
Q9JIM1 Mus musculus 25% 100%
V5BGB1 Trypanosoma cruzi 33% 100%
V5BRM5 Trypanosoma cruzi 30% 100%
V5DSF4 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS