TFIIB_C_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQA7_LEIMU

TriTrypDb:

LmxM.15.1170

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005634	nucleus	5	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1
GO:0097550	transcription preinitiation complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQA7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006383	transcription by RNA polymerase III	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0000992	RNA polymerase III cis-regulatory region sequence-specific DNA binding	7	1
GO:0000995	RNA polymerase III general transcription initiation factor activity	2	1
GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	8	1
GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140223	general transcription initiation factor activity	1	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.271
CLV_NRD_NRD_1	100	102	PF00675	0.461
CLV_NRD_NRD_1	141	143	PF00675	0.338
CLV_NRD_NRD_1	162	164	PF00675	0.246
CLV_NRD_NRD_1	209	211	PF00675	0.226
CLV_NRD_NRD_1	406	408	PF00675	0.717
CLV_PCSK_KEX2_1	100	102	PF00082	0.461
CLV_PCSK_KEX2_1	141	143	PF00082	0.319
CLV_PCSK_KEX2_1	162	164	PF00082	0.239
CLV_PCSK_KEX2_1	209	211	PF00082	0.226
CLV_PCSK_KEX2_1	408	410	PF00082	0.579
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.579
CLV_PCSK_SKI1_1	119	123	PF00082	0.425
CLV_PCSK_SKI1_1	53	57	PF00082	0.464
DOC_CKS1_1	354	359	PF01111	0.367
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.354
DOC_MAPK_gen_1	162	169	PF00069	0.354
DOC_MAPK_MEF2A_6	128	137	PF00069	0.414
DOC_MAPK_MEF2A_6	248	256	PF00069	0.349
DOC_MAPK_MEF2A_6	282	289	PF00069	0.267
DOC_PP1_RVXF_1	293	299	PF00149	0.386
DOC_PP2B_LxvP_1	242	245	PF13499	0.327
DOC_USP7_MATH_1	127	131	PF00917	0.328
DOC_USP7_MATH_1	17	21	PF00917	0.356
DOC_USP7_MATH_1	176	180	PF00917	0.248
DOC_USP7_MATH_1	269	273	PF00917	0.511
DOC_USP7_MATH_1	306	310	PF00917	0.502
DOC_USP7_MATH_1	370	374	PF00917	0.708
DOC_USP7_MATH_1	386	390	PF00917	0.728
DOC_USP7_MATH_1	81	85	PF00917	0.449
DOC_WW_Pin1_4	353	358	PF00397	0.467
DOC_WW_Pin1_4	413	418	PF00397	0.729
LIG_14-3-3_CanoR_1	128	136	PF00244	0.248
LIG_14-3-3_CanoR_1	314	318	PF00244	0.345
LIG_14-3-3_CanoR_1	411	417	PF00244	0.695
LIG_14-3-3_CanoR_1	78	86	PF00244	0.512
LIG_Actin_WH2_2	189	206	PF00022	0.310
LIG_Actin_WH2_2	281	299	PF00022	0.236
LIG_APCC_ABBA_1	274	279	PF00400	0.345
LIG_BIR_II_1	1	5	PF00653	0.375
LIG_BIR_III_3	1	5	PF00653	0.396
LIG_FHA_1	414	420	PF00498	0.655
LIG_FHA_2	1	7	PF00498	0.364
LIG_FHA_2	200	206	PF00498	0.407
LIG_FHA_2	364	370	PF00498	0.597
LIG_FHA_2	47	53	PF00498	0.460
LIG_FHA_2	54	60	PF00498	0.434
LIG_FHA_2	85	91	PF00498	0.580
LIG_LIR_Gen_1	316	325	PF02991	0.287
LIG_LIR_Gen_1	349	357	PF02991	0.459
LIG_LIR_Gen_1	54	61	PF02991	0.437
LIG_LIR_Nem_3	134	139	PF02991	0.248
LIG_LIR_Nem_3	316	321	PF02991	0.402
LIG_LIR_Nem_3	349	353	PF02991	0.439
LIG_LIR_Nem_3	54	60	PF02991	0.438
LIG_NRP_CendR_1	426	428	PF00754	0.504
