Sulfhydryl oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sulfhydryl oxidase

Gene product:

ERV/ALR sulfhydryl oxidase domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AQ95_LEIMU

TriTrypDb:

LmxM.15.0960

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ95

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	9
GO:0016971	flavin-linked sulfhydryl oxidase activity	4	9
GO:0016972	thiol oxidase activity	5	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.375
CLV_C14_Caspase3-7	233	237	PF00656	0.625
CLV_C14_Caspase3-7	288	292	PF00656	0.641
CLV_NRD_NRD_1	116	118	PF00675	0.492
CLV_NRD_NRD_1	158	160	PF00675	0.609
CLV_NRD_NRD_1	199	201	PF00675	0.676
CLV_PCSK_KEX2_1	116	118	PF00082	0.490
CLV_PCSK_KEX2_1	158	160	PF00082	0.614
CLV_PCSK_KEX2_1	295	297	PF00082	0.588
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.588
CLV_PCSK_SKI1_1	104	108	PF00082	0.560
CLV_PCSK_SKI1_1	147	151	PF00082	0.671
CLV_PCSK_SKI1_1	158	162	PF00082	0.413
CLV_PCSK_SKI1_1	201	205	PF00082	0.755
CLV_PCSK_SKI1_1	295	299	PF00082	0.621
DEG_MDM2_SWIB_1	53	60	PF02201	0.310
DOC_CKS1_1	238	243	PF01111	0.691
DOC_CKS1_1	275	280	PF01111	0.713
DOC_PP4_FxxP_1	163	166	PF00568	0.437
DOC_PP4_FxxP_1	199	202	PF00568	0.669
DOC_PP4_FxxP_1	273	276	PF00568	0.722
DOC_USP7_MATH_1	208	212	PF00917	0.716
DOC_USP7_MATH_1	248	252	PF00917	0.748
DOC_USP7_MATH_1	269	273	PF00917	0.806
DOC_USP7_MATH_1	276	280	PF00917	0.572
DOC_USP7_UBL2_3	143	147	PF12436	0.609
DOC_WW_Pin1_4	107	112	PF00397	0.360
DOC_WW_Pin1_4	16	21	PF00397	0.494
DOC_WW_Pin1_4	218	223	PF00397	0.702
DOC_WW_Pin1_4	237	242	PF00397	0.819
DOC_WW_Pin1_4	274	279	PF00397	0.751
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_CtBP_PxDLS_1	20	24	PF00389	0.536
LIG_FHA_1	241	247	PF00498	0.795
LIG_FHA_2	129	135	PF00498	0.560
LIG_FHA_2	143	149	PF00498	0.540
LIG_FHA_2	17	23	PF00498	0.474
LIG_FHA_2	224	230	PF00498	0.644
LIG_FHA_2	286	292	PF00498	0.660
LIG_LIR_Apic_2	161	166	PF02991	0.424
LIG_LIR_Apic_2	271	276	PF02991	0.658
LIG_LIR_Gen_1	26	36	PF02991	0.360
LIG_LIR_Gen_1	55	62	PF02991	0.327
LIG_LIR_Nem_3	195	199	PF02991	0.635
LIG_LIR_Nem_3	26	31	PF02991	0.360
LIG_LIR_Nem_3	55	60	PF02991	0.299
LIG_LIR_Nem_3	64	68	PF02991	0.299
LIG_PCNA_yPIPBox_3	41	54	PF02747	0.360
LIG_Pex14_1	118	122	PF04695	0.452
LIG_Pex14_1	57	61	PF04695	0.301
LIG_Pex14_2	53	57	PF04695	0.290
LIG_SH2_STAP1	61	65	PF00017	0.360
LIG_SH2_STAT5	303	306	PF00017	0.588
LIG_SH2_STAT5	73	76	PF00017	0.301
LIG_SH2_STAT5	90	93	PF00017	0.301
LIG_SH3_1	117	123	PF00018	0.376
LIG_SH3_2	120	125	PF14604	0.573
LIG_SH3_3	117	123	PF00018	0.376
LIG_SH3_3	299	305	PF00018	0.565
LIG_SH3_3	36	42	PF00018	0.301
LIG_SxIP_EBH_1	9	19	PF03271	0.590
LIG_TRAF2_1	131	134	PF00917	0.522
MOD_CDK_SPxK_1	274	280	PF00069	0.723
MOD_CK1_1	231	237	PF00069	0.680
MOD_CK2_1	128	134	PF00069	0.525
MOD_CK2_1	136	142	PF00069	0.521
MOD_CK2_1	16	22	PF00069	0.524
MOD_CK2_1	223	229	PF00069	0.735
MOD_CK2_1	262	268	PF00069	0.686
MOD_GlcNHglycan	25	28	PF01048	0.406
MOD_GlcNHglycan	264	267	PF01048	0.563
MOD_GlcNHglycan	33	36	PF01048	0.510
MOD_GlcNHglycan	42	45	PF01048	0.478
MOD_GSK3_1	179	186	PF00069	0.763
MOD_GSK3_1	214	221	PF00069	0.708
MOD_GSK3_1	228	235	PF00069	0.798
MOD_GSK3_1	260	267	PF00069	0.736
MOD_N-GLC_1	217	222	PF02516	0.797
MOD_NEK2_1	23	28	PF00069	0.504
MOD_NEK2_1	31	36	PF00069	0.360
MOD_NEK2_1	53	58	PF00069	0.325
MOD_NEK2_1	85	90	PF00069	0.350
MOD_PIKK_1	223	229	PF00454	0.814
MOD_PKA_1	158	164	PF00069	0.608
MOD_PKA_2	158	164	PF00069	0.611
MOD_PKA_2	8	14	PF00069	0.723
MOD_Plk_2-3	128	134	PF00069	0.521
MOD_Plk_2-3	285	291	PF00069	0.659
MOD_Plk_4	109	115	PF00069	0.342
MOD_Plk_4	269	275	PF00069	0.802
MOD_ProDKin_1	107	113	PF00069	0.360
MOD_ProDKin_1	16	22	PF00069	0.490
MOD_ProDKin_1	218	224	PF00069	0.699
MOD_ProDKin_1	237	243	PF00069	0.819
MOD_ProDKin_1	274	280	PF00069	0.753
TRG_ER_diArg_1	115	117	PF00400	0.291
TRG_ER_diArg_1	158	160	PF00400	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T9	Leptomonas seymouri	52%	99%
A0A3Q8ICB2	Leishmania donovani	90%	100%
A4H869	Leishmania braziliensis	79%	100%
A4HWJ4	Leishmania infantum	90%	100%
C9ZXU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QF88	Leishmania major	87%	100%
V5DL65	Trypanosoma cruzi	37%	92%