Putative developmentally regulated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

developmentally regulated protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQA5_LEIMU

TriTrypDb:

LmxM.15.1150

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AQA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.389
CLV_NRD_NRD_1	64	66	PF00675	0.551
CLV_NRD_NRD_1	68	70	PF00675	0.509
CLV_PCSK_KEX2_1	43	45	PF00082	0.389
CLV_PCSK_KEX2_1	64	66	PF00082	0.435
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.435
CLV_PCSK_PC7_1	39	45	PF00082	0.391
CLV_PCSK_SKI1_1	33	37	PF00082	0.395
CLV_PCSK_SKI1_1	52	56	PF00082	0.339
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DOC_CKS1_1	20	25	PF01111	0.599
DOC_CYCLIN_RxL_1	132	145	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.565
DOC_MAPK_gen_1	47	56	PF00069	0.560
DOC_MAPK_gen_1	75	84	PF00069	0.507
DOC_PP2B_LxvP_1	117	120	PF13499	0.472
DOC_PP4_FxxP_1	111	114	PF00568	0.542
DOC_USP7_UBL2_3	66	70	PF12436	0.759
DOC_WW_Pin1_4	16	21	PF00397	0.605
LIG_14-3-3_CanoR_1	52	57	PF00244	0.547
LIG_14-3-3_CanoR_1	78	83	PF00244	0.356
LIG_14-3-3_CterR_2	166	169	PF00244	0.459
LIG_BRCT_BRCA1_1	80	84	PF00533	0.356
LIG_MYND_1	115	119	PF01753	0.563
LIG_Pex14_2	84	88	PF04695	0.356
LIG_SH2_STAT5	98	101	PF00017	0.387
LIG_SH3_3	1	7	PF00018	0.565
LIG_SH3_3	113	119	PF00018	0.456
LIG_SH3_3	17	23	PF00018	0.595
LIG_SH3_3	53	59	PF00018	0.538
LIG_SH3_3	9	15	PF00018	0.572
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.518
LIG_SUMO_SIM_par_1	91	97	PF11976	0.518
LIG_WW_2	120	123	PF00397	0.564
LIG_WW_2	4	7	PF00397	0.557
MOD_CK1_1	19	25	PF00069	0.600
MOD_GlcNHglycan	152	155	PF01048	0.756
MOD_GSK3_1	100	107	PF00069	0.416
MOD_GSK3_1	122	129	PF00069	0.466
MOD_N-GLC_1	104	109	PF02516	0.616
MOD_NEK2_1	126	131	PF00069	0.469
MOD_NEK2_1	88	93	PF00069	0.355
MOD_PKA_2	100	106	PF00069	0.414
MOD_PKB_1	50	58	PF00069	0.548
MOD_Plk_4	52	58	PF00069	0.544
MOD_Plk_4	88	94	PF00069	0.355
MOD_ProDKin_1	16	22	PF00069	0.604
MOD_SUMO_rev_2	153	161	PF00179	0.590
TRG_ER_diArg_1	42	44	PF00400	0.591
TRG_ER_diArg_1	49	52	PF00400	0.559
TRG_NES_CRM1_1	133	145	PF08389	0.455
TRG_NLS_MonoExtN_4	66	73	PF00514	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY72	Leptomonas seymouri	69%	100%
A0A3Q8IA45	Leishmania donovani	97%	100%
A4H878	Leishmania braziliensis	86%	100%
A4HWK4	Leishmania infantum	97%	100%
E9AQA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QF77	Leishmania major	95%	100%