DNA repair protein Rad9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein Rad9, putative

Species:

Leishmania mexicana

UniProt:

E9AQ97_LEIMU

TriTrypDb:

LmxM.15.0980

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0030896	checkpoint clamp complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ97

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	7
GO:0000077	DNA damage checkpoint signaling	5	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0007165	signal transduction	2	7
GO:0009987	cellular process	1	7
GO:0010564	regulation of cell cycle process	5	7
GO:0010948	negative regulation of cell cycle process	6	7
GO:0031570	DNA integrity checkpoint signaling	5	7
GO:0033554	cellular response to stress	3	7
GO:0035556	intracellular signal transduction	3	7
GO:0042770	signal transduction in response to DNA damage	4	7
GO:0045786	negative regulation of cell cycle	5	7
GO:0048519	negative regulation of biological process	3	7
GO:0048523	negative regulation of cellular process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0051726	regulation of cell cycle	4	7
GO:0065007	biological regulation	1	7
GO:1901987	regulation of cell cycle phase transition	6	7
GO:1901988	negative regulation of cell cycle phase transition	7	7
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0010212	response to ionizing radiation	4	1
GO:0022402	cell cycle process	2	1
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071479	cellular response to ionizing radiation	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.560
CLV_C14_Caspase3-7	149	153	PF00656	0.482
CLV_C14_Caspase3-7	292	296	PF00656	0.672
CLV_C14_Caspase3-7	565	569	PF00656	0.660
CLV_C14_Caspase3-7	681	685	PF00656	0.650
CLV_NRD_NRD_1	330	332	PF00675	0.769
CLV_NRD_NRD_1	401	403	PF00675	0.607
CLV_NRD_NRD_1	411	413	PF00675	0.547
CLV_NRD_NRD_1	606	608	PF00675	0.748
CLV_NRD_NRD_1	70	72	PF00675	0.675
CLV_PCSK_KEX2_1	330	332	PF00082	0.769
CLV_PCSK_KEX2_1	400	402	PF00082	0.604
CLV_PCSK_KEX2_1	411	413	PF00082	0.534
CLV_PCSK_KEX2_1	70	72	PF00082	0.611
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.604
CLV_PCSK_SKI1_1	13	17	PF00082	0.466
CLV_PCSK_SKI1_1	164	168	PF00082	0.521
CLV_PCSK_SKI1_1	361	365	PF00082	0.500
CLV_PCSK_SKI1_1	401	405	PF00082	0.508
CLV_PCSK_SKI1_1	424	428	PF00082	0.821
CLV_PCSK_SKI1_1	492	496	PF00082	0.776
CLV_PCSK_SKI1_1	62	66	PF00082	0.608
