Putative succinate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ98_LEIMU

TriTrypDb:

LmxM.15.0990

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ98

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.505
CLV_C14_Caspase3-7	66	70	PF00656	0.526
CLV_NRD_NRD_1	50	52	PF00675	0.603
CLV_PCSK_KEX2_1	163	165	PF00082	0.367
CLV_PCSK_KEX2_1	171	173	PF00082	0.420
CLV_PCSK_KEX2_1	190	192	PF00082	0.591
CLV_PCSK_KEX2_1	50	52	PF00082	0.603
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.367
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.420
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.591
CLV_PCSK_SKI1_1	160	164	PF00082	0.361
DEG_APCC_DBOX_1	72	80	PF00400	0.350
DOC_CKS1_1	29	34	PF01111	0.383
DOC_MAPK_MEF2A_6	171	179	PF00069	0.555
DOC_PP4_FxxP_1	102	105	PF00568	0.263
DOC_PP4_FxxP_1	152	155	PF00568	0.345
DOC_USP7_UBL2_3	186	190	PF12436	0.612
DOC_USP7_UBL2_3	38	42	PF12436	0.483
DOC_WW_Pin1_4	12	17	PF00397	0.474
DOC_WW_Pin1_4	164	169	PF00397	0.386
DOC_WW_Pin1_4	25	30	PF00397	0.476
LIG_14-3-3_CanoR_1	164	168	PF00244	0.456
LIG_eIF4E_1	18	24	PF01652	0.588
LIG_FHA_1	130	136	PF00498	0.389
LIG_FHA_1	168	174	PF00498	0.396
LIG_FHA_1	29	35	PF00498	0.564
LIG_FHA_1	47	53	PF00498	0.310
LIG_FHA_2	34	40	PF00498	0.497
LIG_LIR_Apic_2	100	105	PF02991	0.263
LIG_LIR_Gen_1	77	86	PF02991	0.268
LIG_LIR_Nem_3	111	115	PF02991	0.285
LIG_LIR_Nem_3	77	83	PF02991	0.344
LIG_PCNA_yPIPBox_3	50	63	PF02747	0.594
LIG_PTAP_UEV_1	1	6	PF05743	0.550
LIG_PTB_Apo_2	51	58	PF02174	0.441
LIG_PTB_Phospho_1	51	57	PF10480	0.442
LIG_SH2_CRK	13	17	PF00017	0.498
LIG_SH2_STAP1	80	84	PF00017	0.269
LIG_SH2_STAT5	35	38	PF00017	0.539
LIG_SH2_STAT5	57	60	PF00017	0.473
LIG_SH2_STAT5	63	66	PF00017	0.440
LIG_SH3_3	26	32	PF00018	0.401
MOD_CDK_SPK_2	25	30	PF00069	0.433
MOD_CDK_SPxxK_3	164	171	PF00069	0.515
MOD_CK1_1	166	172	PF00069	0.419
MOD_Cter_Amidation	188	191	PF01082	0.590
MOD_GlcNHglycan	2	5	PF01048	0.564
MOD_GSK3_1	163	170	PF00069	0.411
MOD_GSK3_1	24	31	PF00069	0.595
MOD_GSK3_1	84	91	PF00069	0.283
MOD_N-GLC_1	11	16	PF02516	0.617
MOD_N-GLC_1	143	148	PF02516	0.263
MOD_N-GLC_1	25	30	PF02516	0.452
MOD_N-GLC_1	55	60	PF02516	0.599
MOD_N-GLC_2	137	139	PF02516	0.277
MOD_NEK2_1	108	113	PF00069	0.285
MOD_NEK2_1	129	134	PF00069	0.359
MOD_NEK2_1	143	148	PF00069	0.209
MOD_NEK2_1	84	89	PF00069	0.269
MOD_OFUCOSY	82	88	PF10250	0.263
MOD_PKA_1	163	169	PF00069	0.460
MOD_PKA_2	163	169	PF00069	0.465
MOD_Plk_1	143	149	PF00069	0.263
MOD_Plk_1	55	61	PF00069	0.597
MOD_ProDKin_1	12	18	PF00069	0.474
MOD_ProDKin_1	164	170	PF00069	0.383
MOD_ProDKin_1	25	31	PF00069	0.480
MOD_SUMO_rev_2	159	165	PF00179	0.371
TRG_DiLeu_BaEn_1	131	136	PF01217	0.341
TRG_ENDOCYTIC_2	112	115	PF00928	0.277
TRG_ENDOCYTIC_2	20	23	PF00928	0.486
TRG_ENDOCYTIC_2	80	83	PF00928	0.263
TRG_ER_diArg_1	126	129	PF00400	0.389
TRG_ER_diArg_1	50	52	PF00400	0.357
TRG_ER_diArg_1	73	76	PF00400	0.364
TRG_NES_CRM1_1	117	131	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.263
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW5	Leptomonas seymouri	91%	100%
A0A0S4JJX0	Bodo saltans	72%	100%
A0A1X0NUF3	Trypanosomatidae	75%	100%
A0A3S5H6V4	Leishmania donovani	96%	100%
A0A422N147	Trypanosoma rangeli	72%	100%
A4H872	Leishmania braziliensis	93%	100%
A4HWJ7	Leishmania infantum	96%	100%
A5PL98	Danio rerio	41%	70%
B0BM36	Xenopus tropicalis	40%	69%
C9ZXU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
O42772	Zymoseptoria tritici	41%	66%
P21912	Homo sapiens	42%	70%
P21913	Rattus norvegicus	42%	70%
P80480	Reclinomonas americana	40%	82%
Q007T0	Sus scrofa	40%	70%
Q3B8J8	Xenopus laevis	40%	70%
Q3T189	Bos taurus	40%	70%
Q4QF85	Leishmania major	96%	100%
Q55CC2	Dictyostelium discoideum	38%	69%
Q70KF8	Uromyces fabae	40%	70%
Q9CQA3	Mus musculus	43%	70%
Q9YHT2	Gallus gallus	40%	68%