60S ribosomal protein L6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L6, putative

Species:

Leishmania mexicana

UniProt:

E9AQ99_LEIMU

TriTrypDb:

LmxM.15.1000

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

E9AQ99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ99

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17
GO:0043043	peptide biosynthetic process	5	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043603	amide metabolic process	3	17
GO:0043604	amide biosynthetic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044271	cellular nitrogen compound biosynthetic process	4	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901566	organonitrogen compound biosynthetic process	4	17
GO:1901576	organic substance biosynthetic process	3	17
GO:0000027	ribosomal large subunit assembly	7	2
GO:0002181	cytoplasmic translation	5	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.518
CLV_NRD_NRD_1	10	12	PF00675	0.609
CLV_NRD_NRD_1	18	20	PF00675	0.498
CLV_NRD_NRD_1	27	29	PF00675	0.392
CLV_NRD_NRD_1	47	49	PF00675	0.405
CLV_NRD_NRD_1	75	77	PF00675	0.290
CLV_PCSK_FUR_1	45	49	PF00082	0.419
CLV_PCSK_KEX2_1	10	12	PF00082	0.651
CLV_PCSK_KEX2_1	47	49	PF00082	0.405
CLV_PCSK_KEX2_1	75	77	PF00082	0.290
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.651
CLV_PCSK_PC7_1	43	49	PF00082	0.423
CLV_PCSK_SKI1_1	12	16	PF00082	0.573
CLV_PCSK_SKI1_1	130	134	PF00082	0.395
CLV_PCSK_SKI1_1	177	181	PF00082	0.346
DOC_CKS1_1	98	103	PF01111	0.448
DOC_MAPK_gen_1	43	52	PF00069	0.418
DOC_MAPK_RevD_3	61	76	PF00069	0.429
DOC_PP4_FxxP_1	104	107	PF00568	0.498
DOC_USP7_MATH_1	112	116	PF00917	0.542
DOC_USP7_UBL2_3	12	16	PF12436	0.578
DOC_USP7_UBL2_3	123	127	PF12436	0.526
DOC_USP7_UBL2_3	130	134	PF12436	0.484
DOC_USP7_UBL2_3	137	141	PF12436	0.455
DOC_USP7_UBL2_3	6	10	PF12436	0.557
DOC_WW_Pin1_4	18	23	PF00397	0.561
DOC_WW_Pin1_4	97	102	PF00397	0.544
LIG_14-3-3_CanoR_1	177	183	PF00244	0.586
LIG_14-3-3_CanoR_1	28	36	PF00244	0.440
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_3	1	5	PF00653	0.628
LIG_BIR_III_4	166	170	PF00653	0.586
LIG_FHA_1	33	39	PF00498	0.271
LIG_FHA_1	94	100	PF00498	0.483
LIG_FHA_2	111	117	PF00498	0.604
LIG_FHA_2	141	147	PF00498	0.484
LIG_FHA_2	85	91	PF00498	0.490
LIG_LIR_Apic_2	102	107	PF02991	0.498
LIG_LIR_Gen_1	21	32	PF02991	0.582
LIG_LIR_Nem_3	21	27	PF02991	0.534
LIG_SH2_CRK	24	28	PF00017	0.553
LIG_SH2_CRK	69	73	PF00017	0.490
LIG_SH2_SRC	81	84	PF00017	0.490
LIG_SH2_STAT5	175	178	PF00017	0.490
LIG_SH2_STAT5	24	27	PF00017	0.621
LIG_SH2_STAT5	81	84	PF00017	0.484
LIG_SH3_3	2	8	PF00018	0.418
LIG_SH3_3	60	66	PF00018	0.548
LIG_SH3_3	95	101	PF00018	0.575
LIG_SUMO_SIM_anti_2	35	40	PF11976	0.269
LIG_SUMO_SIM_par_1	59	64	PF11976	0.444
LIG_UBA3_1	159	165	PF00899	0.489
MOD_CK1_1	178	184	PF00069	0.488
MOD_CK1_1	18	24	PF00069	0.531
MOD_CK1_1	93	99	PF00069	0.508
MOD_CK2_1	110	116	PF00069	0.498
MOD_Cter_Amidation	138	141	PF01082	0.335
MOD_Cter_Amidation	45	48	PF01082	0.425
MOD_GlcNHglycan	63	66	PF01048	0.413
MOD_GSK3_1	18	25	PF00069	0.555
MOD_GSK3_1	89	96	PF00069	0.507
MOD_NEK2_1	27	32	PF00069	0.540
MOD_NEK2_1	61	66	PF00069	0.411
MOD_NEK2_2	175	180	PF00069	0.490
MOD_PKA_1	133	139	PF00069	0.546
MOD_PKA_1	140	146	PF00069	0.546
MOD_PKA_1	15	21	PF00069	0.577
MOD_PKA_2	27	33	PF00069	0.494
MOD_Plk_1	22	28	PF00069	0.552
MOD_Plk_1	89	95	PF00069	0.528
MOD_Plk_2-3	90	96	PF00069	0.564
MOD_ProDKin_1	18	24	PF00069	0.562
MOD_ProDKin_1	97	103	PF00069	0.544
MOD_SUMO_for_1	107	110	PF00179	0.491
MOD_SUMO_for_1	126	129	PF00179	0.362
TRG_ENDOCYTIC_2	24	27	PF00928	0.558
TRG_ENDOCYTIC_2	69	72	PF00928	0.490
TRG_ER_diArg_1	44	47	PF00400	0.422
TRG_ER_diArg_1	74	76	PF00400	0.490
TRG_NLS_MonoExtN_4	8	14	PF00514	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT06	Leptomonas seymouri	92%	100%
A0A0S4JL50	Bodo saltans	75%	97%
A0A0S4JLI9	Bodo saltans	75%	97%
A0A1D8PCX8	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
A0A1X0NVD8	Trypanosomatidae	79%	100%
A0A1X0P118	Trypanosomatidae	79%	98%
A0A3Q8IAA6	Leishmania donovani	98%	99%
A0A3R7KR31	Trypanosoma rangeli	76%	100%
A0A3R7LKV1	Trypanosoma rangeli	77%	100%
A4H873	Leishmania braziliensis	95%	100%
A4HLB2	Leishmania braziliensis	94%	100%
A4HWJ8	Leishmania infantum	98%	99%
D0A4T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9B3Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	99%
P05739	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P0DJ56	Tetrahymena thermophila (strain SB210)	43%	100%
P34091	Mesembryanthemum crystallinum	41%	82%
P47991	Caenorhabditis elegans	38%	89%
P79071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	99%
Q02326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q02878	Homo sapiens	41%	67%
Q2YGT9	Sus scrofa	41%	68%
Q4Q4D3	Leishmania major	98%	100%
Q4QF84	Leishmania major	97%	100%
Q54D63	Dictyostelium discoideum	44%	82%
Q58DQ3	Bos taurus	40%	67%
Q6QMZ4	Chinchilla lanigera	40%	67%
Q9C9C5	Arabidopsis thaliana	38%	83%
Q9C9C6	Arabidopsis thaliana	37%	83%