CLV_PCSK_SKI1_1	688	692	PF00082	0.594
DEG_APCC_DBOX_1	12	20	PF00400	0.454
DEG_Kelch_Keap1_1	514	519	PF01344	0.762
DEG_SCF_FBW7_1	482	488	PF00400	0.713
DEG_SPOP_SBC_1	234	238	PF00917	0.669
DEG_SPOP_SBC_1	640	644	PF00917	0.627
DOC_CKS1_1	316	321	PF01111	0.725
DOC_CKS1_1	482	487	PF01111	0.713
DOC_CKS1_1	571	576	PF01111	0.737
DOC_MAPK_MEF2A_6	47	55	PF00069	0.428
DOC_MAPK_RevD_3	388	402	PF00069	0.549
DOC_PP1_RVXF_1	606	613	PF00149	0.743
DOC_PP2B_LxvP_1	216	219	PF13499	0.612
DOC_PP2B_LxvP_1	65	68	PF13499	0.642
DOC_PP2B_PxIxI_1	9	15	PF00149	0.588
DOC_PP4_FxxP_1	284	287	PF00568	0.540
DOC_SPAK_OSR1_1	190	194	PF12202	0.550
DOC_USP7_MATH_1	132	136	PF00917	0.735
DOC_USP7_MATH_1	141	145	PF00917	0.601
DOC_USP7_MATH_1	199	203	PF00917	0.505
DOC_USP7_MATH_1	232	236	PF00917	0.623
DOC_USP7_MATH_1	245	249	PF00917	0.662
DOC_USP7_MATH_1	256	260	PF00917	0.598
DOC_USP7_MATH_1	265	269	PF00917	0.406
DOC_USP7_MATH_1	274	278	PF00917	0.372
DOC_USP7_MATH_1	289	293	PF00917	0.676
DOC_USP7_MATH_1	305	309	PF00917	0.543
DOC_USP7_MATH_1	449	453	PF00917	0.573
DOC_USP7_MATH_1	459	463	PF00917	0.808
DOC_USP7_MATH_1	477	481	PF00917	0.523
DOC_USP7_MATH_1	485	489	PF00917	0.680
DOC_USP7_MATH_1	524	528	PF00917	0.795
DOC_USP7_MATH_1	578	582	PF00917	0.771
DOC_USP7_MATH_1	598	602	PF00917	0.659
DOC_USP7_MATH_1	606	610	PF00917	0.739
DOC_USP7_MATH_1	616	620	PF00917	0.645
DOC_USP7_MATH_1	622	626	PF00917	0.620
DOC_USP7_MATH_1	635	639	PF00917	0.771
DOC_USP7_MATH_1	641	645	PF00917	0.655
DOC_USP7_MATH_1	651	655	PF00917	0.543
DOC_USP7_MATH_1	696	700	PF00917	0.602
DOC_WW_Pin1_4	287	292	PF00397	0.685
DOC_WW_Pin1_4	315	320	PF00397	0.745
DOC_WW_Pin1_4	325	330	PF00397	0.765
DOC_WW_Pin1_4	348	353	PF00397	0.429
DOC_WW_Pin1_4	391	396	PF00397	0.516
DOC_WW_Pin1_4	41	46	PF00397	0.455
DOC_WW_Pin1_4	481	486	PF00397	0.732
DOC_WW_Pin1_4	504	509	PF00397	0.837
DOC_WW_Pin1_4	570	575	PF00397	0.738
DOC_WW_Pin1_4	576	581	PF00397	0.720
DOC_WW_Pin1_4	589	594	PF00397	0.501
DOC_WW_Pin1_4	643	648	PF00397	0.720
LIG_14-3-3_CanoR_1	13	22	PF00244	0.419
LIG_14-3-3_CanoR_1	157	163	PF00244	0.479
LIG_14-3-3_CanoR_1	486	494	PF00244	0.852
LIG_14-3-3_CanoR_1	607	611	PF00244	0.794
LIG_BIR_II_1	1	5	PF00653	0.458
LIG_BIR_III_4	295	299	PF00653	0.742
LIG_BIR_III_4	675	679	PF00653	0.506
LIG_BRCT_BRCA1_1	1	5	PF00533	0.468
LIG_BRCT_BRCA1_1	123	127	PF00533	0.498
LIG_BRCT_BRCA1_1	608	612	PF00533	0.742
