SKIP_SNW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKIP/SNW domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQA2_LEIMU

TriTrypDb:

LmxM.15.1030

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:1990904	ribonucleoprotein complex	2	8

Expansion

Sequence features

E9AQA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQA2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	8
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	8
GO:0000398	mRNA splicing, via spliceosome	8	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006397	mRNA processing	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008380	RNA splicing	7	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016071	mRNA metabolic process	6	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.775
CLV_C14_Caspase3-7	51	55	PF00656	0.790
CLV_NRD_NRD_1	137	139	PF00675	0.412
CLV_NRD_NRD_1	151	153	PF00675	0.311
CLV_NRD_NRD_1	212	214	PF00675	0.409
CLV_NRD_NRD_1	242	244	PF00675	0.598
CLV_NRD_NRD_1	352	354	PF00675	0.676
CLV_PCSK_KEX2_1	212	214	PF00082	0.409
CLV_PCSK_KEX2_1	242	244	PF00082	0.662
CLV_PCSK_KEX2_1	93	95	PF00082	0.706
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.706
CLV_PCSK_SKI1_1	226	230	PF00082	0.497
CLV_PCSK_SKI1_1	264	268	PF00082	0.590
CLV_PCSK_SKI1_1	275	279	PF00082	0.565
CLV_PCSK_SKI1_1	421	425	PF00082	0.680
CLV_PCSK_SKI1_1	72	76	PF00082	0.708
DEG_Nend_Nbox_1	1	3	PF02207	0.777
DEG_SPOP_SBC_1	108	112	PF00917	0.674
DOC_ANK_TNKS_1	169	176	PF00023	0.296
DOC_CYCLIN_RxL_1	223	230	PF00134	0.375
DOC_MAPK_gen_1	138	144	PF00069	0.404
DOC_MAPK_gen_1	152	159	PF00069	0.314
DOC_MAPK_gen_1	246	255	PF00069	0.556
DOC_MAPK_gen_1	273	282	PF00069	0.568
DOC_MAPK_HePTP_8	272	284	PF00069	0.566
DOC_MAPK_MEF2A_6	152	159	PF00069	0.379
DOC_MAPK_MEF2A_6	275	284	PF00069	0.567
DOC_PP2B_LxvP_1	155	158	PF13499	0.375
DOC_PP2B_LxvP_1	81	84	PF13499	0.515
DOC_PP4_FxxP_1	329	332	PF00568	0.550
DOC_USP7_MATH_1	109	113	PF00917	0.773
DOC_USP7_MATH_1	22	26	PF00917	0.607
DOC_USP7_MATH_1	310	314	PF00917	0.790
DOC_USP7_MATH_1	318	322	PF00917	0.700
DOC_USP7_MATH_1	46	50	PF00917	0.751
DOC_USP7_MATH_1	84	88	PF00917	0.626
DOC_USP7_MATH_2	83	89	PF00917	0.535
DOC_USP7_UBL2_3	202	206	PF12436	0.428
DOC_USP7_UBL2_3	421	425	PF12436	0.680
DOC_WW_Pin1_4	63	68	PF00397	0.667
LIG_14-3-3_CanoR_1	10	16	PF00244	0.751
LIG_14-3-3_CanoR_1	26	34	PF00244	0.636
LIG_14-3-3_CanoR_1	279	285	PF00244	0.523
LIG_14-3-3_CanoR_1	65	75	PF00244	0.549
LIG_Actin_WH2_2	280	297	PF00022	0.513
LIG_FHA_1	10	16	PF00498	0.677
LIG_FHA_1	38	44	PF00498	0.546
LIG_FHA_1	74	80	PF00498	0.664
LIG_FHA_2	281	287	PF00498	0.541
LIG_FHA_2	49	55	PF00498	0.763
LIG_LIR_Apic_2	327	332	PF02991	0.539
LIG_SH3_3	137	143	PF00018	0.428
LIG_SH3_3	61	67	PF00018	0.665
LIG_SH3_4	33	40	PF00018	0.586
LIG_SUMO_SIM_par_1	110	119	PF11976	0.499
LIG_SUMO_SIM_par_1	39	44	PF11976	0.545
LIG_TRAF2_1	207	210	PF00917	0.428
LIG_TRAF2_1	296	299	PF00917	0.593
MOD_CK1_1	110	116	PF00069	0.706
MOD_CK1_1	122	128	PF00069	0.674
MOD_CK1_1	66	72	PF00069	0.687
MOD_CK1_1	73	79	PF00069	0.644
MOD_CK2_1	293	299	PF00069	0.629
MOD_CK2_1	318	324	PF00069	0.744
MOD_Cter_Amidation	351	354	PF01082	0.579
MOD_GlcNHglycan	101	104	PF01048	0.646
MOD_GlcNHglycan	123	127	PF01048	0.661
MOD_GlcNHglycan	133	136	PF01048	0.599
MOD_GlcNHglycan	28	31	PF01048	0.766
MOD_GlcNHglycan	305	308	PF01048	0.649
MOD_GlcNHglycan	312	315	PF01048	0.667
MOD_GlcNHglycan	363	366	PF01048	0.605
MOD_GlcNHglycan	400	406	PF01048	0.655
MOD_GSK3_1	107	114	PF00069	0.712
MOD_GSK3_1	22	29	PF00069	0.746
MOD_GSK3_1	310	317	PF00069	0.752
MOD_GSK3_1	33	40	PF00069	0.665
MOD_GSK3_1	361	368	PF00069	0.614
MOD_GSK3_1	66	73	PF00069	0.759
MOD_N-GLC_1	280	285	PF02516	0.572
MOD_NEK2_1	107	112	PF00069	0.749
MOD_NEK2_1	144	149	PF00069	0.428
MOD_NEK2_1	2	7	PF00069	0.766
MOD_NEK2_1	39	44	PF00069	0.721
MOD_PIKK_1	33	39	PF00454	0.709
MOD_PKA_1	242	248	PF00069	0.590
MOD_PKA_2	242	248	PF00069	0.643
MOD_PKA_2	85	91	PF00069	0.736
MOD_PKA_2	9	15	PF00069	0.747
MOD_PKB_1	26	34	PF00069	0.775
MOD_PKB_1	273	281	PF00069	0.569
MOD_Plk_1	280	286	PF00069	0.573
MOD_Plk_1	298	304	PF00069	0.597
MOD_Plk_4	111	117	PF00069	0.757
MOD_Plk_4	298	304	PF00069	0.664
MOD_Plk_4	70	76	PF00069	0.664
MOD_ProDKin_1	63	69	PF00069	0.662
MOD_SUMO_for_1	205	208	PF00179	0.428
MOD_SUMO_rev_2	66	74	PF00179	0.597
TRG_ER_diArg_1	252	255	PF00400	0.542
TRG_ER_diArg_1	395	398	PF00400	0.745
TRG_ER_diLys_1	424	429	PF00400	0.681
TRG_NLS_Bipartite_1	138	156	PF00514	0.428
TRG_NLS_MonoExtC_3	423	428	PF00514	0.679
TRG_NLS_MonoExtN_4	421	428	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X6	Leptomonas seymouri	62%	77%
A0A1X0NU15	Trypanosomatidae	45%	93%
A0A3S7WTI8	Leishmania donovani	90%	100%
A4H876	Leishmania braziliensis	84%	98%
A4HWK1	Leishmania infantum	91%	100%
Q4QF81	Leishmania major	91%	99%