LIG_PTAP_UEV_1	396	401	PF05743	0.553
LIG_REV1ctd_RIR_1	134	142	PF16727	0.248
LIG_SH2_NCK_1	57	61	PF00017	0.458
LIG_SH2_PTP2	238	241	PF00017	0.298
LIG_SH2_SRC	384	387	PF00017	0.546
LIG_SH2_SRC	57	60	PF00017	0.455
LIG_SH2_STAP1	318	322	PF00017	0.317
LIG_SH2_STAT5	14	17	PF00017	0.406
LIG_SH2_STAT5	238	241	PF00017	0.281
LIG_SH2_STAT5	7	10	PF00017	0.439
LIG_SH3_3	299	305	PF00018	0.553
LIG_SH3_3	394	400	PF00018	0.740
LIG_SH3_3	414	420	PF00018	0.472
LIG_TRAF2_1	87	90	PF00917	0.584
LIG_WRC_WIRS_1	318	323	PF05994	0.305
MOD_CK1_1	20	26	PF00069	0.389
MOD_CK1_1	313	319	PF00069	0.444
MOD_CK1_1	320	326	PF00069	0.426
MOD_CK1_1	395	401	PF00069	0.588
MOD_CK1_1	412	418	PF00069	0.538
MOD_CK1_1	422	428	PF00069	0.778
MOD_CK1_1	84	90	PF00069	0.476
MOD_CK2_1	363	369	PF00069	0.561
MOD_CK2_1	46	52	PF00069	0.566
MOD_CK2_1	84	90	PF00069	0.682
MOD_DYRK1A_RPxSP_1	413	417	PF00069	0.694
MOD_GlcNHglycan	106	109	PF01048	0.510
MOD_GlcNHglycan	129	132	PF01048	0.354
MOD_GlcNHglycan	307	311	PF01048	0.545
MOD_GlcNHglycan	323	326	PF01048	0.259
MOD_GlcNHglycan	388	391	PF01048	0.628
MOD_GlcNHglycan	394	397	PF01048	0.702
MOD_GlcNHglycan	422	425	PF01048	0.552
MOD_GlcNHglycan	83	86	PF01048	0.441
MOD_GSK3_1	306	313	PF00069	0.491
MOD_GSK3_1	316	323	PF00069	0.491
MOD_GSK3_1	391	398	PF00069	0.675
MOD_GSK3_1	407	414	PF00069	0.657
MOD_GSK3_1	77	84	PF00069	0.465
MOD_NEK2_1	114	119	PF00069	0.474
MOD_NEK2_1	137	142	PF00069	0.354
MOD_NEK2_1	199	204	PF00069	0.294
MOD_NEK2_1	214	219	PF00069	0.294
MOD_NEK2_1	317	322	PF00069	0.578
MOD_PKA_1	407	413	PF00069	0.680
MOD_PKA_2	127	133	PF00069	0.354
MOD_PKA_2	137	143	PF00069	0.354
MOD_PKA_2	313	319	PF00069	0.350
MOD_PKA_2	412	418	PF00069	0.673
MOD_PKA_2	77	83	PF00069	0.523
MOD_PKB_1	407	415	PF00069	0.588
MOD_Plk_1	53	59	PF00069	0.453
MOD_Plk_4	176	182	PF00069	0.248
MOD_Plk_4	313	319	PF00069	0.368
MOD_Plk_4	34	40	PF00069	0.472
MOD_ProDKin_1	353	359	PF00069	0.464
MOD_ProDKin_1	413	419	PF00069	0.728
MOD_SUMO_for_1	376	379	PF00179	0.637
MOD_SUMO_rev_2	379	383	PF00179	0.574
TRG_DiLeu_BaEn_1	349	354	PF01217	0.539
TRG_DiLeu_BaEn_2	272	278	PF01217	0.362
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.455
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.449
TRG_ENDOCYTIC_2	238	241	PF00928	0.404
TRG_ENDOCYTIC_2	318	321	PF00928	0.434
TRG_ENDOCYTIC_2	57	60	PF00928	0.455
TRG_ER_diArg_1	161	163	PF00400	0.229
TRG_ER_diArg_1	294	297	PF00400	0.338
TRG_ER_diArg_1	99	101	PF00400	0.451
TRG_NLS_MonoExtC_3	406	411	PF00514	0.607
TRG_NLS_MonoExtN_4	407	412	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I166	Leptomonas seymouri	68%	100%
A0A1X0NU06	Trypanosomatidae	37%	100%
A0A3R7MLE9	Trypanosoma rangeli	40%	100%
A0A3S5H6V5	Leishmania donovani	95%	100%
A4H880	Leishmania braziliensis	83%	100%
A4HWK6	Leishmania infantum	95%	100%
C9ZXT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QF67	Leishmania major	94%	100%
V5BK49	Trypanosoma cruzi	37%	100%