LIG_EVH1_2	311	315	PF00568	0.547
LIG_FHA_1	105	111	PF00498	0.496
LIG_FHA_1	167	173	PF00498	0.488
LIG_FHA_1	276	282	PF00498	0.592
LIG_FHA_1	355	361	PF00498	0.549
LIG_FHA_2	215	221	PF00498	0.536
LIG_FHA_2	271	277	PF00498	0.577
LIG_FHA_2	292	298	PF00498	0.723
LIG_FHA_2	379	385	PF00498	0.563
LIG_FHA_2	392	398	PF00498	0.429
LIG_FHA_2	586	592	PF00498	0.698
LIG_GBD_Chelix_1	369	377	PF00786	0.490
LIG_LIR_Apic_2	568	574	PF02991	0.780
LIG_LIR_Gen_1	180	191	PF02991	0.613
LIG_LIR_Gen_1	276	287	PF02991	0.615
LIG_LIR_Gen_1	57	68	PF02991	0.442
LIG_LIR_Gen_1	659	667	PF02991	0.569
LIG_LIR_Nem_3	180	186	PF02991	0.639
LIG_LIR_Nem_3	276	282	PF02991	0.592
LIG_LIR_Nem_3	347	353	PF02991	0.732
LIG_LIR_Nem_3	442	446	PF02991	0.575
LIG_LIR_Nem_3	57	63	PF02991	0.422
LIG_LIR_Nem_3	659	663	PF02991	0.571
LIG_Pex14_1	158	162	PF04695	0.464
LIG_Pex14_2	275	279	PF04695	0.504
LIG_PTAP_UEV_1	432	437	PF05743	0.472
LIG_SH2_CRK	183	187	PF00017	0.568
LIG_SH2_CRK	200	204	PF00017	0.470
LIG_SH2_CRK	571	575	PF00017	0.765
LIG_SH2_GRB2like	183	186	PF00017	0.339
LIG_SH2_NCK_1	667	671	PF00017	0.624
LIG_SH2_STAP1	162	166	PF00017	0.479
LIG_SH2_STAT5	102	105	PF00017	0.493
LIG_SH2_STAT5	30	33	PF00017	0.446
LIG_SH2_STAT5	446	449	PF00017	0.570
LIG_SH2_STAT5	667	670	PF00017	0.594
LIG_SH3_1	313	319	PF00018	0.551
LIG_SH3_3	308	314	PF00018	0.757
LIG_SH3_3	4	10	PF00018	0.577
LIG_SH3_3	430	436	PF00018	0.741
LIG_SH3_3	479	485	PF00018	0.702
LIG_SUMO_SIM_anti_2	581	588	PF11976	0.802
LIG_SUMO_SIM_par_1	386	392	PF11976	0.483
LIG_SUMO_SIM_par_1	581	588	PF11976	0.704
LIG_SUMO_SIM_par_1	63	69	PF11976	0.562
LIG_TRAF2_1	381	384	PF00917	0.569
LIG_TRAF2_1	394	397	PF00917	0.448
LIG_TRAF2_1	677	680	PF00917	0.701
LIG_WRC_WIRS_1	440	445	PF05994	0.488
LIG_WW_3	310	314	PF00397	0.542
MOD_CDC14_SPxK_1	328	331	PF00782	0.759
MOD_CDC14_SPxK_1	44	47	PF00782	0.637
MOD_CDK_SPK_2	325	330	PF00069	0.766
MOD_CDK_SPK_2	481	486	PF00069	0.732
MOD_CDK_SPK_2	570	575	PF00069	0.738
MOD_CDK_SPxK_1	325	331	PF00069	0.765
MOD_CDK_SPxK_1	41	47	PF00069	0.506
MOD_CDK_SPxxK_3	589	596	PF00069	0.720
MOD_CK1_1	134	140	PF00069	0.773
MOD_CK1_1	17	23	PF00069	0.538
MOD_CK1_1	206	212	PF00069	0.525
MOD_CK1_1	235	241	PF00069	0.782
MOD_CK1_1	277	283	PF00069	0.520
MOD_CK1_1	333	339	PF00069	0.755
MOD_CK1_1	41	47	PF00069	0.506
MOD_CK1_1	452	458	PF00069	0.638
MOD_CK1_1	473	479	PF00069	0.792
MOD_CK1_1	527	533	PF00069	0.830
MOD_CK1_1	542	548	PF00069	0.716
MOD_CK1_1	560	566	PF00069	0.722
MOD_CK1_1	597	603	PF00069	0.687
MOD_CK1_1	643	649	PF00069	0.545
MOD_CK1_1	69	75	PF00069	0.754
MOD_CK2_1	141	147	PF00069	0.504
MOD_CK2_1	214	220	PF00069	0.518
MOD_CK2_1	245	251	PF00069	0.793
MOD_CK2_1	270	276	PF00069	0.537
MOD_CK2_1	378	384	PF00069	0.555
MOD_CK2_1	391	397	PF00069	0.430
MOD_CK2_1	534	540	PF00069	0.828
MOD_CK2_1	576	582	PF00069	0.724
MOD_CK2_1	666	672	PF00069	0.710
MOD_GlcNHglycan	136	139	PF01048	0.759
MOD_GlcNHglycan	149	152	PF01048	0.509
MOD_GlcNHglycan	16	19	PF01048	0.350
MOD_GlcNHglycan	209	212	PF01048	0.504
MOD_GlcNHglycan	220	223	PF01048	0.489
MOD_GlcNHglycan	239	242	PF01048	0.715
MOD_GlcNHglycan	247	250	PF01048	0.667
MOD_GlcNHglycan	251	254	PF01048	0.706
MOD_GlcNHglycan	258	261	PF01048	0.675
MOD_GlcNHglycan	291	294	PF01048	0.703
MOD_GlcNHglycan	335	338	PF01048	0.748
MOD_GlcNHglycan	342	345	PF01048	0.642
MOD_GlcNHglycan	39	43	PF01048	0.466
MOD_GlcNHglycan	405	408	PF01048	0.617
MOD_GlcNHglycan	433	436	PF01048	0.734
MOD_GlcNHglycan	453	457	PF01048	0.548
MOD_GlcNHglycan	459	462	PF01048	0.720
MOD_GlcNHglycan	479	482	PF01048	0.487
MOD_GlcNHglycan	497	500	PF01048	0.739
MOD_GlcNHglycan	526	529	PF01048	0.847
MOD_GlcNHglycan	532	535	PF01048	0.749
MOD_GlcNHglycan	568	571	PF01048	0.844
MOD_GlcNHglycan	596	599	PF01048	0.777
MOD_GlcNHglycan	600	603	PF01048	0.790
MOD_GlcNHglycan	635	638	PF01048	0.789
MOD_GlcNHglycan	668	671	PF01048	0.634
MOD_GlcNHglycan	7	10	PF01048	0.454
MOD_GlcNHglycan	75	80	PF01048	0.712
MOD_GSK3_1	106	113	PF00069	0.430
MOD_GSK3_1	117	124	PF00069	0.502
MOD_GSK3_1	128	135	PF00069	0.563
MOD_GSK3_1	158	165	PF00069	0.469
MOD_GSK3_1	199	206	PF00069	0.462
MOD_GSK3_1	214	221	PF00069	0.405
MOD_GSK3_1	232	239	PF00069	0.697
MOD_GSK3_1	241	248	PF00069	0.616
MOD_GSK3_1	266	273	PF00069	0.535
MOD_GSK3_1	287	294	PF00069	0.684
MOD_GSK3_1	340	347	PF00069	0.732
MOD_GSK3_1	469	476	PF00069	0.717
MOD_GSK3_1	477	484	PF00069	0.684
MOD_GSK3_1	486	493	PF00069	0.677
MOD_GSK3_1	523	530	PF00069	0.831
MOD_GSK3_1	539	546	PF00069	0.716
MOD_GSK3_1	562	569	PF00069	0.771
MOD_GSK3_1	570	577	PF00069	0.678
MOD_GSK3_1	585	592	PF00069	0.530
MOD_GSK3_1	594	601	PF00069	0.743
MOD_GSK3_1	623	630	PF00069	0.751
MOD_GSK3_1	635	642	PF00069	0.719
MOD_GSK3_1	643	650	PF00069	0.700
MOD_GSK3_1	690	697	PF00069	0.594
MOD_GSK3_1	75	82	PF00069	0.764
MOD_N-GLC_1	184	189	PF02516	0.385
MOD_N-GLC_1	528	533	PF02516	0.754
MOD_N-GLC_1	563	568	PF02516	0.829
MOD_N-GLC_1	623	628	PF02516	0.541
MOD_N-GLC_2	212	214	PF02516	0.611
MOD_NEK2_1	106	111	PF00069	0.484
MOD_NEK2_1	166	171	PF00069	0.589
MOD_NEK2_1	203	208	PF00069	0.493
MOD_NEK2_1	275	280	PF00069	0.602
MOD_NEK2_1	3	8	PF00069	0.455
MOD_NEK2_1	426	431	PF00069	0.775
MOD_NEK2_1	543	548	PF00069	0.816
MOD_NEK2_1	585	590	PF00069	0.807
MOD_NEK2_1	663	668	PF00069	0.576
MOD_NEK2_1	690	695	PF00069	0.590
MOD_NEK2_2	258	263	PF00069	0.634
MOD_NEK2_2	651	656	PF00069	0.753
MOD_PK_1	330	336	PF00069	0.761
MOD_PKA_1	330	336	PF00069	0.761
MOD_PKA_1	401	407	PF00069	0.517
MOD_PKA_2	249	255	PF00069	0.806
MOD_PKA_2	330	336	PF00069	0.761
MOD_PKA_2	401	407	PF00069	0.616
MOD_PKA_2	457	463	PF00069	0.833
MOD_PKA_2	485	491	PF00069	0.746
MOD_PKA_2	557	563	PF00069	0.751
MOD_PKA_2	574	580	PF00069	0.828
MOD_PKA_2	606	612	PF00069	0.744
MOD_PKA_2	69	75	PF00069	0.668
MOD_Plk_1	184	190	PF00069	0.611
MOD_Plk_1	275	281	PF00069	0.532
MOD_Plk_1	38	44	PF00069	0.465
MOD_Plk_1	469	475	PF00069	0.793
MOD_Plk_1	539	545	PF00069	0.818
MOD_Plk_1	563	569	PF00069	0.831
MOD_Plk_1	623	629	PF00069	0.542
MOD_Plk_4	106	112	PF00069	0.488
MOD_Plk_4	166	172	PF00069	0.484
MOD_Plk_4	178	184	PF00069	0.529
MOD_Plk_4	199	205	PF00069	0.486
MOD_Plk_4	267	273	PF00069	0.539
MOD_Plk_4	330	336	PF00069	0.761
MOD_Plk_4	436	442	PF00069	0.545
MOD_Plk_4	651	657	PF00069	0.756
MOD_ProDKin_1	287	293	PF00069	0.690
MOD_ProDKin_1	315	321	PF00069	0.746
MOD_ProDKin_1	325	331	PF00069	0.764
MOD_ProDKin_1	348	354	PF00069	0.414
MOD_ProDKin_1	391	397	PF00069	0.520
MOD_ProDKin_1	41	47	PF00069	0.464
MOD_ProDKin_1	481	487	PF00069	0.734
MOD_ProDKin_1	504	510	PF00069	0.834
MOD_ProDKin_1	570	576	PF00069	0.735
MOD_ProDKin_1	589	595	PF00069	0.503
MOD_ProDKin_1	643	649	PF00069	0.720
TRG_DiLeu_BaEn_2	685	691	PF01217	0.603
TRG_DiLeu_BaEn_3	383	389	PF01217	0.528
TRG_ENDOCYTIC_2	102	105	PF00928	0.493
TRG_ENDOCYTIC_2	183	186	PF00928	0.625
TRG_ENDOCYTIC_2	200	203	PF00928	0.332
TRG_ER_diArg_1	329	331	PF00400	0.757
TRG_ER_diArg_1	401	403	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	492	497	PF00026	0.775
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I126	Leptomonas seymouri	47%	90%
A0A3Q8IIS7	Leishmania donovani	88%	98%
A4H871	Leishmania braziliensis	73%	97%
A4HWJ6	Leishmania infantum	87%	82%
Q4QF86	Leishmania major	87%	100%